Details of the Target

General Information of Target

Target ID LDTP02760
Target Name Serine/threonine-protein kinase B-raf (BRAF)
Gene Name BRAF
Gene ID 673
Synonyms
BRAF1; RAFB1; Serine/threonine-protein kinase B-raf; EC 2.7.11.1; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
Target Type
Successful
Target Bioclass
Enzyme
Family
Protein kinase superfamily, TKL Ser/Thr protein kinase family, RAF subfamily
Subcellular location
Nucleus
Function
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway. Phosphorylates PFKFB2. May play a role in the postsynaptic responses of hippocampal neurons.
TTD ID
T99089
Uniprot ID
P15056
DrugMap ID
TT9591D
Ensemble ID
ENST00000646891.2
HGNC ID
HGNC:1097
ChEMBL ID
CHEMBL5145

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.92  LDD0402  [1]
STPyne
 Probe Info  		K164(7.14)  LDD0277  [2]
DBIA
 Probe Info  		C261(3.97); C264(3.97)  LDD0080  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C748(0.00); C696(0.00)  LDD0037  [5]
Compound 10
 Probe Info  		N.A.  LDD2216  [6]
Compound 11
 Probe Info  		N.A.  LDD2213  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
AOyne
 Probe Info  		14.50  LDD0443  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C696(1.04); C748(1.16); C194(1.00)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C696(1.05); C748(1.03); C194(0.88)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C696(0.98); C261(1.12); C280(1.01)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C748(1.01); C264(0.96); C194(1.01)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C696(0.95); C748(0.95); C261(1.17); C194(0.93)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C696(1.00); C748(0.97); C261(1.09); C264(1.02)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C696(1.05); C748(1.11); C194(0.88)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C696(1.00); C748(1.05); C194(0.83)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C696(1.02); C261(0.96); C280(0.82)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C696(1.01); C748(1.11); C194(1.04)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C748(1.00); C264(0.99); C194(0.87)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C696(1.00); C748(0.93); C261(1.13)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C696(0.90); C748(1.03); C261(1.05); C194(1.00)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C696(0.98); C748(0.91); C261(1.04); C264(0.90)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C696(0.97); C748(0.97); C261(1.05); C194(1.21)  LDD1523  [10]
 LDCM0285  AC25 HCT 116 C261(0.94); C264(0.94)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C261(0.94); C264(0.94)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C261(0.87); C264(0.87)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C261(0.80); C264(0.80)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C261(0.85); C264(0.85)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C696(1.04); C261(1.03); C280(0.93)  LDD1529  [10]
 LDCM0291  AC30 HCT 116 C261(0.88); C264(0.88)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C261(0.83); C264(0.83)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C261(0.84); C264(0.84)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C261(0.85); C264(0.85)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C261(0.77); C264(0.77)  LDD0612  [3]
 LDCM0296  AC35 HEK-293T C696(1.00); C261(1.12); C280(0.99)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C748(0.98); C264(1.06); C194(1.11)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C696(0.94); C748(0.83); C261(0.99)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C696(0.93); C748(0.89); C261(1.18); C194(1.04)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C696(0.96); C748(1.07); C261(0.91); C264(1.03)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C748(1.03); C264(0.96); C194(0.94)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C696(1.03); C748(1.06); C261(1.28); C194(0.98)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C696(1.08); C748(1.15); C194(1.00)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C696(0.96); C748(1.07); C194(0.96)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C696(1.03); C261(1.10); C280(0.90)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C748(0.99); C264(1.02); C194(1.07)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C696(1.05); C748(0.95); C261(1.13)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C696(0.95); C748(0.91); C261(1.14); C194(1.15)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C696(1.03); C748(0.98); C261(0.88); C264(1.02)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C696(1.00); C748(1.03); C261(1.00); C194(1.10)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C696(0.98); C748(1.13); C194(0.84)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C696(1.03); C748(0.97); C261(1.10)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C696(1.01); C748(1.07); C194(0.91)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C696(1.02); C261(1.00); C280(1.04)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C748(1.04); C264(1.10); C194(0.98)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C696(1.02); C748(0.93); C261(0.97)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C696(0.96); C748(1.00); C261(0.95); C194(0.89)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C696(1.00); C748(0.87); C261(0.97); C264(1.12)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C696(0.98); C748(1.05); C261(1.08); C194(0.96)  LDD1558  [10]
