Details of the Target

General Information of Target

Target ID LDTP02273
Target Name Porphobilinogen deaminase (HMBS)
Gene Name HMBS
Gene ID 3145
Synonyms
PBGD; UPS; Porphobilinogen deaminase; PBG-D; EC 2.5.1.61; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGNGNAAATAEENSPKMRVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTG
DKILDTALSKIGEKSLFTKELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPH
DAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQ
QEFSAIILATAGLQRMGWHNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHD
PETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIH
VPAQHEDGPEDDPQLVGITARNIPRGPQLAAQNLGISLANLLLSKGAKNILDVARQLNDA
H
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
HMBS family
Subcellular location
Cytoplasm
Function
As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen. Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact.
TTD ID
T47466
Uniprot ID
P08397
DrugMap ID
TTT0HW3
Ensemble ID
ENST00000392841.1
HGNC ID
HGNC:4982
ChEMBL ID
CHEMBL3988601

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
RH30 SNV: p.Y46C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		3.24  LDD0215  [1]
ONAyne
 Probe Info  		N.A.  LDD0273  [2]
DBIA
 Probe Info  		C211(1.42)  LDD3335  [3]
ATP probe
 Probe Info  		K74(0.00); K70(0.00); K87(0.00)  LDD0199  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
ATP probe
 Probe Info  		N.A.  LDD0035  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [7]
NAIA_4
 Probe Info  		C114(0.00); C211(0.00)  LDD2226  [8]
IPM
 Probe Info  		N.A.  LDD2156  [9]
NHS
 Probe Info  		N.A.  LDD0010  [10]
STPyne
 Probe Info  		N.A.  LDD0009  [10]
1c-yne
 Probe Info  		N.A.  LDD0228  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
NAIA_5
 Probe Info  		C114(0.00); C261(0.00)  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0068  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C114(0.44)  LDD1093  [14]
 LDCM0215  AC10 HEK-293T C261(0.98); C211(1.14); C114(1.05)  LDD1508  [15]
 LDCM0216  AC100 PaTu 8988t C114(0.83)  LDD1095  [14]
 LDCM0217  AC101 PaTu 8988t C114(0.89)  LDD1096  [14]
 LDCM0218  AC102 PaTu 8988t C114(0.70)  LDD1097  [14]
 LDCM0219  AC103 PaTu 8988t C114(0.67)  LDD1098  [14]
 LDCM0220  AC104 PaTu 8988t C114(0.74)  LDD1099  [14]
 LDCM0221  AC105 PaTu 8988t C114(0.92)  LDD1100  [14]
 LDCM0222  AC106 PaTu 8988t C114(0.76)  LDD1101  [14]
 LDCM0223  AC107 PaTu 8988t C114(1.08)  LDD1102  [14]
