Details of the Target

General Information of Target

Target ID LDTP02993
Target Name DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E)
Gene Name POLR2E
Gene ID 5434
Synonyms
DNA-directed RNA polymerases I, II, and III subunit RPABC1; RNA polymerases I, II, and III subunit ABC1; DNA-directed RNA polymerase II 23 kDa polypeptide; DNA-directed RNA polymerase II subunit E; RPB5 homolog; XAP4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQSGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ
Target Bioclass
Enzyme
Family
Archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family
Subcellular location
Nucleus
Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPABC1 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template.
Uniprot ID
P19388
Ensemble ID
ENST00000586746.5
HGNC ID
HGNC:9192

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K115(20.00)  LDD2217  [1]
BTD
 Probe Info  		C21(1.15)  LDD2093  [2]
DBIA
 Probe Info  		C21(1.08)  LDD0532  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C21(1.45)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C21(1.74)  LDD2152  [2]
 LDCM0215  AC10 HCT 116 C21(1.08)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C21(0.44)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C21(0.55)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C21(0.52)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C21(0.26)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C21(0.30)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C21(0.29)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C21(0.28)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C21(0.45)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C21(0.21)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C21(0.34)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C21(1.12)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C21(0.31)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C21(0.34)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C21(0.29)  LDD0546  [3]
 LDCM0230  AC113 PaTu 8988t C21(1.10)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C21(0.98)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C21(0.93)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C21(1.31)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C21(1.29)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C21(0.87)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C21(0.70)  LDD1115  [3]
 LDCM0237  AC12 HCT 116 C21(0.98)  LDD0554  [3]
 LDCM0238  AC120 PaTu 8988t C21(0.93)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C21(0.63)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C21(1.23)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C21(0.89)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C21(0.64)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C21(0.87)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C21(1.16)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C21(0.63)  LDD1124  [3]
 LDCM0246  AC128 PaTu 8988t C21(0.64)  LDD1125  [3]
 LDCM0247  AC129 PaTu 8988t C21(0.56)  LDD1126  [3]
 LDCM0249  AC130 PaTu 8988t C21(0.71)  LDD1128  [3]
 LDCM0250  AC131 PaTu 8988t C21(0.57)  LDD1129  [3]
 LDCM0251  AC132 PaTu 8988t C21(0.67)  LDD1130  [3]
 LDCM0252  AC133 PaTu 8988t C21(0.30)  LDD1131  [3]
 LDCM0253  AC134 PaTu 8988t C21(0.43)  LDD1132  [3]
 LDCM0254  AC135 PaTu 8988t C21(0.33)  LDD1133  [3]
 LDCM0255  AC136 PaTu 8988t C21(0.42)  LDD1134  [3]
 LDCM0256  AC137 PaTu 8988t C21(0.28)  LDD1135  [3]
 LDCM0257  AC138 PaTu 8988t C21(0.51)  LDD1136  [3]
 LDCM0258  AC139 PaTu 8988t C21(0.52)  LDD1137  [3]
 LDCM0259  AC14 HCT 116 C21(0.89)  LDD0576  [3]
 LDCM0260  AC140 PaTu 8988t C21(0.65)  LDD1139  [3]
 LDCM0261  AC141 PaTu 8988t C21(0.81)  LDD1140  [3]
 LDCM0262  AC142 PaTu 8988t C21(0.47)  LDD1141  [3]
 LDCM0263  AC143 HCT 116 C21(0.76)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C21(0.31)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C21(0.61)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C21(0.42)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C21(0.32)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C21(0.14)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C21(0.28)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C21(0.91)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C21(0.88)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C21(0.55)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C21(0.24)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C21(0.13)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C21(0.43)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C21(0.46)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C21(0.72)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C21(0.77)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C21(0.76)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C21(0.36)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C21(0.66)  LDD0595  [3]
 LDCM0280  AC20 HCT 116 C21(0.80)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C21(0.58)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C21(0.78)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C21(0.75)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C21(0.84)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C21(1.03)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C21(0.73)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C21(0.67)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C21(0.60)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C21(0.67)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C21(1.10)  LDD1529  [8]
