Details of the Target

General Information of Target

Target ID LDTP03098
Target Name Cyclin-dependent kinase 11B (CDK11B)
Gene Name CDK11B
Gene ID 984
Synonyms
CDC2L1; CDK11; PITSLREA; PK58; Cyclin-dependent kinase 11B; EC 2.7.11.22; Cell division cycle 2-like protein kinase 1; CLK-1; Cell division protein kinase 11B; Galactosyltransferase-associated protein kinase p58/GTA; PITSLRE serine/threonine-protein kinase CDC2L1; p58 CLK-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI
TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK
HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
ERFELGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG
SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSED
EERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQ
ELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPI
TSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVK
TLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVT
LWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEK
IWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKH
EYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTT
NQGASAAGPGFSLKF
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Subcellular location
Cytoplasm
Function
Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.
TTD ID
T15722
Uniprot ID
P21127
DrugMap ID
TT5Q79O
Ensemble ID
ENST00000340677.9
HGNC ID
HGNC:1729
ChEMBL ID
CHEMBL5808

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH216
 Probe Info  		Y681(8.14)  LDD0259  [1]
ONAyne
 Probe Info  		K719(5.16)  LDD0274  [2]
Probe 1
 Probe Info  		Y449(9.26)  LDD3495  [3]
BTD
 Probe Info  		C432(2.04)  LDD2090  [4]
AHL-Pu-1
 Probe Info  		C440(2.01)  LDD0168  [5]
HHS-475
 Probe Info  		Y453(0.82)  LDD0264  [6]
IPM
 Probe Info  		C432(4.91); C440(3.15)  LDD1701  [4]
HHS-465
 Probe Info  		Y681(10.00)  LDD2237  [7]
DBIA
 Probe Info  		C440(1.05); C432(0.96)  LDD0078  [8]
ATP probe
 Probe Info  		K564(0.00); K20(0.00); K21(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C626(0.00); C432(0.00); C440(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C626(0.00); C440(0.00); C432(0.00)  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		C626(0.00); C440(0.00); C432(0.00)  LDD0037  [10]
Compound 10
 Probe Info  		C432(0.00); C440(0.00)  LDD2216  [11]
Compound 11
 Probe Info  		C432(0.00); C440(0.00)  LDD2213  [11]
STPyne
 Probe Info  		N.A.  LDD0009  [12]
1c-yne
 Probe Info  		N.A.  LDD0228  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C432(0.83)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C432(0.83)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C432(1.23)  LDD2117  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C432(1.80)  LDD2103  [4]
 LDCM0025  4SU-RNA HEK-293T C440(2.01)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C440(2.97)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C432(0.93); C440(1.08)  LDD0812  [8]
