Details of the Target

General Information of Target

Target ID LDTP01086
Target Name E3 ubiquitin-protein ligase PPP1R11 (PPP1R11)
Gene Name PPP1R11
Gene ID 6992
Synonyms
HCGV; TCTE5; E3 ubiquitin-protein ligase PPP1R11; EC 2.3.2.27; Hemochromatosis candidate gene V protein; HCG V; Protein phosphatase 1 regulatory subunit 11; Protein phosphatase inhibitor 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEAGAGLSETVTETTVTVTTEPENRSLTIKLRKRKPEKKVEWTSDTVDNEHMGRRSSKC
CCIYEKPRAFGESSTESDEEEEEGCGHTHCVRGHRKGRRRATLGPTPTTPPQPPDPSQPP
PGPMQH
Target Bioclass
Enzyme
Function
Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1.
Uniprot ID
O60927
Ensemble ID
ENST00000376772.8
HGNC ID
HGNC:9285

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K31(7.69)  LDD0277  [1]
m-APA
 Probe Info  		11.24  LDD0403  [2]
HHS-475
 Probe Info  		Y64(0.62)  LDD0264  [3]
DBIA
 Probe Info  		C85(4.42); C90(4.42)  LDD0080  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
IA-alkyne
 Probe Info  		C60(0.00); C61(0.00); C62(0.00)  LDD0036  [6]
TFBX
 Probe Info  		C60(0.00); C62(0.00); C61(0.00)  LDD0027  [7]
IPM
 Probe Info  		C60(0.00); C85(0.00)  LDD2156  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C60(1.02); C61(0.93); C62(1.51)  LDD0812  [4]
 LDCM0215  AC10 HEK-293T C60(1.00); C61(1.02); C62(1.42)  LDD0813  [4]
 LDCM0216  AC100 HCT 116 C60(1.10); C61(1.10); C62(1.10)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C60(1.25); C61(1.25); C62(1.25)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C60(0.96); C61(0.96); C62(0.96)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C60(1.36); C61(1.36); C62(1.36)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C60(1.11); C61(1.11); C62(1.11)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C60(1.45); C61(1.45); C62(1.45)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C60(1.66); C61(1.66); C62(1.66)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C60(1.18); C61(1.18); C62(1.18)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C60(0.90); C61(0.90); C62(0.90)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C60(0.72); C61(0.72); C62(0.72)  LDD0542  [4]
 LDCM0226  AC11 HEK-293T C60(1.06); C61(1.06); C62(1.62)  LDD0824  [4]
 LDCM0227  AC110 HCT 116 C60(1.18); C61(1.18); C62(1.18)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C60(1.30); C61(1.30); C62(1.30)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C60(1.20); C61(1.20); C62(1.20)  LDD0546  [4]
 LDCM0230  AC113 HEK-293T C62(0.96)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C62(1.03)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C62(1.25)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C62(1.16)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C62(0.90)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C62(1.11)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C62(1.10)  LDD0834  [4]
 LDCM0237  AC12 HEK-293T C60(0.92); C61(0.95); C62(1.42)  LDD0835  [4]
 LDCM0238  AC120 HEK-293T C62(1.06)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C62(1.19)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C62(1.43)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C62(1.31)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C62(1.00)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C62(1.03)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C62(1.57)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C62(1.71)  LDD0843  [4]
 LDCM0246  AC128 HEK-293T C62(1.21)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C62(1.97)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C62(1.44)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C62(1.09)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C62(1.72)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C62(1.24)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C62(1.56)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C62(1.59)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C62(1.91)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C62(1.77)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C62(1.80)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C62(1.50)  LDD0856  [4]
 LDCM0259  AC14 HEK-293T C60(1.23); C61(1.27); C62(2.05)  LDD0857  [4]
 LDCM0260  AC140 HEK-293T C62(1.50)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C62(1.75)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C62(1.27)  LDD0860  [4]
