Details of the Target

General Information of Target

Target ID LDTP04332
Target Name 5-formyltetrahydrofolate cyclo-ligase (MTHFS)
Gene Name MTHFS
Gene ID 10588
Synonyms
5-formyltetrahydrofolate cyclo-ligase; EC 6.3.3.2; 5,10-methenyl-tetrahydrofolate synthetase; MTHFS; Methenyl-THF synthetase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAVSSAKRSLRGELKQRLRAMSAEERLRQSRVLSQKVIAHSEYQKSKRISIFLSMQD
EIETEEIIKDIFQRGKICFIPRYRFQSNHMDMVRIESPEEISLLPKTSWNIPQPGEGDVR
EEALSTGGLDLIFMPGLGFDKHGNRLGRGKGYYDAYLKRCLQHQEVKPYTLALAFKEQIC
LQVPVNENDMKVDEVLYEDSSTA
Target Bioclass
Enzyme
Family
5-formyltetrahydrofolate cyclo-ligase family
Subcellular location
Cytoplasm
Function
Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate.
Uniprot ID
P49914
Ensemble ID
ENST00000258874.4
HGNC ID
HGNC:7437

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MCC13 Substitution: p.S53F .
NB1 SNV: p.I179V .
NCIH1650 SNV: p.V119I DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y46(18.93); Y156(7.67)  LDD3495  [1]
DBIA
 Probe Info  		C160(0.84)  LDD0531  [2]
5E-2FA
 Probe Info  		H163(0.00); H89(0.00); H43(0.00)  LDD2235  [3]
ATP probe
 Probe Info  		K150(0.00); K10(0.00)  LDD0199  [4]
m-APA
 Probe Info  		H163(0.00); H89(0.00); H43(0.00)  LDD2231  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
STPyne
 Probe Info  		N.A.  LDD0009  [6]
NAIA_5
 Probe Info  		C160(0.00); C78(0.00)  LDD2223  [7]
HHS-482
 Probe Info  		Y152(1.16)  LDD2239  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C160(0.84)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C160(0.86); C180(1.09)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C160(0.92); C180(0.99)  LDD1509  [9]
 LDCM0230  AC113 HCT 116 C160(0.80)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C160(0.77)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C160(0.69)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C160(0.80)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C160(0.88)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C160(0.94)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C160(0.85)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C160(0.84)  LDD1510  [9]
 LDCM0238  AC120 HCT 116 C160(0.57)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C160(1.04)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C160(0.93)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C160(1.02)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C160(1.00)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C160(0.90)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C160(0.96)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C160(1.12)  LDD0562  [2]
 LDCM0259  AC14 HEK-293T C160(0.94); C180(1.18)  LDD1512  [9]
 LDCM0263  AC143 HCT 116 C160(0.99)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C160(1.23)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C160(1.02)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C160(1.21)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C160(1.03)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C160(1.10)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C160(1.24)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C160(0.98); C180(1.01)  LDD1513  [9]
 LDCM0271  AC150 HCT 116 C160(1.09)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C160(1.10)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C160(1.24)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C160(1.62)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C160(1.15)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C160(1.43)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C160(1.33)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C160(1.33)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C160(1.12)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C160(0.68)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C160(0.71)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C160(0.86)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C160(0.76)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C160(0.86)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C160(0.76)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C160(0.85)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C160(1.02)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C160(0.90); C180(0.95)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C160(0.87); C180(1.15)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C160(0.88); C180(0.95)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C160(0.92)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C180(0.96)  LDD1528  [9]
 LDCM0290  AC3 HCT 116 C160(1.03)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C160(0.93); C180(1.03)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C160(1.27); C180(1.21)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C160(0.94)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C160(0.76); C180(0.94)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C160(0.86); C180(0.95)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C160(0.85); C180(0.94)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C160(0.85)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C180(0.93)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C160(0.95); C180(0.99)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C160(0.86); C180(0.97)  LDD1539  [9]
 LDCM0301  AC4 HCT 116 C160(1.23)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C160(0.94)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C160(0.87); C180(0.96)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C160(0.86); C180(0.98)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C160(0.94); C180(0.94)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C160(0.87)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C180(0.99)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C160(0.94); C180(0.99)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C160(1.01); C180(1.10)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C160(1.01)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C160(0.91); C180(0.96)  LDD1550  [9]
 LDCM0312  AC5 HCT 116 C160(1.19)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C160(0.93); C180(1.04)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C160(0.90); C180(1.00)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C160(0.88)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C180(0.99)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C160(0.88); C180(1.02)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C160(0.86); C180(1.05)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C160(0.95)  LDD1558  [9]
 LDCM0320  AC57 HCT 116 C160(1.01)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C160(0.97)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C160(0.60)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C160(0.98); C180(1.03)  LDD1562  [9]
 LDCM0324  AC60 HCT 116 C160(0.50)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C160(0.96)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C160(0.61)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C160(0.80)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C160(0.71)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C160(0.77)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C160(1.01)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C160(0.61)  LDD0648  [2]
 LDCM0334  AC7 HEK-293T C160(0.92); C180(0.97)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C160(0.93)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C180(0.98)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C160(0.90); C180(0.92)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C160(0.95)  LDD1514  [9]
 LDCM0367  CL1 HEK-293T C160(0.82); C180(1.02)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C160(1.79); C180(0.90)  LDD1572  [9]
 LDCM0369  CL100 HCT 116 C160(0.78)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C160(0.94); C180(1.07)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C180(0.86)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C160(0.84); C180(1.10)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C160(0.91)  LDD1577  [9]
 LDCM0374  CL105 HCT 116 C160(0.91)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C160(0.90)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C160(0.71)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C160(1.05)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C160(0.82)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C160(1.65); C180(1.17)  LDD1583  [9]