 LDCM0320  AC57 HCT 116 C261(1.11); C264(1.11)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C261(1.11); C264(1.11)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C261(0.98); C264(0.98)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C696(0.97); C748(1.07); C261(1.08); C194(1.02)  LDD1562  [10]
 LDCM0324  AC60 HCT 116 C261(0.99); C264(0.99)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C261(1.25); C264(1.25)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C261(0.93); C264(0.93)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C261(1.02); C264(1.02)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C261(0.88); C264(0.88)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C261(1.28); C264(1.28)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C261(1.23); C264(1.23)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C261(0.80); C264(0.80)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C261(0.89); C264(0.89)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C261(0.81); C264(0.81)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C696(1.06); C748(0.94); C261(0.99); C264(1.02)  LDD1568  [10]
 LDCM0335  AC70 HCT 116 C261(0.64); C264(0.64)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C261(1.06); C264(1.06)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C261(0.83); C264(0.83)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C261(0.69); C264(0.69)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C261(0.68); C264(0.68)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C261(0.63); C264(0.63)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C261(0.82); C264(0.82)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C261(0.97); C264(0.97)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C261(0.83); C264(0.83)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C261(0.91); C264(0.91)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C696(1.01); C748(1.05); C261(1.15); C194(1.04)  LDD1569  [10]
 LDCM0346  AC80 HCT 116 C261(0.80); C264(0.80)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C261(0.78); C264(0.78)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C261(0.45); C264(0.45)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C261(0.74); C264(0.74)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C261(0.70); C264(0.70)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C261(0.78); C264(0.78)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C261(0.94); C264(0.94)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C261(0.96); C264(0.96)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C261(0.94); C264(0.94)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C261(0.92); C264(0.92)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C261(1.44); C264(1.44)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C261(0.82); C264(0.82)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C261(0.84); C264(0.84)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C261(0.86); C264(0.86)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C261(1.05); C264(1.05)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C261(0.92); C264(0.92)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C261(0.79); C264(0.79)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C261(0.75); C264(0.75)  LDD0681  [3]
 LDCM0248  AKOS034007472 HEK-293T C696(0.95); C748(0.96); C261(1.15)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C696(1.06); C748(1.16); C194(0.90)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C696(1.00); C748(1.05); C261(1.08); C194(1.08)  LDD1514  [10]
 LDCM0367  CL1 HCT 116 C261(1.05); C264(1.05)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C261(0.84); C264(0.84)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C748(1.00); C261(0.91); C194(0.99)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C696(0.95); C748(1.04); C261(1.05); C264(0.96)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C696(0.90); C748(0.95); C261(1.18); C194(0.93)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C696(1.01); C748(1.04); C261(1.06); C194(1.00)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C748(1.04); C261(1.04); C194(1.05)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C696(0.98); C748(0.88); C261(1.11); C264(1.06)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C696(0.93); C748(0.96); C261(1.03); C194(1.00)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C696(0.95); C748(1.15); C261(1.01); C194(0.92)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C748(0.95); C261(1.13); C194(1.00)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C696(0.97); C748(0.98); C261(0.93); C264(1.04)  LDD1582  [10]
 LDCM0379  CL11 HCT 116 C261(1.01); C264(1.01)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C696(0.93); C748(0.97); C261(1.24); C194(0.95)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C696(0.93); C748(1.00); C261(1.00); C194(1.01)  LDD1585  [10]
 LDCM0382  CL112 HCT 116 C261(0.95); C264(0.95)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C261(0.78); C264(0.78)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C261(0.74); C264(0.74)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C261(0.78); C264(0.78)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C261(0.84); C264(0.84)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C696(1.01); C748(1.05); C261(0.91); C264(1.10)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C696(0.91); C748(0.97); C261(1.16); C194(0.98)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C696(0.96); C748(1.01); C261(1.10); C194(1.02)  LDD1593  [10]