 LDCM0224  AC108 PaTu 8988t C114(0.71)  LDD1103  [14]
 LDCM0225  AC109 PaTu 8988t C114(0.66)  LDD1104  [14]
 LDCM0226  AC11 HEK-293T C261(1.05); C211(1.12)  LDD1509  [15]
 LDCM0227  AC110 PaTu 8988t C114(0.56)  LDD1106  [14]
 LDCM0228  AC111 PaTu 8988t C114(0.63)  LDD1107  [14]
 LDCM0229  AC112 PaTu 8988t C114(0.72)  LDD1108  [14]
 LDCM0230  AC113 PaTu 8988t C114(1.71)  LDD1109  [14]
 LDCM0231  AC114 PaTu 8988t C114(0.82)  LDD1110  [14]
 LDCM0232  AC115 PaTu 8988t C114(1.12)  LDD1111  [14]
 LDCM0233  AC116 PaTu 8988t C114(1.47)  LDD1112  [14]
 LDCM0234  AC117 PaTu 8988t C114(1.28)  LDD1113  [14]
 LDCM0235  AC118 PaTu 8988t C114(0.68)  LDD1114  [14]
 LDCM0236  AC119 PaTu 8988t C114(1.22)  LDD1115  [14]
 LDCM0237  AC12 HEK-293T C261(0.96); C211(0.91); C114(0.96)  LDD1510  [15]
 LDCM0238  AC120 PaTu 8988t C114(1.04)  LDD1117  [14]
 LDCM0239  AC121 PaTu 8988t C114(1.00)  LDD1118  [14]
 LDCM0240  AC122 PaTu 8988t C114(0.90)  LDD1119  [14]
 LDCM0241  AC123 PaTu 8988t C114(1.10)  LDD1120  [14]
 LDCM0242  AC124 PaTu 8988t C114(1.26)  LDD1121  [14]
 LDCM0243  AC125 PaTu 8988t C114(0.93)  LDD1122  [14]
 LDCM0244  AC126 PaTu 8988t C114(0.95)  LDD1123  [14]
 LDCM0245  AC127 PaTu 8988t C114(0.94)  LDD1124  [14]
 LDCM0246  AC128 PaTu 8988t C114(0.71)  LDD1125  [14]
 LDCM0247  AC129 PaTu 8988t C114(0.71)  LDD1126  [14]
 LDCM0249  AC130 PaTu 8988t C114(0.81)  LDD1128  [14]
 LDCM0250  AC131 PaTu 8988t C114(0.81)  LDD1129  [14]
 LDCM0251  AC132 PaTu 8988t C114(0.96)  LDD1130  [14]
 LDCM0252  AC133 PaTu 8988t C114(0.71)  LDD1131  [14]
 LDCM0253  AC134 PaTu 8988t C114(0.76)  LDD1132  [14]
 LDCM0254  AC135 PaTu 8988t C114(0.71)  LDD1133  [14]
 LDCM0255  AC136 PaTu 8988t C114(0.63)  LDD1134  [14]
 LDCM0256  AC137 PaTu 8988t C114(0.85)  LDD1135  [14]
 LDCM0257  AC138 PaTu 8988t C114(0.70)  LDD1136  [14]
 LDCM0258  AC139 PaTu 8988t C114(0.73)  LDD1137  [14]
 LDCM0259  AC14 HEK-293T C261(1.13); C211(0.95); C114(0.99)  LDD1512  [15]
 LDCM0260  AC140 PaTu 8988t C114(0.90)  LDD1139  [14]
 LDCM0261  AC141 PaTu 8988t C114(0.80)  LDD1140  [14]
 LDCM0262  AC142 PaTu 8988t C114(0.85)  LDD1141  [14]
 LDCM0263  AC143 PaTu 8988t C114(1.09)  LDD1142  [14]
 LDCM0264  AC144 PaTu 8988t C114(0.85)  LDD1143  [14]
 LDCM0265  AC145 PaTu 8988t C114(0.73)  LDD1144  [14]
 LDCM0266  AC146 PaTu 8988t C114(0.46)  LDD1145  [14]
 LDCM0267  AC147 PaTu 8988t C114(0.72)  LDD1146  [14]
 LDCM0268  AC148 PaTu 8988t C114(0.81)  LDD1147  [14]
