Details of the Target

General Information of Target

Target ID LDTP01142
Target Name Lysine-specific demethylase PHF2 (PHF2)
Gene Name PHF2
Gene ID 5253
Synonyms
CENP-35; KIAA0662; Lysine-specific demethylase PHF2; EC 1.14.11.-; GRC5; PHD finger protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYHCPNCEKTHGKS
TLKKKRTWHKHGPGQAPDVKPVQNGSQLFIKELRSRTFPSAEDVVARVPGSQLTLGYMEE
HGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDY
YYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWVENYWPDDALLAKPKVTKYCLIC
VKDSYTDFHIDSGGASAWYHVLKGEKTFYLIRPASANISLYERWRSASNHSEMFFADQVD
KCYKCIVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSL
TQFPNFETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAEHED
ELPEHFKPSQLIKDLAKEIRLSENASKAVRPEVNTVASSDEVCDGDREKEEPPSPIEATP
PQSLLEKVSKKKTPKTVKMPKPSKIPKPPKPPKPPRPPKTLKLKDGGKKKGKKSRESASP
TIPNLDLLEAHTKEALTKMEPPKKGKATKSVLSVPNKDVVHMQNDVERLEIREQTKSKSE
AKWKYKNSKPDSLLKMEEEQKLEKSPLAGNKDNKFSFSFSNKKLLGSKALRPPTSPGVFG
ALQNFKEDKPKPVRDEYEYVSDDGELKIDEFPIRRKKNAPKRDLSFLLDKKAVLPTPVTK
PKLDSAAYKSDDSSDEGSLHIDTDTKPGRNARVKKESGSSAAGILDLLQASEEVGALEYN
PSSQPPASPSTQEAIQGMLSMANLQASDSCLQTTWGAGQAKGSSLAAHGARKNGGGSGKS
AGKRLLKRAAKNSVDLDDYEEEQDHLDACFKDSDYVYPSLESDEDNPIFKSRSKKRKGSD
DAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKSKKKKSAKRKLT
PNTTSPSTSTSISAGTTSTSTTPASTTPASTTPASTSTASSQASQEGSSPEPPPESHSSS
LADHEYTAAGTFTGAQAGRTSQPMAPGVFLTQRRPSASSPNNNTAAKGKRTKKGMATAKQ
RLGKILKIHRNGKLLL
Target Bioclass
Enzyme
Family
JHDM1 histone demethylase family, JHDM1D subfamily
Subcellular location
Nucleus, nucleolus
Function
Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters.
Uniprot ID
O75151
Ensemble ID
ENST00000359246.9
HGNC ID
HGNC:8920
ChEMBL ID
CHEMBL4295672

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K498(10.00)  LDD0277  [1]
IPM
 Probe Info  		C463(1.36)  LDD1701  [2]
DBIA
 Probe Info  		C23(0.98); C26(0.98)  LDD0078  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
W1
 Probe Info  		N.A.  LDD0236  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C23(0.99); C26(0.99)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C240(1.22)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C23(0.84); C237(0.76); C26(0.84)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C23(0.95); C237(0.61); C26(0.95)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C23(0.93); C237(0.70); C26(0.93)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C23(0.85); C237(0.65); C26(0.85)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C23(0.93); C237(0.37); C26(0.93)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C23(0.86); C237(0.80); C26(0.86)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C23(1.06); C237(0.59); C26(1.06)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C23(0.86); C237(0.39); C26(0.86)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C23(0.98); C237(0.82); C26(0.98)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C23(0.87); C237(0.46); C26(0.87)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C240(1.02)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C23(0.93); C237(0.56); C26(0.93)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C23(0.94); C237(0.35); C26(0.94)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C23(0.87); C237(0.47); C26(0.87)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C23(0.92); C237(1.05); C240(1.05); C26(0.92)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C23(0.85); C237(1.26); C240(1.26); C26(0.96)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C23(0.68); C237(1.42); C240(1.42); C26(0.89)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C23(1.04); C237(1.44); C240(1.44); C26(0.81)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C23(0.79); C237(1.11); C240(1.11); C26(0.72)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C23(0.77); C237(1.16); C240(1.16); C26(0.71)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C23(0.79); C237(1.21); C240(1.21); C26(0.73)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C240(0.84)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C23(0.90); C237(1.38); C240(1.38); C26(0.70)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C23(0.84); C237(1.05); C240(1.05); C26(0.91)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C23(0.73); C237(1.24); C240(1.24); C26(0.78)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C23(0.56); C237(1.07); C240(1.07); C26(0.45)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C23(0.75); C237(1.09); C240(1.09); C26(0.94)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C23(0.86); C237(1.15); C240(1.15); C26(0.94)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C23(0.92); C237(1.31); C240(1.31); C26(0.71)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C23(0.72); C237(1.22); C240(1.22); C26(0.72)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C23(0.47); C26(0.47)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C23(0.44); C26(0.44)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C23(0.51); C26(0.51)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C23(0.48); C26(0.48)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C23(0.51); C26(0.51)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C23(0.59); C26(0.59)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C23(0.53); C26(0.53)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C23(0.59); C26(0.59)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C23(0.54); C26(0.54)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C23(0.57); C26(0.57)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C23(0.52); C26(0.52)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C23(0.55); C26(0.55)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C240(1.07)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C23(0.56); C26(0.56)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