Details of the Target

General Information of Target

Target ID LDTP00423
Target Name Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
Gene Name TNFRSF10B
Gene ID 8795
Synonyms
DR5; KILLER; TRAILR2; TRICK2; ZTNFR9; Tumor necrosis factor receptor superfamily member 10B; Death receptor 5; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; TRAIL-R2; CD antigen CD262
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQD
LAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCD
SGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVH
KESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKV
LPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGV
NMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRK
LGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIED
HLLSSGKFMYLEGNADSAMS
Target Type
Clinical trial
Target Bioclass
Cytokine and receptor
Subcellular location
Membrane
Function
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
TTD ID
T70067
Uniprot ID
O14763
DrugMap ID
TTW20TU
Ensemble ID
ENST00000276431.9
HGNC ID
HGNC:11905
ChEMBL ID
CHEMBL1075153

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A204 SNV: p.K388N DBIA    Probe Info 
A2780 SNV: p.I418V .
COLO320 SNV: p.A221P .
DEL SNV: p.C341S .
HEC1 SNV: p.C153Ter .
KASUMI2 SNV: p.G426A .
NCIH2286 SNV: p.D254Y .
OCUM1 SNV: p.N134S DBIA    Probe Info 
SW1271 SNV: p.S234A .
TC71 SNV: p.Q58H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K360(3.70); K372(10.00)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K72(3.31)  LDD3494  [3]
BTD
 Probe Info  		C248(1.49)  LDD2090  [4]
DBIA
 Probe Info  		C248(1.16)  LDD0531  [5]
IA-alkyne
 Probe Info  		C81(0.00); C113(0.00)  LDD0162  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
IPM
 Probe Info  		N.A.  LDD0005  [8]
W1
 Probe Info  		N.A.  LDD0236  [9]
AOyne
 Probe Info  		14.60  LDD0443  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C248(0.99)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C248(1.39)  LDD2112  [4]
 LDCM0214  AC1 HCT 116 C248(1.16)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C248(1.26)  LDD0532  [5]
 LDCM0226  AC11 HCT 116 C248(1.27)  LDD0543  [5]
 LDCM0237  AC12 HCT 116 C248(0.95)  LDD0554  [5]
 LDCM0246  AC128 PaTu 8988t C248(0.76)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C248(1.11)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C248(0.95)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C248(1.30)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C248(0.90)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C248(0.89)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C248(0.90)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C248(0.94)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C248(0.88)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C248(0.75)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C248(0.99)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C248(1.01)  LDD1137  [5]
 LDCM0259  AC14 HCT 116 C248(1.62)  LDD0576  [5]
 LDCM0260  AC140 PaTu 8988t C248(0.96)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C248(0.77)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C248(1.81)  LDD1141  [5]
 LDCM0270  AC15 HCT 116 C248(1.44)  LDD0587  [5]
 LDCM0276  AC17 HCT 116 C248(1.01)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C248(1.50)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C248(1.08)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C248(1.30)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C248(1.08)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C248(1.00)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C248(0.84)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C248(0.87)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C248(0.88)  LDD0601  [5]
 LDCM0285  AC25 HEK-293T C248(1.15); C341(1.05)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C248(0.98); C341(1.08)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C248(0.98); C341(0.98)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C248(0.86); C341(1.05)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C248(1.10); C341(1.06)  LDD1528  [11]
 LDCM0290  AC3 HCT 116 C248(1.47)  LDD0607  [5]
 LDCM0291  AC30 HEK-293T C248(1.01); C341(1.00); C178(0.99)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C248(0.94); C341(1.12)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C248(1.02); C341(1.02); C178(1.28)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C248(0.95); C341(1.17)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C248(0.92); C341(1.15)  LDD1534  [11]
 LDCM0296  AC35 HCT 116 C248(0.63)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C248(0.92)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C248(0.86)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C248(1.05)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C248(0.92)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C248(1.23)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C248(0.94)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C248(1.04)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C248(1.09)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C248(1.13)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C248(1.09)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C248(1.13)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C248(1.29)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C248(0.74)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C248(0.89)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C248(1.24)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C248(1.59)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C248(1.64)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C248(0.62)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C248(0.78)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C248(0.69)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C248(1.21)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C248(1.58)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C248(1.34)  LDD0636  [5]
 LDCM0320  AC57 HEK-293T C248(1.09); C341(1.06)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C248(1.00); C341(0.94)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C248(0.92); C341(1.22)  LDD1561  [11]
 LDCM0323  AC6 HCT 116 C248(1.07)  LDD0640  [5]
 LDCM0324  AC60 HEK-293T C248(0.70); C341(0.90)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C248(1.11); C341(1.22)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C248(1.10); C341(0.94); C178(1.21)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C248(0.96); C341(0.95)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C248(1.00); C341(1.15); C178(1.16)  LDD1567  [11]
 LDCM0334  AC7 HCT 116 C248(1.19)  LDD0651  [5]
 LDCM0345  AC8 HCT 116 C248(1.82)  LDD0662  [5]
 LDCM0248  AKOS034007472 HCT 116 C248(0.99)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C248(1.15)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C248(1.96)  LDD0592  [5]
 LDCM0367  CL1 HEK-293T C248(1.06); C341(1.01)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C248(1.39); C341(0.79); C178(0.98)  LDD1572  [11]
 LDCM0369  CL100 HCT 116 C248(1.27)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C248(1.19)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C248(1.07)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C248(1.34)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C248(0.86)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C248(1.12)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C248(1.55)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C248(1.42)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C248(1.66)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C248(1.32)  LDD0695  [5]
 LDCM0379  CL11 HEK-293T C248(1.00); C341(1.00)  LDD1583  [11]
 LDCM0380  CL110 HCT 116 C248(1.29)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C248(1.19)  LDD0698  [5]
 LDCM0382  CL112 HEK-293T C248(0.95); C341(1.08)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C248(0.98); C341(0.90)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C248(0.92); C341(0.95)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C248(0.92); C341(1.12)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C248(0.88); C341(0.97)  LDD1590  [11]
 LDCM0387  CL117 HCT 116 C248(1.24)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C248(0.96)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C248(0.96)  LDD0706  [5]
