Details of the Target

General Information of Target

Target ID LDTP00456
Target Name 5-oxoprolinase (OPLAH)
Gene Name OPLAH
Gene ID 26873
Synonyms
5-oxoprolinase; EC 3.5.2.9; 5-oxo-L-prolinase; 5-OPase; Pyroglutamase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSPEGRFHFAIDRGGTFTDVFAQCPGGHVRVLKLLSEDPANYADAPTEGIRRILEQEAG
MLLPRDQPLDSSHIASIRMGTTVATNALLERKGERVALLVTRGFRDLLHIGTQARGDLFD
LAVPMPEVLYEEVLEVDERVVLHRGEAGTGTPVKGRTGDLLEVQQPVDLGALRGKLEGLL
SRGIRSLAVVLMHSYTWAQHEQQVGVLARELGFTHVSLSSEAMPMVRIVPRGHTACADAY
LTPAIQRYVQGFCRGFQGQLKDVQVLFMRSDGGLAPMDTFSGSSAVLSGPAGGVVGYSAT
TYQQEGGQPVIGFDMGGTSTDVSRYAGEFEHVFEASTAGVTLQAPQLDINTVAAGGGSRL
FFRSGLFVVGPESAGAHPGPACYRKGGPVTVTDANLVLGRLLPASFPCIFGPGENQPLSP
EASRKALEAVATEVNSFLTNGPCPASPLSLEEVAMGFVRVANEAMCRPIRALTQARGHDP
SAHVLACFGGAGGQHACAIARALGMDTVHIHRHSGLLSALGLALADVVHEAQEPCSLLYA
PETFVQLDQRLSRLEEQCVDALQAQGFPRSQISTESFLHLRYQGTDCALMVSAHQHPATA
RSPRAGDFGAAFVERYMREFGFVIPERPVVVDDVRVRGTGRSGLRLEDAPKAQTGPPRVD
KMTQCYFEGGYQETPVYLLAELGYGHKLHGPCLIIDSNSTILVEPGCQAEVTKTGDICIS
VGAEVPGTVGPQLDPIQLSIFSHRFMSIAEQMGRILQRTAISTNIKERLDFSCALFGPDG
GLVSNAPHIPVHLGAMQETVQFQIQHLGADLHPGDVLLSNHPSAGGSHLPDLTVITPVFW
PGQTRPVFYVASRGHHADIGGITPGSMPPHSTMLQQEGAVFLSFKLVQGGVFQEEAVTEA
LRAPGKVPNCSGTRNLHDNLSDLRAQVAANQKGIQLVGELIGQYGLDVVQAYMGHIQANA
ELAVRDMLRAFGTSRQARGLPLEVSSEDHMDDGSPIRLRVQISLSQGSAVFDFSGTGPEV
FGNLNAPRAVTLSALIYCLRCLVGRDIPLNQGCLAPVRVVIPRGSILDPSPEAAVVGGNV
LTSQRVVDVILGAFGACAASQGCMNNVTLGNAHMGYYETVAGGAGAGPSWHGRSGVHSHM
TNTRITDPEILESRYPVILRRFELRRGSGGRGRFRGGDGVTRELLFREEALLSVLTERRA
FRPYGLHGGEPGARGLNLLIRKNGRTVNLGGKTSVTVYPGDVFCLHTPGGGGYGDPEDPA
PPPGSPPQALAFPEHGSVYEYRRAQEAV
Target Bioclass
Enzyme
Family
Oxoprolinase family
Function Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
Uniprot ID
O14841
Ensemble ID
ENST00000618853.5
HGNC ID
HGNC:8149

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C408(1.26)  LDD2227  [1]
DBIA
 Probe Info  		C910(141.50)  LDD0209  [2]
Acrolein
 Probe Info  		N.A.  LDD0221  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1038(0.00); C236(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C25(0.00); C382(0.00); C236(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C25(0.00); C382(0.00); C466(0.00); C253(0.00)  LDD0037  [4]
NAIA_4
 Probe Info  		C25(0.00); C236(0.00); C408(0.00)  LDD2226  [1]
TFBX
 Probe Info  		C25(0.00); C408(0.00); C253(0.00)  LDD0148  [5]
W1
 Probe Info  		C466(0.00); C408(0.00)  LDD0236  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C408(2.61)  LDD1093  [7]
 LDCM0215  AC10 HCT 116 C408(1.16)  LDD0532  [7]
 LDCM0216  AC100 PaTu 8988t C408(0.92)  LDD1095  [7]
 LDCM0217  AC101 PaTu 8988t C408(1.32)  LDD1096  [7]
 LDCM0218  AC102 PaTu 8988t C408(1.55)  LDD1097  [7]
