Details of the Target

General Information of Target

Target ID LDTP02095
Target Name Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCA)
Gene Name PCCA
Gene ID 5095
Synonyms
Propionyl-CoA carboxylase alpha chain, mitochondrial; PCCase subunit alpha; EC 6.4.1.3; Propanoyl-CoA:carbon dioxide ligase subunit alpha
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGFWVGTAPLVAAGRRGRWPPQQLMLSAALRTLKHVLYYSRQCLMVSRNLGSVGYDPNE
KTFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKS
YLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIES
KLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRD
GFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVV
EEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPV
TECITGLDLVQEMIRVAKGYPLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQY
QEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRGVTH
NIALLREVIINSRFVKGDISTKFLSDVYPDGFKGHMLTKSEKNQLLAIASSLFVAFQLRA
QHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSVEVDGSKLNVTSTWNLAS
PLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLAAELNKFMLEKVTEDTSS
VLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHCQAGDTVGE
GDLLVELE
Target Type
Clinical trial
Target Bioclass
Enzyme
Subcellular location
Mitochondrion matrix
Function
This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA. Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA. Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate. Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA.
TTD ID
T63212
Uniprot ID
P05165
DrugMap ID
TT1JDE3
Ensemble ID
ENST00000376279.7
HGNC ID
HGNC:8653

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.L323V DBIA    Probe Info 
CCFSTTG1 SNV: p.M466L .
ICC9 SNV: p.R486L DBIA    Probe Info 
IPC298 Substitution: p.W5Ter DBIA    Probe Info 
JURKAT Deletion: p.L308WfsTer14 .
SUPT1 Deletion: p.L308WfsTer14 DBIA    Probe Info 
TE4 SNV: p.E487V; p.V488L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		3.77  LDD0215  [1]
BTD
 Probe Info  		C76(4.12)  LDD1699  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
DBIA
 Probe Info  		C85(0.74)  LDD3310  [4]
P21
 Probe Info  		1.90  LDD0408  [5]
AHL-Pu-1
 Probe Info  		C76(3.76)  LDD0170  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C363(0.00); C111(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C363(0.00); C111(0.00); C155(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C363(0.00); C111(0.00); C616(0.00)  LDD0037  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
VSF
 Probe Info  		N.A.  LDD0007  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
Crotonaldehyde
 Probe Info  		C111(0.00); C398(0.00)  LDD0219  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
W1
 Probe Info  		N.A.  LDD0236  [3]
MPP-AC
 Probe Info  		N.A.  LDD0428  [13]
NAIA_5
 Probe Info  		C155(0.00); C76(0.00); C111(0.00)  LDD2223  [14]
TER-AC
