Details of the Target

General Information of Target

Target ID LDTP05223
Target Name FYVE, RhoGEF and PH domain-containing protein 1 (FGD1)
Gene Name FGD1
Gene ID 2245
Synonyms
FGDY; ZFYVE3; FYVE, RhoGEF and PH domain-containing protein 1; Faciogenital dysplasia 1 protein; Rho/Rac guanine nucleotide exchange factor FGD1; Rho/Rac GEF; Zinc finger FYVE domain-containing protein 3
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MHGHRAPGGAGPSEPEHPATNPPGAAPPACADSDPGASEPGLLARRGSGSALGGPLDPQF
VGPSDTSLGAAPGHRVLPCGPSPQHHRALRFSYHLEGSQPRPGLHQGNRILVKSLSLDPG
QSLEPHPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKPSYLQMPRMPPPLEPI
PPPPSRPLPADPRVAKGLAPRAEASPSSAAVSSLIEKFEREPVIVASDRPVPGPSPGPPE
PVMLPQPTSQPPVPQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEETCFV
SDDGPPSHSLCPGPPALASVPVALADPHRPGSQEVDSDLEEEDDEEEEEEKDREIPVPLM
ERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHG
IFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVEL
VNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPD
SKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKL
SAKNGTTQDRYLILFNDRLLYCVPRLRLLGQKFSVRARIDVDGMELKESSNLNLPRTFLV
SGKQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFKLLNSTNREDEDTPPNSPNVDL
GKRAPTPIREKEVTMCMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARLVYDNNRSNR
VCTDCYVALHGVPGSSPACSQHTPQRRRSILEKQASVAAENSVICSFLHYMEKGGKGWHK
AWFVVPENEPLVLYIYGAPQDVKAQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWY
FSPETEELQRRWMAVLGRAGRGDTFCPGPTLSEDREMEEAPVAALGATAEPPESPQTRDK
T
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.
Uniprot ID
P98174
Ensemble ID
ENST00000375135.4
HGNC ID
HGNC:3663
ChEMBL ID
CHEMBL2862

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C756(0.84); C761(0.84)  LDD0078  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
IPM
 Probe Info  		C264(0.00); C79(0.00)  LDD0147  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
AOyne
 Probe Info  		12.00  LDD0443  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C264(1.01)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C264(1.37)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C264(0.80)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C264(0.86)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C264(0.82)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C264(1.05)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C264(0.86)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C264(1.08)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C264(0.98)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C264(0.77)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C264(1.22)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C264(1.37)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C264(1.71)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C264(1.08)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C264(0.95)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C264(0.85)  LDD0546  [1]
 LDCM0230  AC113 HEK-293T C264(1.07)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C264(1.08)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C264(1.13)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C264(0.93)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C264(1.11)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C264(0.73)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C264(0.93)  LDD0834  [1]
 LDCM0237  AC12 HCT 116 C264(1.45)  LDD0554  [1]
 LDCM0238  AC120 HEK-293T C264(0.88)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C264(1.57)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C264(1.19)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C264(1.26)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C264(1.24)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C264(1.35)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C264(1.80)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C264(1.24)  LDD0843  [1]
 LDCM0246  AC128 HEK-293T C264(1.07); C756(0.72); C761(0.72)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C264(1.42); C756(0.77); C761(0.77)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C264(1.37); C756(0.78); C761(0.78)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C264(1.05); C756(0.92); C761(0.92)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C264(1.37); C756(0.82); C761(0.82)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C264(1.35); C756(0.80); C761(0.80)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C264(1.48); C756(0.81); C761(0.81)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C264(1.13); C756(0.74); C761(0.74)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C264(1.13); C756(1.14); C761(1.14)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C264(1.07); C756(1.12); C761(1.12)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C264(1.57); C756(1.17); C761(1.17)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C264(1.37); C756(1.09); C761(1.09)  LDD0856  [1]
 LDCM0259  AC14 HCT 116 C264(1.30)  LDD0576  [1]
 LDCM0260  AC140 HEK-293T C264(1.29); C756(0.64); C761(0.64)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C264(1.11); C756(1.18); C761(1.18)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C264(1.34); C756(0.87); C761(0.87)  LDD0860  [1]
 LDCM0263  AC143 HEK-293T C264(0.85)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C264(0.93)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C264(0.99)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C264(0.96)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C264(0.68)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C264(0.72)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C264(0.92)  LDD0867  [1]
 LDCM0270  AC15 HCT 116 C264(1.47)  LDD0587  [1]