C23(0.50); C26(0.50)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C23(0.54); C26(0.54)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C237(1.18); C240(1.18)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C237(1.50); C240(1.50)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C237(1.34); C240(1.34)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C237(1.47); C240(1.47)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C237(1.57); C240(1.57)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C237(2.28); C240(2.28)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C237(1.67); C240(1.67)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C240(1.14)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C237(1.21); C240(1.21)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C237(1.15); C240(1.15)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C237(1.75); C240(1.75)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C237(2.60); C240(2.60)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C237(1.41); C240(1.41)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C237(1.39); C240(1.39)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C237(1.04); C240(1.04)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C237(0.95); C240(0.95)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C23(0.83); C26(0.83)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C23(0.82); C26(0.82)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C23(0.79); C26(0.79)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C23(0.92); C26(0.92)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C23(0.80); C26(0.80)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C23(0.79); C26(0.79)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C23(0.83); C26(0.83)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C23(0.71); C26(0.71)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C23(0.68); C26(0.68)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C23(0.58); C26(0.58)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C23(0.75); C26(0.75)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C23(0.73); C26(0.73)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C23(0.70); C26(0.70)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C23(0.73); C26(0.73)  LDD0887  [3]
 LDCM0290  AC3 HCT 116 C23(0.93); C26(0.93)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C23(0.73); C26(0.73)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C23(0.74); C26(0.74)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C23(0.79); C26(0.79)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C23(0.83); C26(0.83)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C23(0.80); C26(0.80)  LDD0893  [3]
 LDCM0296  AC35 HCT 116 C240(0.99); C237(1.43)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C240(1.17); C237(1.59)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C240(0.93); C237(1.17)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C240(0.98); C237(1.07)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C240(1.08); C237(1.36)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C23(1.00); C26(1.00)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C240(1.04); C237(1.66)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C240(1.09); C237(1.24)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C237(1.02); C240(1.12)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C237(1.10); C240(1.24)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C240(1.10); C237(1.28)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C240(1.13); C237(1.44)  LDD0624  [3]
 LDCM0308  AC46 HEK-293T C23(1.25); C26(1.03)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C23(1.30); C26(1.07)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C23(1.40); C26(1.16)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C23(1.34); C26(1.28)  LDD0909  [3]
 LDCM0312  AC5 HCT 116 C23(1.06); C26(1.06)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C23(1.35); C26(1.12)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C23(1.47); C26(1.17)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C23(1.43); C26(1.17)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C23(1.39); C26(1.16)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C23(1.56); C26(1.26)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C23(1.36); C26(1.21)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C23(1.35); C26(1.20)  LDD0917  [3]
 LDCM0320  AC57 HEK-293T C23(1.03); C26(0.82)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C23(0.98); C26(1.07)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C23(1.02); C26(1.33)  LDD0920  [3]
 LDCM0323  AC6 HCT 116 C240(0.98)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C23(0.89); C26(1.06)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C23(1.28); C26(0.73)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C23(0.99); C26(1.02)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C23(1.28); C26(0.87)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C23(1.06); C26(0.78)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C23(1.18); C26(0.97)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C23(1.07); C26(0.95)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C23(1.21); C26(1.11)  LDD0929  [3]
 LDCM0332  AC68 HEK-293T C23(1.01); C26(0.94)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C23(1.01); C26(1.07)  LDD0931  [3]
 LDCM0334  AC7 HCT 116 C240(2.68)  LDD0651  [3]