 Probe Info  		N.A.  LDD0426  [13]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C76(3.76)  LDD0170  [6]
 LDCM0214  AC1 HEK-293T C616(0.98); C111(1.03); C155(1.00)  LDD1507  [16]
 LDCM0215  AC10 HEK-293T C616(1.08); C111(0.94); C155(1.00)  LDD1508  [16]
 LDCM0226  AC11 HEK-293T C616(1.04); C111(1.00); C155(0.97)  LDD1509  [16]
 LDCM0237  AC12 HEK-293T C616(0.99); C111(0.94); C155(0.91)  LDD1510  [16]
 LDCM0259  AC14 HEK-293T C616(1.02); C111(1.04); C155(1.00); C363(0.91)  LDD1512  [16]
 LDCM0270  AC15 HEK-293T C616(1.03); C111(1.01); C155(0.99)  LDD1513  [16]
 LDCM0276  AC17 HEK-293T C616(0.98); C111(0.95); C155(0.96)  LDD1515  [16]
 LDCM0277  AC18 HEK-293T C616(1.08); C111(1.00); C155(0.95)  LDD1516  [16]
 LDCM0278  AC19 HEK-293T C616(1.04); C111(0.95); C155(1.19)  LDD1517  [16]
 LDCM0279  AC2 HEK-293T C616(0.63); C111(0.98); C155(1.02)  LDD1518  [16]
 LDCM0280  AC20 HEK-293T C616(1.01); C111(0.97); C155(0.97)  LDD1519  [16]
 LDCM0281  AC21 HEK-293T C616(0.91); C111(1.02); C155(1.03)  LDD1520  [16]
 LDCM0282  AC22 HEK-293T C616(1.06); C111(0.96); C155(0.98); C363(0.95)  LDD1521  [16]
 LDCM0283  AC23 HEK-293T C616(0.99); C111(0.94); C155(0.99)  LDD1522  [16]
 LDCM0284  AC24 HEK-293T C616(1.01); C111(1.09); C155(0.96); C363(0.97)  LDD1523  [16]
 LDCM0285  AC25 HEK-293T C616(0.96); C111(1.01); C155(0.89)  LDD1524  [16]
 LDCM0286  AC26 HEK-293T C616(1.03); C111(1.01); C155(1.01)  LDD1525  [16]
 LDCM0287  AC27 HEK-293T C616(0.99); C111(1.04); C155(1.00)  LDD1526  [16]
 LDCM0288  AC28 HEK-293T C616(1.00); C111(1.17); C155(0.89)  LDD1527  [16]
 LDCM0289  AC29 HEK-293T C616(1.09); C111(1.00); C155(1.04)  LDD1528  [16]
 LDCM0290  AC3 HEK-293T C616(0.90); C111(0.93); C155(1.05)  LDD1529  [16]
 LDCM0291  AC30 HEK-293T C616(0.95); C111(1.04); C155(1.03); C363(1.07)  LDD1530  [16]
 LDCM0292  AC31 HEK-293T C616(1.03); C111(1.00); C155(1.05)  LDD1531  [16]
 LDCM0293  AC32 HEK-293T C616(0.98); C111(0.96); C155(0.93); C363(1.16)  LDD1532  [16]
 LDCM0294  AC33 HEK-293T C616(1.00); C111(0.96); C155(1.10)  LDD1533  [16]
 LDCM0295  AC34 HEK-293T C616(0.94); C111(0.94); C155(1.02)  LDD1534  [16]
 LDCM0296  AC35 HEK-293T C616(1.01); C111(0.99); C155(1.03)  LDD1535  [16]
 LDCM0297  AC36 HEK-293T C616(1.04); C111(0.99); C155(0.88)  LDD1536  [16]
 LDCM0298  AC37 HEK-293T C616(1.03); C111(1.08); C155(1.03)  LDD1537  [16]
 LDCM0299  AC38 HEK-293T C616(1.03); C111(0.94); C155(0.98); C363(0.96)  LDD1538  [16]
 LDCM0300  AC39 HEK-293T C616(1.05); C111(1.02); C155(1.03)  LDD1539  [16]
 LDCM0301  AC4 HEK-293T C616(0.95); C111(0.94); C155(0.86)  LDD1540  [16]
 LDCM0302  AC40 HEK-293T C616(1.02); C111(0.92); C155(1.04); C363(1.16)  LDD1541  [16]
 LDCM0303  AC41 HEK-293T C616(1.00); C111(0.96); C155(1.15)  LDD1542  [16]
 LDCM0304  AC42 HEK-293T C616(0.99); C111(1.01); C155(1.00)  LDD1543  [16]
 LDCM0305  AC43 HEK-293T C616(1.02); C111(0.94); C155(1.09)  LDD1544  [16]
 LDCM0306  AC44 HEK-293T C616(1.02); C111(1.03); C155(0.94)  LDD1545  [16]
