Details of the Target

General Information of Target

Target ID LDTP04747
Target Name Transmembrane protein 50B (TMEM50B)
Gene Name TMEM50B
Gene ID 757
Synonyms
C21orf4; Transmembrane protein 50B; HCV p7-trans-regulated protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGFLDNFRWPECECIDWSERRNAVASVVAGILFFTGWWIMIDAAVVYPKPEQLNHAFHT
CGVFSTLAFFMINAVSNAQVRGDSYESGCLGRTGARVWLFIGFMLMFGSLIASMWILFGA
YVTQNTDVYPGLAVFFQNALIFFSTLIYKFGRTEELWT
Target Bioclass
Transporter and channel
Family
UPF0220 family
Subcellular location
Endoplasmic reticulum membrane
Uniprot ID
P56557
Ensemble ID
ENST00000420455.5
HGNC ID
HGNC:1280

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C89(10.18)  LDD0209  [1]
IA-alkyne
 Probe Info  		C89(2.33)  LDD2187  [2]
IPM
 Probe Info  		C89(1.49)  LDD1701  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
WYneN
 Probe Info  		N.A.  LDD0021  [5]
VSF
 Probe Info  		N.A.  LDD0007  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C13(1.55); C15(1.55)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C13(1.61); C15(1.61)  LDD0532  [6]
 LDCM0216  AC100 HEK-293T C15(0.49)  LDD0814  [6]
 LDCM0217  AC101 HEK-293T C15(0.58)  LDD0815  [6]
 LDCM0218  AC102 HEK-293T C15(0.55)  LDD0816  [6]
 LDCM0219  AC103 HEK-293T C15(0.74)  LDD0817  [6]
 LDCM0220  AC104 HEK-293T C15(0.54)  LDD0818  [6]
 LDCM0221  AC105 HEK-293T C15(0.69)  LDD0819  [6]
 LDCM0222  AC106 HEK-293T C15(0.92)  LDD0820  [6]
 LDCM0223  AC107 HEK-293T C15(0.49)  LDD0821  [6]
 LDCM0224  AC108 HEK-293T C15(0.97)  LDD0822  [6]
 LDCM0225  AC109 HEK-293T C15(0.77)  LDD0823  [6]
 LDCM0226  AC11 HCT 116 C13(1.11); C15(1.11)  LDD0543  [6]
 LDCM0227  AC110 HEK-293T C15(0.54)  LDD0825  [6]
 LDCM0228  AC111 HEK-293T C15(0.59)  LDD0826  [6]
 LDCM0229  AC112 HEK-293T C15(0.48)  LDD0827  [6]
 LDCM0230  AC113 HCT 116 C13(1.07); C15(1.07); C89(1.26)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C13(1.07); C15(1.07); C89(0.93)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C13(1.26); C15(1.26); C89(1.16)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C13(1.22); C15(1.22); C89(0.90)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C13(1.38); C15(1.38); C89(0.95)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C13(1.62); C15(1.62); C89(0.88)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C13(1.68); C15(1.68); C89(0.92)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C13(0.93); C15(0.93)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C13(0.95); C15(0.95); C89(1.16)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C13(1.12); C15(1.12); C89(0.83)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C13(1.78); C15(1.78); C89(0.89)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C13(0.82); C15(0.82); C89(0.74)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C13(1.20); C15(1.20); C89(0.80)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C13(1.11); C15(1.11); C89(0.95)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C13(1.03); C15(1.03); C89(0.82)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C13(1.32); C15(1.32); C89(0.75)  LDD0562  [6]
 LDCM0246  AC128 HEK-293T C13(1.12)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C13(1.01)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C13(1.13)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C13(1.26)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C13(1.13)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C13(1.11)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C13(0.90)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C13(0.87)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C13(0.94)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C13(1.41)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C13(1.40)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C13(1.40)  LDD0856  [6]
 LDCM0259  AC14 HCT 116 C13(1.24); C15(1.24)  LDD0576  [6]
 LDCM0260  AC140 HEK-293T C13(1.09)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C13(1.46)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C13(1.09)  LDD0860  [6]
 LDCM0263  AC143 HCT 116 C89(1.20)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C89(1.12)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C89(1.42)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C89(1.43)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C89(1.77)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C89(1.54)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C89(1.05)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C13(1.26); C15(1.26)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C89(1.00)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C89(1.51)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C89(0.82)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C89(0.84)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C89(0.98)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C89(0.75)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C89(1.25)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C89(1.02)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C13(0.94); C15(0.94)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C13(1.15); C15(1.15)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C13(1.08); C15(1.08)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C13(1.50); C15(1.50)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C13(0.95); C15(0.95)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C13(0.98); C15(0.98)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C13(0.95); C15(0.95)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C13(1.47); C15(1.47)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C13(0.99); C15(0.99)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C13(0.93); C15(0.93); C89(0.97)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C89(0.65); C13(1.14); C15(1.14)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C89(0.75); C13(1.12); C15(1.12)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C13(1.12); C15(1.12); C89(1.40)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C89(0.74); C13(1.05); C15(1.05)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C13(1.85); C15(1.85)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C89(0.44); C13(1.12); C15(1.12)