 LDCM0269  AC149 PaTu 8988t C114(0.80)  LDD1148  [14]
 LDCM0270  AC15 HEK-293T C261(1.02); C114(1.01)  LDD1513  [15]
 LDCM0271  AC150 PaTu 8988t C114(0.63)  LDD1150  [14]
 LDCM0272  AC151 PaTu 8988t C114(0.46)  LDD1151  [14]
 LDCM0273  AC152 PaTu 8988t C114(0.68)  LDD1152  [14]
 LDCM0274  AC153 PaTu 8988t C114(0.55)  LDD1153  [14]
 LDCM0621  AC154 PaTu 8988t C114(0.54)  LDD2166  [14]
 LDCM0622  AC155 PaTu 8988t C114(0.53)  LDD2167  [14]
 LDCM0623  AC156 PaTu 8988t C114(0.39)  LDD2168  [14]
 LDCM0624  AC157 PaTu 8988t C114(0.52)  LDD2169  [14]
 LDCM0276  AC17 HEK-293T C261(1.11); C114(0.86)  LDD1515  [15]
 LDCM0277  AC18 HEK-293T C261(0.98); C211(1.05); C114(1.02)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C261(0.98); C211(0.90)  LDD1517  [15]
 LDCM0279  AC2 PaTu 8988t C114(0.70)  LDD1158  [14]
 LDCM0280  AC20 HEK-293T C261(1.03); C211(0.93); C114(0.92)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C261(0.96); C211(0.84); C114(0.95)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C261(1.08); C211(0.89); C114(1.07)  LDD1521  [15]
 LDCM0283  AC23 HEK-293T C261(1.06); C114(0.85)  LDD1522  [15]
 LDCM0284  AC24 HEK-293T C261(1.06); C211(1.06); C114(1.11)  LDD1523  [15]
 LDCM0285  AC25 PaTu 8988t C114(1.80)  LDD1164  [14]
 LDCM0286  AC26 PaTu 8988t C114(1.34)  LDD1165  [14]
 LDCM0287  AC27 PaTu 8988t C114(1.15)  LDD1166  [14]
 LDCM0288  AC28 PaTu 8988t C114(1.12)  LDD1167  [14]
 LDCM0289  AC29 PaTu 8988t C114(1.09)  LDD1168  [14]
 LDCM0290  AC3 PaTu 8988t C114(0.52)  LDD1169  [14]
 LDCM0291  AC30 PaTu 8988t C114(1.12)  LDD1170  [14]
 LDCM0292  AC31 PaTu 8988t C114(1.28)  LDD1171  [14]
 LDCM0293  AC32 PaTu 8988t C114(0.99)  LDD1172  [14]
 LDCM0294  AC33 PaTu 8988t C114(0.99)  LDD1173  [14]
 LDCM0295  AC34 PaTu 8988t C114(0.88)  LDD1174  [14]
 LDCM0296  AC35 PaTu 8988t C114(0.65)  LDD1175  [14]
 LDCM0297  AC36 PaTu 8988t C114(0.61)  LDD1176  [14]
 LDCM0298  AC37 PaTu 8988t C114(1.01)  LDD1177  [14]
 LDCM0299  AC38 PaTu 8988t C114(0.63)  LDD1178  [14]
 LDCM0300  AC39 PaTu 8988t C114(0.62)  LDD1179  [14]
 LDCM0301  AC4 PaTu 8988t C114(0.64)  LDD1180  [14]
 LDCM0302  AC40 PaTu 8988t C114(0.59)  LDD1181  [14]
 LDCM0303  AC41 PaTu 8988t C114(1.11)  LDD1182  [14]
 LDCM0304  AC42 PaTu 8988t C114(0.98)  LDD1183  [14]
 LDCM0305  AC43 PaTu 8988t C114(0.83)  LDD1184  [14]
 LDCM0306  AC44 PaTu 8988t C114(0.89)  LDD1185  [14]
 LDCM0307  AC45 PaTu 8988t C114(0.94)  LDD1186  [14]
