Details of the Target

General Information of Target

Target ID LDTP03142
Target Name CD9 antigen (CD9)
Gene Name CD9
Gene ID 928
Synonyms
MIC3; TSPAN29; CD9 antigen; 5H9 antigen; Cell growth-inhibiting gene 2 protein; Leukocyte antigen MIC3; Motility-related protein; MRP-1; Tetraspanin-29; Tspan-29; p24; CD antigen CD9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPVKGGTKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQETNNNNSSFYTGV
YILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAIWGYSHKDEVIKE
VQEFYKDTYNKLKTKDEPQRETLKAIHYALNCCGLAGGVEQFISDICPKKDVLETFTVKS
CPDAIKEVFDNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRNREMV
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Tetraspanin (TM4SF) family
Subcellular location
Cell membrane
Function
Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion. In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration. In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles. Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption. Acts as a receptor for PSG17. Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis.
TTD ID
T50574
Uniprot ID
P21926
DrugMap ID
TTZEIBV
Ensemble ID
ENST00000009180.10
HGNC ID
HGNC:1709

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		25.09  LDD0318  [1]
STPyne
 Probe Info  		K170(6.72)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K135(3.43); K133(5.95); K131(7.57)  LDD3494  [3]
BTD
 Probe Info  		C181(0.53)  LDD2101  [4]
DBIA
 Probe Info  		C181(1.11)  LDD0637  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
NHS
 Probe Info  		K170(0.00); K126(0.00)  LDD0010  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C181(0.97)  LDD1512  [8]
 LDCM0282  AC22 HEK-293T C181(1.01)  LDD1521  [8]
 LDCM0291  AC30 HEK-293T C181(1.02)  LDD1530  [8]
 LDCM0299  AC38 HEK-293T C181(1.11)  LDD1538  [8]
 LDCM0308  AC46 HEK-293T C181(0.99)  LDD1547  [8]
 LDCM0317  AC54 HEK-293T C181(0.96)  LDD1556  [8]
 LDCM0320  AC57 HCT 116 C181(1.11)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C181(0.76)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C181(0.66)  LDD0639  [5]
 LDCM0323  AC6 HEK-293T C181(0.95)  LDD1562  [8]
 LDCM0324  AC60 HCT 116 C181(0.54)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C181(0.56)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C181(0.65)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C181(0.81)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C181(0.53)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C181(1.66)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C181(1.63)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C181(0.75)  LDD0648  [5]
 LDCM0367  CL1 HCT 116 C181(1.50)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C181(0.81)  LDD0685  [5]
 LDCM0369  CL100 HEK-293T C181(0.79)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C181(0.94)  LDD1574  [8]
 LDCM0372  CL103 HEK-293T C181(1.17)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C181(0.86)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C181(1.01)  LDD1578  [8]
 LDCM0376  CL107 HEK-293T C181(1.09)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C181(0.87)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C181(0.93)  LDD1582  [8]
 LDCM0379  CL11 HCT 116 C181(0.96)  LDD0696  [5]
 LDCM0381  CL111 HEK-293T C181(1.03)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C181(0.83)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C181(1.00)  LDD1587  [8]
 LDCM0385  CL115 HEK-293T C181(1.04)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C181(0.95)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C181(0.99)  LDD1591  [8]
 LDCM0389  CL119 HEK-293T C181(1.10)  LDD1593  [8]
 LDCM0390  CL12 HCT 116 C181(1.02)  LDD0707  [5]
 LDCM0391  CL120 HEK-293T C181(0.93)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C181(1.04)  LDD1596  [8]
 LDCM0394  CL123 HEK-293T C181(1.19)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C181(0.78)  LDD1599  [8]
 LDCM0396  CL125 HCT 116 C181(1.33)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C181(1.36)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C181(1.57)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C181(1.03)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C181(0.78)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C181(1.32)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C181(0.39)  LDD0719  [5]
 LDCM0403  CL16 HEK-293T C181(1.00)  LDD1607  [8]
 LDCM0407  CL2 HCT 116 C181(1.50)  LDD0724  [5]
 LDCM0410  CL22 HEK-293T C181(1.21)  LDD1614  [8]
 LDCM0413  CL25 HEK-293T C181(1.10)  LDD1617  [8]
 LDCM0415  CL27 HEK-293T C181(1.13)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C181(0.91)  LDD1620  [8]
 LDCM0418  CL3 HCT 116 C181(1.35)  LDD0735  [5]
 LDCM0420  CL31 HCT 116 C181(1.01)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C181(0.68)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C181(0.82)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C181(0.57)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C181(0.84)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C181(0.92)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C181(0.56)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C181(0.54)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C181(1.34)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C181(0.77)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C181(0.73)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C181(0.75)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C181(0.66)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C181(0.54)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C181(0.40)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C181(2.38)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C181(2.33)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C181(2.17)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C181(1.89)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C181(1.17)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C181(2.01)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C181(2.01)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C181(2.02)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C181(2.19)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C181(2.16)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C181(2.13)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C181(2.09)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C181(2.05)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C181(2.18)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C181(1.98)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C181(0.77)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C181(1.96)  LDD0769  [5]
 LDCM0453  CL61 HEK-293T C181(0.99)  LDD1656  [8]
 LDCM0455  CL63 HEK-293T C181(1.17)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C181(0.95)  LDD1659  [8]
 LDCM0462  CL7 HCT 116 C181(0.86)  LDD0779  [5]
 LDCM0463  CL70 HEK-293T C181(1.22)  LDD1666  [8]
 LDCM0466  CL73 HEK-293T C181(1.02)  LDD1669  [8]
 LDCM0469  CL76 HCT 116 C181(0.90)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C181(1.41)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C181(1.08)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C181(0.84)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C181(1.10)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C181(0.98)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C181(1.00)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C181(0.68)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C181(0.89)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C181(0.81)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C181(1.06)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C181(1.29)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C181(1.16)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C181(0.82)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C181(0.58)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C181(1.32)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C181(1.60)  LDD0802  [5]
 LDCM0489  CL94 HEK-293T C181(1.11)  LDD1692  [8]
 LDCM0492  CL97 HEK-293T C181(1.01)  LDD1695  [8]
 LDCM0494  CL99 HEK-293T C181(1.06)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C181(1.22)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C181(1.00)  LDD1671  [8]
 LDCM0427  Fragment51 HCT 116 C181(0.60)  LDD0744  [5]
 LDCM0022  KB02 HEK-293T C181(1.06)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C181(0.92)  LDD1497  [8]
 LDCM0024  KB05 COLO792 C181(2.34)  LDD3310  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C181(0.53)  LDD2101  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neprilysin (MME) Peptidase M13 family P08473
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) . O14672
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prostaglandin F2 receptor negative regulator (PTGFRN) . Q9P2B2
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Outer dense fiber protein 4 (ODF4) . Q2M2E3

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
C31g . DB05398

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840