 LDCM0219  AC103 PaTu 8988t C408(1.41)  LDD1098  [7]
 LDCM0220  AC104 PaTu 8988t C408(0.92)  LDD1099  [7]
 LDCM0221  AC105 PaTu 8988t C408(0.89)  LDD1100  [7]
 LDCM0222  AC106 PaTu 8988t C408(1.42)  LDD1101  [7]
 LDCM0223  AC107 PaTu 8988t C408(1.35)  LDD1102  [7]
 LDCM0224  AC108 PaTu 8988t C408(1.02)  LDD1103  [7]
 LDCM0225  AC109 PaTu 8988t C408(1.52)  LDD1104  [7]
 LDCM0226  AC11 HCT 116 C408(0.97)  LDD0543  [7]
 LDCM0227  AC110 PaTu 8988t C408(1.16)  LDD1106  [7]
 LDCM0228  AC111 PaTu 8988t C408(1.64)  LDD1107  [7]
 LDCM0229  AC112 PaTu 8988t C408(1.22)  LDD1108  [7]
 LDCM0230  AC113 PaTu 8988t C408(0.63)  LDD1109  [7]
 LDCM0231  AC114 PaTu 8988t C408(0.74)  LDD1110  [7]
 LDCM0232  AC115 PaTu 8988t C408(0.74)  LDD1111  [7]
 LDCM0233  AC116 PaTu 8988t C408(0.61)  LDD1112  [7]
 LDCM0234  AC117 PaTu 8988t C408(0.76)  LDD1113  [7]
 LDCM0235  AC118 PaTu 8988t C408(0.83)  LDD1114  [7]
 LDCM0236  AC119 PaTu 8988t C408(0.76)  LDD1115  [7]
 LDCM0237  AC12 HCT 116 C408(1.31)  LDD0554  [7]
 LDCM0238  AC120 PaTu 8988t C408(0.68)  LDD1117  [7]
 LDCM0239  AC121 PaTu 8988t C408(0.53)  LDD1118  [7]
 LDCM0240  AC122 PaTu 8988t C408(0.90)  LDD1119  [7]
 LDCM0241  AC123 PaTu 8988t C408(1.06)  LDD1120  [7]
 LDCM0242  AC124 PaTu 8988t C408(1.41)  LDD1121  [7]
 LDCM0243  AC125 PaTu 8988t C408(0.77)  LDD1122  [7]
 LDCM0244  AC126 PaTu 8988t C408(0.87)  LDD1123  [7]
 LDCM0245  AC127 PaTu 8988t C408(0.97)  LDD1124  [7]
 LDCM0246  AC128 PaTu 8988t C408(0.51)  LDD1125  [7]
 LDCM0247  AC129 PaTu 8988t C408(0.68)  LDD1126  [7]
 LDCM0249  AC130 PaTu 8988t C408(0.79)  LDD1128  [7]
 LDCM0250  AC131 PaTu 8988t C408(0.60)  LDD1129  [7]
 LDCM0251  AC132 PaTu 8988t C408(0.86)  LDD1130  [7]
 LDCM0252  AC133 PaTu 8988t C408(0.64)  LDD1131  [7]
 LDCM0253  AC134 PaTu 8988t C408(0.59)  LDD1132  [7]
 LDCM0254  AC135 PaTu 8988t C408(0.54)  LDD1133  [7]
 LDCM0255  AC136 PaTu 8988t C408(0.57)  LDD1134  [7]
 LDCM0256  AC137 PaTu 8988t C408(0.64)  LDD1135  [7]
 LDCM0257  AC138 PaTu 8988t C408(0.59)  LDD1136  [7]
 LDCM0258  AC139 PaTu 8988t C408(0.59)  LDD1137  [7]
 LDCM0259  AC14 HCT 116 C408(1.18)  LDD0576  [7]
 LDCM0260  AC140 PaTu 8988t C408(0.64)  LDD1139  [7]
 LDCM0261  AC141 PaTu 8988t C408(0.72)  LDD1140  [7]
 LDCM0262  AC142 PaTu 8988t C408(0.73)  LDD1141  [7]
 LDCM0263  AC143 PaTu 8988t C408(0.90)  LDD1142  [7]
 LDCM0264  AC144 PaTu 8988t C408(0.85)  LDD1143  [7]
 LDCM0265  AC145 PaTu 8988t C408(0.86)  LDD1144  [7]
 LDCM0266  AC146 PaTu 8988t C408(1.01)  LDD1145  [7]
 LDCM0267  AC147 PaTu 8988t C408(0.74)  LDD1146  [7]
 LDCM0268  AC148 PaTu 8988t C408(1.08)  LDD1147  [7]
 LDCM0269  AC149 PaTu 8988t C408(1.02)  LDD1148  [7]