 LDCM0308  AC46 PaTu 8988t C114(0.98)  LDD1187  [14]
 LDCM0309  AC47 PaTu 8988t C114(0.98)  LDD1188  [14]
 LDCM0310  AC48 PaTu 8988t C114(1.11)  LDD1189  [14]
 LDCM0311  AC49 PaTu 8988t C114(0.79)  LDD1190  [14]
 LDCM0312  AC5 PaTu 8988t C114(0.49)  LDD1191  [14]
 LDCM0313  AC50 PaTu 8988t C114(0.83)  LDD1192  [14]
 LDCM0314  AC51 PaTu 8988t C114(0.29)  LDD1193  [14]
 LDCM0315  AC52 PaTu 8988t C114(0.72)  LDD1194  [14]
 LDCM0316  AC53 PaTu 8988t C114(0.76)  LDD1195  [14]
 LDCM0317  AC54 PaTu 8988t C114(0.79)  LDD1196  [14]
 LDCM0318  AC55 PaTu 8988t C114(0.66)  LDD1197  [14]
 LDCM0319  AC56 PaTu 8988t C114(0.67)  LDD1198  [14]
 LDCM0320  AC57 PaTu 8988t C114(0.64)  LDD1199  [14]
 LDCM0321  AC58 PaTu 8988t C114(0.59)  LDD1200  [14]
 LDCM0322  AC59 PaTu 8988t C114(0.79)  LDD1201  [14]
 LDCM0323  AC6 HEK-293T C261(1.04); C211(1.07); C114(1.18)  LDD1562  [15]
 LDCM0324  AC60 PaTu 8988t C114(0.71)  LDD1203  [14]
 LDCM0325  AC61 PaTu 8988t C114(0.85)  LDD1204  [14]
 LDCM0326  AC62 PaTu 8988t C114(0.77)  LDD1205  [14]
 LDCM0327  AC63 PaTu 8988t C114(0.75)  LDD1206  [14]
 LDCM0328  AC64 PaTu 8988t C114(0.92)  LDD1207  [14]
 LDCM0329  AC65 PaTu 8988t C114(0.95)  LDD1208  [14]
 LDCM0330  AC66 PaTu 8988t C114(0.80)  LDD1209  [14]
 LDCM0331  AC67 PaTu 8988t C114(0.98)  LDD1210  [14]
 LDCM0332  AC68 PaTu 8988t C114(0.72)  LDD1211  [14]
 LDCM0333  AC69 PaTu 8988t C114(0.59)  LDD1212  [14]
 LDCM0334  AC7 HEK-293T C261(0.97); C114(1.10)  LDD1568  [15]
 LDCM0335  AC70 PaTu 8988t C114(0.68)  LDD1214  [14]
 LDCM0336  AC71 PaTu 8988t C114(0.73)  LDD1215  [14]
 LDCM0337  AC72 PaTu 8988t C114(0.99)  LDD1216  [14]
 LDCM0338  AC73 PaTu 8988t C114(0.86)  LDD1217  [14]
 LDCM0339  AC74 PaTu 8988t C114(0.63)  LDD1218  [14]
 LDCM0340  AC75 PaTu 8988t C114(0.67)  LDD1219  [14]
 LDCM0341  AC76 PaTu 8988t C114(0.96)  LDD1220  [14]
 LDCM0342  AC77 PaTu 8988t C114(0.78)  LDD1221  [14]
 LDCM0343  AC78 PaTu 8988t C114(0.65)  LDD1222  [14]
 LDCM0344  AC79 PaTu 8988t C114(0.63)  LDD1223  [14]
 LDCM0345  AC8 HEK-293T C261(1.06); C211(0.97); C114(0.99)  LDD1569  [15]
 LDCM0346  AC80 PaTu 8988t C114(0.83)  LDD1225  [14]
 LDCM0347  AC81 PaTu 8988t C114(0.75)  LDD1226  [14]
 LDCM0348  AC82 PaTu 8988t C114(0.58)  LDD1227  [14]
 LDCM0349  AC83 PaTu 8988t C114(1.43)  LDD1228  [14]
 LDCM0350  AC84 PaTu 8988t C114(1.33)  LDD1229  [14]
 LDCM0351  AC85 PaTu 8988t C114(1.69)  LDD1230  [14]
 LDCM0352  AC86 PaTu 8988t C114(1.23)  LDD1231  [14]