 LDCM0271  AC150 HEK-293T C264(0.78)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C264(0.75)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C264(0.95)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C264(0.99)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C264(0.86)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C264(1.00)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C264(0.92)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C264(1.02)  LDD2165  [1]
 LDCM0276  AC17 HCT 116 C264(1.39)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C264(1.21)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C264(1.54)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C264(1.09)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C264(1.22)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C264(1.23)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C264(1.12)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C264(1.29)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C264(1.11)  LDD0601  [1]
 LDCM0285  AC25 HEK-293T C756(1.23); C761(1.23)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C756(1.26); C761(1.26)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C756(1.18); C761(1.18)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C756(2.39); C761(2.39)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C756(1.37); C761(1.37)  LDD0887  [1]
 LDCM0290  AC3 HCT 116 C264(1.12)  LDD0607  [1]
 LDCM0291  AC30 HEK-293T C756(1.22); C761(1.22)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C756(1.12); C761(1.12)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C756(1.07); C761(1.07)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C756(1.38); C761(1.38)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C756(0.99); C761(0.99)  LDD0893  [1]
 LDCM0296  AC35 HCT 116 C264(1.12)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C264(1.10)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C264(1.25)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C264(1.22)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C264(1.00)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C264(1.03)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C264(0.85)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C264(1.32)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C264(1.28)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C264(1.29)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C264(1.21)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C264(1.29)  LDD0624  [1]
 LDCM0308  AC46 HEK-293T C264(0.95); C400(1.22)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C264(0.93); C400(1.17)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C264(0.78); C400(1.14)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C264(0.90); C400(1.19)  LDD0909  [1]
 LDCM0312  AC5 HCT 116 C264(1.04)  LDD0629  [1]
 LDCM0313  AC50 HEK-293T C264(1.16); C400(1.17)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C264(1.06); C400(1.61)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C264(1.21); C400(1.06)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C264(1.19); C400(1.27)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C264(1.19); C400(1.55)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C264(1.13); C400(1.34)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C264(1.02); C400(1.33)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C264(1.05); C400(1.02); C756(1.20); C761(1.20)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C264(1.06); C400(1.23); C756(1.18); C761(1.18)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C264(1.02); C400(1.57); C756(1.03); C761(1.03)  LDD0920  [1]
 LDCM0323  AC6 HCT 116 C264(1.24)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C264(0.99); C400(1.24); C756(3.14); C761(3.14)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C264(1.12); C400(1.00); C756(1.55); C761(1.55)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C264(1.08); C400(1.25); C756(1.35); C761(1.35)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C264(1.10); C400(1.41); C756(1.68); C761(1.68)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C264(1.02); C400(1.28); C756(1.58); C761(1.58)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C264(1.10); C400(0.92); C756(2.00); C761(2.00)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C264(1.02); C400(1.25); C756(1.24); C761(1.24)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C264(1.12); C400(1.57); C756(1.67); C761(1.67)  LDD0929  [1]
 LDCM0332  AC68 HEK-293T C264(0.90); C400(1.20); C756(0.92); C761(0.92)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C264(0.92); C400(1.37); C756(1.07); C761(1.07)  LDD0931  [1]
 LDCM0334  AC7 HCT 116 C264(1.37)  LDD0651  [1]
 LDCM0335  AC70 HEK-293T C264(1.04); C400(1.28); C756(0.98); C761(0.98)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C264(0.98); C400(1.25); C756(1.08); C761(1.08)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C264(1.04); C400(1.52); C756(1.11); C761(1.11)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C264(1.01); C400(1.27); C756(1.17); C761(1.17)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C264(0.97); C400(1.52); C756(1.24); C761(1.24)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C264(0.98); C400(1.63); C756(0.97); C761(0.97)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C264(0.94); C400(1.53); C756(0.85); C761(0.85)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C264(0.98); C400(1.15); C756(1.10); C761(1.10)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C264(1.17); C400(1.26); C756(1.18); C761(1.18)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C264(0.99); C400(1.05); C756(0.80); C761(0.80)  LDD0942  [1]
 LDCM0345  AC8 HCT 116 C264(1.55)  LDD0662  [1]