 LDCM0335  AC70 HEK-293T C23(1.13); C26(1.00)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C23(1.03); C26(1.04)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C23(1.00); C26(0.94)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C23(1.02); C26(0.93)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C23(0.95); C26(1.04)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C23(1.00); C26(0.98)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C23(1.00); C26(0.94)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C23(1.17); C26(1.19)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C23(1.05); C26(0.96)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C23(1.00); C26(1.16)  LDD0942  [3]
 LDCM0345  AC8 HCT 116 C240(0.99)  LDD0662  [3]
 LDCM0346  AC80 HEK-293T C23(1.00); C26(0.96)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C23(1.07); C26(1.13)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C23(1.30); C26(1.74)  LDD0946  [3]
 LDCM0349  AC83 HCT 116 C23(1.12); C26(1.12)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C23(1.11); C26(1.11)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C23(0.98); C26(0.98)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C23(1.11); C26(1.11)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C23(1.09); C26(1.09)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C23(1.06); C26(1.06)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C23(1.26); C26(1.26)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C23(1.13); C26(1.13)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C23(1.21); C26(1.21)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C23(1.08); C26(1.08)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C23(1.03); C26(1.03)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C23(1.07); C26(1.07)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C23(1.16); C26(1.16)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C23(1.16); C26(1.16)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C23(1.14); C26(1.14)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C237(0.78); C23(0.90); C26(0.90)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C23(0.81); C26(0.81); C237(1.01)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C240(0.93)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C240(1.12)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C240(0.94)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C23(0.98); C26(0.98)  LDD0078  [3]
 LDCM0367  CL1 HCT 116 C23(0.85); C26(0.85)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C23(1.03); C26(1.03)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C23(1.02); C26(1.02)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C240(1.01)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C240(1.07)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C240(1.07)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C240(1.05)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C23(0.77); C26(0.77)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C23(0.77); C26(0.77)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C23(0.88); C26(0.88)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C23(0.68); C26(0.68)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C23(0.81); C26(0.81)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C23(0.90); C26(0.90)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C23(0.80); C26(0.80)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C23(0.79); C26(0.79)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C23(0.79); C26(0.79)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C23(0.76); C26(0.76)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C23(0.75); C26(0.75)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C23(0.74); C26(0.74)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C23(0.79); C26(0.79)  LDD0984  [3]
 LDCM0387  CL117 HCT 116 C237(1.08); C240(1.35)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C237(1.12); C240(1.17)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C240(1.15); C237(1.46)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C23(0.94); C26(0.94)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C240(1.12); C237(1.27)  LDD0708  [3]
 LDCM0392  CL121 HEK-293T C23(1.38); C26(1.31)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C23(1.36); C26(1.12)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C23(1.28); C26(0.96)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C23(1.32); C26(1.15)  LDD0993  [3]
 LDCM0396  CL125 HEK-293T C23(1.11); C26(0.84)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C23(1.17); C26(0.78)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C23(1.06); C26(0.73)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C23(0.97); C26(0.77)  LDD0997  [3]
 LDCM0400  CL13 HCT 116 C23(0.78); C26(0.78)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C23(0.90); C26(0.90)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C23(0.80); C26(0.80)  LDD0719  [3]
 LDCM0403  CL16 HEK-293T C23(1.06); C26(1.66)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C23(1.16); C26(1.21)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C23(1.02); C26(1.55)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C23(1.02); C26(1.19)  LDD1004  [3]
 LDCM0407  CL2 HCT 116 C23(1.05); C26(1.05)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C23(0.98); C26(1.16)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C23(1.35); C26(0.95)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C23(1.17); C26(1.22)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C23(1.02); C26(0.91)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C23(0.85); C26(1.23)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C23(1.06); C26(1.17)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C23(1.05); C26(1.09)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C23(1.15); C26(1.00)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C23(0.91); C26(0.84)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C23(0.95); C26(1.07)  LDD1015  [3]