 LDCM0291  AC30 HCT 116 C21(0.65)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C21(0.66)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C21(0.46)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C21(0.53)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C21(0.40)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C21(1.33)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C21(1.80)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C21(1.41)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C21(1.24)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C21(0.99)  LDD0617  [3]
 LDCM0302  AC40 HCT 116 C21(0.68)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C21(1.23)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C21(0.96)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C21(1.08)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C21(0.85)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C21(0.67)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C21(1.15)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C21(1.01)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C21(1.17)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C21(0.48)  LDD0628  [3]
 LDCM0313  AC50 HCT 116 C21(0.55)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C21(1.34)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C21(1.11)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C21(0.67)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C21(0.71)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C21(0.50)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C21(0.34)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C21(0.67)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C21(0.49)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C21(0.45)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C21(1.13)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C21(0.59)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C21(0.86)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C21(0.38)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C21(0.65)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C21(0.40)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C21(0.55)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C21(0.61)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C21(0.22)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C21(0.74)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C21(0.69)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C21(1.10)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C21(0.41)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C21(0.90)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C21(0.71)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C21(0.35)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C21(0.37)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C21(0.30)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C21(0.56)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C21(0.55)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C21(0.82)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C21(0.81)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C21(0.88)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C21(0.66)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C21(0.78)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C21(0.25)  LDD0665  [3]
 LDCM0365  AC98 HCT 116 C21(0.06)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C21(0.53)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C21(1.06)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C21(1.11)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C21(0.97)  LDD0592  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0367  CL1 PaTu 8988t C21(1.01)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C21(0.42)  LDD1247  [3]
 LDCM0370  CL101 HCT 116 C21(1.08)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C21(1.48)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C21(1.24)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C21(1.37)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C21(0.50)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C21(0.24)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C21(0.34)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C21(0.25)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C21(0.48)  LDD0695  [3]
 LDCM0379  CL11 PaTu 8988t C21(0.91)  LDD1258  [3]
 LDCM0380  CL110 HCT 116 C21(0.37)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C21(0.54)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C21(1.15)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C21(0.50)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C21(0.75)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C21(0.68)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C21(0.80)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C21(0.37)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C21(0.88)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C21(0.81)  LDD0706  [3]
 LDCM0390  CL12 PaTu 8988t C21(0.82)  LDD1269  [3]
 LDCM0391  CL120 HCT 116 C21(1.31)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C21(0.84)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C21(0.83)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C21(0.63)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C21(0.54)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C21(2.01)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C21(1.15)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C21(1.09)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C21(0.52)  LDD0716  [3]
 LDCM0400  CL13 PaTu 8988t C21(0.29)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C21(0.22)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C21(0.65)  LDD1281  [3]
 LDCM0403  CL16 PaTu 8988t C21(0.94)  LDD1282  [3]
 LDCM0404  CL17 PaTu 8988t C21(1.02)  LDD1283  [3]
 LDCM0405  CL18 PaTu 8988t C21(0.89)  LDD1284  [3]
 LDCM0406  CL19 PaTu 8988t C21(0.69)  LDD1285  [3]
 LDCM0407  CL2 PaTu 8988t C21(0.75)  LDD1286  [3]
 LDCM0408  CL20 PaTu 8988t C21(0.69)  LDD1287  [3]
 LDCM0409  CL21 PaTu 8988t C21(0.59)  LDD1288  [3]