 LDCM0390  CL12 HCT 116 C261(0.97); C264(0.97)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C748(0.94); C261(0.81); C194(1.01)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C696(0.87); C748(0.93); C261(0.92); C264(1.01)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C696(0.99); C748(0.94); C261(1.06); C194(0.88)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C696(0.96); C748(0.95); C261(1.06); C194(0.88)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C748(1.08); C261(1.00); C194(0.82)  LDD1599  [10]
 LDCM0396  CL125 HCT 116 C261(1.34); C264(1.34)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C261(1.19); C264(1.19)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C261(1.32); C264(1.32)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C261(1.04); C264(1.04)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C261(1.12); C264(1.12)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C261(0.95); C264(0.95)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C261(1.15); C264(1.15)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C261(1.04); C264(1.04)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C261(0.99); C264(0.99)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C261(1.20); C264(1.20)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C261(1.29); C264(1.29)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C261(1.10); C264(1.10)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C261(1.21); C264(1.21)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C261(1.17); C264(1.17)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C261(1.07); C264(1.07)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C261(1.36); C264(1.36)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C261(1.12); C264(1.12)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C261(1.10); C264(1.10)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C261(1.13); C264(1.13)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C261(1.37); C264(1.37)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C261(0.98); C264(0.98)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C261(1.14); C264(1.14)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C261(1.02); C264(1.02)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C261(1.06); C264(1.06)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C261(0.93); C264(0.93)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C261(1.07); C264(1.07)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C261(0.78); C264(0.78)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C261(0.84); C264(0.84)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C261(0.80); C264(0.80)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C261(0.87); C264(0.87)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C261(0.83); C264(0.83)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C261(0.82); C264(0.82)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C261(1.15); C264(1.15)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C261(0.89); C264(0.89)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C261(0.86); C264(0.86)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C261(0.71); C264(0.71)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C261(0.77); C264(0.77)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C261(0.75); C264(0.75)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C261(0.81); C264(0.81)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C696(0.95); C748(0.98); C261(1.34); C194(0.78)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C696(1.10); C748(0.89); C261(1.37); C264(1.21)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C696(1.11); C748(1.04); C261(1.23); C194(1.02)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C696(1.06); C748(1.02); C261(0.99); C264(0.97)  LDD1643  [10]
 LDCM0440  CL5 HCT 116 C261(1.09); C264(1.09)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C696(0.89); C748(0.92); C261(1.35); C194(1.25)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C748(1.10); C261(0.99); C194(1.05)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C696(1.21); C748(1.09); C194(0.92)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C696(1.11); C748(1.08); C194(1.18)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C696(1.11); C261(1.08); C280(1.04)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C748(0.99); C264(1.18); C194(1.19)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C696(1.10); C748(1.03); C261(1.19)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C696(1.14); C748(0.93); C261(1.33); C194(0.94)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C696(1.03); C748(0.96); C261(1.20); C264(1.04)  LDD1653  [10]
 LDCM0451  CL6 HCT 116 C261(1.22); C264(1.22)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C696(1.06); C748(0.97); C261(1.13); C194(1.04)  LDD1655  [10]
 LDCM0453  CL61 HCT 116 C261(0.90); C264(0.90)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C261(0.97); C264(0.97)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C261(0.91); C264(0.91)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C261(1.04); C264(1.04)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C261(0.91); C264(0.91)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C261(0.91); C264(0.91)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C261(0.89); C264(0.89)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C261(0.96); C264(0.96)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C261(1.00); C264(1.00)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C261(1.02); C264(1.02)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C261(1.05); C264(1.05)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C261(0.87); C264(0.87)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C261(0.91); C264(0.91)