 LDCM0263  AC143 HCT 116 C61(1.13); C62(1.13)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C61(1.09); C62(1.09)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C61(1.02); C62(1.02)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C61(1.25); C62(1.25)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C61(1.26); C62(1.26)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C61(1.45); C62(1.45)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C61(1.33); C62(1.33)  LDD0586  [4]
 LDCM0270  AC15 HEK-293T C60(1.03); C61(1.12); C62(1.72)  LDD0868  [4]
 LDCM0271  AC150 HCT 116 C61(1.13); C62(1.13)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C61(1.01); C62(1.01)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C61(1.30); C62(1.30)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C61(1.87); C62(1.87)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C61(1.35); C62(1.35)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C61(1.22); C62(1.22)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C61(1.08); C62(1.08)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C61(0.90); C62(0.90)  LDD2161  [4]
 LDCM0276  AC17 HEK-293T C60(1.09); C61(1.22); C62(1.33)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C60(1.03); C61(1.17); C62(1.09)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C60(1.04); C61(1.20); C62(1.19)  LDD0876  [4]
 LDCM0279  AC2 HEK-293T C60(0.94); C61(0.87); C62(1.44)  LDD0877  [4]
 LDCM0280  AC20 HEK-293T C60(1.02); C61(1.23); C62(1.45)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C60(1.00); C61(1.17); C62(1.22)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C60(0.94); C61(1.04); C62(1.20)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C60(0.96); C61(1.14); C62(1.25)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C60(1.17); C61(1.46); C62(1.32)  LDD0882  [4]
 LDCM0285  AC25 HEK-293T C60(0.96); C61(0.96)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C60(0.70); C61(0.70)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C60(0.70); C61(0.70)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C60(0.91); C61(0.91)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C60(0.70); C61(0.70)  LDD0887  [4]
 LDCM0290  AC3 HEK-293T C60(0.89); C61(0.87); C62(1.55)  LDD0888  [4]
 LDCM0291  AC30 HEK-293T C60(0.73); C61(0.73)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C60(0.82); C61(0.82)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C60(0.85); C61(0.85)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C60(1.05); C61(1.05)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C60(0.87); C61(0.87)  LDD0893  [4]
 LDCM0296  AC35 HEK-293T C60(1.10)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C85(1.16); C60(1.00)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C85(1.06)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C85(0.87)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C85(1.36); C60(1.03)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C60(1.02); C61(0.98); C62(1.58)  LDD0899  [4]
 LDCM0302  AC40 HEK-293T C85(1.25)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C85(1.10); C60(1.06)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C60(1.07)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C60(1.02)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C85(0.94); C60(1.00)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C85(0.93)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C60(1.01); C61(1.04); C62(1.10)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C60(0.87); C61(1.06); C62(1.17)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C60(0.94); C61(1.02); C62(1.09)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C60(0.91); C61(0.99); C62(0.96)  LDD0909  [4]
 LDCM0312  AC5 HEK-293T C60(0.95); C61(0.92); C62(1.26)  LDD0910  [4]
 LDCM0313  AC50 HEK-293T C60(0.98); C61(1.09); C62(1.18)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C60(0.80); C61(1.13); C62(1.26)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C60(0.80); C61(1.05); C62(1.16)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C60(0.87); C61(1.03); C62(1.10)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C60(0.78); C61(1.12); C62(1.28)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C60(0.83); C61(1.10); C62(1.27)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C60(0.87); C61(0.92); C62(0.85)  LDD0917  [4]
 LDCM0320  AC57 HEK-293T C60(1.22); C61(1.22); C62(0.94)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C60(1.16); C61(1.16); C62(0.97)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C60(1.27); C61(1.27); C62(1.08)  LDD0920  [4]
 LDCM0323  AC6 HEK-293T C60(1.11); C61(1.16); C62(1.12)  LDD0921  [4]