 LDCM0353  AC87 PaTu 8988t C114(1.63)  LDD1232  [14]
 LDCM0354  AC88 PaTu 8988t C114(1.72)  LDD1233  [14]
 LDCM0355  AC89 PaTu 8988t C114(1.56)  LDD1234  [14]
 LDCM0357  AC90 PaTu 8988t C114(2.21)  LDD1236  [14]
 LDCM0358  AC91 PaTu 8988t C114(1.46)  LDD1237  [14]
 LDCM0359  AC92 PaTu 8988t C114(1.15)  LDD1238  [14]
 LDCM0360  AC93 PaTu 8988t C114(1.76)  LDD1239  [14]
 LDCM0361  AC94 PaTu 8988t C114(1.37)  LDD1240  [14]
 LDCM0362  AC95 PaTu 8988t C114(1.28)  LDD1241  [14]
 LDCM0363  AC96 PaTu 8988t C114(2.36)  LDD1242  [14]
 LDCM0364  AC97 PaTu 8988t C114(1.61)  LDD1243  [14]
 LDCM0365  AC98 PaTu 8988t C114(0.64)  LDD1244  [14]
 LDCM0366  AC99 PaTu 8988t C114(0.85)  LDD1245  [14]
 LDCM0248  AKOS034007472 HEK-293T C261(0.95); C211(0.85); C114(1.12)  LDD1511  [15]
 LDCM0356  AKOS034007680 HEK-293T C261(1.01); C114(0.90)  LDD1570  [15]
 LDCM0275  AKOS034007705 HEK-293T C261(0.99); C211(1.02); C114(0.99)  LDD1514  [15]
 LDCM0632  CL-Sc Hep-G2 C261(0.68)  LDD2227  [8]
 LDCM0367  CL1 PaTu 8988t C114(0.77)  LDD1246  [14]
 LDCM0368  CL10 PaTu 8988t C114(0.48)  LDD1247  [14]
 LDCM0369  CL100 PaTu 8988t C114(0.59)  LDD1248  [14]
 LDCM0370  CL101 HEK-293T C261(0.96)  LDD1574  [15]
 LDCM0371  CL102 HEK-293T C261(1.04); C211(1.04); C114(0.76)  LDD1575  [15]
 LDCM0372  CL103 HEK-293T C261(1.00); C211(0.93); C114(0.86)  LDD1576  [15]
 LDCM0373  CL104 HEK-293T C261(1.08); C211(1.08)  LDD1577  [15]
 LDCM0374  CL105 HEK-293T C261(0.90)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C261(0.99); C211(1.07); C114(0.84)  LDD1579  [15]
 LDCM0376  CL107 HEK-293T C261(0.97); C211(0.64); C114(0.98)  LDD1580  [15]
 LDCM0377  CL108 HEK-293T C261(1.02); C211(1.06)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C261(0.96)  LDD1582  [15]
 LDCM0379  CL11 PaTu 8988t C114(0.72)  LDD1258  [14]
 LDCM0380  CL110 HEK-293T C261(1.07); C211(0.86); C114(0.99)  LDD1584  [15]
 LDCM0381  CL111 HEK-293T C261(0.94); C211(1.02); C114(0.94)  LDD1585  [15]
 LDCM0382  CL112 PaTu 8988t C114(1.09)  LDD1261  [14]
 LDCM0383  CL113 PaTu 8988t C114(1.12)  LDD1262  [14]
 LDCM0384  CL114 PaTu 8988t C114(0.95)  LDD1263  [14]
 LDCM0385  CL115 PaTu 8988t C114(1.38)  LDD1264  [14]
 LDCM0386  CL116 PaTu 8988t C114(0.91)  LDD1265  [14]
 LDCM0387  CL117 PaTu 8988t C114(1.22)  LDD1266  [14]
 LDCM0388  CL118 PaTu 8988t C114(1.30)  LDD1267  [14]
 LDCM0389  CL119 PaTu 8988t C114(1.00)  LDD1268  [14]
 LDCM0390  CL12 PaTu 8988t C114(0.67)  LDD1269  [14]