 LDCM0270  AC15 HCT 116 C408(1.63)  LDD0587  [7]
 LDCM0271  AC150 PaTu 8988t C408(0.99)  LDD1150  [7]
 LDCM0272  AC151 PaTu 8988t C408(1.08)  LDD1151  [7]
 LDCM0273  AC152 PaTu 8988t C408(0.93)  LDD1152  [7]
 LDCM0274  AC153 PaTu 8988t C408(1.04)  LDD1153  [7]
 LDCM0621  AC154 PaTu 8988t C408(1.14)  LDD2166  [7]
 LDCM0622  AC155 PaTu 8988t C408(1.13)  LDD2167  [7]
 LDCM0623  AC156 PaTu 8988t C408(0.96)  LDD2168  [7]
 LDCM0624  AC157 PaTu 8988t C408(0.98)  LDD2169  [7]
 LDCM0276  AC17 PaTu 8988t C408(1.20)  LDD1155  [7]
 LDCM0277  AC18 PaTu 8988t C408(1.57)  LDD1156  [7]
 LDCM0278  AC19 PaTu 8988t C408(1.43)  LDD1157  [7]
 LDCM0279  AC2 PaTu 8988t C408(1.22)  LDD1158  [7]
 LDCM0280  AC20 PaTu 8988t C408(1.30)  LDD1159  [7]
 LDCM0281  AC21 PaTu 8988t C408(1.41)  LDD1160  [7]
 LDCM0282  AC22 PaTu 8988t C408(1.27)  LDD1161  [7]
 LDCM0283  AC23 PaTu 8988t C408(1.34)  LDD1162  [7]
 LDCM0284  AC24 PaTu 8988t C408(1.64)  LDD1163  [7]
 LDCM0285  AC25 HCT 116 C408(2.06)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C408(1.34)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C408(1.53)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C408(2.02)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C408(1.61)  LDD0606  [7]
 LDCM0290  AC3 PaTu 8988t C408(1.17)  LDD1169  [7]
 LDCM0291  AC30 HCT 116 C408(2.15)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C408(1.75)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C408(2.24)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C408(2.32)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C408(1.84)  LDD0612  [7]
 LDCM0296  AC35 PaTu 8988t C408(1.03)  LDD1175  [7]
 LDCM0297  AC36 PaTu 8988t C408(1.09)  LDD1176  [7]
 LDCM0298  AC37 PaTu 8988t C408(1.14)  LDD1177  [7]
 LDCM0299  AC38 PaTu 8988t C408(1.29)  LDD1178  [7]
 LDCM0300  AC39 PaTu 8988t C408(1.34)  LDD1179  [7]
 LDCM0301  AC4 PaTu 8988t C408(1.23)  LDD1180  [7]
 LDCM0302  AC40 PaTu 8988t C408(1.28)  LDD1181  [7]
 LDCM0303  AC41 PaTu 8988t C408(1.01)  LDD1182  [7]
 LDCM0304  AC42 PaTu 8988t C408(1.04)  LDD1183  [7]
 LDCM0305  AC43 PaTu 8988t C408(0.99)  LDD1184  [7]
 LDCM0306  AC44 PaTu 8988t C408(1.26)  LDD1185  [7]
 LDCM0307  AC45 PaTu 8988t C408(1.22)  LDD1186  [7]
 LDCM0308  AC46 PaTu 8988t C408(1.34)  LDD1187  [7]
 LDCM0309  AC47 PaTu 8988t C408(1.49)  LDD1188  [7]
 LDCM0310  AC48 PaTu 8988t C408(1.34)  LDD1189  [7]
 LDCM0311  AC49 PaTu 8988t C408(1.76)  LDD1190  [7]
 LDCM0312  AC5 PaTu 8988t C408(1.70)  LDD1191  [7]
 LDCM0313  AC50 PaTu 8988t C408(1.50)  LDD1192  [7]
 LDCM0314  AC51 PaTu 8988t C408(1.51)  LDD1193  [7]
 LDCM0315  AC52 PaTu 8988t C408(1.78)  LDD1194  [7]