 LDCM0215  AC10 HEK-293T C432(1.07)  LDD0813  [8]
 LDCM0216  AC100 HEK-293T C432(1.04); C440(1.34)  LDD0814  [8]
 LDCM0217  AC101 HEK-293T C432(1.16); C440(1.15)  LDD0815  [8]
 LDCM0218  AC102 HEK-293T C432(1.02); C440(0.92)  LDD0816  [8]
 LDCM0219  AC103 HEK-293T C432(1.36); C440(0.96)  LDD0817  [8]
 LDCM0220  AC104 HEK-293T C432(1.07); C440(1.15)  LDD0818  [8]
 LDCM0221  AC105 HEK-293T C432(1.35); C440(1.07)  LDD0819  [8]
 LDCM0222  AC106 HEK-293T C432(1.11); C440(1.19)  LDD0820  [8]
 LDCM0223  AC107 HEK-293T C432(1.06); C440(0.84)  LDD0821  [8]
 LDCM0224  AC108 HEK-293T C432(1.07); C440(0.99)  LDD0822  [8]
 LDCM0225  AC109 HEK-293T C432(1.12); C440(1.06)  LDD0823  [8]
 LDCM0226  AC11 HEK-293T C432(0.97)  LDD0824  [8]
 LDCM0227  AC110 HEK-293T C432(1.12); C440(0.89)  LDD0825  [8]
 LDCM0228  AC111 HEK-293T C432(1.08); C440(1.14)  LDD0826  [8]
 LDCM0229  AC112 HEK-293T C432(1.16); C440(0.92)  LDD0827  [8]
 LDCM0230  AC113 HEK-293T C432(0.98)  LDD0828  [8]
 LDCM0231  AC114 HEK-293T C432(0.94)  LDD0829  [8]
 LDCM0232  AC115 HEK-293T C432(1.12)  LDD0830  [8]
 LDCM0233  AC116 HEK-293T C432(1.02)  LDD0831  [8]
 LDCM0234  AC117 HEK-293T C432(1.00)  LDD0832  [8]
 LDCM0235  AC118 HEK-293T C432(1.24)  LDD0833  [8]
 LDCM0236  AC119 HEK-293T C432(1.02)  LDD0834  [8]
 LDCM0237  AC12 HEK-293T C432(1.03)  LDD0835  [8]
 LDCM0238  AC120 HEK-293T C432(0.99)  LDD0836  [8]
 LDCM0239  AC121 HEK-293T C432(1.04)  LDD0837  [8]
 LDCM0240  AC122 HEK-293T C432(1.03)  LDD0838  [8]
 LDCM0241  AC123 HEK-293T C432(0.96)  LDD0839  [8]
 LDCM0242  AC124 HEK-293T C432(1.10)  LDD0840  [8]
 LDCM0243  AC125 HEK-293T C432(0.95)  LDD0841  [8]
 LDCM0244  AC126 HEK-293T C432(1.13)  LDD0842  [8]
 LDCM0245  AC127 HEK-293T C432(0.97)  LDD0843  [8]
 LDCM0246  AC128 HEK-293T C432(1.04); C440(1.64)  LDD0844  [8]
 LDCM0247  AC129 HEK-293T C432(1.12); C440(1.60)  LDD0845  [8]
 LDCM0249  AC130 HEK-293T C432(1.40); C440(0.96)  LDD0847  [8]
 LDCM0250  AC131 HEK-293T C432(1.05); C440(1.29)  LDD0848  [8]
 LDCM0251  AC132 HEK-293T C432(0.98); C440(1.69)  LDD0849  [8]
 LDCM0252  AC133 HEK-293T C432(1.04); C440(1.24)  LDD0850  [8]
 LDCM0253  AC134 HEK-293T C432(1.10); C440(1.43)  LDD0851  [8]
 LDCM0254  AC135 HEK-293T C432(1.39); C440(1.49)  LDD0852  [8]
 LDCM0255  AC136 HEK-293T C432(1.08); C440(1.35)  LDD0853  [8]
 LDCM0256  AC137 HEK-293T C432(0.83); C440(1.23)  LDD0854  [8]
 LDCM0257  AC138 HEK-293T C432(1.15); C440(1.40)  LDD0855  [8]
 LDCM0258  AC139 HEK-293T C432(1.05); C440(3.71)  LDD0856  [8]
 LDCM0259  AC14 HEK-293T C432(1.01)  LDD0857  [8]
 LDCM0260  AC140 HEK-293T C432(0.99); C440(1.25)  LDD0858  [8]
 LDCM0261  AC141 HEK-293T C432(1.00); C440(1.59)  LDD0859  [8]
 LDCM0262  AC142 HEK-293T C432(1.22); C440(1.73)  LDD0860  [8]
