Details of the Target

General Information of Target

Target ID LDTP01235
Target Name Transcriptional adapter 2-alpha (TADA2A)
Gene Name TADA2A
Gene ID 6871
Synonyms
TADA2L; Transcriptional adapter 2-alpha; Transcriptional adapter 2-like; ADA2-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDRLGPFSNDPSDKPPCRGCSSYLMEPYIKCAECGPPPFFLCLQCFTRGFEYKKHQSDHT
YEIMTSDFPVLDPSWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHYMKHFIN
NPLFASTLLNLKQAEEAKTADTAIPFHSTDDPPRPTFDSLLSRDMAGYMPARADFIEEFD
NYAEWDLRDIDFVEDDSDILHALKMAVVDIYHSRLKERQRRKKIIRDHGLINLRKFQLME
RRYPKEVQDLYETMRRFARIVGPVEHDKFIESHALEFELRREIKRLQEYRTAGITNFCSA
RTYDHLKKTREEERLKRTMLSEVLQYIQDSSACQQWLRRQADIDSGLSPSIPMASNSGRR
SAPPLNLTGLPGTEKLNEKEKELCQMVRLVPGAYLEYKSALLNECNKQGGLRLAQARALI
KIDVNKTRKIYDFLIREGYITKG
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
Uniprot ID
O75478
Ensemble ID
ENST00000617828.4
HGNC ID
HGNC:11531

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C298(0.92)  LDD0078  [1]
N1
 Probe Info  		N.A.  LDD0245  [2]
IPM
 Probe Info  		N.A.  LDD0025  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [3]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C298(0.70)  LDD0812  [1]
 LDCM0215  AC10 HCT 116 C298(1.00)  LDD0532  [1]
 LDCM0216  AC100 HEK-293T C298(0.96)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C298(0.85)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C298(0.95)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C298(0.94)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C298(0.99)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C298(1.04)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C298(1.07)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C298(0.95)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C298(0.92)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C298(0.94)  LDD0823  [1]
 LDCM0226  AC11 HCT 116 C298(1.36)  LDD0543  [1]
 LDCM0227  AC110 HEK-293T C298(0.98)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C298(1.22)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C298(1.02)  LDD0827  [1]
 LDCM0230  AC113 HEK-293T C298(0.83)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C298(1.01)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C298(0.94)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C298(0.78)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C298(0.82)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C298(1.01)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C298(0.88)  LDD0834  [1]
 LDCM0237  AC12 HCT 116 C298(1.37)  LDD0554  [1]
 LDCM0238  AC120 HEK-293T C298(0.79)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C298(0.83)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C298(0.90)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C298(0.85)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C298(0.84)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C298(0.79)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C298(0.94)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C298(1.03)  LDD0843  [1]
 LDCM0246  AC128 HCT 116 C298(0.93)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C298(0.87)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C298(1.00)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C298(1.00)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C298(1.05)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C298(0.95)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C298(1.18)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C298(1.04)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C298(1.15)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C298(1.07)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C298(1.36)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C298(1.32)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C298(1.24)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C298(1.37)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C298(1.44)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C298(1.11)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C298(1.08)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C298(1.00)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C298(1.02)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C298(1.00)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C298(1.02)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C298(0.96)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C298(0.97)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C298(0.92)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C298(1.10)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C298(0.96)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C298(0.95)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C298(0.99)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C298(0.97)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C298(0.90)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C298(0.99)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C298(1.02)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C298(0.98)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C298(1.09)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C298(0.96)  LDD0595  [1]
 LDCM0279  AC2 HEK-293T C298(0.84)  LDD0877  [1]
 LDCM0280  AC20 HCT 116 C298(1.05)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C298(1.07)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C298(0.99)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C298(1.04)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C298(0.88)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C298(1.00)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C298(1.30)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C298(1.10)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C298(1.17)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C298(1.37)  LDD0606  [1]