 LDCM0307  AC45 HEK-293T C616(1.00); C111(1.03); C155(1.11)  LDD1546  [16]
 LDCM0308  AC46 HEK-293T C616(1.07); C111(1.02); C155(0.89); C363(0.90)  LDD1547  [16]
 LDCM0309  AC47 HEK-293T C616(1.07); C111(0.97); C155(0.95)  LDD1548  [16]
 LDCM0310  AC48 HEK-293T C616(1.09); C111(1.01); C155(0.94); C363(0.96)  LDD1549  [16]
 LDCM0311  AC49 HEK-293T C616(0.98); C111(0.98); C155(1.00)  LDD1550  [16]
 LDCM0312  AC5 HEK-293T C616(0.97); C111(1.03); C155(1.07)  LDD1551  [16]
 LDCM0313  AC50 HEK-293T C616(0.95); C111(1.00); C155(1.07)  LDD1552  [16]
 LDCM0314  AC51 HEK-293T C616(1.05); C111(0.96); C155(1.09)  LDD1553  [16]
 LDCM0315  AC52 HEK-293T C616(1.01); C111(1.07); C155(0.92)  LDD1554  [16]
 LDCM0316  AC53 HEK-293T C616(0.94); C111(1.03); C155(1.05)  LDD1555  [16]
 LDCM0317  AC54 HEK-293T C616(1.02); C111(1.01); C155(0.99); C363(0.94)  LDD1556  [16]
 LDCM0318  AC55 HEK-293T C616(1.07); C111(1.04); C155(1.03)  LDD1557  [16]
 LDCM0319  AC56 HEK-293T C616(1.00); C111(0.97); C155(0.94); C363(1.18)  LDD1558  [16]
 LDCM0320  AC57 HEK-293T C616(1.01); C111(0.99); C155(1.01)  LDD1559  [16]
 LDCM0321  AC58 HEK-293T C616(1.00); C111(1.04); C155(0.98)  LDD1560  [16]
 LDCM0322  AC59 HEK-293T C616(1.00); C111(0.98); C155(0.94)  LDD1561  [16]
 LDCM0323  AC6 HEK-293T C616(0.92); C111(0.95); C155(0.91); C363(1.02)  LDD1562  [16]
 LDCM0324  AC60 HEK-293T C616(0.99); C111(0.94); C155(0.92)  LDD1563  [16]
 LDCM0325  AC61 HEK-293T C616(0.92); C111(1.02); C155(1.10)  LDD1564  [16]
 LDCM0326  AC62 HEK-293T C616(1.00); C111(1.02); C155(1.03); C363(1.04)  LDD1565  [16]
 LDCM0327  AC63 HEK-293T C616(1.06); C111(1.01); C155(1.06)  LDD1566  [16]
 LDCM0328  AC64 HEK-293T C616(1.07); C111(0.96); C155(1.07); C363(0.98)  LDD1567  [16]
 LDCM0334  AC7 HEK-293T C616(0.88); C111(1.02); C155(1.01)  LDD1568  [16]
 LDCM0345  AC8 HEK-293T C616(0.94); C111(0.95); C155(0.97); C363(1.11)  LDD1569  [16]
 LDCM0520  AKOS000195272 MDA-MB-231 C290(0.77)  LDD2113  [2]
 LDCM0248  AKOS034007472 HEK-293T C616(1.03); C111(1.04); C155(1.01)  LDD1511  [16]
 LDCM0356  AKOS034007680 HEK-293T C616(0.99); C111(1.00); C155(1.12)  LDD1570  [16]
 LDCM0275  AKOS034007705 HEK-293T C616(1.06); C111(1.05); C155(0.94); C363(1.09)  LDD1514  [16]
 LDCM0108  Chloroacetamide HeLa C111(0.00); H542(0.00)  LDD0222  [12]
 LDCM0367  CL1 HEK-293T C616(0.96); C111(0.98); C155(1.03)  LDD1571  [16]
 LDCM0368  CL10 HEK-293T C616(1.29); C111(1.02); C155(0.95); C363(1.09)  LDD1572  [16]
 LDCM0369  CL100 HEK-293T C616(0.94); C111(0.98); C155(1.04); C363(1.19)  LDD1573  [16]
 LDCM0370  CL101 HEK-293T C616(1.00); C111(1.00); C155(1.11)  LDD1574  [16]
 LDCM0371  CL102 HEK-293T C616(0.99); C111(0.70); C155(1.01); C363(1.01)  LDD1575  [16]
 LDCM0372  CL103 HEK-293T C616(0.99); C111(1.06)  LDD1576  [16]
 LDCM0373  CL104 HEK-293T C616(0.89); C111(0.95); C155(1.09); C363(1.09)  LDD1577  [16]
