Details of the Target

General Information of Target

Target ID LDTP03525
Target Name Cell division cycle protein 27 homolog (CDC27)
Gene Name CDC27
Gene ID 996
Synonyms
ANAPC3; D0S1430E; D17S978E; Cell division cycle protein 27 homolog; Anaphase-promoting complex subunit 3; APC3; CDC27 homolog; CDC27Hs; H-NUC
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRL
LKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSL
LGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSNCL
PNSCTTQVPNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSAVI
SPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALSPLTPSFGILPLETPSPGDGSYLQN
YTNTPPVIDVPSTGAPSKKSVARIGQTGTKSVFSQSGNSREVTPILAQTQSSGPQTSTTP
QVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGITQ
PNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYN
CKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYS
TTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNY
AYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQK
ALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYK
SALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAID
KRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF
Target Bioclass
Enzyme
Family
APC3/CDC27 family
Subcellular location
Nucleus
Function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Uniprot ID
P30260
Ensemble ID
ENST00000066544.8
HGNC ID
HGNC:1728

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL23 SNV: p.G417R .
HT115 SNV: p.M758I .
IGROV1 SNV: p.P280L DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.K749R .
NCIH1793 SNV: p.H195Y DBIA    Probe Info 
SG231 SNV: p.T560A DBIA    Probe Info 
SH4 SNV: p.R625Q DBIA    Probe Info 
SUIT2 SNV: p.L713V .
TE1 SNV: p.P360R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.00  LDD0402  [1]
STPyne
 Probe Info  		K718(6.08)  LDD0277  [2]
IPM
 Probe Info  		C137(0.00); C71(0.00)  LDD0241  [3]
DBIA
 Probe Info  		C629(5.35)  LDD3311  [4]
BTD
 Probe Info  		C623(1.92); C66(1.29); C71(1.23)  LDD1700  [5]
AHL-Pu-1
 Probe Info  		C184(2.57)  LDD0168  [6]
Acrolein
 Probe Info  		N.A.  LDD0222  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C137(0.00); C156(0.00); C673(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C156(0.00); C623(0.00); C673(0.00); C137(0.00)  LDD0036  [8]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [9]
Lodoacetamide azide
 Probe Info  		C623(0.00); C156(0.00); C673(0.00); C137(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		C156(0.00); C705(0.00)  LDD2226  [10]
Compound 10
 Probe Info  		N.A.  LDD2216  [11]
TFBX
 Probe Info  		C623(0.00); C179(0.00)  LDD0148  [12]
Phosphinate-6
 Probe Info  		C184(0.00); C179(0.00)  LDD0018  [13]
W1
 Probe Info  		N.A.  LDD0236  [3]
AOyne
 Probe Info  		13.00  LDD0443  [14]
NAIA_5
 Probe Info  		C481(0.00); C623(0.00); C705(0.00); C673(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C041
 Probe Info  		7.21  LDD1741  [15]
C122
 Probe Info  		5.46  LDD1808  [15]
C327
 Probe Info  		6.32  LDD1991  [15]
FFF probe13
 Probe Info  		5.49  LDD0475  [16]
FFF probe15
 Probe Info  		5.50  LDD0478  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C623(1.10); C137(1.13)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C623(1.18); C71(1.04); C66(1.09)  LDD2152  [5]
 LDCM0025  4SU-RNA HEK-293T C184(2.57)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C184(2.63)  LDD0169  [6]
 LDCM0214  AC1 HEK-293T C673(1.21); C156(0.88); C137(0.85); C503(0.99)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C673(1.13); C156(0.96); C137(0.95); C503(1.19)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C673(0.94); C156(0.90); C137(0.98); C503(1.08)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C673(0.91); C156(0.96); C137(1.05); C503(0.93)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C673(0.89); C156(1.17); C137(1.00); C503(0.88)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C673(1.03); C156(1.07); C137(1.08); C503(1.13)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C673(1.05); C156(0.83); C137(0.83); C503(0.99)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C673(1.09); C156(0.95); C137(1.05); C503(1.05)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C673(0.93); C156(0.86); C137(0.91); C503(0.90)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C673(1.05); C156(1.00); C137(0.94); C503(1.18)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C673(0.90); C156(1.03); C137(0.94); C503(0.84)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C673(0.99); C156(0.89); C137(0.96); C503(1.01)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C673(1.00); C156(1.07); C137(1.16); C503(0.81)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C673(0.98); C156(0.99); C137(0.97); C503(1.03)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C673(0.98); C156(0.93); C137(0.98); C503(1.11)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C673(1.13); C156(0.87); C137(0.86); C503(1.06)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C673(1.03); C156(1.10); C137(1.02); C503(1.02)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