Details of the Target

General Information of Target

Target ID LDTP04850
Target Name Protein transport protein Sec61 subunit gamma (SEC61G)
Gene Name SEC61G
Gene ID 23480
Synonyms
Protein transport protein Sec61 subunit gamma
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIP
INNIIVGG
Target Bioclass
Transporter and channel
Family
SecE/SEC61-gamma family
Subcellular location
Endoplasmic reticulum membrane
Function
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER.
Uniprot ID
P60059
Ensemble ID
ENST00000352861.9
HGNC ID
HGNC:18277

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K16(0.50)  LDD0274  [1]
STPyne
 Probe Info  		K16(9.09); K27(1.45)  LDD0277  [1]
BTD
 Probe Info  		C25(4.07)  LDD1699  [2]
Acrolein
 Probe Info  		N.A.  LDD0222  [3]
DBIA
 Probe Info  		C25(1.28)  LDD1507  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
ENE
 Probe Info  		N.A.  LDD0006  [6]
IPM
 Probe Info  		N.A.  LDD0005  [6]
NPM
 Probe Info  		N.A.  LDD0016  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C25(0.83)  LDD2142  [2]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C25(1.27)  LDD2112  [2]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C25(0.77)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C25(1.28)  LDD2152  [2]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C25(0.77)  LDD2103  [2]
 LDCM0214  AC1 HEK-293T C25(1.28)  LDD1507  [4]
 LDCM0226  AC11 HEK-293T C25(0.90)  LDD1509  [4]
 LDCM0259  AC14 HEK-293T C25(0.79)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C25(0.95)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C25(0.98)  LDD1515  [4]
 LDCM0278  AC19 HEK-293T C25(0.97)  LDD1517  [4]
 LDCM0282  AC22 HEK-293T C25(0.88)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C25(0.91)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C25(0.94)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C25(1.14)  LDD1524  [4]
 LDCM0287  AC27 HEK-293T C25(0.98)  LDD1526  [4]
 LDCM0290  AC3 HEK-293T C25(1.12)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C25(1.15)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C25(0.98)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C25(0.85)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C25(0.99)  LDD1533  [4]
 LDCM0296  AC35 HEK-293T C25(0.89)  LDD1535  [4]
 LDCM0299  AC38 HEK-293T C25(0.84)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C25(1.00)  LDD1539  [4]
 LDCM0302  AC40 HEK-293T C25(0.79)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C25(1.01)  LDD1542  [4]
 LDCM0305  AC43 HEK-293T C25(0.93)  LDD1544  [4]
 LDCM0308  AC46 HEK-293T C25(0.88)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C25(1.15)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C25(0.88)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C25(1.14)  LDD1550  [4]
 LDCM0314  AC51 HEK-293T C25(0.94)  LDD1553  [4]
 LDCM0317  AC54 HEK-293T C25(0.90)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C25(0.98)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C25(0.90)  LDD1558  [4]
 LDCM0320  AC57 HEK-293T C25(1.16)  LDD1559  [4]
 LDCM0322  AC59 HEK-293T C25(1.07)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C25(1.15)  LDD1562  [4]
 LDCM0326  AC62 HEK-293T C25(1.21)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C25(1.26)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C25(1.22)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C25(0.93)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C25(0.90)  LDD1569  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C25(0.60)  LDD2113  [2]
 LDCM0356  AKOS034007680 HEK-293T C25(1.01)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C25(0.87)  LDD1514  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0632  CL-Sc Hep-G2 C25(20.00); C25(0.83)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C25(0.90)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C25(1.07)  LDD1572  [4]
 LDCM0370  CL101 HEK-293T C25(1.03)  LDD1574  [4]
 LDCM0374  CL105 HEK-293T C25(0.96)  LDD1578  [4]
 LDCM0378  CL109 HEK-293T C25(1.19)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C25(0.59)  LDD1583  [4]
 LDCM0383  CL113 HEK-293T C25(0.87)  LDD1587  [4]
 LDCM0387  CL117 HEK-293T C25(0.96)  LDD1591  [4]
 LDCM0390  CL12 HEK-293T C25(0.46)  LDD1594  [4]
 LDCM0392  CL121 HEK-293T C25(0.99)  LDD1596  [4]
 LDCM0396  CL125 HEK-293T C25(1.75)  LDD1600  [4]
 LDCM0400  CL13 HEK-293T C25(0.95)  LDD1604  [4]
 LDCM0404  CL17 HEK-293T C25(1.09)  LDD1608  [4]
 LDCM0406  CL19 HEK-293T C25(0.64)  LDD1610  [4]
 LDCM0410  CL22 HEK-293T C25(0.43)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C25(0.52)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C25(0.45)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C25(2.21)  LDD1617  [4]
 LDCM0417  CL29 HEK-293T C25(0.91)  LDD1621  [4]
 LDCM0420  CL31 HEK-293T C25(0.77)  LDD1624  [4]
 LDCM0423  CL34 HEK-293T C25(0.51)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C25(0.49)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C25(0.45)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C25(1.57)  LDD1630  [4]
 LDCM0431  CL41 HEK-293T C25(1.03)  LDD1635  [4]
 LDCM0433  CL43 HEK-293T C25(0.64)  LDD1637  [4]
 LDCM0436  CL46 HEK-293T C25(0.47)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C25(0.50)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C25(0.52)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C25(1.44)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C25(0.94)  LDD1644  [4]
 LDCM0444  CL53 HEK-293T C25(1.05)  LDD1647  [4]
 LDCM0446  CL55 HEK-293T C25(0.60)  LDD1649  [4]
 LDCM0449  CL58 HEK-293T C25(0.49)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C25(0.60)  LDD1653  [4]
 LDCM0452  CL60 HEK-293T C25(0.42)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C25(1.48)  LDD1656  [4]
 LDCM0457  CL65 HEK-293T C25(0.92)  LDD1660  [4]
 LDCM0459  CL67 HEK-293T C25(0.74)  LDD1662  [4]
 LDCM0462  CL7 HEK-293T C25(0.74)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C25(0.49)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C25(0.60)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C25(0.44)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C25(1.60)  LDD1669  [4]