 LDCM0290  AC3 HEK-293T C298(0.93)  LDD0888  [1]
 LDCM0291  AC30 HCT 116 C298(1.52)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C298(1.21)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C298(1.43)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C298(1.11)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C298(1.20)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C298(0.78)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C298(0.84)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C298(0.73)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C298(0.97)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C298(0.91)  LDD0617  [1]
 LDCM0301  AC4 HEK-293T C298(1.13)  LDD0899  [1]
 LDCM0302  AC40 HCT 116 C298(0.82)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C298(0.92)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C298(1.00)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C298(1.04)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C298(0.74)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C298(0.68)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C298(1.14)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C298(1.03)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C298(1.03)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C298(1.25)  LDD0628  [1]
 LDCM0312  AC5 HEK-293T C298(0.75)  LDD0910  [1]
 LDCM0313  AC50 HCT 116 C298(1.09)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C298(1.20)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C298(0.97)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C298(1.28)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C298(1.05)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C298(1.18)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C298(1.09)  LDD0636  [1]
 LDCM0323  AC6 HCT 116 C298(0.96)  LDD0640  [1]
 LDCM0334  AC7 HCT 116 C298(1.13)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C298(1.08)  LDD0662  [1]
 LDCM0365  AC98 HEK-293T C298(0.97)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C298(0.93)  LDD0964  [1]
 LDCM0248  AKOS034007472 HCT 116 C298(1.06)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C298(1.12)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C298(1.22)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C298(0.92)  LDD0078  [1]
 LDCM0367  CL1 HCT 116 C298(0.93)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C298(1.00)  LDD0685  [1]
 LDCM0369  CL100 HEK-293T C298(0.76)  LDD0967  [1]
 LDCM0370  CL101 HCT 116 C298(1.42)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C298(1.45)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C298(1.56)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C298(1.49)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C298(0.96)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C298(0.91)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C298(1.12)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C298(1.06)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C298(1.13)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C298(0.89)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C298(0.96)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C298(1.12)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C298(1.09)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C298(1.28)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C298(1.60)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C298(1.42)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C298(1.15)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C298(1.06)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C298(1.04)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C298(0.99)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C298(0.92)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C298(1.03)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C298(1.07)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C298(1.05)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C298(0.93)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C298(1.06)  LDD0712  [1]
 LDCM0400  CL13 HCT 116 C298(0.87)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C298(0.89)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C298(0.89)  LDD0719  [1]
 LDCM0403  CL16 HEK-293T C298(1.02)  LDD1001  [1]
 LDCM0404  CL17 HEK-293T C298(1.03)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C298(0.92)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C298(1.07)  LDD1004  [1]
 LDCM0407  CL2 HCT 116 C298(0.94)  LDD0724  [1]
 LDCM0408  CL20 HEK-293T C298(0.98)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C298(1.00)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C298(1.02)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C298(0.98)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C298(0.96)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C298(1.10)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C298(1.06)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C298(0.94)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C298(1.07)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C298(1.11)  LDD1015  [1]
 LDCM0418  CL3 HCT 116 C298(0.88)  LDD0735  [1]
 LDCM0419  CL30 HEK-293T C298(1.06)  LDD1017  [1]