C673(0.95); C156(0.92); C137(0.97); C503(1.03)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C673(0.85); C156(1.03); C137(1.01); C503(0.80)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C673(0.93); C156(0.92); C137(1.12); C503(1.03)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C673(1.02); C156(0.94); C137(0.94); C503(1.14)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C673(0.86); C156(1.01); C137(1.08); C503(0.96)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C673(0.92); C156(1.03); C137(0.99); C503(1.11)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C673(1.09); C156(1.02); C137(1.02); C503(1.04)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C673(1.27); C156(0.84); C137(0.91); C503(0.97)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C673(1.04); C156(0.97); C137(0.97); C503(1.11)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C673(0.98); C156(0.82); C137(0.95); C503(1.07)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C673(0.87); C156(1.00); C137(0.82); C503(0.90)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C673(1.00); C156(1.03); C137(1.08); C503(0.92)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C673(0.97); C156(1.47); C137(1.03); C503(0.79)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C673(1.05); C156(1.01); C137(0.92); C503(1.07)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C673(0.98); C156(1.00); C137(0.97); C503(1.00)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C673(0.98); C156(1.00); C137(0.96); C503(0.93)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C673(1.18); C156(0.84); C137(0.90); C503(1.13)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C673(1.12); C156(0.95); C137(0.94); C503(1.00)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C673(0.93); C156(0.90); C137(1.01); C503(1.04)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C673(0.97); C156(0.96); C137(0.99); C503(0.98)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C673(0.97); C156(0.78); C137(1.04); C503(0.90)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C673(1.14); C156(1.16); C137(0.95); C503(0.90)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C673(0.98); C156(1.02); C137(0.92); C503(0.94)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C673(1.09); C156(1.01); C137(0.97); C503(1.04)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C673(1.22); C156(0.84); C137(0.90); C503(0.95)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C673(1.06); C156(0.92); C137(1.06); C503(0.93)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C673(1.07); C156(1.01); C137(0.99); C503(1.01)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C673(0.96); C156(0.91); C137(0.98); C503(1.08)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C673(0.94); C156(1.00); C137(0.95); C503(0.89)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C673(1.02); C156(0.76); C137(0.98); C503(0.96)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C673(0.96); C156(1.31); C137(1.00); C503(0.92)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C673(0.99); C156(0.92); C137(1.01); C503(1.01)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C673(1.10); C156(1.06); C137(0.97); C503(0.93)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C673(1.25); C156(0.95); C137(0.84); C503(1.00)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C673(1.11); C156(1.07); C137(1.01); C503(1.05)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C673(1.02); C156(0.92); C137(0.99); C503(1.09)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C673(0.99); C156(1.27); C137(0.97); C503(0.92)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C673(0.97); C156(0.90); C137(0.92); C503(0.90)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C673(1.08); C156(0.81); C137(0.96); C503(0.92)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C673(1.03); C156(1.14); C137(1.05); C503(0.89)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C673(1.12); C156(1.15); C137(0.90); C503(0.98)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C673(1.23); C156(1.07); C137(0.97); C503(1.08)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C673(1.02); C156(1.12); C137(0.86); C503(1.02)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C673(1.06); C156(1.09); C137(0.93); C503(0.99)  LDD1569  [17]
 LDCM0520  AKOS000195272 MDA-MB-231 C66(0.99)  LDD2113  [5]
 LDCM0248  AKOS034007472 HEK-293T C673(0.93); C156(0.79); C137(1.06); C503(0.93)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C673(1.09); C156(0.81); C137(0.89); C503(1.04)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C673(1.04); C156(1.08); C137(1.00); C503(0.94)  LDD1514  [17]