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C89(0.66); C13(1.19); C15(1.19)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C89(0.44); C13(1.30); C15(1.30)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C89(0.53); C13(1.32); C15(1.32)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C89(0.47); C13(1.43); C15(1.43)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C13(0.86); C15(0.86); C89(1.20)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C13(0.82); C15(0.82); C89(1.25)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C13(0.95); C15(0.95); C89(1.02)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C89(0.86); C13(1.00); C15(1.00)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C13(0.94); C15(0.94); C89(1.37)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C13(1.53); C15(1.53)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C89(0.94); C13(1.05); C15(1.05)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C89(0.60); C13(0.84); C15(0.84)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C89(0.70); C13(0.99); C15(0.99)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C89(0.76); C13(1.04); C15(1.04)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C89(0.55); C13(1.04); C15(1.04)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C89(0.76); C13(1.14); C15(1.14)  LDD0624  [6]
 LDCM0312  AC5 HCT 116 C13(2.12); C15(2.12)  LDD0629  [6]
 LDCM0315  AC52 HEK-293T C89(0.73)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C89(1.02)  LDD1555  [7]
 LDCM0320  AC57 HCT 116 C13(0.86); C15(0.86); C89(1.26)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C89(0.61); C13(1.02); C15(1.02)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C89(0.85); C13(0.86); C15(0.86)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C13(0.90); C15(0.90)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C89(0.79); C13(0.97); C15(0.97)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C89(0.81); C13(1.08); C15(1.08)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C13(0.94); C15(0.94); C89(1.14)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C89(0.96); C13(1.05); C15(1.05)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C13(0.88); C15(0.88); C89(0.98)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C89(0.78); C13(1.12); C15(1.12)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C89(0.60); C13(1.18); C15(1.18)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C13(0.81); C15(0.81); C89(1.13)  LDD0648  [6]
 LDCM0332  AC68 HEK-293T C13(0.94); C15(1.04)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C13(1.34); C15(1.06)  LDD0931  [6]
 LDCM0334  AC7 HCT 116 C13(1.01); C15(1.01)  LDD0651  [6]
 LDCM0335  AC70 HEK-293T C13(1.03); C15(0.88)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C13(0.89); C15(0.95)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C13(1.09); C15(1.02)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C13(0.75); C15(0.68)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C13(0.86); C15(0.79)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C13(0.74); C15(0.82)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C13(0.70); C15(0.80)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C13(0.89); C15(0.73)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C13(0.77); C15(0.68)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C13(0.83); C15(0.81)  LDD0942  [6]
 LDCM0345  AC8 HCT 116 C13(1.17); C15(1.17)  LDD0662  [6]
 LDCM0346  AC80 HEK-293T C13(0.70); C15(0.67)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C13(0.74); C15(0.74)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C13(1.02); C15(0.75)  LDD0946  [6]
 LDCM0349  AC83 HCT 116 C13(1.03); C15(1.03)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C13(1.07); C15(1.07)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C13(1.16); C15(1.16)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C13(1.56); C15(1.56)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C13(1.17); C15(1.17)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C13(1.41); C15(1.41)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C13(1.27); C15(1.27)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C13(1.21); C15(1.21)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C13(1.08); C15(1.08)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C13(1.29); C15(1.29)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C13(1.20); C15(1.20)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C13(1.50); C15(1.50)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C13(1.25); C15(1.25)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C13(1.17); C15(1.17)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C13(1.25); C15(1.25)  LDD0681  [6]
 LDCM0365  AC98 HEK-293T C15(1.31)  LDD0963  [6]
 LDCM0366  AC99 HEK-293T C15(1.59)  LDD0964  [6]
 LDCM0248  AKOS034007472 HCT 116 C13(1.26); C15(1.26)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C13(1.07); C15(1.07)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C13(1.83); C15(1.83)  LDD0592  [6]
 LDCM0020  ARS-1620 HCC44 C89(1.19)  LDD2171  [6]
 LDCM0367  CL1 HEK-293T C89(0.84)  LDD1571  [7]
 LDCM0369  CL100 HCT 116 C13(2.05); C15(2.05)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C13(1.93); C15(1.93)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C13(1.09); C15(1.09)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C13(1.40); C15(1.40)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C13(0.99); C15(0.99)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C13(1.33); C15(1.33)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C13(1.35); C15(1.35)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C13(1.24); C15(1.24)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C13(1.42); C15(1.42)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C13(1.69); C15(1.69)  LDD0695  [6]
 LDCM0380  CL110 HCT 116 C13(2.61); C15(2.61)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C13(1.38); C15(1.38)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C89(0.67); C13(1.12); C15(1.12)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C89(0.31); C13(1.19); C15(1.19)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C89(0.29); C13(2.90); C15(2.90)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C89(0.42); C13(1.21); C15(1.21)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C89(0.47); C13(1.11); C15(1.11)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C89(0.66); C13(1.35); C15(1.35)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C89(1.08); C13(1.13); C15(1.13)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C13(1.15); C15(1.15); C89(1.79)  LDD0706  [6]