 LDCM0420  CL31 HCT 116 C298(0.95)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C298(0.91)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C298(1.05)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C298(0.90)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C298(0.99)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C298(1.07)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C298(1.14)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C298(1.02)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C298(0.83)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C298(1.23)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C298(0.91)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C298(1.12)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C298(1.14)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C298(0.93)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C298(0.88)  LDD0752  [1]
 LDCM0436  CL46 HEK-293T C298(0.81)  LDD1034  [1]
 LDCM0437  CL47 HEK-293T C298(0.98)  LDD1035  [1]
 LDCM0438  CL48 HEK-293T C298(0.94)  LDD1036  [1]
 LDCM0439  CL49 HEK-293T C298(0.95)  LDD1037  [1]
 LDCM0440  CL5 HCT 116 C298(0.83)  LDD0757  [1]
 LDCM0441  CL50 HEK-293T C298(0.89)  LDD1039  [1]
 LDCM0442  CL51 HEK-293T C298(0.93)  LDD1040  [1]
 LDCM0443  CL52 HEK-293T C298(1.43)  LDD1041  [1]
 LDCM0444  CL53 HEK-293T C298(1.43)  LDD1042  [1]
 LDCM0445  CL54 HEK-293T C298(1.01)  LDD1043  [1]
 LDCM0446  CL55 HEK-293T C298(1.02)  LDD1044  [1]
 LDCM0447  CL56 HEK-293T C298(1.06)  LDD1045  [1]
 LDCM0448  CL57 HEK-293T C298(1.01)  LDD1046  [1]
 LDCM0449  CL58 HEK-293T C298(1.11)  LDD1047  [1]
 LDCM0450  CL59 HEK-293T C298(1.03)  LDD1048  [1]
 LDCM0451  CL6 HCT 116 C298(0.89)  LDD0768  [1]
 LDCM0452  CL60 HEK-293T C298(0.98)  LDD1050  [1]
 LDCM0453  CL61 HCT 116 C298(1.09)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C298(1.14)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C298(1.00)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C298(0.99)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C298(0.95)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C298(1.18)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C298(0.98)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C298(0.99)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C298(1.30)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C298(0.81)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C298(1.03)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C298(1.06)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C298(1.11)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C298(0.98)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C298(1.10)  LDD0784  [1]
 LDCM0473  CL8 HCT 116 C298(0.92)  LDD0790  [1]
 LDCM0484  CL9 HCT 116 C298(0.96)  LDD0801  [1]
 LDCM0486  CL91 HEK-293T C298(1.19)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C298(1.20)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C298(1.05)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C298(0.79)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C298(0.69)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C298(0.71)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C298(0.82)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C298(0.95)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C298(1.05)  LDD1092  [1]
 LDCM0468  Fragment33 HCT 116 C298(1.09)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C298(1.48)  LDD0744  [1]
 LDCM0022  KB02 HCT 116 C20(1.17)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C20(1.14)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C20(1.39)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glutamine--tRNA ligase (QARS1) Class-I aminoacyl-tRNA synthetase family P47897
Phenylalanine--tRNA ligase, mitochondrial (FARS2) Class-II aminoacyl-tRNA synthetase family O95363
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Importin subunit alpha-1 (KPNA2) Importin alpha family P52292
Protein mago nashi homolog (MAGOH) Mago nashi family P61326
Metaxin-2 (MTX2) Metaxin family O75431
THO complex subunit 1 (THOC1) . Q96FV9
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear factor erythroid 2-related factor 2 (NFE2L2) BZIP family Q16236
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 564 (ZNF564) Krueppel C2H2-type zinc-finger protein family Q8TBZ8
Other
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein AATF (AATF) AATF family Q9NY61
Coiled-coil domain-containing protein 134 (CCDC134) CCDC134 family Q9H6E4
Eukaryotic translation initiation factor 4E type 2 (EIF4E2) Eukaryotic initiation factor 4E family O60573
Retrotransposon Gag-like protein 8B (RTL8B) FAM127 family Q17RB0
Kinesin light chain 4 (KLC4) Kinesin light chain family Q9NSK0
Protein mago nashi homolog 2 (MAGOHB) Mago nashi family Q96A72
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
Splicing factor 3A subunit 3 (SF3A3) SF3A3 family Q12874
Tektin-4 (TEKT4) Tektin family Q8WW24
Tetratricopeptide repeat protein 9C (TTC9C) TTC9 family Q8N5M4
Vacuolar protein-sorting-associated protein 25 (VPS25) VPS25 family Q9BRG1
Zinc finger CCHC domain-containing protein 12 (ZCCHC12) ZCCHC12 family Q6PEW1
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Cell division cycle-associated 7-like protein (CDCA7L) . Q96GN5
Coiled-coil domain-containing protein 116 (CCDC116) . Q8IYX3
G-protein-signaling modulator 3 (GPSM3) . Q9Y4H4
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Kelch-like protein 38 (KLHL38) . Q2WGJ6
Protein phosphatase 1 regulatory inhibitor subunit 16B (PPP1R16B) . Q96T49
Putative uncharacterized protein MGC163334 . Q5W150
Rhombotin-1 (LMO1) . P25800
Tetratricopeptide repeat protein 23 (TTC23) . Q5W5X9

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004