 LDCM0391  CL120 PaTu 8988t C114(0.76)  LDD1270  [14]
 LDCM0392  CL121 PaTu 8988t C114(1.02)  LDD1271  [14]
 LDCM0393  CL122 PaTu 8988t C114(0.92)  LDD1272  [14]
 LDCM0394  CL123 PaTu 8988t C114(0.82)  LDD1273  [14]
 LDCM0395  CL124 PaTu 8988t C114(1.18)  LDD1274  [14]
 LDCM0396  CL125 PaTu 8988t C114(0.98)  LDD1275  [14]
 LDCM0397  CL126 PaTu 8988t C114(0.81)  LDD1276  [14]
 LDCM0398  CL127 PaTu 8988t C114(0.93)  LDD1277  [14]
 LDCM0399  CL128 PaTu 8988t C114(0.81)  LDD1278  [14]
 LDCM0400  CL13 PaTu 8988t C114(0.55)  LDD1279  [14]
 LDCM0401  CL14 PaTu 8988t C114(0.47)  LDD1280  [14]
 LDCM0402  CL15 PaTu 8988t C114(0.61)  LDD1281  [14]
 LDCM0403  CL16 HEK-293T C261(1.12); C211(1.30)  LDD1607  [15]
 LDCM0404  CL17 HEK-293T C261(1.05); C114(0.77)  LDD1608  [15]
 LDCM0405  CL18 HEK-293T C261(0.97); C211(1.09); C114(0.99)  LDD1609  [15]
 LDCM0406  CL19 HEK-293T C261(1.05); C211(1.26)  LDD1610  [15]
 LDCM0407  CL2 PaTu 8988t C114(0.67)  LDD1286  [14]
 LDCM0408  CL20 HEK-293T C261(0.98); C211(0.97); C114(1.15)  LDD1612  [15]
 LDCM0409  CL21 HEK-293T C261(1.17); C211(0.88); C114(0.88)  LDD1613  [15]
 LDCM0410  CL22 HEK-293T C261(1.15); C211(0.96); C114(1.16)  LDD1614  [15]
 LDCM0411  CL23 HEK-293T C261(1.08); C114(0.96)  LDD1615  [15]
 LDCM0412  CL24 HEK-293T C261(1.17); C211(1.26); C114(1.04)  LDD1616  [15]
 LDCM0413  CL25 HEK-293T C261(0.91)  LDD1617  [15]
 LDCM0414  CL26 HEK-293T C261(0.96); C211(0.94); C114(0.86)  LDD1618  [15]
 LDCM0415  CL27 HEK-293T C261(1.09); C211(0.71); C114(1.06)  LDD1619  [15]
 LDCM0416  CL28 HEK-293T C261(1.07); C211(1.30)  LDD1620  [15]
 LDCM0417  CL29 HEK-293T C261(1.02); C114(0.94)  LDD1621  [15]
 LDCM0418  CL3 PaTu 8988t C114(0.37)  LDD1297  [14]
 LDCM0419  CL30 HEK-293T C261(1.06); C211(1.17); C114(1.08)  LDD1623  [15]
 LDCM0420  CL31 PaTu 8988t C114(0.80)  LDD1299  [14]
 LDCM0421  CL32 PaTu 8988t C114(0.64)  LDD1300  [14]
 LDCM0422  CL33 PaTu 8988t C114(0.65)  LDD1301  [14]
 LDCM0423  CL34 PaTu 8988t C114(0.66)  LDD1302  [14]
 LDCM0424  CL35 PaTu 8988t C114(0.80)  LDD1303  [14]
 LDCM0425  CL36 PaTu 8988t C114(0.40)  LDD1304  [14]
 LDCM0426  CL37 PaTu 8988t C114(0.70)  LDD1305  [14]
 LDCM0428  CL39 PaTu 8988t C114(0.69)  LDD1307  [14]
 LDCM0429  CL4 PaTu 8988t C114(0.44)  LDD1308  [14]
 LDCM0430  CL40 PaTu 8988t C114(0.78)  LDD1309  [14]
 LDCM0431  CL41 PaTu 8988t C114(0.68)  LDD1310  [14]
 LDCM0432  CL42 PaTu 8988t C114(0.74)  LDD1311  [14]