 LDCM0374  CL105 HEK-293T C616(1.00); C111(0.97); C155(0.92)  LDD1578  [16]
 LDCM0375  CL106 HEK-293T C616(0.99); C111(0.98); C155(1.03); C363(1.09)  LDD1579  [16]
 LDCM0376  CL107 HEK-293T C616(1.00); C111(1.04)  LDD1580  [16]
 LDCM0377  CL108 HEK-293T C616(1.04); C111(1.00); C155(0.99); C363(1.04)  LDD1581  [16]
 LDCM0378  CL109 HEK-293T C616(1.02); C111(0.97); C155(0.99)  LDD1582  [16]
 LDCM0379  CL11 HEK-293T C616(1.12); C111(1.24); C155(1.30)  LDD1583  [16]
 LDCM0380  CL110 HEK-293T C616(0.95); C111(0.99); C155(1.01); C363(1.10)  LDD1584  [16]
 LDCM0381  CL111 HEK-293T C616(1.00); C111(1.11)  LDD1585  [16]
 LDCM0382  CL112 HEK-293T C616(0.83); C111(1.03); C155(1.10); C363(0.96)  LDD1586  [16]
 LDCM0383  CL113 HEK-293T C616(0.94); C111(0.96); C155(0.98)  LDD1587  [16]
 LDCM0384  CL114 HEK-293T C616(0.99); C111(0.90); C155(1.18); C363(1.01)  LDD1588  [16]
 LDCM0385  CL115 HEK-293T C616(1.03); C111(1.04)  LDD1589  [16]
 LDCM0386  CL116 HEK-293T C616(0.77); C111(0.99); C155(0.99); C363(1.17)  LDD1590  [16]
 LDCM0387  CL117 HEK-293T C616(0.97); C111(0.94); C155(0.96)  LDD1591  [16]
 LDCM0388  CL118 HEK-293T C616(1.00); C111(0.92); C155(1.16); C363(1.05)  LDD1592  [16]
 LDCM0389  CL119 HEK-293T C616(1.03); C111(1.02)  LDD1593  [16]
 LDCM0390  CL12 HEK-293T C616(1.08); C111(1.18); C155(1.13); C363(1.12)  LDD1594  [16]
 LDCM0391  CL120 HEK-293T C616(0.87); C111(1.00); C155(1.21); C363(1.05)  LDD1595  [16]
 LDCM0392  CL121 HEK-293T C616(1.02); C111(1.00); C155(1.07)  LDD1596  [16]
 LDCM0393  CL122 HEK-293T C616(1.03); C111(0.99); C155(1.10); C363(0.94)  LDD1597  [16]
 LDCM0394  CL123 HEK-293T C616(1.12); C111(1.04)  LDD1598  [16]
 LDCM0395  CL124 HEK-293T C616(0.90); C111(0.95); C155(1.18); C363(1.01)  LDD1599  [16]
 LDCM0396  CL125 HEK-293T C616(1.10); C111(0.99); C155(1.07)  LDD1600  [16]
 LDCM0397  CL126 HEK-293T C616(0.96); C111(0.87); C155(1.11); C363(1.00)  LDD1601  [16]
 LDCM0398  CL127 HEK-293T C616(1.09); C111(1.04)  LDD1602  [16]
 LDCM0399  CL128 HEK-293T C616(0.93); C111(0.99); C155(0.99); C363(1.06)  LDD1603  [16]
 LDCM0400  CL13 HEK-293T C616(0.93); C111(1.10); C155(1.14)  LDD1604  [16]
 LDCM0401  CL14 HEK-293T C616(0.93); C111(0.95); C155(1.09); C363(0.87)  LDD1605  [16]
 LDCM0402  CL15 HEK-293T C616(1.03); C111(1.08)  LDD1606  [16]
 LDCM0403  CL16 HEK-293T C616(0.79); C111(0.98); C155(1.00); C363(1.05)  LDD1607  [16]
 LDCM0404  CL17 HEK-293T C616(0.94); C111(1.37); C155(1.12)  LDD1608  [16]
 LDCM0405  CL18 HEK-293T C616(1.00); C111(0.86); C155(0.94)  LDD1609  [16]
 LDCM0406  CL19 HEK-293T C616(1.03); C111(1.09); C155(1.13)  LDD1610  [16]
 LDCM0407  CL2 HEK-293T C616(0.93); C111(0.91); C155(0.98); C363(1.00)  LDD1611  [16]
 LDCM0408  CL20 HEK-293T C616(1.11); C111(0.98); C155(0.97)  LDD1612  [16]
 LDCM0409  CL21 HEK-293T C616(1.13); C111(1.32); C155(1.22)  LDD1613  [16]
 LDCM0410  CL22 HEK-293T C616(0.69); C111(1.03); C155(1.05); C363(1.14)  LDD1614  [16]