 LDCM0156  Aniline NCI-H1299 11.67  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0367  CL1 HEK-293T C673(1.03); C156(1.13); C137(1.07); C503(1.00)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C673(0.83); C156(0.84); C137(0.58); C503(1.03)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C673(1.18); C156(0.90); C137(0.94); C503(0.81)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C673(1.03); C156(0.99); C137(0.97); C503(0.98)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C673(1.40); C156(0.90); C137(0.95); C503(1.10)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C673(0.93); C156(1.12); C137(1.01); C503(1.17)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C673(1.00); C156(1.05); C137(0.99); C503(1.05)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C673(0.98); C156(0.98); C137(1.05); C503(0.93)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C673(1.11); C156(0.90); C137(1.05); C503(1.02)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C673(0.94); C156(1.00); C137(0.99); C503(1.06)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C673(1.03); C156(1.02); C137(1.04); C503(0.88)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C673(1.00); C156(0.96); C137(1.04); C503(0.96)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C673(0.85); C156(0.89); C137(0.89); C503(1.13)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C673(1.16); C156(0.96); C137(1.13); C503(1.15)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C673(0.94); C156(1.05); C137(1.05); C503(1.08)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C673(1.06); C156(0.98); C137(0.96); C503(0.90)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C673(1.00); C156(1.12); C137(1.06); C503(1.02)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C673(1.11); C156(0.92); C137(1.00); C503(1.17)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C673(0.95); C156(1.00); C137(0.99); C503(1.06)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C673(1.04); C156(0.93); C137(0.97); C503(0.98)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C673(1.05); C156(1.10); C137(1.07); C503(0.89)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C673(1.12); C156(0.98); C137(1.01); C503(1.03)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C673(0.91); C156(1.03); C137(0.97); C503(0.99)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C673(0.86); C156(0.91); C137(0.93); C503(0.95)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C673(1.07); C156(1.08); C137(0.99); C503(0.99)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C673(1.01); C156(0.94); C137(0.95); C503(0.97)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C673(1.12); C156(0.93); C137(1.00); C503(1.14)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C673(1.30); C156(1.00); C137(0.97); C503(0.97)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C673(1.02); C156(0.95); C137(0.98); C503(0.83)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C673(1.30); C156(1.00); C137(1.10); C503(0.68)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C673(1.19); C156(0.89); C137(1.03); C503(0.96)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C673(1.07); C156(0.99); C137(0.98); C503(0.91)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C673(1.16); C156(0.95); C137(0.97); C503(1.02)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C673(0.90); C156(1.08); C137(0.99); C503(1.00)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C673(1.07); C156(1.07); C137(1.21); C503(1.09)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C673(0.85); C156(0.98); C137(0.96); C503(1.10)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C673(0.93); C156(1.06); C137(0.99); C503(1.13)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C673(1.09); C156(0.80); C137(0.94); C503(0.94)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C673(1.01); C156(1.01); C137(1.01); C503(1.21)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C673(0.77); C156(0.86); C137(0.95); C503(1.09)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C673(0.96); C156(0.98); C137(1.08); C503(1.06)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C673(0.73); C156(0.93); C137(1.04); C503(1.07)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C673(1.67); C156(0.71); C137(0.93); C503(1.04)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C673(0.76); C156(0.86); C137(0.98); C503(1.25)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C673(0.76); C156(0.94); C137(0.86); C503(1.06)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C673(0.85); C156(0.97); C137(0.92); C503(1.14)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C673(1.07); C156(0.95); C137(1.06); C503(0.88)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C673(1.01); C156(0.99); C137(1.12); C503(0.95)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C673(0.88); C156(1.03); C137(1.00); C503(0.97)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C673(0.97); C156(0.94); C137(1.01); C503(1.02)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C673(0.93); C156(0.89); C137(0.95); C503(1.04)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C673(0.93); C156(0.96); C137(0.91); C503(1.08)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C673(0.95); C156(1.00); C137(1.06); C503(0.95)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C673(0.75); C156(0.86); C137(1.02); C503(1.01)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