 LDCM0324  AC60 HEK-293T C60(1.06); C61(1.06); C62(0.91)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C60(0.77); C61(0.77); C62(0.69)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C60(0.95); C61(0.95); C62(0.76)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C60(1.01); C61(1.01); C62(0.87)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C60(0.99); C61(0.99); C62(0.81)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C60(0.94); C61(0.94); C62(0.80)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C60(1.04); C61(1.04); C62(0.87)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C60(0.98); C61(0.98); C62(0.86)  LDD0929  [4]
 LDCM0332  AC68 HCT 116 C61(1.30); C62(1.30)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C61(1.42); C62(1.42)  LDD0650  [4]
 LDCM0334  AC7 HEK-293T C60(0.94); C61(0.97); C62(0.99)  LDD0932  [4]
 LDCM0335  AC70 HCT 116 C61(0.71); C62(0.71)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C61(1.18); C62(1.18)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C61(1.52); C62(1.52)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C61(1.87); C62(1.87)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C61(1.86); C62(1.86)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C61(2.18); C62(2.18)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C61(1.51); C62(1.51)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C61(1.68); C62(1.68)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C61(1.18); C62(1.18)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C61(1.43); C62(1.43)  LDD0661  [4]
 LDCM0345  AC8 HEK-293T C60(0.94); C61(0.92); C62(1.17)  LDD0943  [4]
 LDCM0346  AC80 HCT 116 C61(1.43); C62(1.43)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C61(1.58); C62(1.58)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C61(1.66); C62(1.66)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C60(1.67); C61(1.67); C62(1.67)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C60(1.32); C61(1.32); C62(1.32)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C60(0.98); C61(0.98); C62(0.98)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C60(0.99); C61(0.99); C62(0.99)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C60(1.05); C61(1.05); C62(1.05)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C60(1.12); C61(1.12); C62(1.12)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C60(1.44); C61(1.44); C62(1.44)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C60(1.79); C61(1.79); C62(1.79)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C60(1.31); C61(1.31); C62(1.31)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C60(1.09); C61(1.09); C62(1.09)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C60(0.87); C61(0.87); C62(0.87)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C60(0.72); C61(0.72); C62(0.72)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C60(1.25); C61(1.25); C62(1.25)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C60(0.76); C61(0.76); C62(0.76)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C60(1.43); C61(1.43); C62(1.43)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C60(1.47); C61(1.47); C62(1.47)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C60(1.04); C61(1.04); C62(1.04)  LDD0683  [4]
 LDCM0248  AKOS034007472 HEK-293T C60(1.22); C61(1.21); C62(2.02)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C60(1.00); C61(1.04); C62(1.43)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C60(1.11); C61(1.15); C62(1.97)  LDD0873  [4]
 LDCM0156  Aniline NCI-H1299 11.24  LDD0403  [2]
 LDCM0367  CL1 HEK-293T C85(0.80); C60(1.01)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C85(1.22)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C60(0.86); C61(0.86); C62(1.41)  LDD0967  [4]
 LDCM0370  CL101 HEK-293T C60(0.99); C61(1.02); C62(1.21)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C60(1.11); C61(1.19); C62(2.17)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C60(0.88); C61(0.96); C62(0.91)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C60(0.93); C61(1.08); C62(1.12)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C60(0.96); C61(1.19); C62(1.18)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C60(1.06); C61(1.27); C62(1.12)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C60(1.01); C61(1.14); C62(1.10)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C60(0.93); C61(1.10); C62(1.09)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C60(1.25); C61(1.51); C62(1.42)  LDD0976  [4]
 LDCM0379  CL11 HEK-293T C85(2.42); C60(1.00)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C60(1.26); C61(1.57); C62(1.36)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C60(1.14); C61(1.39); C62(1.41)  LDD0979  [4]