 LDCM0418  CL3 HCT 116 C23(1.04); C26(1.04)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C23(1.18); C26(1.26)  LDD1017  [3]
 LDCM0420  CL31 HEK-293T C23(1.06); C26(1.51)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C23(1.02); C26(1.32)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C23(1.25); C26(1.12)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C23(1.05); C26(1.04)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C23(1.15); C26(1.18)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C23(1.09); C26(1.04)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C23(1.20); C26(1.17)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C23(1.57); C26(1.35)  LDD1026  [3]
 LDCM0429  CL4 HCT 116 C23(0.96); C26(0.96)  LDD0746  [3]
 LDCM0430  CL40 HEK-293T C23(1.02); C26(1.03)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C23(1.26); C26(1.16)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C23(1.52); C26(1.15)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C23(1.28); C26(1.09)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C23(1.05); C26(1.13)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C23(1.60); C26(1.14)  LDD1033  [3]
 LDCM0436  CL46 HCT 116 C237(0.73); C240(0.73)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C237(0.81); C240(0.81)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C237(0.79); C240(0.79)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C237(0.83); C240(0.83)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C23(0.98); C26(0.98)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C237(0.77); C240(0.77)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C237(0.79); C240(0.79)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C237(0.76); C240(0.76)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C237(0.71); C240(0.71)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C237(0.73); C240(0.73)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C237(0.70); C240(0.70)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C237(0.94); C240(0.94)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C237(0.69); C240(0.69)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C237(0.76); C240(0.76)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C237(0.77); C240(0.77)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C23(0.97); C26(0.97)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C237(0.80); C240(0.80)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C23(1.02)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C23(1.43)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C23(1.72)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C23(1.29)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C23(1.39)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C23(1.46)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C23(1.24)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C23(1.45)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C23(1.14)  LDD1059  [3]
 LDCM0462  CL7 HCT 116 C23(1.00); C26(1.00)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C23(1.29)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C23(1.17)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C23(1.11)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C23(1.47)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C23(1.95)  LDD1065  [3]
 LDCM0469  CL76 HCT 116 C23(0.72); C26(0.72)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C23(0.64); C26(0.64)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C23(0.72); C26(0.72)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C23(0.81); C26(0.81)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C23(0.74); C26(0.74)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C23(0.78); C26(0.78)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C23(0.62); C26(0.62)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C23(0.59); C26(0.59)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C23(0.71); C26(0.71)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C23(0.87); C26(0.87)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C23(0.83); C26(0.83)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C23(0.82); C26(0.82)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C23(0.66); C26(0.66)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C23(0.68); C26(0.68)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C23(0.71); C26(0.71)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C23(0.90); C26(0.90)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C23(0.64); C26(0.64)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C23(0.95); C26(0.95)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C23(0.84); C26(0.84)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C23(0.91); C26(0.91)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C23(1.10); C26(1.10)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C23(0.86); C26(0.86)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C23(1.03); C26(1.03)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C23(1.03); C26(1.03)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C23(0.92); C26(0.92)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C23(1.01); C26(1.01)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C463(1.04)  LDD1698  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C463(0.68)  LDD1702  [2]
 LDCM0468  Fragment33 HEK-293T C23(1.90)  LDD1066  [3]
 LDCM0427  Fragment51 HEK-293T C23(1.23); C26(1.30)  LDD1025  [3]
 LDCM0022  KB02 HCT 116 C23(1.55); C26(1.55)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C23(2.19); C26(2.19)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C23(1.61); C26(1.61)  LDD0082  [3]
 LDCM0021  THZ1 HCT 116 C23(1.20); C26(1.20)  LDD2173  [3]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402