 LDCM0346  AC80 HEK-293T C264(1.19); C400(1.62); C756(1.16); C761(1.16)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C264(1.10); C400(1.34); C756(1.13); C761(1.13)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C264(1.17); C400(1.18); C756(1.35); C761(1.35)  LDD0946  [1]
 LDCM0349  AC83 HEK-293T C264(1.26); C400(1.33); C756(0.73); C761(0.73)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C264(1.20); C400(0.94); C756(0.72); C761(0.72)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C264(1.25); C400(1.30); C756(0.69); C761(0.69)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C264(1.30); C400(0.80); C756(0.68); C761(0.68)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C264(1.17); C400(1.01); C756(0.71); C761(0.71)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C264(0.93); C400(0.95); C756(0.79); C761(0.79)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C264(1.38); C400(1.01); C756(0.96); C761(0.96)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C264(1.30); C400(0.81); C756(0.89); C761(0.89)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C264(1.17); C400(1.30); C756(0.68); C761(0.68)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C264(1.31); C400(1.28); C756(0.85); C761(0.85)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C264(1.10); C400(0.89); C756(0.89); C761(0.89)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C264(1.00); C400(0.89); C756(0.88); C761(0.88)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C264(1.20); C400(1.06); C756(0.71); C761(0.71)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C264(1.10); C400(1.44); C756(0.73); C761(0.73)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C264(1.06); C400(1.11); C756(1.13); C761(1.13)  LDD0962  [1]
 LDCM0365  AC98 HCT 116 C264(1.31)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C264(0.76)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C264(1.36)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C264(1.64)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C264(1.51)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C756(0.84); C761(0.84)  LDD0078  [1]
 LDCM0367  CL1 HEK-293T C264(1.81)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C264(1.25)  LDD0966  [1]
 LDCM0369  CL100 HCT 116 C264(1.10)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C264(1.05)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C264(1.16)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C264(1.37)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C264(1.57)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C264(1.18)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C264(1.40)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C264(1.17)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C264(1.22)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C264(1.20)  LDD0695  [1]
 LDCM0379  CL11 HEK-293T C264(1.38)  LDD0977  [1]
 LDCM0380  CL110 HCT 116 C264(1.53)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C264(1.56)  LDD0698  [1]
 LDCM0382  CL112 HEK-293T C756(1.45); C761(1.45)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C756(1.20); C761(1.20)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C756(1.66); C761(1.66)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C756(1.09); C761(1.09)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C756(1.30); C761(1.30)  LDD0984  [1]
 LDCM0387  CL117 HCT 116 C264(1.03)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C264(1.20)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C264(1.20)  LDD0706  [1]
 LDCM0390  CL12 HEK-293T C264(1.32)  LDD0988  [1]
 LDCM0391  CL120 HCT 116 C264(1.16)  LDD0708  [1]
 LDCM0392  CL121 HEK-293T C264(1.03); C400(1.57)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C264(1.46); C400(1.27)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C264(0.81); C400(1.23)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C264(0.92); C400(1.36)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C264(1.01); C400(1.00); C756(1.49); C761(1.49)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C264(1.00); C400(1.46); C756(1.34); C761(1.34)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C264(1.04); C400(1.08); C756(1.47); C761(1.47)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C264(0.98); C400(1.25); C756(1.02); C761(1.02)  LDD0997  [1]
 LDCM0400  CL13 HEK-293T C264(1.32)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C264(1.88)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C264(1.49)  LDD1000  [1]
 LDCM0403  CL16 HCT 116 C264(0.98)  LDD0720  [1]
 LDCM0404  CL17 HEK-293T C264(0.93); C400(1.08); C756(1.55); C761(1.55)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C264(1.27); C400(1.05); C756(0.85); C761(0.85)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C264(0.86); C400(0.88); C756(0.89); C761(0.89)  LDD1004  [1]
 LDCM0407  CL2 HEK-293T C264(1.29)  LDD1005  [1]
 LDCM0408  CL20 HEK-293T C264(0.99); C400(0.94); C756(1.08); C761(1.08)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C264(1.09); C400(1.37); C756(2.44); C761(2.44)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C264(1.18); C400(1.11); C756(1.56); C761(1.56)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C264(0.73); C400(1.12); C756(1.01); C761(1.01)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C264(0.95); C400(1.30); C756(0.96); C761(0.96)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C264(1.23); C400(1.12); C756(1.22); C761(1.22)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C264(0.42); C400(0.97); C756(0.99); C761(0.99)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C264(0.99); C400(1.13); C756(0.94); C761(0.94)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C264(0.78); C400(1.53); C756(0.81); C761(0.81)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C264(0.81); C400(0.91); C756(1.05); C761(1.05)  LDD1015  [1]