 LDCM0411  CL23 HEK-293T C616(1.19); C111(1.15); C155(1.13)  LDD1615  [16]
 LDCM0412  CL24 HEK-293T C616(1.10); C111(1.12); C155(0.98); C363(1.14)  LDD1616  [16]
 LDCM0413  CL25 HEK-293T C616(1.01); C111(0.91); C155(1.06)  LDD1617  [16]
 LDCM0414  CL26 HEK-293T C616(0.92); C111(0.96); C155(1.08); C363(0.97)  LDD1618  [16]
 LDCM0415  CL27 HEK-293T C616(1.03); C111(1.02)  LDD1619  [16]
 LDCM0416  CL28 HEK-293T C616(0.96); C111(1.07); C155(0.89); C363(0.91)  LDD1620  [16]
 LDCM0417  CL29 HEK-293T C616(0.97); C111(1.07); C155(0.96)  LDD1621  [16]
 LDCM0418  CL3 HEK-293T C616(1.09); C111(1.18)  LDD1622  [16]
 LDCM0419  CL30 HEK-293T C616(1.06); C111(1.09); C155(0.98)  LDD1623  [16]
 LDCM0420  CL31 HEK-293T C616(1.03); C111(1.08); C155(0.98)  LDD1624  [16]
 LDCM0421  CL32 HEK-293T C616(1.08); C111(0.94); C155(0.81)  LDD1625  [16]
 LDCM0422  CL33 HEK-293T C616(1.13); C111(1.23); C155(1.01)  LDD1626  [16]
 LDCM0423  CL34 HEK-293T C616(1.11); C111(1.05); C155(1.08); C363(1.19)  LDD1627  [16]
 LDCM0424  CL35 HEK-293T C616(1.08); C111(1.15); C155(1.12)  LDD1628  [16]
 LDCM0425  CL36 HEK-293T C616(1.08); C111(1.08); C155(0.90); C363(1.12)  LDD1629  [16]
 LDCM0426  CL37 HEK-293T C616(0.95); C111(0.99); C155(0.96)  LDD1630  [16]
 LDCM0428  CL39 HEK-293T C616(1.06); C111(0.99)  LDD1632  [16]
 LDCM0429  CL4 HEK-293T C616(1.02); C111(1.14); C155(1.05); C363(1.22)  LDD1633  [16]
 LDCM0430  CL40 HEK-293T C616(1.33); C111(0.95); C155(1.02); C363(1.04)  LDD1634  [16]
 LDCM0431  CL41 HEK-293T C616(0.99); C111(1.15); C155(1.06)  LDD1635  [16]
 LDCM0432  CL42 HEK-293T C616(1.04); C111(1.08); C155(0.98)  LDD1636  [16]
 LDCM0433  CL43 HEK-293T C616(1.07); C111(1.03); C155(1.10)  LDD1637  [16]
 LDCM0434  CL44 HEK-293T C616(1.09); C111(0.99); C155(0.95)  LDD1638  [16]
 LDCM0435  CL45 HEK-293T C616(1.04); C111(1.17); C155(1.06)  LDD1639  [16]
 LDCM0436  CL46 HEK-293T C616(1.07); C111(1.10); C155(1.09); C363(1.00)  LDD1640  [16]
 LDCM0437  CL47 HEK-293T C616(1.10); C111(1.18); C155(1.08)  LDD1641  [16]
 LDCM0438  CL48 HEK-293T C616(1.17); C111(1.10); C155(1.00); C363(1.17)  LDD1642  [16]
 LDCM0439  CL49 HEK-293T C616(1.01); C111(0.96); C155(1.11)  LDD1643  [16]
 LDCM0440  CL5 HEK-293T C616(0.96); C111(1.01); C155(1.02)  LDD1644  [16]
 LDCM0441  CL50 HEK-293T C616(1.02); C111(0.92); C155(0.92); C363(1.15)  LDD1645  [16]
 LDCM0443  CL52 HEK-293T C616(0.84); C111(1.04); C155(0.99); C363(1.16)  LDD1646  [16]
 LDCM0444  CL53 HEK-293T C616(1.05); C111(1.24); C155(0.98)  LDD1647  [16]
 LDCM0445  CL54 HEK-293T C616(1.10); C111(1.00); C155(1.11)  LDD1648  [16]
 LDCM0446  CL55 HEK-293T C616(1.13); C111(1.02); C155(1.16)  LDD1649  [16]
 LDCM0447  CL56 HEK-293T C616(1.13); C111(0.95); C155(0.93)  LDD1650  [16]
 LDCM0448  CL57 HEK-293T C616(1.13); C111(1.19); C155(1.09)  LDD1651  [16]
 LDCM0449  CL58 HEK-293T C616(1.17); C111(1.09); C155(1.01); C363(1.27)  LDD1652  [16]