 LDCM0263  AC143 HEK-293T C440(0.92)  LDD0861  [8]
 LDCM0264  AC144 HEK-293T C440(0.92)  LDD0862  [8]
 LDCM0265  AC145 HEK-293T C440(1.10)  LDD0863  [8]
 LDCM0266  AC146 HEK-293T C440(1.09)  LDD0864  [8]
 LDCM0267  AC147 HEK-293T C440(0.95)  LDD0865  [8]
 LDCM0268  AC148 HEK-293T C440(0.94)  LDD0866  [8]
 LDCM0269  AC149 HEK-293T C440(1.06)  LDD0867  [8]
 LDCM0270  AC15 HEK-293T C432(0.98)  LDD0868  [8]
 LDCM0271  AC150 HEK-293T C440(0.84)  LDD0869  [8]
 LDCM0272  AC151 HEK-293T C440(1.08)  LDD0870  [8]
 LDCM0273  AC152 HEK-293T C440(0.84)  LDD0871  [8]
 LDCM0274  AC153 HEK-293T C440(1.08)  LDD0872  [8]
 LDCM0621  AC154 HEK-293T C440(0.90)  LDD2162  [8]
 LDCM0622  AC155 HEK-293T C440(1.44)  LDD2163  [8]
 LDCM0623  AC156 HEK-293T C440(1.27)  LDD2164  [8]
 LDCM0624  AC157 HEK-293T C440(0.85)  LDD2165  [8]
 LDCM0276  AC17 HEK-293T C432(0.82)  LDD0874  [8]
 LDCM0277  AC18 HEK-293T C432(0.90)  LDD0875  [8]
 LDCM0278  AC19 HEK-293T C432(0.93)  LDD0876  [8]
 LDCM0279  AC2 HEK-293T C432(0.98); C440(1.86)  LDD0877  [8]
 LDCM0280  AC20 HEK-293T C432(0.90)  LDD0878  [8]
 LDCM0281  AC21 HEK-293T C432(0.83)  LDD0879  [8]
 LDCM0282  AC22 HEK-293T C432(0.94)  LDD0880  [8]
 LDCM0283  AC23 HEK-293T C432(0.82)  LDD0881  [8]
 LDCM0284  AC24 HEK-293T C432(0.86)  LDD0882  [8]
 LDCM0285  AC25 HEK-293T C432(0.99); C440(0.69)  LDD0883  [8]
 LDCM0286  AC26 HEK-293T C432(0.99); C440(0.73)  LDD0884  [8]
 LDCM0287  AC27 HEK-293T C432(1.00); C440(0.73)  LDD0885  [8]
 LDCM0288  AC28 HEK-293T C432(0.96); C440(0.73)  LDD0886  [8]
 LDCM0289  AC29 HEK-293T C432(0.92); C440(0.65)  LDD0887  [8]
 LDCM0290  AC3 HEK-293T C432(1.12); C440(1.20)  LDD0888  [8]
 LDCM0291  AC30 HEK-293T C432(0.94); C440(0.82)  LDD0889  [8]
 LDCM0292  AC31 HEK-293T C432(0.89); C440(0.68)  LDD0890  [8]
 LDCM0293  AC32 HEK-293T C432(0.84); C440(0.71)  LDD0891  [8]
 LDCM0294  AC33 HEK-293T C432(0.92); C440(0.66)  LDD0892  [8]
 LDCM0295  AC34 HEK-293T C432(0.92); C440(0.76)  LDD0893  [8]
 LDCM0296  AC35 HEK-293T C432(1.00)  LDD0894  [8]
 LDCM0297  AC36 HEK-293T C432(1.04)  LDD0895  [8]
 LDCM0298  AC37 HEK-293T C432(0.95)  LDD0896  [8]
 LDCM0299  AC38 HEK-293T C432(1.15)  LDD0897  [8]
 LDCM0300  AC39 HEK-293T C432(1.01)  LDD0898  [8]
 LDCM0301  AC4 HEK-293T C432(0.99); C440(1.72)  LDD0899  [8]
 LDCM0302  AC40 HEK-293T C432(1.17)  LDD0900  [8]
 LDCM0303  AC41 HEK-293T C432(1.01)  LDD0901  [8]
 LDCM0304  AC42 HEK-293T C432(0.97)  LDD0902  [8]
 LDCM0305  AC43 HEK-293T C432(1.00)  LDD0903  [8]
 LDCM0306  AC44 HEK-293T C432(1.07)  LDD0904  [8]
 LDCM0307  AC45 HEK-293T C432(0.92)  LDD0905  [8]
 LDCM0308  AC46 HEK-293T C432(0.83)  LDD0906  [8]
 LDCM0309  AC47 HEK-293T C432(0.77)  LDD0907  [8]
 LDCM0310  AC48 HEK-293T C432(0.87)  LDD0908  [8]
 LDCM0311  AC49 HEK-293T C432(0.80)  LDD0909  [8]
 LDCM0312  AC5 HEK-293T C432(0.94); C440(0.84)  LDD0910  [8]