 LDCM0418  CL3 HEK-293T C264(1.17)  LDD1016  [1]
 LDCM0419  CL30 HEK-293T C264(0.83); C400(1.18); C756(1.21); C761(1.21)  LDD1017  [1]
 LDCM0420  CL31 HEK-293T C264(1.30); C756(1.44); C761(1.44)  LDD1018  [1]
 LDCM0421  CL32 HCT 116 C264(0.81)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C264(1.03)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C264(1.12)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C264(0.95)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C264(1.20)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C264(0.99)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C264(1.20)  LDD0745  [1]
 LDCM0429  CL4 HEK-293T C264(1.35)  LDD1027  [1]
 LDCM0430  CL40 HCT 116 C264(1.15)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C264(1.08)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C264(1.10)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C264(1.04)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C264(0.98)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C264(1.02)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C264(1.11)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C264(1.18)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C264(1.35)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C264(1.30)  LDD0756  [1]
 LDCM0440  CL5 HEK-293T C264(1.10)  LDD1038  [1]
 LDCM0441  CL50 HCT 116 C264(1.13)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C264(1.34)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C264(1.41)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C264(1.37)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C264(1.13)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C264(1.26)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C264(1.28)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C264(1.15)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C264(1.42)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C264(1.28)  LDD0767  [1]
 LDCM0451  CL6 HEK-293T C264(1.73)  LDD1049  [1]
 LDCM0452  CL60 HCT 116 C264(1.10)  LDD0769  [1]
 LDCM0453  CL61 HEK-293T C264(0.66); C756(1.23); C761(1.23)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C264(0.78); C756(1.08); C761(1.08)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C264(0.86); C756(0.95); C761(0.95)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C264(0.93); C756(1.02); C761(1.02)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C264(0.90); C756(0.98); C761(0.98)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C264(0.98); C756(0.95); C761(0.95)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C264(0.89); C756(0.89); C761(0.89)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C264(0.79); C756(0.92); C761(0.92)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C264(0.89); C756(1.00); C761(1.00)  LDD1059  [1]
 LDCM0462  CL7 HEK-293T C264(0.99)  LDD1060  [1]
 LDCM0463  CL70 HEK-293T C264(0.81); C756(0.97); C761(0.97)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C264(0.78); C756(0.97); C761(0.97)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C264(0.90); C756(0.91); C761(0.91)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C264(0.89); C756(0.90); C761(0.90)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C264(0.87); C756(1.33); C761(1.33)  LDD1065  [1]
 LDCM0469  CL76 HEK-293T C264(1.31); C756(0.92); C761(0.92)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C264(1.18); C756(0.94); C761(0.94)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C264(1.14); C756(1.04); C761(1.04)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C264(1.08); C756(1.28); C761(1.28)  LDD1070  [1]
 LDCM0473  CL8 HEK-293T C264(2.22)  LDD1071  [1]
 LDCM0474  CL80 HEK-293T C264(1.17); C756(0.91); C761(0.91)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C264(1.13); C756(1.20); C761(1.20)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C264(1.00); C756(0.69); C761(0.69)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C264(1.26); C756(0.90); C761(0.90)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C264(1.23); C756(1.02); C761(1.02)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C264(1.59); C756(1.07); C761(1.07)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C264(1.34); C756(1.60); C761(1.60)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C264(1.40); C756(1.24); C761(1.24)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C264(1.41); C756(1.16); C761(1.16)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C264(1.00); C756(1.13); C761(1.13)  LDD1081  [1]
 LDCM0484  CL9 HEK-293T C264(0.93)  LDD1082  [1]
 LDCM0485  CL90 HEK-293T C264(1.43); C756(1.08); C761(1.08)  LDD1083  [1]
 LDCM0486  CL91 HCT 116 C264(1.03)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C264(1.01)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C264(0.95)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C264(1.08)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C264(1.13)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C264(1.03)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C264(1.13)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C264(1.02)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C264(1.13)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C264(1.22)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C264(0.98); C756(1.06); C761(1.06)  LDD1066  [1]
 LDCM0427  Fragment51 HCT 116 C264(1.07)  LDD0744  [1]
 LDCM0022  KB02 HCT 116 C400(2.06)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C400(4.37)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C400(1.99)  LDD0082  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402