 LDCM0450  CL59 HEK-293T C616(1.17); C111(1.02); C155(1.08)  LDD1653  [16]
 LDCM0451  CL6 HEK-293T C616(1.05); C111(1.05); C155(1.12)  LDD1654  [16]
 LDCM0452  CL60 HEK-293T C616(1.19); C111(1.16); C155(1.04); C363(1.18)  LDD1655  [16]
 LDCM0453  CL61 HEK-293T C616(1.02); C111(0.93); C155(1.01)  LDD1656  [16]
 LDCM0454  CL62 HEK-293T C616(0.99); C111(0.87); C155(1.06); C363(1.12)  LDD1657  [16]
 LDCM0455  CL63 HEK-293T C616(1.05); C111(1.13)  LDD1658  [16]
 LDCM0456  CL64 HEK-293T C616(1.02); C111(1.08); C155(1.04); C363(0.99)  LDD1659  [16]
 LDCM0457  CL65 HEK-293T C616(0.99); C111(1.04); C155(1.08)  LDD1660  [16]
 LDCM0458  CL66 HEK-293T C616(1.00); C111(1.03); C155(1.06)  LDD1661  [16]
 LDCM0459  CL67 HEK-293T C616(1.06); C111(1.08); C155(1.05)  LDD1662  [16]
 LDCM0460  CL68 HEK-293T C616(1.11); C111(1.01); C155(1.00)  LDD1663  [16]
 LDCM0461  CL69 HEK-293T C616(1.08); C111(1.30); C155(1.12)  LDD1664  [16]
 LDCM0462  CL7 HEK-293T C616(1.04); C111(1.08); C155(1.22)  LDD1665  [16]
 LDCM0463  CL70 HEK-293T C616(1.15); C111(1.07); C155(1.12); C363(1.10)  LDD1666  [16]
 LDCM0464  CL71 HEK-293T C616(1.11); C111(1.13); C155(1.04)  LDD1667  [16]
 LDCM0465  CL72 HEK-293T C616(1.14); C111(1.04); C155(0.97); C363(1.26)  LDD1668  [16]
 LDCM0466  CL73 HEK-293T C616(1.00); C111(0.93); C155(1.02)  LDD1669  [16]
 LDCM0467  CL74 HEK-293T C616(1.00); C111(0.96); C155(1.02); C363(1.19)  LDD1670  [16]
 LDCM0469  CL76 HEK-293T C616(1.00); C111(1.02); C155(1.08); C363(0.79)  LDD1672  [16]
 LDCM0470  CL77 HEK-293T C616(1.00); C111(1.25); C155(1.25)  LDD1673  [16]
 LDCM0471  CL78 HEK-293T C616(1.04); C111(1.09); C155(0.97)  LDD1674  [16]
 LDCM0472  CL79 HEK-293T C616(1.05); C111(1.04); C155(0.97)  LDD1675  [16]
 LDCM0473  CL8 HEK-293T C616(1.20); C111(0.81); C155(1.01)  LDD1676  [16]
 LDCM0474  CL80 HEK-293T C616(1.09); C111(1.06); C155(0.92)  LDD1677  [16]
 LDCM0475  CL81 HEK-293T C616(1.04); C111(1.13); C155(1.10)  LDD1678  [16]
 LDCM0476  CL82 HEK-293T C616(1.15); C111(1.01); C155(1.03); C363(0.97)  LDD1679  [16]
 LDCM0477  CL83 HEK-293T C616(1.17); C111(1.10); C155(1.16)  LDD1680  [16]
 LDCM0478  CL84 HEK-293T C616(1.09); C111(1.14); C155(0.93); C363(1.22)  LDD1681  [16]
 LDCM0479  CL85 HEK-293T C616(0.99); C111(0.97); C155(1.00)  LDD1682  [16]
 LDCM0480  CL86 HEK-293T C616(1.01); C111(0.92); C155(1.02); C363(1.01)  LDD1683  [16]
 LDCM0481  CL87 HEK-293T C616(1.05); C111(1.07)  LDD1684  [16]
 LDCM0482  CL88 HEK-293T C616(0.97); C111(1.01); C155(1.05); C363(1.10)  LDD1685  [16]
 LDCM0483  CL89 HEK-293T C616(1.05); C111(1.00); C155(1.07)  LDD1686  [16]
 LDCM0484  CL9 HEK-293T C616(1.06); C111(1.23); C155(1.09)  LDD1687  [16]
 LDCM0485  CL90 HEK-293T C616(0.92); C111(0.84); C155(1.19)  LDD1688  [16]
 LDCM0486  CL91 HEK-293T C616(1.01); C111(1.02); C155(0.99)  LDD1689  [16]
 LDCM0487  CL92 HEK-293T C616(1.11); C111(1.00); C155(0.94)  LDD1690  [16]
