Details of the Target

General Information of Target

Target ID LDTP00352
Target Name Suppressor of cytokine signaling 2 (SOCS2)
Gene Name SOCS2
Gene ID 8835
Synonyms
CIS2; SSI2; STATI2; Suppressor of cytokine signaling 2; SOCS-2; Cytokine-inducible SH2 protein 2; CIS-2; STAT-induced STAT inhibitor 2; SSI-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTLRCLEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKE
KLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFD
SVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPSLQHLCRLTINKCTGAIWG
LPLPTRLKDYLEEYKFQV
Target Bioclass
Other
Function
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Uniprot ID
O14508
Ensemble ID
ENST00000340600.6
HGNC ID
HGNC:19382

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C174(0.84)  LDD0533  [1]
NAIA_5
 Probe Info  		N.A.  LDD2224  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C111(0.87); C133(1.00)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C111(1.00); C133(0.80)  LDD1508  [3]
 LDCM0216  AC100 HCT 116 C174(0.84)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C174(0.90)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C174(0.87)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C174(0.91)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C174(0.93)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C174(1.04)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C174(0.91)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C174(0.90)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C174(0.94)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C174(0.79)  LDD0542  [1]
 LDCM0226  AC11 HEK-293T C111(0.98)  LDD1509  [3]
 LDCM0227  AC110 HCT 116 C174(1.02)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C174(0.91)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C174(0.90)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C174(0.96)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C174(0.95)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C174(0.92)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C174(0.81)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C174(0.93)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C174(0.97)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C174(0.91)  LDD0553  [1]
 LDCM0237  AC12 HEK-293T C133(1.00)  LDD1510  [3]
 LDCM0238  AC120 HCT 116 C174(0.99)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C174(0.83)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C174(0.77)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C174(0.70)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C174(0.92)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C174(0.99)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C174(1.11)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C174(0.97)  LDD0562  [1]
 LDCM0259  AC14 HEK-293T C111(0.98); C133(1.35)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C111(0.95)  LDD1513  [3]
 LDCM0276  AC17 HCT 116 C174(1.07)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C174(0.68)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C174(1.11)  LDD0595  [1]
 LDCM0279  AC2 HEK-293T C111(1.05); C133(0.99)  LDD1518  [3]
 LDCM0280  AC20 HCT 116 C174(1.17)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C174(0.87)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C174(0.97)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C174(0.98)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C174(1.02)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C174(1.05)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C174(0.96)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C174(1.24)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C174(0.90)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C174(1.23)  LDD0606  [1]
 LDCM0290  AC3 HEK-293T C111(1.07)  LDD1529  [3]
 LDCM0291  AC30 HCT 116 C174(1.15)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C174(1.13)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C174(1.27)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C174(1.15)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C174(1.07)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C174(0.78)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C174(0.91)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C174(1.04)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C174(1.12)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C174(0.87)  LDD0617  [1]
 LDCM0301  AC4 HEK-293T C133(0.96)  LDD1540  [3]
 LDCM0302  AC40 HCT 116 C174(1.09)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C174(1.01)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C174(0.90)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C174(1.02)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C174(1.00)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C174(1.10)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C174(1.05)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C174(1.24)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C174(1.17)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C174(1.06)  LDD0628  [1]
 LDCM0312  AC5 HEK-293T C111(0.95)  LDD1551  [3]
 LDCM0313  AC50 HCT 116 C174(1.24)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C174(1.18)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C174(0.96)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C174(1.33)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C174(1.20)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C174(1.24)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C174(1.45)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C174(0.90)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C174(0.95)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C174(0.98)  LDD0639  [1]
 LDCM0323  AC6 HEK-293T C111(1.15); C133(0.89)  LDD1562  [3]
 LDCM0324  AC60 HCT 116 C174(0.78)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C174(0.82)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C174(1.12)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C174(0.85)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C174(1.08)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C174(0.96)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C174(0.97)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C174(0.94)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C174(1.01)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C174(1.16)  LDD0650  [1]
 LDCM0334  AC7 HEK-293T C111(0.96)  LDD1568  [3]
 LDCM0335  AC70 HCT 116 C174(1.13)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C174(1.22)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C174(1.04)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C174(1.54)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C174(1.52)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C174(1.70)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C174(1.23)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C174(1.21)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C174(1.09)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C174(1.39)  LDD0661  [1]
 LDCM0345  AC8 HEK-293T C111(1.18)  LDD1569  [3]
 LDCM0346  AC80 HCT 116 C174(1.18)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C174(0.65)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C174(1.18)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C174(1.09)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C174(0.86)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C174(0.96)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C174(1.10)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C174(0.74)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C174(0.90)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C174(0.87)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C174(1.40)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C174(1.17)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C174(1.18)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C174(0.76)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C174(0.91)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C174(0.89)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C174(0.95)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C174(0.93)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C174(0.98)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C174(1.02)  LDD0683  [1]
 LDCM0248  AKOS034007472 HEK-293T C111(1.06)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C111(0.84); C133(1.21)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C111(1.09)  LDD1514  [3]
 LDCM0367  CL1 HCT 116 C174(0.91)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C174(0.96)  LDD0685  [1]