 LDCM0410  CL22 PaTu 8988t C21(0.72)  LDD1289  [3]
 LDCM0411  CL23 PaTu 8988t C21(0.91)  LDD1290  [3]
 LDCM0412  CL24 PaTu 8988t C21(1.04)  LDD1291  [3]
 LDCM0413  CL25 PaTu 8988t C21(1.27)  LDD1292  [3]
 LDCM0414  CL26 PaTu 8988t C21(0.79)  LDD1293  [3]
 LDCM0415  CL27 PaTu 8988t C21(1.12)  LDD1294  [3]
 LDCM0416  CL28 PaTu 8988t C21(0.68)  LDD1295  [3]
 LDCM0417  CL29 PaTu 8988t C21(0.76)  LDD1296  [3]
 LDCM0418  CL3 PaTu 8988t C21(0.96)  LDD1297  [3]
 LDCM0419  CL30 PaTu 8988t C21(1.11)  LDD1298  [3]
 LDCM0420  CL31 HEK-293T C21(1.07)  LDD1624  [8]
 LDCM0423  CL34 HEK-293T C21(1.07)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C21(0.87)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C21(0.91)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C21(0.90)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C21(0.99)  LDD1632  [8]
 LDCM0429  CL4 PaTu 8988t C21(1.09)  LDD1308  [3]
 LDCM0433  CL43 HEK-293T C21(1.04)  LDD1637  [8]
 LDCM0436  CL46 HEK-293T C21(1.02)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C21(0.88)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C21(0.97)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C21(1.02)  LDD1643  [8]
 LDCM0440  CL5 PaTu 8988t C21(0.37)  LDD1319  [3]
 LDCM0446  CL55 HEK-293T C21(1.13)  LDD1649  [8]
 LDCM0449  CL58 HEK-293T C21(0.98)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C21(0.90)  LDD1653  [8]
 LDCM0451  CL6 PaTu 8988t C21(0.49)  LDD1330  [3]
 LDCM0452  CL60 HEK-293T C21(1.05)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C21(0.98)  LDD1656  [8]
 LDCM0455  CL63 HEK-293T C21(0.95)  LDD1658  [8]
 LDCM0459  CL67 HEK-293T C21(1.20)  LDD1662  [8]
 LDCM0462  CL7 PaTu 8988t C21(0.46)  LDD1341  [3]
 LDCM0463  CL70 HEK-293T C21(1.04)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C21(0.84)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C21(0.92)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C21(1.02)  LDD1669  [8]
 LDCM0469  CL76 HCT 116 C21(0.84)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C21(0.71)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C21(0.81)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C21(0.65)  LDD0789  [3]
 LDCM0473  CL8 PaTu 8988t C21(0.60)  LDD1352  [3]
 LDCM0474  CL80 HCT 116 C21(0.94)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C21(0.65)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C21(0.41)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C21(0.49)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C21(0.35)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C21(0.86)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C21(0.79)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C21(0.82)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C21(0.52)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C21(0.33)  LDD0800  [3]
 LDCM0484  CL9 PaTu 8988t C21(0.39)  LDD1363  [3]
 LDCM0485  CL90 HCT 116 C21(0.90)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C21(1.07)  LDD1689  [8]
 LDCM0489  CL94 HEK-293T C21(0.92)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C21(0.86)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C21(0.95)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C21(0.91)  LDD1695  [8]
 LDCM0494  CL99 HEK-293T C21(1.08)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C21(1.02)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C21(1.03)  LDD1671  [8]
 LDCM0107  IAA HeLa N.A.  LDD0221  [6]
 LDCM0022  KB02 HEK-293T C21(1.01)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C21(1.01)  LDD1497  [8]
 LDCM0024  KB05 COLO792 C21(1.33)  LDD3310  [9]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C21(1.15)  LDD2093  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C21(1.31)  LDD2099  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C21(1.11)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C21(0.66)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C21(1.41)  LDD2111  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C21(1.80)  LDD2119  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C21(0.43)  LDD2120  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C21(1.09)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C21(1.15)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C21(1.45)  LDD2127  [2]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C21(0.75); C91(1.39)  LDD2128  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C21(1.58)  LDD2129  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C21(0.46)  LDD2134  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C21(2.03)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C21(1.45)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C21(1.44)  LDD2137  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C21(0.42)  LDD2143  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C21(1.97)  LDD2144  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C21(1.26)  LDD2146  [2]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C21(0.91)  LDD2147  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Inositol hexakisphosphate kinase 3 (IP6K3) Inositol phosphokinase (IPK) family Q96PC2
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Unconventional prefoldin RPB5 interactor 1 (URI1) RNA polymerase II subunit 5-mediating protein family O94763
Transcription initiation factor IIB (GTF2B) TFIIB family Q00403
Coagulation factor XIII A chain (F13A1) Transglutaminase family P00488
Ubiquitin-conjugating enzyme E2 D4 (UBE2D4) Ubiquitin-conjugating enzyme family Q9Y2X8
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) Glutamate-gated ion channel family Q14957
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) Dynein heavy chain family Q14204
Protein Dr1 (DR1) NC2 beta/DR1 family Q01658
General transcription factor 3C polypeptide 3 (GTF3C3) . Q9Y5Q9
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

1 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840