 LDCM0391  CL120 HCT 116 C13(0.93); C15(0.93); C89(1.39)  LDD0708  [6]
 LDCM0392  CL121 HEK-293T C89(0.97)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C89(1.21)  LDD1597  [7]
 LDCM0396  CL125 HCT 116 C13(1.01); C15(1.01); C89(1.04)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C89(0.67); C13(1.16); C15(1.16)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C89(0.77); C13(1.11); C15(1.11)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C13(0.92); C15(0.92); C89(1.21)  LDD0716  [6]
 LDCM0400  CL13 HEK-293T C89(1.09)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C89(1.22)  LDD1605  [7]
 LDCM0407  CL2 HEK-293T C89(1.09)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C89(0.85)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C89(1.49)  LDD1613  [7]
 LDCM0413  CL25 HEK-293T C89(1.14)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C89(1.03)  LDD1618  [7]
 LDCM0421  CL32 HEK-293T C89(0.95)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C89(1.94)  LDD1626  [7]
 LDCM0426  CL37 HEK-293T C89(0.91)  LDD1630  [7]
 LDCM0434  CL44 HEK-293T C89(0.74)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C89(1.36)  LDD1639  [7]
 LDCM0439  CL49 HEK-293T C89(0.93)  LDD1643  [7]
 LDCM0441  CL50 HEK-293T C89(1.04)  LDD1645  [7]
 LDCM0447  CL56 HEK-293T C89(0.88)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C89(1.40)  LDD1651  [7]
 LDCM0453  CL61 HCT 116 C13(0.92); C15(0.92)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C13(0.94); C15(0.94)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C13(1.36); C15(1.36)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C13(2.93); C15(2.93)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C13(1.20); C15(1.20)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C13(1.37); C15(1.37)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C13(1.25); C15(1.25)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C13(1.44); C15(1.44)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C13(1.51); C15(1.51)  LDD0778  [6]
 LDCM0463  CL70 HCT 116 C13(0.85); C15(0.85)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C13(1.24); C15(1.24)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C13(1.06); C15(1.06)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C13(2.11); C15(2.11)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C13(1.12); C15(1.12)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C13(1.05); C15(1.05)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C13(1.24); C15(1.24)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C13(1.19); C15(1.19)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C13(1.20); C15(1.20)  LDD0789  [6]
 LDCM0473  CL8 HEK-293T C89(1.49)  LDD1676  [7]
 LDCM0474  CL80 HCT 116 C13(1.01); C15(1.01)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C13(1.14); C15(1.14)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C13(1.47); C15(1.47)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C13(1.53); C15(1.53)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C13(2.06); C15(2.06)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C13(1.22); C15(1.22)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C13(1.18); C15(1.18)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C13(1.40); C15(1.40)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C13(1.38); C15(1.38)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C13(1.73); C15(1.73)  LDD0800  [6]
 LDCM0484  CL9 HEK-293T C89(1.24)  LDD1687  [7]
 LDCM0485  CL90 HCT 116 C13(2.21); C15(2.21)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C13(1.24); C15(1.24)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C13(2.35); C15(2.35)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C13(2.42); C15(2.42)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C13(2.27); C15(2.27)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C13(2.06); C15(2.06)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C13(2.28); C15(2.28)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C13(2.79); C15(2.79)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C13(2.56); C15(2.56)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C13(1.69); C15(1.69)  LDD0811  [6]
 LDCM0625  F8 Ramos C89(2.33)  LDD2187  [2]
 LDCM0573  Fragment11 Ramos C89(10.35)  LDD2190  [2]
 LDCM0576  Fragment14 Ramos C89(6.74)  LDD2193  [2]
 LDCM0580  Fragment21 Ramos C89(2.60)  LDD2195  [2]
 LDCM0578  Fragment27 Ramos C89(1.02)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C89(0.48)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C89(1.82)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C89(1.13)  LDD2200  [2]
 LDCM0468  Fragment33 HCT 116 C13(1.06); C15(1.06)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C89(3.00)  LDD2203  [2]
 LDCM0427  Fragment51 HEK-293T C89(0.93)  LDD1631  [7]
 LDCM0614  Fragment56 Ramos C89(1.29)  LDD2205  [2]
 LDCM0023  KB03 Jurkat C89(10.18)  LDD0209  [1]
 LDCM0021  THZ1 HCT 116 C89(1.19)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Transporter and channel
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 1 (BCL2L1) Bcl-2 family Q07817
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Clarin-1 (CLRN1) Clarin family P58418
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Monocarboxylate transporter 13 (SLC16A13) Monocarboxylate porter (TC 2.A.1.13) family Q7RTY0
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amphoterin-induced protein 1 (AMIGO1) AMIGO family Q86WK6
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ectodysplasin-A (EDA) Tumor necrosis factor family Q92838
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Leptin receptor gene-related protein (LEPROT) OB-RGRP/VPS55 family O15243
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
Transmembrane protein 88 (TMEM88) TMEM88 family Q6PEY1
Transmembrane protein 52B (TMEM52B) . Q4KMG9

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402