 LDCM0380  CL110 HCT 116 C160(1.15)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C160(0.59)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C160(0.91)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C160(0.88); C180(1.06)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C180(0.89)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C160(0.89); C180(1.02)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C160(0.91)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C160(0.88); C180(1.03)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C180(0.98)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C160(0.93); C180(1.12)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C160(1.58)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C160(0.95)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C160(0.96); C180(1.04)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C180(0.98)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C160(1.01); C180(0.93)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C160(0.93)  LDD1599  [9]
 LDCM0396  CL125 HCT 116 C160(0.78)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C160(0.79)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C160(0.66)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C160(1.17)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C160(0.85); C180(0.96)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C180(0.99)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C160(0.89); C180(0.96)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C160(0.86)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C160(0.91); C180(0.94)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C160(1.02); C180(1.29)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C160(1.22); C180(1.18)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C180(1.04)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C160(1.38)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C180(0.95)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C160(1.85); C180(1.14)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C160(1.24); C180(1.19)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C160(1.71)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C160(0.87); C180(0.94)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C180(0.94)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C160(0.95); C180(1.00)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C160(0.93)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C160(1.07); C180(1.02)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C160(0.90); C180(1.04)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C160(1.16); C180(1.00)  LDD1623  [9]
 LDCM0420  CL31 HCT 116 C160(1.04)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C160(1.25)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C160(0.97)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C160(0.94)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C160(0.75)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C160(0.80)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C160(0.71)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C160(1.16)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C160(0.86)  LDD1633  [9]
 LDCM0430  CL40 HCT 116 C160(1.06)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C160(0.94)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C160(0.93)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C160(1.26)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C160(0.91)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C160(0.94)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C160(1.59); C180(1.28)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C160(1.20); C180(1.35)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C160(2.28)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C160(0.83); C180(1.07)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C160(0.97); C180(0.98)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C180(0.94)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C160(0.90)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C160(1.02); C180(0.92)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C160(1.03); C180(0.73)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C160(1.32); C180(1.12)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C160(1.38)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C180(0.99)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C160(1.70); C180(1.24)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C160(1.18); C180(1.33)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C160(1.04); C180(1.06)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C160(1.95)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C160(0.87); C180(1.11)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C180(1.10)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C160(0.88); C180(1.03)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C160(0.87)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C160(0.95); C180(0.99)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C160(1.05); C180(1.08)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C160(1.15); C180(1.12)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C160(1.30)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C180(1.05)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C160(1.13); C180(1.09)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C160(1.71); C180(1.14)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C160(1.75); C180(1.23)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C160(1.56)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C160(0.96); C180(0.98)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C180(0.98)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C160(0.93)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C160(0.96); C180(0.91)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C160(1.05); C180(1.15)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C160(1.23); C180(1.05)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C160(1.24)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C160(1.36)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C180(0.94)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C160(1.50); C180(1.13)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C160(1.23); C180(1.13)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C160(1.47)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C160(0.85); C180(1.02)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C180(0.96)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C160(0.81); C180(0.99)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C160(0.90)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C160(0.91); C180(1.00)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C180(1.08)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C160(1.01); C180(1.30)  LDD1688  [9]
 LDCM0486  CL91 HCT 116 C160(1.07)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C160(1.22)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C160(1.67)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C160(1.04)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C160(1.27)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C160(1.11)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C160(0.90)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C160(0.85)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C160(0.94)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C160(0.84); C180(1.05)  LDD1698  [9]
 LDCM0574  Fragment12 Ramos C78(0.42)  LDD2191  [10]
 LDCM0575  Fragment13 Ramos C78(1.09)  LDD2192  [10]
 LDCM0579  Fragment20 Ramos C78(0.49)  LDD2194  [10]
 LDCM0580  Fragment21 Ramos C78(0.64)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C78(1.01)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C78(0.59)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C78(1.30)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C78(0.77)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C78(0.87)  LDD2200  [10]
 LDCM0590  Fragment32 Ramos C78(0.43)  LDD2201  [10]
 LDCM0468  Fragment33 HEK-293T C160(1.06); C180(1.04)  LDD1671  [9]
 LDCM0596  Fragment38 Ramos C78(0.91)  LDD2203  [10]
 LDCM0427  Fragment51 HCT 116 C160(1.02)  LDD0744  [2]
 LDCM0610  Fragment52 Ramos C78(0.59)  LDD2204  [10]
 LDCM0614  Fragment56 Ramos C78(1.05)  LDD2205  [10]
 LDCM0571  Fragment9 Ramos C78(0.83)  LDD2188  [10]
 LDCM0022  KB02 697 C180(1.00)  LDD2245  [11]
 LDCM0023  KB03 697 C180(1.07)  LDD2662  [11]
 LDCM0024  KB05 COLO792 C180(0.99); C78(2.98)  LDD3310  [11]

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840