 LDCM0313  AC50 HEK-293T C432(0.75)  LDD0911  [8]
 LDCM0314  AC51 HEK-293T C432(0.83)  LDD0912  [8]
 LDCM0315  AC52 HEK-293T C432(0.72)  LDD0913  [8]
 LDCM0316  AC53 HEK-293T C432(0.74)  LDD0914  [8]
 LDCM0317  AC54 HEK-293T C432(0.81)  LDD0915  [8]
 LDCM0318  AC55 HEK-293T C432(0.79)  LDD0916  [8]
 LDCM0319  AC56 HEK-293T C432(0.77)  LDD0917  [8]
 LDCM0320  AC57 HEK-293T C432(0.98); C440(0.93)  LDD0918  [8]
 LDCM0321  AC58 HEK-293T C432(0.86); C440(0.98)  LDD0919  [8]
 LDCM0322  AC59 HEK-293T C432(0.97); C440(1.04)  LDD0920  [8]
 LDCM0323  AC6 HEK-293T C432(0.94)  LDD0921  [8]
 LDCM0324  AC60 HEK-293T C432(1.07); C440(1.04)  LDD0922  [8]
 LDCM0325  AC61 HEK-293T C432(0.90); C440(0.95)  LDD0923  [8]
 LDCM0326  AC62 HEK-293T C432(0.94); C440(0.99)  LDD0924  [8]
 LDCM0327  AC63 HEK-293T C432(0.96); C440(0.91)  LDD0925  [8]
 LDCM0328  AC64 HEK-293T C432(0.81); C440(1.12)  LDD0926  [8]
 LDCM0329  AC65 HEK-293T C432(0.93); C440(0.98)  LDD0927  [8]
 LDCM0330  AC66 HEK-293T C432(0.90); C440(0.97)  LDD0928  [8]
 LDCM0331  AC67 HEK-293T C432(0.89); C440(0.88)  LDD0929  [8]
 LDCM0332  AC68 HEK-293T C432(0.89); C440(0.66)  LDD0930  [8]
 LDCM0333  AC69 HEK-293T C432(0.91); C440(0.81)  LDD0931  [8]
 LDCM0334  AC7 HEK-293T C432(0.99)  LDD0932  [8]
 LDCM0335  AC70 HEK-293T C432(1.13); C440(0.86)  LDD0933  [8]
 LDCM0336  AC71 HEK-293T C432(1.17); C440(0.79)  LDD0934  [8]
 LDCM0337  AC72 HEK-293T C432(0.98); C440(1.00)  LDD0935  [8]
 LDCM0338  AC73 HEK-293T C432(1.28); C440(0.88)  LDD0936  [8]
 LDCM0339  AC74 HEK-293T C432(1.16); C440(0.73)  LDD0937  [8]
 LDCM0340  AC75 HEK-293T C432(1.10); C440(0.84)  LDD0938  [8]
 LDCM0341  AC76 HEK-293T C432(1.15); C440(0.95)  LDD0939  [8]
 LDCM0342  AC77 HEK-293T C432(0.95); C440(0.88)  LDD0940  [8]
 LDCM0343  AC78 HEK-293T C432(0.99); C440(0.73)  LDD0941  [8]
 LDCM0344  AC79 HEK-293T C432(0.94); C440(0.76)  LDD0942  [8]
 LDCM0345  AC8 HEK-293T C432(1.14)  LDD0943  [8]
 LDCM0346  AC80 HEK-293T C432(1.02); C440(0.86)  LDD0944  [8]
 LDCM0347  AC81 HEK-293T C432(0.92); C440(0.72)  LDD0945  [8]
 LDCM0348  AC82 HEK-293T C432(1.02); C440(0.83)  LDD0946  [8]
 LDCM0349  AC83 HEK-293T C432(0.94); C440(0.83)  LDD0947  [8]
 LDCM0350  AC84 HEK-293T C432(0.90); C440(1.31)  LDD0948  [8]
 LDCM0351  AC85 HEK-293T C432(0.94); C440(1.12)  LDD0949  [8]
 LDCM0352  AC86 HEK-293T C432(1.03); C440(0.95)  LDD0950  [8]
 LDCM0353  AC87 HEK-293T C432(0.90); C440(1.01)  LDD0951  [8]
 LDCM0354  AC88 HEK-293T C432(1.17); C440(1.20)  LDD0952  [8]
 LDCM0355  AC89 HEK-293T C432(0.86); C440(1.25)  LDD0953  [8]
 LDCM0357  AC90 HEK-293T C432(1.16); C440(1.07)  LDD0955  [8]
 LDCM0358  AC91 HEK-293T C432(1.02); C440(0.80)  LDD0956  [8]
 LDCM0359  AC92 HEK-293T C432(0.87); C440(0.73)  LDD0957  [8]
 LDCM0360  AC93 HEK-293T C432(0.98); C440(0.94)  LDD0958  [8]