 LDCM0382  CL112 HEK-293T C60(0.77); C61(0.77)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C60(0.65); C61(0.65)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C60(0.57); C61(0.57)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C60(0.69); C61(0.69)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C60(0.71); C61(0.71)  LDD0984  [4]
 LDCM0387  CL117 HEK-293T C85(0.79); C60(0.71)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C85(0.95); C60(1.08)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C85(0.82); C60(1.02)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C85(2.07)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C60(1.11)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C60(0.90); C61(0.94); C62(0.98)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C60(0.89); C61(1.09); C62(1.19)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C60(0.86); C61(0.76); C62(0.72)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C60(0.91); C61(0.96); C62(0.98)  LDD0993  [4]
 LDCM0396  CL125 HEK-293T C60(1.21); C61(1.21); C62(1.03)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C60(1.10); C61(1.10); C62(1.07)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C60(1.19); C61(1.19); C62(1.05)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C60(1.24); C61(1.24); C62(0.98)  LDD0997  [4]
 LDCM0400  CL13 HEK-293T C85(0.72); C60(0.67)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C85(0.97); C60(1.12)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C85(0.70); C60(0.89)  LDD1606  [10]
 LDCM0403  CL16 HCT 116 C60(0.82); C61(0.82); C62(0.82)  LDD0720  [4]
 LDCM0404  CL17 PaTu 8988t C60(1.34); C62(1.34)  LDD1283  [4]
 LDCM0405  CL18 PaTu 8988t C60(1.78); C62(1.78)  LDD1284  [4]
 LDCM0406  CL19 PaTu 8988t C60(1.84); C62(1.84)  LDD1285  [4]
 LDCM0407  CL2 HEK-293T C85(0.68); C60(1.29)  LDD1611  [10]
 LDCM0408  CL20 PaTu 8988t C60(2.52); C62(2.52)  LDD1287  [4]
 LDCM0409  CL21 PaTu 8988t C60(2.92); C62(2.92)  LDD1288  [4]
 LDCM0410  CL22 PaTu 8988t C60(2.19); C62(2.19)  LDD1289  [4]
 LDCM0411  CL23 PaTu 8988t C60(2.49); C62(2.49)  LDD1290  [4]
 LDCM0412  CL24 PaTu 8988t C60(1.38); C62(1.38)  LDD1291  [4]
 LDCM0413  CL25 PaTu 8988t C60(1.17); C62(1.17)  LDD1292  [4]
 LDCM0414  CL26 PaTu 8988t C60(2.12); C62(2.12)  LDD1293  [4]
 LDCM0415  CL27 PaTu 8988t C60(1.05); C62(1.05)  LDD1294  [4]
 LDCM0416  CL28 PaTu 8988t C60(2.22); C62(2.22)  LDD1295  [4]
 LDCM0417  CL29 PaTu 8988t C60(2.08); C62(2.08)  LDD1296  [4]
 LDCM0418  CL3 HEK-293T C85(0.69); C60(1.13)  LDD1622  [10]
 LDCM0419  CL30 PaTu 8988t C60(1.80); C62(1.80)  LDD1298  [4]
 LDCM0420  CL31 HEK-293T C60(1.04); C61(1.04); C62(0.79)  LDD1018  [4]
 LDCM0421  CL32 HCT 116 C60(1.23); C61(1.23); C62(1.23)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C60(1.75); C61(1.75); C62(1.75)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C60(2.42); C61(2.42); C62(2.42)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C60(0.83); C61(0.83); C62(0.83)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C60(0.75); C61(0.75); C62(0.75)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C60(0.93); C61(0.93); C62(0.93)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C60(1.19); C61(1.19); C62(1.19)  LDD0745  [4]
 LDCM0429  CL4 HEK-293T C60(1.15)  LDD1633  [10]
 LDCM0430  CL40 HCT 116 C60(1.41); C61(1.41); C62(1.41)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C60(0.98); C61(0.98); C62(0.98)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C60(0.79); C61(0.79); C62(0.79)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C60(0.99); C61(0.99); C62(0.99)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C60(0.83); C61(0.83); C62(0.83)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C60(0.73); C61(0.73); C62(0.73)  LDD0752  [4]
 LDCM0436  CL46 HEK-293T C60(0.90); C61(0.90); C62(0.77)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C60(0.86); C61(0.86); C62(0.68)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C60(0.95); C61(0.95); C62(0.73)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C60(0.84); C61(0.84); C62(0.78)  LDD1037  [4]