 LDCM0316  AC53 PaTu 8988t C408(1.74)  LDD1195  [7]
 LDCM0317  AC54 PaTu 8988t C408(2.08)  LDD1196  [7]
 LDCM0318  AC55 PaTu 8988t C408(1.80)  LDD1197  [7]
 LDCM0319  AC56 PaTu 8988t C408(1.43)  LDD1198  [7]
 LDCM0320  AC57 PaTu 8988t C408(1.73)  LDD1199  [7]
 LDCM0321  AC58 PaTu 8988t C408(1.39)  LDD1200  [7]
 LDCM0322  AC59 PaTu 8988t C408(1.39)  LDD1201  [7]
 LDCM0323  AC6 HCT 116 C408(1.29)  LDD0640  [7]
 LDCM0324  AC60 PaTu 8988t C408(1.48)  LDD1203  [7]
 LDCM0325  AC61 PaTu 8988t C408(1.59)  LDD1204  [7]
 LDCM0326  AC62 PaTu 8988t C408(1.56)  LDD1205  [7]
 LDCM0327  AC63 PaTu 8988t C408(1.46)  LDD1206  [7]
 LDCM0328  AC64 PaTu 8988t C408(1.58)  LDD1207  [7]
 LDCM0329  AC65 PaTu 8988t C408(1.49)  LDD1208  [7]
 LDCM0330  AC66 PaTu 8988t C408(1.73)  LDD1209  [7]
 LDCM0331  AC67 PaTu 8988t C408(1.31)  LDD1210  [7]
 LDCM0332  AC68 PaTu 8988t C408(0.77)  LDD1211  [7]
 LDCM0333  AC69 PaTu 8988t C408(0.99)  LDD1212  [7]
 LDCM0334  AC7 HCT 116 C408(1.21)  LDD0651  [7]
 LDCM0335  AC70 PaTu 8988t C408(1.29)  LDD1214  [7]
 LDCM0336  AC71 PaTu 8988t C408(0.84)  LDD1215  [7]
 LDCM0337  AC72 PaTu 8988t C408(0.80)  LDD1216  [7]
 LDCM0338  AC73 PaTu 8988t C408(1.03)  LDD1217  [7]
 LDCM0339  AC74 PaTu 8988t C408(0.90)  LDD1218  [7]
 LDCM0340  AC75 PaTu 8988t C408(1.26)  LDD1219  [7]
 LDCM0341  AC76 PaTu 8988t C408(1.11)  LDD1220  [7]
 LDCM0342  AC77 PaTu 8988t C408(0.83)  LDD1221  [7]
 LDCM0343  AC78 PaTu 8988t C408(1.24)  LDD1222  [7]
 LDCM0344  AC79 PaTu 8988t C408(1.07)  LDD1223  [7]
 LDCM0345  AC8 HCT 116 C408(1.14)  LDD0662  [7]
 LDCM0346  AC80 PaTu 8988t C408(0.92)  LDD1225  [7]
 LDCM0347  AC81 PaTu 8988t C408(1.04)  LDD1226  [7]
 LDCM0348  AC82 PaTu 8988t C408(1.20)  LDD1227  [7]
 LDCM0349  AC83 PaTu 8988t C408(1.29)  LDD1228  [7]
 LDCM0350  AC84 PaTu 8988t C408(1.28)  LDD1229  [7]
 LDCM0351  AC85 PaTu 8988t C408(1.39)  LDD1230  [7]
 LDCM0352  AC86 PaTu 8988t C408(1.25)  LDD1231  [7]
 LDCM0353  AC87 PaTu 8988t C408(1.08)  LDD1232  [7]
 LDCM0354  AC88 PaTu 8988t C408(1.30)  LDD1233  [7]
 LDCM0355  AC89 PaTu 8988t C408(1.18)  LDD1234  [7]
 LDCM0357  AC90 PaTu 8988t C408(1.15)  LDD1236  [7]
 LDCM0358  AC91 PaTu 8988t C408(1.08)  LDD1237  [7]
 LDCM0359  AC92 PaTu 8988t C408(1.19)  LDD1238  [7]
 LDCM0360  AC93 PaTu 8988t C408(1.16)  LDD1239  [7]
 LDCM0361  AC94 PaTu 8988t C408(1.50)  LDD1240  [7]
 LDCM0362  AC95 PaTu 8988t C408(1.35)  LDD1241  [7]
 LDCM0363  AC96 PaTu 8988t C408(1.08)  LDD1242  [7]
 LDCM0364  AC97 PaTu 8988t C408(1.10)  LDD1243  [7]
 LDCM0365  AC98 PaTu 8988t C408(1.53)  LDD1244  [7]
 LDCM0366  AC99 PaTu 8988t C408(1.08)  LDD1245  [7]