C673(0.73); C156(0.95); C137(1.05); C503(0.93)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C673(0.66); C156(0.82); C137(1.03); C503(0.94)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C673(0.83); C156(1.16); C137(1.07); C503(1.08)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C673(0.71); C156(0.93); C137(1.03); C503(1.17)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C673(0.83); C156(0.92); C137(0.95); C503(1.16)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C673(1.06); C156(1.18); C137(1.09); C503(0.78)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C673(1.01); C156(0.85); C137(0.98); C503(0.88)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C673(1.07); C156(0.93); C137(0.90); C503(1.04)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C673(0.94); C156(0.93); C137(1.02); C503(0.95)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C673(0.97); C156(0.79); C137(1.15); C503(1.12)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C673(1.02); C156(0.98); C137(1.07); C503(1.03)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C673(0.73); C156(0.87); C137(1.17); C503(1.01)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C673(0.78); C156(0.93); C137(0.96); C503(0.88)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C673(0.78); C156(0.71); C137(1.05); C503(0.95)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C673(0.83); C156(1.07); C137(1.05); C503(0.97)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C673(0.81); C156(0.93); C137(0.95); C503(0.98)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C673(0.83); C156(1.06); C137(1.06); C503(1.06)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C673(1.10); C156(1.29); C137(1.09); C503(1.06)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C673(1.19); C156(0.79); C137(0.95); C503(1.02)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C673(1.16); C156(1.08); C137(1.11); C503(1.23)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C673(0.94); C156(1.05); C137(0.99); C503(0.80)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C673(1.25); C156(0.80); C137(0.87); C503(1.07)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C673(1.31); C156(0.81); C137(0.91); C503(1.18)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C673(0.75); C156(0.97); C137(1.08); C503(1.14)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C673(0.71); C156(0.95); C137(1.03); C503(0.90)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C673(0.73); C156(0.68); C137(0.95); C503(1.23)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C673(0.77); C156(0.93); C137(1.06); C503(0.87)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C673(0.79); C156(0.95); C137(1.05); C503(0.95)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C673(0.99); C156(0.81); C137(0.95); C503(1.05)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C673(0.76); C156(1.14); C137(1.01); C503(0.98)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C673(1.18); C156(1.05); C137(1.18); C503(1.05)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C673(1.15); C156(1.09); C137(1.05); C503(1.06)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C673(1.01); C156(1.04); C137(1.07); C503(1.04)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C673(0.87); C156(0.89); C137(0.95); C503(0.92)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C673(1.11); C156(0.80); C137(1.01); C503(1.03)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C673(1.04); C156(0.95); C137(0.94); C503(1.14)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C673(0.79); C156(0.95); C137(1.04); C503(1.09)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C673(0.70); C156(1.00); C137(1.06); C503(1.15)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C673(0.91); C156(1.03); C137(1.10); C503(1.00)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C673(0.75); C156(0.93); C137(0.95); C503(1.12)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C673(0.71); C156(1.00); C137(1.01); C503(1.06)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C673(0.68); C156(0.93); C137(1.03); C503(1.13)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C673(0.78); C156(1.05); C137(1.08); C503(1.00)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C673(1.10); C156(1.05); C137(1.15); C503(0.84)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C673(1.09); C156(1.10); C137(1.02); C503(1.22)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C673(1.05); C156(1.03); C137(0.99); C503(1.06)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C673(1.28); C156(0.85); C137(0.96); C503(1.08)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C673(0.99); C156(1.05); C137(1.09); C503(1.17)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C673(0.85); C156(0.91); C137(1.03); C503(1.05)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C673(0.87); C156(0.55); C137(0.56); C503(0.94)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C673(0.82); C156(0.97); C137(1.08); C503(0.96)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C673(0.79); C156