 LDCM0433  CL43 PaTu 8988t C114(0.67)  LDD1312  [14]
 LDCM0434  CL44 PaTu 8988t C114(0.56)  LDD1313  [14]
 LDCM0435  CL45 PaTu 8988t C114(0.58)  LDD1314  [14]
 LDCM0436  CL46 PaTu 8988t C114(0.92)  LDD1315  [14]
 LDCM0437  CL47 PaTu 8988t C114(0.78)  LDD1316  [14]
 LDCM0438  CL48 PaTu 8988t C114(0.84)  LDD1317  [14]
 LDCM0439  CL49 PaTu 8988t C114(0.87)  LDD1318  [14]
 LDCM0440  CL5 PaTu 8988t C114(0.56)  LDD1319  [14]
 LDCM0441  CL50 PaTu 8988t C114(0.82)  LDD1320  [14]
 LDCM0442  CL51 PaTu 8988t C114(0.98)  LDD1321  [14]
 LDCM0443  CL52 PaTu 8988t C114(0.91)  LDD1322  [14]
 LDCM0444  CL53 PaTu 8988t C114(0.65)  LDD1323  [14]
 LDCM0445  CL54 PaTu 8988t C114(0.86)  LDD1324  [14]
 LDCM0446  CL55 PaTu 8988t C114(0.90)  LDD1325  [14]
 LDCM0447  CL56 PaTu 8988t C114(0.84)  LDD1326  [14]
 LDCM0448  CL57 PaTu 8988t C114(0.98)  LDD1327  [14]
 LDCM0449  CL58 PaTu 8988t C114(0.87)  LDD1328  [14]
 LDCM0450  CL59 PaTu 8988t C114(0.97)  LDD1329  [14]
 LDCM0451  CL6 PaTu 8988t C114(0.70)  LDD1330  [14]
 LDCM0452  CL60 PaTu 8988t C114(0.95)  LDD1331  [14]
 LDCM0453  CL61 PaTu 8988t C114(1.09)  LDD1332  [14]
 LDCM0454  CL62 PaTu 8988t C114(0.76)  LDD1333  [14]
 LDCM0455  CL63 PaTu 8988t C114(0.91)  LDD1334  [14]
 LDCM0456  CL64 PaTu 8988t C114(0.97)  LDD1335  [14]
 LDCM0457  CL65 PaTu 8988t C114(0.96)  LDD1336  [14]
 LDCM0458  CL66 PaTu 8988t C114(0.83)  LDD1337  [14]
 LDCM0459  CL67 PaTu 8988t C114(0.99)  LDD1338  [14]
 LDCM0460  CL68 PaTu 8988t C114(0.88)  LDD1339  [14]
 LDCM0461  CL69 PaTu 8988t C114(0.80)  LDD1340  [14]
 LDCM0462  CL7 PaTu 8988t C114(0.56)  LDD1341  [14]
 LDCM0463  CL70 PaTu 8988t C114(0.87)  LDD1342  [14]
 LDCM0464  CL71 PaTu 8988t C114(1.07)  LDD1343  [14]
 LDCM0465  CL72 PaTu 8988t C114(1.00)  LDD1344  [14]
 LDCM0466  CL73 PaTu 8988t C114(0.63)  LDD1345  [14]
 LDCM0467  CL74 PaTu 8988t C114(0.84)  LDD1346  [14]
 LDCM0469  CL76 PaTu 8988t C114(1.07)  LDD1348  [14]
 LDCM0470  CL77 PaTu 8988t C114(0.89)  LDD1349  [14]
 LDCM0471  CL78 PaTu 8988t C114(0.91)  LDD1350  [14]
 LDCM0472  CL79 PaTu 8988t C114(0.94)  LDD1351  [14]
 LDCM0473  CL8 PaTu 8988t C114(0.51)  LDD1352  [14]
 LDCM0474  CL80 PaTu 8988t C114(0.97)  LDD1353  [14]
 LDCM0475  CL81 PaTu 8988t C114(0.87)  LDD1354  [14]
 LDCM0476  CL82 PaTu 8988t C114(1.00)  LDD1355  [14]
 LDCM0477  CL83 PaTu 8988t C114(0.80)  LDD1356  [14]
 LDCM0478  CL84 PaTu 8988t C114(0.74)  LDD1357  [14]
 LDCM0479  CL85 PaTu 8988t C114(0.85)  LDD1358  [14]