 LDCM0361  AC94 HEK-293T C432(0.97); C440(1.11)  LDD0959  [8]
 LDCM0362  AC95 HEK-293T C432(1.07); C440(0.93)  LDD0960  [8]
 LDCM0363  AC96 HEK-293T C432(1.10); C440(0.77)  LDD0961  [8]
 LDCM0364  AC97 HEK-293T C432(0.90); C440(0.81)  LDD0962  [8]
 LDCM0365  AC98 HEK-293T C432(1.13); C440(1.06)  LDD0963  [8]
 LDCM0366  AC99 HEK-293T C432(1.02); C440(1.04)  LDD0964  [8]
 LDCM0545  Acetamide MDA-MB-231 C432(1.12)  LDD2138  [4]
 LDCM0248  AKOS034007472 HEK-293T C432(0.93)  LDD0846  [8]
 LDCM0356  AKOS034007680 HEK-293T C432(1.03)  LDD0954  [8]
 LDCM0275  AKOS034007705 HEK-293T C432(0.81)  LDD0873  [8]
 LDCM0020  ARS-1620 HCC44 C440(1.05); C432(0.96)  LDD0078  [8]
 LDCM0367  CL1 HEK-293T C432(1.00)  LDD0965  [8]
 LDCM0368  CL10 HEK-293T C432(0.99)  LDD0966  [8]
 LDCM0369  CL100 HEK-293T C432(1.08); C440(1.25)  LDD0967  [8]
 LDCM0370  CL101 HEK-293T C432(0.97)  LDD0968  [8]
 LDCM0371  CL102 HEK-293T C432(0.73)  LDD0969  [8]
 LDCM0372  CL103 HEK-293T C432(0.89)  LDD0970  [8]
 LDCM0373  CL104 HEK-293T C432(0.99)  LDD0971  [8]
 LDCM0374  CL105 HEK-293T C432(0.86)  LDD0972  [8]
 LDCM0375  CL106 HEK-293T C432(0.88)  LDD0973  [8]
 LDCM0376  CL107 HEK-293T C432(1.01)  LDD0974  [8]
 LDCM0377  CL108 HEK-293T C432(1.00)  LDD0975  [8]
 LDCM0378  CL109 HEK-293T C432(0.83)  LDD0976  [8]
 LDCM0379  CL11 HEK-293T C432(0.79)  LDD0977  [8]
 LDCM0380  CL110 HEK-293T C432(1.00)  LDD0978  [8]
 LDCM0381  CL111 HEK-293T C432(0.91)  LDD0979  [8]
 LDCM0382  CL112 HEK-293T C432(0.27); C440(0.94)  LDD0980  [8]
 LDCM0383  CL113 HEK-293T C432(1.02); C440(0.56)  LDD0981  [8]
 LDCM0384  CL114 HEK-293T C432(0.66); C440(0.88)  LDD0982  [8]
 LDCM0385  CL115 HEK-293T C432(0.95); C440(0.86)  LDD0983  [8]
 LDCM0386  CL116 HEK-293T C432(0.95); C440(0.60)  LDD0984  [8]
 LDCM0387  CL117 HEK-293T C432(0.94)  LDD0985  [8]
 LDCM0388  CL118 HEK-293T C432(1.08)  LDD0986  [8]
 LDCM0389  CL119 HEK-293T C432(1.02)  LDD0987  [8]
 LDCM0390  CL12 HEK-293T C432(0.79)  LDD0988  [8]
 LDCM0391  CL120 HEK-293T C432(1.00)  LDD0989  [8]
 LDCM0392  CL121 HEK-293T C432(0.91)  LDD0990  [8]
 LDCM0393  CL122 HEK-293T C432(0.80)  LDD0991  [8]
 LDCM0394  CL123 HEK-293T C432(0.76)  LDD0992  [8]
 LDCM0395  CL124 HEK-293T C432(0.89)  LDD0993  [8]
 LDCM0396  CL125 HEK-293T C432(0.94); C440(1.21)  LDD0994  [8]
 LDCM0397  CL126 HEK-293T C432(1.15); C440(0.75)  LDD0995  [8]
 LDCM0398  CL127 HEK-293T C432(1.03); C440(1.27)  LDD0996  [8]
 LDCM0399  CL128 HEK-293T C432(0.99); C440(1.02)  LDD0997  [8]
 LDCM0400  CL13 HEK-293T C432(0.97)  LDD0998  [8]
 LDCM0401  CL14 HEK-293T C432(1.13)  LDD0999  [8]
 LDCM0402  CL15 HEK-293T C432(1.08)  LDD1000  [8]
 LDCM0403  CL16 HEK-293T C432(0.95)  LDD1001  [8]
 LDCM0404  CL17 HEK-293T C432(0.81)  LDD1002  [8]
 LDCM0405  CL18 HEK-293T C432(0.96)  LDD1003  [8]
 LDCM0406  CL19 HEK-293T C432(0.86)  LDD1004  [8]