 LDCM0488  CL93 HEK-293T C616(1.02); C111(1.17); C155(1.01)  LDD1691  [16]
 LDCM0489  CL94 HEK-293T C616(1.05); C111(1.00); C155(1.02); C363(1.09)  LDD1692  [16]
 LDCM0490  CL95 HEK-293T C616(1.15); C111(1.00); C155(1.33)  LDD1693  [16]
 LDCM0491  CL96 HEK-293T C616(1.13); C111(1.08); C155(1.14); C363(1.15)  LDD1694  [16]
 LDCM0492  CL97 HEK-293T C616(0.99); C111(1.06); C155(1.14)  LDD1695  [16]
 LDCM0493  CL98 HEK-293T C616(0.91); C111(0.99); C155(0.98); C363(0.97)  LDD1696  [16]
 LDCM0494  CL99 HEK-293T C616(1.01); C111(1.03)  LDD1697  [16]
 LDCM0495  E2913 HEK-293T C616(1.03); C111(1.07)  LDD1698  [16]
 LDCM0468  Fragment33 HEK-293T C616(1.06); C111(1.06)  LDD1671  [16]
 LDCM0427  Fragment51 HEK-293T C616(0.97); C111(1.04); C155(1.03); C363(0.94)  LDD1631  [16]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0022  KB02 HEK-293T C616(0.89); C111(0.92); C155(0.94); C363(0.91)  LDD1492  [16]
 LDCM0023  KB03 HEK-293T C616(1.02); C111(1.04); C155(1.07); C363(1.04)  LDD1497  [16]
 LDCM0024  KB05 COLO792 C85(0.74)  LDD3310  [4]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C76(1.28)  LDD2102  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [12]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C76(1.17)  LDD2090  [2]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C76(0.23)  LDD2096  [2]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C76(0.49)  LDD2100  [2]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C290(0.74)  LDD2101  [2]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C76(0.61)  LDD2118  [2]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C76(0.38)  LDD2122  [2]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C76(0.43)  LDD2124  [2]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C76(0.37)  LDD2126  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C76(0.45)  LDD2141  [2]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C76(0.24); C616(1.25)  LDD2145  [2]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C76(0.42)  LDD2149  [2]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C76(0.43)  LDD2151  [2]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C76(1.40)  LDD2153  [2]
 LDCM0158  P27 BxPC-3 1.90  LDD0408  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Propionyl-CoA carboxylase beta chain, mitochondrial (PCCB) AccD/PCCB family P05166
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Colorectal mutant cancer protein (MCC) MCC family P23508

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Biotin Small molecular drug DB00121

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Integrated phenotypic screening and activity-based protein profiling to reveal potential therapy targets of pancreatic cancer. Chem Commun (Camb). 2019 Jan 31;55(11):1596-1599. doi: 10.1039/c8cc08753a.
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402