 LDCM0480  CL86 PaTu 8988t C114(0.99)  LDD1359  [14]
 LDCM0481  CL87 PaTu 8988t C114(0.83)  LDD1360  [14]
 LDCM0482  CL88 PaTu 8988t C114(0.81)  LDD1361  [14]
 LDCM0483  CL89 PaTu 8988t C114(0.85)  LDD1362  [14]
 LDCM0484  CL9 PaTu 8988t C114(0.53)  LDD1363  [14]
 LDCM0485  CL90 PaTu 8988t C114(0.87)  LDD1364  [14]
 LDCM0486  CL91 PaTu 8988t C114(0.76)  LDD1365  [14]
 LDCM0487  CL92 PaTu 8988t C114(0.62)  LDD1366  [14]
 LDCM0488  CL93 PaTu 8988t C114(0.66)  LDD1367  [14]
 LDCM0489  CL94 PaTu 8988t C114(0.56)  LDD1368  [14]
 LDCM0490  CL95 PaTu 8988t C114(0.49)  LDD1369  [14]
 LDCM0491  CL96 PaTu 8988t C114(0.59)  LDD1370  [14]
 LDCM0492  CL97 PaTu 8988t C114(0.62)  LDD1371  [14]
 LDCM0493  CL98 PaTu 8988t C114(0.46)  LDD1372  [14]
 LDCM0494  CL99 PaTu 8988t C114(0.64)  LDD1373  [14]
 LDCM0495  E2913 HEK-293T C261(1.09); C211(0.65); C114(0.81)  LDD1698  [15]
 LDCM0572  Fragment10 Ramos C261(2.88)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C261(1.71)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C261(3.64)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C261(0.90)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C261(1.04)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C261(3.56)  LDD2194  [16]
 LDCM0582  Fragment23 Ramos C261(3.34)  LDD2196  [16]
 LDCM0586  Fragment28 Ramos C261(0.48)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C261(3.67)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C261(0.92)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C261(3.70)  LDD2201  [16]
 LDCM0468  Fragment33 PaTu 8988t C114(0.88)  LDD1347  [14]
 LDCM0596  Fragment38 Ramos C261(1.10)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C261(0.64)  LDD2184  [16]
 LDCM0427  Fragment51 PaTu 8988t C114(0.55)  LDD1306  [14]
 LDCM0610  Fragment52 Ramos C261(1.89)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C261(1.99)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C261(1.46)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C261(2.36)  LDD2188  [16]
 LDCM0022  KB02 HEK-293T C261(0.96); C114(1.04)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C261(1.02); C114(0.95)  LDD1497  [15]
 LDCM0024  KB05 MONO-MAC-6 C211(1.42)  LDD3335  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PRKCA-binding protein (PICK1) . Q9NRD5

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
P-9808 . D0C9IS

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578