 LDCM0470  CL77 HEK-293T C25(1.31)  LDD1673  [4]
 LDCM0472  CL79 HEK-293T C25(0.78)  LDD1675  [4]
 LDCM0476  CL82 HEK-293T C25(0.53)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C25(0.77)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C25(0.68)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C25(2.39)  LDD1682  [4]
 LDCM0483  CL89 HEK-293T C25(1.59)  LDD1686  [4]
 LDCM0486  CL91 HEK-293T C25(1.08)  LDD1689  [4]
 LDCM0489  CL94 HEK-293T C25(0.61)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C25(2.28)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C25(1.12)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C25(1.29)  LDD1695  [4]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C25(83.36)  LDD1702  [2]
 LDCM0625  F8 Ramos C25(1.91)  LDD2187  [10]
 LDCM0572  Fragment10 Ramos C25(0.35)  LDD2189  [10]
 LDCM0573  Fragment11 Ramos C25(0.89)  LDD2190  [10]
 LDCM0574  Fragment12 Ramos C25(14.45)  LDD2191  [10]
 LDCM0575  Fragment13 Ramos C25(1.30)  LDD2192  [10]
 LDCM0576  Fragment14 Ramos C25(10.34)  LDD2193  [10]
 LDCM0580  Fragment21 Ramos C25(0.91)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C25(2.74)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C25(2.23)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C25(0.69)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C25(1.75)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C25(1.23)  LDD2200  [10]
 LDCM0468  Fragment33 Ramos C25(2.30)  LDD2202  [10]
 LDCM0596  Fragment38 Ramos C25(20.00)  LDD2203  [10]
 LDCM0566  Fragment4 Ramos C25(10.33)  LDD2184  [10]
 LDCM0610  Fragment52 Ramos C25(6.26)  LDD2204  [10]
 LDCM0614  Fragment56 Ramos C25(0.63)  LDD2205  [10]
 LDCM0569  Fragment7 Ramos C25(7.45)  LDD2186  [10]
 LDCM0571  Fragment9 Ramos C25(20.00)  LDD2188  [10]
 LDCM0022  KB02 Ramos C25(17.23)  LDD2182  [10]
 LDCM0023  KB03 MDA-MB-231 C25(89.13)  LDD1701  [2]
 LDCM0024  KB05 Ramos C25(20.00)  LDD2185  [10]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C25(1.31)  LDD2102  [2]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C25(0.54)  LDD2121  [2]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C25(1.03)  LDD2089  [2]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C25(1.28)  LDD2090  [2]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C25(0.71)  LDD2092  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C25(0.76)  LDD2093  [2]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C25(0.91)  LDD2094  [2]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C25(1.02)  LDD2096  [2]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C25(1.06)  LDD2097  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C25(2.01)  LDD2098  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C25(0.86)  LDD2099  [2]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C25(2.78)  LDD2100  [2]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C25(0.96)  LDD2101  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C25(1.32)  LDD2104  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C25(1.00)  LDD2105  [2]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C25(1.28)  LDD2106  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C25(0.72)  LDD2107  [2]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C25(0.86)  LDD2108  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C25(0.95)  LDD2109  [2]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C25(2.98)  LDD2110  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C25(0.75)  LDD2111  [2]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C25(0.92)  LDD2114  [2]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C25(0.37)  LDD2115  [2]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C25(1.01)  LDD2116  [2]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C25(1.59)  LDD2118  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C25(1.86)  LDD2119  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C25(1.05)  LDD2120  [2]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C25(0.97)  LDD2122  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C25(0.72)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C25(0.68)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C25(1.43)  LDD2127  [2]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C25(1.46)  LDD2128  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C25(0.39)  LDD2129  [2]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C25(0.27)  LDD2133  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C25(0.49)  LDD2134  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C25(0.64)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C25(2.33)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C25(0.85)  LDD2137  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C25(1.31)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C25(1.04)  LDD2140  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C25(1.17)  LDD2141  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C25(1.44)  LDD2143  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C25(3.09)  LDD2144  [2]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C25(10.04)  LDD2145  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C25(0.51)  LDD2146  [2]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C25(7.24)  LDD2147  [2]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C25(1.15)  LDD2149  [2]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C25(0.87)  LDD2151  [2]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C25(1.84)  LDD2153  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Peroxisome assembly protein 12 (PEX12) Pex2/pex10/pex12 family O00623
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neutrophil gelatinase-associated lipocalin (LCN2) Lipocalin family P80188
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Leucine-rich repeat-containing protein 25 (LRRC25) . Q8N386
Pulmonary surfactant-associated protein C (SFTPC) . P11686
Transmembrane protein 51 (TMEM51) . Q9NW97

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578