 LDCM0248  AKOS034007472 HCT 116 C408(1.32)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C408(1.41)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C408(1.73)  LDD0592  [7]
 LDCM0108  Chloroacetamide HeLa C587(0.00); C25(0.00); C558(0.00)  LDD0222  [3]
 LDCM0632  CL-Sc Hep-G2 C408(1.26)  LDD2227  [1]
 LDCM0367  CL1 HCT 116 C408(0.76)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C408(0.75)  LDD0685  [7]
 LDCM0369  CL100 PaTu 8988t C408(1.19)  LDD1248  [7]
 LDCM0370  CL101 HCT 116 C408(1.37)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C408(1.61)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C408(1.21)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C408(1.44)  LDD0690  [7]
 LDCM0374  CL105 PaTu 8988t C408(1.07)  LDD1253  [7]
 LDCM0375  CL106 PaTu 8988t C408(1.37)  LDD1254  [7]
 LDCM0376  CL107 PaTu 8988t C408(1.03)  LDD1255  [7]
 LDCM0377  CL108 PaTu 8988t C408(1.04)  LDD1256  [7]
 LDCM0378  CL109 PaTu 8988t C408(1.26)  LDD1257  [7]
 LDCM0379  CL11 HCT 116 C408(0.93)  LDD0696  [7]
 LDCM0380  CL110 PaTu 8988t C408(1.11)  LDD1259  [7]
 LDCM0381  CL111 PaTu 8988t C408(1.62)  LDD1260  [7]
 LDCM0382  CL112 HCT 116 C408(1.78)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C408(1.82)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C408(1.43)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C408(1.38)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C408(2.25)  LDD0703  [7]
 LDCM0387  CL117 PaTu 8988t C408(1.05)  LDD1266  [7]
 LDCM0388  CL118 PaTu 8988t C408(0.97)  LDD1267  [7]
 LDCM0389  CL119 PaTu 8988t C408(1.07)  LDD1268  [7]
 LDCM0390  CL12 HCT 116 C408(0.81)  LDD0707  [7]
 LDCM0391  CL120 PaTu 8988t C408(1.01)  LDD1270  [7]
 LDCM0392  CL121 PaTu 8988t C408(1.25)  LDD1271  [7]
 LDCM0393  CL122 PaTu 8988t C408(1.54)  LDD1272  [7]
 LDCM0394  CL123 PaTu 8988t C408(1.48)  LDD1273  [7]
 LDCM0395  CL124 PaTu 8988t C408(1.52)  LDD1274  [7]
 LDCM0396  CL125 PaTu 8988t C408(1.36)  LDD1275  [7]
 LDCM0397  CL126 PaTu 8988t C408(1.13)  LDD1276  [7]
 LDCM0398  CL127 PaTu 8988t C408(1.44)  LDD1277  [7]
 LDCM0399  CL128 PaTu 8988t C408(1.36)  LDD1278  [7]
 LDCM0400  CL13 HCT 116 C408(0.84)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C408(0.80)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C408(0.80)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C408(1.13)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C408(0.85)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C408(1.43)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C408(1.14)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C408(0.46)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C408(2.21)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C408(1