 LDCM0390  CL12 HEK-293T C248(1.01); C341(1.06); C178(1.41)  LDD1594  [11]
 LDCM0391  CL120 HCT 116 C248(0.94)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C248(1.01)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C248(0.78)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C248(1.38)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C248(1.10)  LDD0712  [5]
 LDCM0396  CL125 HEK-293T C248(0.94); C341(1.10)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C248(0.82); C341(0.95)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C248(0.98); C341(1.07)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C248(0.85); C341(1.01)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C248(0.83); C341(1.05)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C248(0.82); C341(1.03)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C248(0.93); C341(1.05)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C248(0.79); C341(1.05)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C248(1.06); C341(1.07)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C248(0.85); C341(1.05)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C248(0.90); C341(1.03)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C248(0.82); C341(1.14)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C248(0.94); C341(0.89)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C248(1.18); C341(1.05)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C248(1.11); C341(0.90); C178(1.18)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C248(0.89); C341(1.13)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C248(1.03); C341(0.93); C178(1.45)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C248(1.17); C341(1.09)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C248(0.90); C341(0.96)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C248(0.95); C341(1.17)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C248(0.85); C341(1.11)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C248(0.96); C341(1.00)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C248(0.88); C341(1.24)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C248(0.80); C341(1.04)  LDD1623  [11]
 LDCM0420  CL31 HCT 116 C248(1.52)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C248(0.92)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C248(1.33)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C248(1.06)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C248(1.28)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C248(1.89)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C248(1.10)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C248(1.00)  LDD0745  [5]
 LDCM0429  CL4 HEK-293T C248(0.90); C341(1.09)  LDD1633  [11]
 LDCM0430  CL40 HCT 116 C248(2.11)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C248(0.96)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C248(1.20)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C248(1.04)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C248(1.09)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C248(1.43)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C248(0.78)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C248(0.71)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C248(1.21)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C248(0.74)  LDD0756  [5]
 LDCM0440  CL5 HEK-293T C248(0.89); C341(1.23)  LDD1644  [11]
 LDCM0441  CL50 HCT 116 C248(0.98)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C248(1.05)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C248(0.90)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C248(1.16)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C248(1.10)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C248(0.93)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C248(0.69)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C248(1.04)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C248(1.28)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C248(0.88)  LDD0767  [5]
 LDCM0451  CL6 HEK-293T C248(0.95); C341(0.91)  LDD1654  [11]
 LDCM0452  CL60 HCT 116 C248(0.70)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C248(1.19)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C248(1.32)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C248(0.99)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C248(0.92)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C248(1.17)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C248(1.18)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C248(1.22)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C248(1.21)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C248(0.90)  LDD0778  [5]
 LDCM0462  CL7 HEK-293T C248(0.95); C341(1.30)  LDD1665  [11]
 LDCM0463  CL70 HCT 116 C248(1.19)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C248(0.99)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C248(1.09)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C248(1.41)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C248(0.90)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C248(2.36)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C248(1.01)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C248(3.39)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C248(1.91)  LDD0789  [5]
 LDCM0473  CL8 HEK-293T C248(1.90); C341(0.94)  LDD1676  [11]
 LDCM0474  CL80 HCT 116 C248(1.53)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C248(1.69)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C248(4.29)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C248(2.66)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C248(2.17)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C248(1.92)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C248(1.33)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C248(1.87)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C248(2.75)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C248(3.07)  LDD0800  [5]
 LDCM0484  CL9 HEK-293T C248(1.03); C341(0.99)  LDD1687  [11]
 LDCM0485  CL90 HCT 116 C248(1.95)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C248(1.23)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C248(1.40)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C248(1.34)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C248(1.12)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C248(1.52)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C248(1.24)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C248(1.50)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C248(1.24)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C248(1.33)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C248(0.91); C341(1.35)  LDD1698  [11]
 LDCM0468  Fragment33 HCT 116 C248(0.88)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C248(4.99)  LDD0744  [5]
 LDCM0022  KB02 HEK-293T C248(0.86); C341(1.10)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C248(0.87); C341(1.05)  LDD1497  [11]
 LDCM0024  KB05 UACC257 C180(1.25)  LDD3325  [12]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C248(1.49)  LDD2090  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C248(1.99)  LDD2100  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C248(0.63)  LDD2114  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C248(0.87)  LDD2125  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C248(2.07)  LDD2136  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C248(0.96)  LDD2141  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C129(0.97)  LDD2150  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Palmitoyltransferase ZDHHC15 (ZDHHC15) DHHC palmitoyltransferase family Q96MV8
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) Tumor necrosis factor family P50591

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lexatumumab Antibody D0MW7S
Anti-dr5 Cells CAR T Cell Therapy D0LW4A
Conatumumab Monoclonal antibody D00WME
Phase 1
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bi 905711 Antibody D9Y8ZU
Ds-8273 Antibody DH17JI
Gen1029 Antibody DVX4P3
Igm-8444 Antibody D48UEV
Inbrx-109 Antibody drug conjugate D56ERU
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ad5-10 Antibody D04UYY
Dr-5/Dr-4 Cross Reactive Mabs Antibody D0X3PN
Discontinued
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Hgs-tr2j Antibody D06JBA
Lby-135 Antibody D05CHR
Rhapo2l/Trail . D08JRT

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840