 LDCM0440  CL5 HEK-293T C85(1.00); C60(1.03)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C60(0.85); C61(0.85); C62(0.90)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C60(1.04); C61(1.04); C62(1.03)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C60(0.93); C61(0.93); C62(0.87)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C60(1.18); C61(1.18); C62(1.17)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C60(1.14); C61(1.14); C62(1.21)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C60(0.86); C61(0.86); C62(0.92)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C60(1.04); C61(1.04); C62(0.88)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C60(1.68); C61(1.68); C62(1.61)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C60(0.96); C61(0.96); C62(1.02)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C60(1.05); C61(1.05); C62(0.93)  LDD1048  [4]
 LDCM0451  CL6 HEK-293T C60(0.90)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C60(0.96); C61(0.96); C62(0.88)  LDD1050  [4]
 LDCM0453  CL61 HCT 116 C60(1.01); C61(1.01); C62(1.01)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C60(1.07); C61(1.07); C62(1.07)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C60(0.90); C61(0.90); C62(0.90)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C60(0.70); C61(0.70); C62(0.70)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C60(0.94); C61(0.94); C62(0.94)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C60(0.95); C61(0.95); C62(0.95)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C60(1.15); C61(1.15); C62(1.15)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C60(0.88); C61(0.88); C62(0.88)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C60(1.10); C61(1.10); C62(1.10)  LDD0778  [4]
 LDCM0462  CL7 HEK-293T C60(1.11)  LDD1665  [10]
 LDCM0463  CL70 HCT 116 C60(1.06); C61(1.06); C62(1.06)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C60(1.01); C61(1.01); C62(1.01)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C60(0.96); C61(0.96); C62(0.96)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C60(0.94); C61(0.94); C62(0.94)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C60(1.18); C61(1.18); C62(1.18)  LDD0784  [4]
 LDCM0469  CL76 HEK-293T C62(1.18)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C62(1.08)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C62(1.28)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C62(1.05)  LDD1070  [4]
 LDCM0473  CL8 HEK-293T C85(1.13); C60(0.87)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C62(0.96)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C62(1.72)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C62(1.01)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C62(1.46)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C62(1.42)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C62(1.42)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C62(1.39)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C62(1.13)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C62(0.99)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C62(1.21)  LDD1081  [4]
 LDCM0484  CL9 HEK-293T C85(2.45)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C62(1.37)  LDD1083  [4]
 LDCM0486  CL91 HEK-293T C60(1.49); C61(1.42); C62(1.65)  LDD1084  [4]
 LDCM0487  CL92 HEK-293T C60(1.01); C61(1.28); C62(1.49)  LDD1085  [4]
 LDCM0488  CL93 HEK-293T C60(0.96); C61(1.08); C62(1.70)  LDD1086  [4]
 LDCM0489  CL94 HEK-293T C60(0.98); C61(1.06); C62(1.61)  LDD1087  [4]
 LDCM0490  CL95 HEK-293T C60(1.24); C61(1.35); C62(1.63)  LDD1088  [4]
 LDCM0491  CL96 HEK-293T C60(0.92); C61(0.95); C62(1.24)  LDD1089  [4]
 LDCM0492  CL97 HEK-293T C60(1.19); C61(1.37); C62(1.75)  LDD1090  [4]
 LDCM0493  CL98 HEK-293T C60(0.95); C61(1.10); C62(1.26)  LDD1091  [4]
 LDCM0494  CL99 HEK-293T C60(1.10); C61(1.19); C62(1.44)  LDD1092  [4]
 LDCM0495  E2913 HEK-293T C85(0.76); C60(0.92)  LDD1698  [10]
 LDCM0468  Fragment33 HCT 116 C60(0.87); C61(0.87); C62(0.87)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C60(0.80); C61(0.80); C62(0.80)  LDD0744  [4]
 LDCM0116  HHS-0101 DM93 Y64(0.62)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y64(1.23)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y64(1.18)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y64(1.59)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y64(1.28)  LDD0268  [3]
 LDCM0022  KB02 HCT 116 C85(4.42); C90(4.42)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C85(1.92); C90(1.92)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C85(2.01); C90(2.01)  LDD0082  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-6 (CASP6) Peptidase C14A family P55212
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB) PPP phosphatase family P62140
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PPP1CC) PPP phosphatase family P36873
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Optineurin (OPTN) . Q96CV9
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402