 LDCM0407  CL2 HEK-293T C432(0.88)  LDD1005  [8]
 LDCM0408  CL20 HEK-293T C432(0.94)  LDD1006  [8]
 LDCM0409  CL21 HEK-293T C432(0.83)  LDD1007  [8]
 LDCM0410  CL22 HEK-293T C432(0.84)  LDD1008  [8]
 LDCM0411  CL23 HEK-293T C432(0.89)  LDD1009  [8]
 LDCM0412  CL24 HEK-293T C432(0.88)  LDD1010  [8]
 LDCM0413  CL25 HEK-293T C432(0.78)  LDD1011  [8]
 LDCM0414  CL26 HEK-293T C432(0.88)  LDD1012  [8]
 LDCM0415  CL27 HEK-293T C432(0.87)  LDD1013  [8]
 LDCM0416  CL28 HEK-293T C432(1.03)  LDD1014  [8]
 LDCM0417  CL29 HEK-293T C432(0.95)  LDD1015  [8]
 LDCM0418  CL3 HEK-293T C432(1.01)  LDD1016  [8]
 LDCM0419  CL30 HEK-293T C432(0.91)  LDD1017  [8]
 LDCM0420  CL31 HEK-293T C432(1.09); C440(0.63)  LDD1018  [8]
 LDCM0421  CL32 HEK-293T C432(1.02); C440(0.95)  LDD1019  [8]
 LDCM0422  CL33 HEK-293T C432(0.90); C440(1.03)  LDD1020  [8]
 LDCM0423  CL34 HEK-293T C432(1.05); C440(0.65)  LDD1021  [8]
 LDCM0424  CL35 HEK-293T C432(1.14); C440(0.82)  LDD1022  [8]
 LDCM0425  CL36 HEK-293T C432(1.12); C440(0.65)  LDD1023  [8]
 LDCM0426  CL37 HEK-293T C432(1.00); C440(1.07)  LDD1024  [8]
 LDCM0428  CL39 HEK-293T C432(0.96); C440(1.30)  LDD1026  [8]
 LDCM0429  CL4 HEK-293T C432(0.86)  LDD1027  [8]
 LDCM0430  CL40 HEK-293T C432(1.11); C440(0.84)  LDD1028  [8]
 LDCM0431  CL41 HEK-293T C432(1.05); C440(0.74)  LDD1029  [8]
 LDCM0432  CL42 HEK-293T C432(1.00); C440(0.79)  LDD1030  [8]
 LDCM0433  CL43 HEK-293T C432(1.00); C440(0.51)  LDD1031  [8]
 LDCM0434  CL44 HEK-293T C432(1.02); C440(0.97)  LDD1032  [8]
 LDCM0435  CL45 HEK-293T C432(0.99); C440(1.01)  LDD1033  [8]
 LDCM0436  CL46 HEK-293T C432(1.02); C440(0.99)  LDD1034  [8]
 LDCM0437  CL47 HEK-293T C432(0.84); C440(0.59)  LDD1035  [8]
 LDCM0438  CL48 HEK-293T C432(1.01); C440(0.87)  LDD1036  [8]
 LDCM0439  CL49 HEK-293T C432(0.88); C440(0.54)  LDD1037  [8]
 LDCM0440  CL5 HEK-293T C432(1.14)  LDD1038  [8]
 LDCM0441  CL50 HEK-293T C432(0.82); C440(0.52)  LDD1039  [8]
 LDCM0442  CL51 HEK-293T C432(0.84); C440(0.62)  LDD1040  [8]
 LDCM0443  CL52 HEK-293T C432(1.05); C440(0.50)  LDD1041  [8]
 LDCM0444  CL53 HEK-293T C432(0.95); C440(0.84)  LDD1042  [8]
 LDCM0445  CL54 HEK-293T C432(0.83); C440(0.77)  LDD1043  [8]
 LDCM0446  CL55 HEK-293T C432(0.76); C440(0.93)  LDD1044  [8]
 LDCM0447  CL56 HEK-293T C432(0.88); C440(1.23)  LDD1045  [8]
 LDCM0448  CL57 HEK-293T C432(0.82); C440(0.85)  LDD1046  [8]
 LDCM0449  CL58 HEK-293T C432(0.94); C440(0.75)  LDD1047  [8]
 LDCM0450  CL59 HEK-293T C432(0.83); C440(0.70)  LDD1048  [8]
 LDCM0451  CL6 HEK-293T C432(0.87)  LDD1049  [8]
 LDCM0452  CL60 HEK-293T C432(1.00); C440(1.13)  LDD1050  [8]
 LDCM0453  CL61 HEK-293T C432(1.09)  LDD1051  [8]
 LDCM0454  CL62 HEK-293T C432(0.94)  LDD1052  [8]
 LDCM0455  CL63 HEK-293T C432(1.15)  LDD1053  [8]
 LDCM0456  CL64 HEK-293T C432(1.08)  LDD1054  [8]
 LDCM0457  CL65 HEK-293T C432(1.14)  LDD1055  [8]