(0.74); C137(1.07); C503(1.02)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C673(0.79); C156(1.20); C137(1.11); C503(0.98)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C673(0.94); C156(0.89); C137(0.97); C503(0.96)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C673(0.86); C156(0.86); C137(1.04); C503(1.06)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C673(1.30); C156(1.14); C137(1.11); C503(0.81)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C673(1.39); C156(0.94); C137(1.09); C503(1.09)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C673(1.12); C156(1.03); C137(1.03); C503(1.13)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C673(1.14); C156(1.01); C137(0.95); C503(0.93)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C673(1.23); C156(0.92); C137(0.99); C503(1.03)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C673(0.85); C156(0.69); C137(1.06); C503(0.99)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C673(1.07); C156(1.02); C137(0.87); C503(1.20)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C673(0.87); C156(0.95); C137(1.16); C503(1.00)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C673(0.97); C156(0.95); C137(0.93); C503(1.08)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C673(0.84); C156(0.81); C137(1.05); C503(1.04)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C673(0.90); C156(1.17); C137(0.92); C503(0.83)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C673(0.79); C156(0.73); C137(0.82); C503(1.04)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C673(1.03); C156(1.00); C137(0.90); C503(0.89)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C673(1.07); C156(0.96); C137(0.95); C503(1.11)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C673(1.19); C156(1.13); C137(1.00); C503(1.15)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C673(1.06); C156(0.96); C137(0.91); C503(1.06)  LDD1697  [17]
 LDCM0495  E2913 HEK-293T C673(0.89); C156(1.23); C137(1.20); C503(1.20)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C623(3.78); C71(1.94)  LDD1702  [5]
 LDCM0468  Fragment33 HEK-293T C673(0.95); C156(1.11); C137(1.00); C503(0.97)  LDD1671  [17]
 LDCM0427  Fragment51 HEK-293T C673(1.20); C156(1.12); C137(1.05); C503(1.07)  LDD1631  [17]
 LDCM0022  KB02 HEK-293T C137(0.95); C503(0.94); C673(1.10); C156(1.00)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C137(0.92); C503(1.02); C673(1.09); C156(0.95)  LDD1497  [17]
 LDCM0024  KB05 G361 C629(5.35)  LDD3311  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C623(1.14); C71(0.95); C66(1.00)  LDD2093  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C623(1.33); C71(1.33); C66(0.81); C137(0.99)  LDD2099  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C623(1.03); C71(0.91); C137(0.93)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C623(0.84); C71(0.79); C137(0.84)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C623(1.16); C71(0.88); C66(1.12)  LDD2111  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C623(0.94); C71(0.77); C137(0.78)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C71(1.35); C137(0.93)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C623(1.11); C66(1.18); C137(0.88)  LDD2127  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C623(0.76)  LDD2128  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C623(1.18); C71(0.75)  LDD2129  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C623(1.54); C66(0.83)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C623(1.05); C66(1.00); C137(1.06)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C623(1.05); C71(0.93)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C623(1.92); C66(1.29); C71(1.23)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C623(0.80); C66(0.58); C137(1.38)  LDD2140  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C623(0.82)  LDD2143  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C623(2.25); C71(1.82)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C623(1.04); C71(0.73); C66(0.83)  LDD2146  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C623(0.74)  LDD2148  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase Nek2 (NEK2) NEK Ser/Thr protein kinase family P51955
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) PTEN phosphatase protein family P60484
Fizzy-related protein homolog (FZR1) WD repeat CDC20/Fizzy family Q9UM11
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G1/S-specific cyclin-D1 (CCND1) Cyclin family P24385
Cell division cycle protein 20 homolog (CDC20) WD repeat CDC20/Fizzy family Q12834
Cadherin-1 (CDH1) . P12830
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Forkhead box protein O3 (FOXO3) . O43524
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anaphase-promoting complex subunit 4 (ANAPC4) APC4 family Q9UJX5
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) MAD2 family Q13257
F-box only protein 5 (FBXO5) . Q9UKT4
Mitotic spindle assembly checkpoint protein MAD2B (MAD2L2) . Q9UI95
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402