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C261(0.81); C264(0.81)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C261(1.00); C264(1.00)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C261(0.94); C264(0.94)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C261(0.74); C264(0.74)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C261(1.03); C264(1.03)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C261(0.79); C264(0.79)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C261(0.95); C264(0.95)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C261(0.96); C264(0.96)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C261(0.87); C264(0.87)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C261(0.73); C264(0.73)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C261(0.78); C264(0.78)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C261(0.82); C264(0.82)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C261(0.86); C264(0.86)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C261(0.82); C264(0.82)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C261(0.79); C264(0.79)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C261(0.87); C264(0.87)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C261(0.67); C264(0.67)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C261(1.03); C264(1.03)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C261(0.70); C264(0.70)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C696(1.04); C261(1.01); C280(0.94)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C748(0.92); C264(1.21); C194(1.03)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C696(0.99); C748(0.98); C261(1.27)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C696(0.99); C748(1.09); C261(1.22); C194(0.85)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C696(1.16); C748(0.85); C261(1.41); C264(1.22)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C696(1.11); C748(1.06); C261(1.24); C194(1.07)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C696(0.96); C748(1.05); C261(0.84); C264(0.96)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C696(0.93); C748(0.93); C261(1.13); C194(1.06)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C696(0.96); C748(1.12); C261(0.99); C194(0.96)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C696(0.99); C748(0.99); C261(1.14); C194(1.20)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C173(1.36)  LDD1702  [11]
 LDCM0625  F8 Ramos C748(0.74)  LDD2187  [12]
 LDCM0573  Fragment11 Ramos C748(1.81)  LDD2190  [12]
 LDCM0576  Fragment14 Ramos C748(0.74)  LDD2193  [12]
 LDCM0586  Fragment28 Ramos C748(0.79)  LDD2198  [12]
 LDCM0468  Fragment33 HCT 116 C261(0.86); C264(0.86)  LDD0785  [3]
 LDCM0566  Fragment4 Ramos C748(0.71)  LDD2184  [12]
 LDCM0427  Fragment51 HCT 116 C261(0.90); C264(0.90)  LDD0744  [3]
 LDCM0569  Fragment7 Ramos C748(1.29)  LDD2186  [12]
 LDCM0022  KB02 HCT 116 C261(3.97); C264(3.97)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C261(4.09); C264(4.09)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C261(2.85); C264(2.85)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein kinase C epsilon type (PRKCE) AGC Ser/Thr protein kinase family Q02156
Ribosomal protein S6 kinase alpha-2 (RPS6KA2) AGC Ser/Thr protein kinase family Q15349
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) STE Ser/Thr protein kinase family Q13233
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) STE Ser/Thr protein kinase family Q02750
Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) STE Ser/Thr protein kinase family P36507
RAF proto-oncogene serine/threonine-protein kinase (RAF1) TKL Ser/Thr protein kinase family P04049
Serine/threonine-protein kinase B-raf (BRAF) TKL Ser/Thr protein kinase family P15056
GTPase HRas (HRAS) Ras family P01112
GTPase NRas (NRAS) Ras family P01111
TNF receptor-associated factor 3 (TRAF3) TNF receptor-associated factor family Q13114
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein beta/alpha (YWHAB) 14-3-3 family P31946
14-3-3 protein sigma (SFN) 14-3-3 family P31947
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) . P46940

The Drug(s) Related To This Target

Approved
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dabrafenib Small molecular drug DB08912
Encorafenib Small molecular drug DB11718
Fostamatinib Small molecular drug DB12010
Regorafenib Small molecular drug DB08896
Sorafenib Small molecular drug DB00398
Vemurafenib Small molecular drug DB08881
Ripretinib . DB14840
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Mln2480 Small molecular drug D07IEU
Phase 1
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Spn-803 Antisense drug D02DXC
Plx-4720 Small molecular drug D0F5JZ
Rg7304 . D06EFW
Investigative
Click To Hide/Show 17 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Isis 13727 Antisense drug D0X7MU
Isis 13730 Antisense drug D0C5BL
Isis 13740 Antisense drug D09AIJ
Isis 13741 Antisense drug D07LZP
Isis 13743 Antisense drug D0O9XE
Isis 14144 Antisense drug D07TDZ
2-(Benzylamino)-6-(3-acetamidophenyl)Pyrazine Small molecular drug D0OR5S
2-(Phenylamino)-6-(3-acetamidophenyl)Pyrazine Small molecular drug D01DDB
L-779450 Small molecular drug D06WJA
Pmid26061392c2 Small molecular drug D07UFK
Zm-336372 Small molecular drug D00NWF
(1e)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1h-pyrazol-4-yl)-23-dihydro-1h-inden-1-one Oxime . DB08553
N-{24-difluoro-3-[(5-pyridin-3-yl-1h-pyrrolo[23-b]Pyridin-3-yl)Carbonyl]Phenyl}Ethanesulfonamide . DB07000
Plx-ori3 . D06YMT
Pyrazolo[1,5-a]Pyrimidine-3-carboxylate . D0P5VF
Raf-265 . DB05984
Xl281 . DB05190

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578