 LDCM0458  CL66 HEK-293T C432(1.02)  LDD1056  [8]
 LDCM0459  CL67 HEK-293T C432(1.14)  LDD1057  [8]
 LDCM0460  CL68 HEK-293T C432(0.85)  LDD1058  [8]
 LDCM0461  CL69 HEK-293T C432(1.17)  LDD1059  [8]
 LDCM0462  CL7 HEK-293T C432(1.09)  LDD1060  [8]
 LDCM0463  CL70 HEK-293T C432(1.19)  LDD1061  [8]
 LDCM0464  CL71 HEK-293T C432(1.10)  LDD1062  [8]
 LDCM0465  CL72 HEK-293T C432(1.13)  LDD1063  [8]
 LDCM0466  CL73 HEK-293T C432(0.96)  LDD1064  [8]
 LDCM0467  CL74 HEK-293T C432(1.09)  LDD1065  [8]
 LDCM0469  CL76 HEK-293T C432(0.89); C440(0.99)  LDD1067  [8]
 LDCM0470  CL77 HEK-293T C432(0.78); C440(2.07)  LDD1068  [8]
 LDCM0471  CL78 HEK-293T C432(0.81); C440(0.89)  LDD1069  [8]
 LDCM0472  CL79 HEK-293T C432(0.96); C440(0.75)  LDD1070  [8]
 LDCM0473  CL8 HEK-293T C432(1.19)  LDD1071  [8]
 LDCM0474  CL80 HEK-293T C432(1.01); C440(0.79)  LDD1072  [8]
 LDCM0475  CL81 HEK-293T C432(0.91); C440(0.81)  LDD1073  [8]
 LDCM0476  CL82 HEK-293T C432(0.92); C440(0.69)  LDD1074  [8]
 LDCM0477  CL83 HEK-293T C432(0.96); C440(1.04)  LDD1075  [8]
 LDCM0478  CL84 HEK-293T C432(0.88); C440(0.79)  LDD1076  [8]
 LDCM0479  CL85 HEK-293T C432(0.84); C440(0.99)  LDD1077  [8]
 LDCM0480  CL86 HEK-293T C432(0.76); C440(0.97)  LDD1078  [8]
 LDCM0481  CL87 HEK-293T C432(0.87); C440(0.97)  LDD1079  [8]
 LDCM0482  CL88 HEK-293T C432(0.89); C440(1.20)  LDD1080  [8]
 LDCM0483  CL89 HEK-293T C432(1.00); C440(0.78)  LDD1081  [8]
 LDCM0484  CL9 HEK-293T C432(1.04)  LDD1082  [8]
 LDCM0485  CL90 HEK-293T C432(0.95); C440(0.87)  LDD1083  [8]
 LDCM0486  CL91 HEK-293T C432(0.94); C440(1.19)  LDD1084  [8]
 LDCM0487  CL92 HEK-293T C432(1.00); C440(0.74)  LDD1085  [8]
 LDCM0488  CL93 HEK-293T C432(0.95); C440(2.62)  LDD1086  [8]
 LDCM0489  CL94 HEK-293T C432(0.84); C440(1.19)  LDD1087  [8]
 LDCM0490  CL95 HEK-293T C432(0.79); C440(1.50)  LDD1088  [8]
 LDCM0491  CL96 HEK-293T C432(1.09); C440(1.58)  LDD1089  [8]
 LDCM0492  CL97 HEK-293T C432(0.85); C440(1.96)  LDD1090  [8]
 LDCM0493  CL98 HEK-293T C432(0.97); C440(0.92)  LDD1091  [8]
 LDCM0494  CL99 HEK-293T C432(0.96); C440(1.50)  LDD1092  [8]
 LDCM0625  F8 Ramos C440(1.08); C432(0.86)  LDD2187  [14]
 LDCM0572  Fragment10 Ramos C440(2.60); C432(1.03)  LDD2189  [14]
 LDCM0573  Fragment11 Ramos C440(20.00)  LDD2190  [14]
 LDCM0574  Fragment12 Ramos C440(1.60); C432(0.99)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C440(1.06); C432(0.91)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C440(1.48); C432(0.85)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C440(2.28); C432(1.13)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C440(1.33); C432(0.69)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C440(1.11); C432(0.89)  LDD2196  [14]