.16)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C408(1.44)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C408(1.16)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C408(1.10)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C408(1.23)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C408(1.06)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C408(1.29)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C408(0.86)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C408(1.22)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C408(0.50)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C408(0.82)  LDD0736  [7]
 LDCM0420  CL31 PaTu 8988t C408(1.25)  LDD1299  [7]
 LDCM0421  CL32 PaTu 8988t C408(1.06)  LDD1300  [7]
 LDCM0422  CL33 PaTu 8988t C408(1.44)  LDD1301  [7]
 LDCM0423  CL34 PaTu 8988t C408(1.77)  LDD1302  [7]
 LDCM0424  CL35 PaTu 8988t C408(1.49)  LDD1303  [7]
 LDCM0425  CL36 PaTu 8988t C408(1.06)  LDD1304  [7]
 LDCM0426  CL37 PaTu 8988t C408(1.12)  LDD1305  [7]
 LDCM0428  CL39 PaTu 8988t C408(1.89)  LDD1307  [7]
 LDCM0429  CL4 HCT 116 C408(0.86)  LDD0746  [7]
 LDCM0430  CL40 PaTu 8988t C408(1.26)  LDD1309  [7]
 LDCM0431  CL41 PaTu 8988t C408(1.25)  LDD1310  [7]
 LDCM0432  CL42 PaTu 8988t C408(1.64)  LDD1311  [7]
 LDCM0433  CL43 PaTu 8988t C408(1.72)  LDD1312  [7]
 LDCM0434  CL44 PaTu 8988t C408(1.60)  LDD1313  [7]
 LDCM0435  CL45 PaTu 8988t C408(1.43)  LDD1314  [7]
 LDCM0436  CL46 PaTu 8988t C408(1.13)  LDD1315  [7]
 LDCM0437  CL47 PaTu 8988t C408(0.98)  LDD1316  [7]
 LDCM0438  CL48 PaTu 8988t C408(0.86)  LDD1317  [7]
 LDCM0439  CL49 PaTu 8988t C408(1.06)  LDD1318  [7]
 LDCM0440  CL5 HCT 116 C408(0.72)  LDD0757  [7]
 LDCM0441  CL50 PaTu 8988t C408(1.25)  LDD1320  [7]
 LDCM0442  CL51 PaTu 8988t C408(1.00)  LDD1321  [7]
 LDCM0443  CL52 PaTu 8988t C408(1.22)  LDD1322  [7]
 LDCM0444  CL53 PaTu 8988t C408(0.99)  LDD1323  [7]
 LDCM0445  CL54 PaTu 8988t C408(1.19)  LDD1324  [7]
 LDCM0446  CL55 PaTu 8988t C408(1.32)  LDD1325  [7]
 LDCM0447  CL56 PaTu 8988t C408(0.76)  LDD1326  [7]
 LDCM0448  CL57 PaTu 8988t C408(1.84)  LDD1327  [7]
 LDCM0449  CL58 PaTu 8988t C408(1.38)  LDD1328  [7]
 LDCM0450  CL59 PaTu 8988t C408(1.48)  LDD1329  [7]
 LDCM0451  CL6 HCT 116 C408(1.54)  LDD0768  [7]
 LDCM0452  CL60 PaTu 8988t C408(1.56)  LDD1331  [7]
 LDCM0453  CL61 PaTu 8988t C408(1.00)  LDD1332  [7]
 LDCM0454  CL62 PaTu 8988t C408(1.02)  LDD1333  [7]
 LDCM0455  CL63 PaTu 8988t C408(0.94)  LDD1334  [7]
 LDCM0456  CL64 PaTu 8988t C408(1.02)  LDD1335  [7]
 LDCM0457  CL65 PaTu 8988t C408(0.99)  LDD1336  [7]
 LDCM0458  CL66 PaTu 8988t C408(1.10)  LDD1337  [7]
 LDCM0459  CL67 PaTu 8988t C408(1.14)  LDD1338  [7]