 LDCM0369  CL100 HEK-293T C111(0.91); C133(0.78)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C111(1.00)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C111(1.03); C133(0.89)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C111(1.12)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C111(0.98); C133(1.13)  LDD1577  [3]
 LDCM0374  CL105 HCT 116 C174(1.00)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C174(0.97)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C174(1.03)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C174(0.98)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C174(0.90)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C174(0.93)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C174(0.89)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C174(0.88)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C174(0.94)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C174(0.96)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C174(0.99)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C174(0.99)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C174(1.03)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C174(1.15)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C174(0.90)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C174(0.92)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C174(0.78)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C174(1.00)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C174(0.93)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C174(1.03)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C174(1.07)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C174(1.51)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C174(0.93)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C174(0.92)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C174(0.86)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C174(0.93)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C174(0.94)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C174(0.83)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C174(0.84)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C174(0.93)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C174(0.97)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C174(0.94)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C174(0.97)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C174(0.88)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C174(1.17)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C174(1.14)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C174(1.46)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C174(1.13)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C174(1.08)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C174(1.04)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C174(0.86)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C174(1.15)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C174(1.03)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C174(1.11)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C174(0.73)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C174(1.04)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C174(0.87)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C174(0.79)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C174(0.90)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C174(1.20)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C174(1.14)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C174(1.22)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C174(1.04)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C174(1.00)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C174(0.79)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C174(0.97)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C174(1.03)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C174(1.16)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C174(1.10)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C174(1.11)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C174(1.12)  LDD0752  [1]
 LDCM0436  CL46 HEK-293T C111(1.64); C133(0.79)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C111(2.06)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C111(1.58)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C111(0.91)  LDD1643  [3]
 LDCM0440  CL5 HCT 116 C174(1.00)  LDD0757  [1]
 LDCM0441  CL50 HEK-293T C111(0.83); C133(1.03)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C111(1.06); C133(0.92)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C111(1.26); C133(0.75)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C111(1.59); C133(0.49)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C111(1.60)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C133(1.06)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C111(2.04)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C111(1.59); C133(0.99)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C111(1.73)  LDD1653  [3]
 LDCM0451  CL6 HCT 116 C174(1.06)  LDD0768  [1]
 LDCM0452  CL60 HEK-293T C111(1.54)  LDD1655  [3]
 LDCM0453  CL61 HCT 116 C174(1.18)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C174(0.97)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C174(0.93)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C174(1.25)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C174(0.98)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C174(1.09)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C174(1.00)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C174(1.08)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C174(0.94)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C174(1.03)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C174(0.93)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C174(0.93)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C174(1.13)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C174(1.07)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C174(0.99)  LDD0784  [1]
 LDCM0469  CL76 HEK-293T C111(0.97); C133(1.73)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C111(1.34); C133(0.79)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C111(1.46); C133(1.01)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C111(1.38)  LDD1675  [3]
 LDCM0473  CL8 HCT 116 C174(0.87)  LDD0790  [1]
 LDCM0474  CL80 HEK-293T C133(0.89)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C111(1.48)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C111(1.35); C133(0.85)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C111(1.32)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C111(1.19)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C111(0.81)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C111(1.27); C133(1.30)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C111(0.67)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C111(0.89); C133(0.79)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C111(0.90); C133(0.88)  LDD1686  [3]
 LDCM0484  CL9 HCT 116 C174(0.87)  LDD0801  [1]
 LDCM0485  CL90 HEK-293T C111(1.43); C133(0.87)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C111(1.00)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C133(1.10)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C111(1.37)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C111(1.39); C133(1.02)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C111(1.62)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C111(1.14)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C111(1.01)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C111(1.33); C133(1.31)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C111(1.23)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C111(1.20)  LDD1698  [3]
 LDCM0468  Fragment33 HCT 116 C174(0.81)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C174(1.36)  LDD0744  [1]
 LDCM0022  KB02 A204 C111(4.54); C133(0.72)  LDD2252  [4]
 LDCM0023  KB03 A204 C111(6.63); C133(3.09)  LDD2669  [4]
 LDCM0024  KB05 NALM-6 C5(3.39); C174(1.62); C111(7.10)  LDD3339  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cullin-5 (CUL5) Cullin family Q93034
Serine/threonine-protein kinase 16 (STK16) Ser/Thr protein kinase family O75716
Mast/stem cell growth factor receptor Kit (KIT) Tyr protein kinase family P10721
Tyrosine-protein kinase Yes (YES1) Tyr protein kinase family P07947
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Erythropoietin receptor (EPOR) Type I cytokine receptor family P19235
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Elongin-C (ELOC) SKP1 family Q15369

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840