 LDCM0578  Fragment27 Ramos C440(1.13); C432(0.68)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C440(0.85); C432(0.79)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C440(1.36); C432(0.73)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C440(1.05); C432(0.98)  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C440(1.31); C432(0.70)  LDD2201  [14]
 LDCM0468  Fragment33 HEK-293T C432(1.31)  LDD1066  [8]
 LDCM0596  Fragment38 Ramos C440(0.99); C432(0.79)  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C440(1.95); C432(0.99)  LDD2184  [14]
 LDCM0427  Fragment51 HEK-293T C432(1.00); C440(1.04)  LDD1025  [8]
 LDCM0610  Fragment52 Ramos C440(1.27); C432(1.09)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C440(1.25); C432(0.98)  LDD2205  [14]
 LDCM0569  Fragment7 Ramos C440(1.72); C432(1.14)  LDD2186  [14]
 LDCM0571  Fragment9 Ramos C440(2.14); C432(1.20)  LDD2188  [14]
 LDCM0116  HHS-0101 DM93 Y453(0.82)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y453(0.69)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y453(0.57)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y453(0.59)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y453(0.69)  LDD0268  [6]
 LDCM0022  KB02 HCT 116 C440(2.76); C432(1.62)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C440(1.40); C432(1.34)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C440(2.88); C432(1.83)  LDD0082  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C432(2.04)  LDD2090  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C432(1.29)  LDD2092  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C432(0.96)  LDD2098  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C432(0.73)  LDD2100  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C432(0.65)  LDD2104  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C440(0.51)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C432(1.46); C440(1.07)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C432(0.86)  LDD2108  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C432(2.01)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C440(1.09)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C440(1.00)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C432(1.48)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C432(1.26)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C440(1.31)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C440(1.10)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C432(1.17)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C432(1.95)  LDD2140  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C440(1.13)  LDD2146  [4]
 LDCM0021  THZ1 HCT 116 C432(0.89)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 3 subunit F (EIF3F) EIF-3 subunit F family O00303
Serine/threonine-protein kinase PAK 1 (PAK1) STE Ser/Thr protein kinase family Q13153

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578