 LDCM0460  CL68 PaTu 8988t C408(0.94)  LDD1339  [7]
 LDCM0461  CL69 PaTu 8988t C408(1.21)  LDD1340  [7]
 LDCM0462  CL7 HCT 116 C408(0.73)  LDD0779  [7]
 LDCM0463  CL70 PaTu 8988t C408(1.05)  LDD1342  [7]
 LDCM0464  CL71 PaTu 8988t C408(0.82)  LDD1343  [7]
 LDCM0465  CL72 PaTu 8988t C408(0.89)  LDD1344  [7]
 LDCM0466  CL73 PaTu 8988t C408(1.04)  LDD1345  [7]
 LDCM0467  CL74 PaTu 8988t C408(0.87)  LDD1346  [7]
 LDCM0469  CL76 HCT 116 C408(1.14)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C408(2.09)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C408(1.02)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C408(1.33)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C408(0.79)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C408(1.03)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C408(1.28)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C408(1.83)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C408(2.11)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C408(1.18)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C408(1.29)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C408(0.96)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C408(1.86)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C408(1.74)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C408(1.61)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C408(0.64)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C408(0.66)  LDD0802  [7]
 LDCM0486  CL91 PaTu 8988t C408(1.27)  LDD1365  [7]
 LDCM0487  CL92 PaTu 8988t C408(1.73)  LDD1366  [7]
 LDCM0488  CL93 PaTu 8988t C408(1.71)  LDD1367  [7]
 LDCM0489  CL94 PaTu 8988t C408(1.68)  LDD1368  [7]
 LDCM0490  CL95 PaTu 8988t C408(1.48)  LDD1369  [7]
 LDCM0491  CL96 PaTu 8988t C408(1.17)  LDD1370  [7]
 LDCM0492  CL97 PaTu 8988t C408(1.42)  LDD1371  [7]
 LDCM0493  CL98 PaTu 8988t C408(1.53)  LDD1372  [7]
 LDCM0494  CL99 PaTu 8988t C408(1.68)  LDD1373  [7]
 LDCM0468  Fragment33 PaTu 8988t C408(0.99)  LDD1347  [7]
 LDCM0427  Fragment51 PaTu 8988t C408(1.26)  LDD1306  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0022  KB02 22RV1 C25(1.27); C408(2.20); C466(1.04)  LDD2243  [8]
 LDCM0023  KB03 Jurkat C910(141.50)  LDD0209  [2]
 LDCM0024  KB05 COLO792 C1053(1.53); C25(1.31); C408(0.90); C466(1.32)  LDD3310  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5-oxoprolinase (OPLAH) Oxoprolinase family O14841
Thiamin pyrophosphokinase 1 (TPK1) Thiamine pyrophosphokinase family Q9H3S4
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Glutamic Acid Small molecular drug DB00142

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840