Details of the Target

General Information of Target

Target ID LDTP00283
Target Name TNF receptor-associated factor 5 (TRAF5)
Gene Name TRAF5
Gene ID 7188
Synonyms
RNF84; TNF receptor-associated factor 5; RING finger protein 84
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGC
GHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKV
ILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINL
QNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQ
HEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFG
KNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLE
NNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREA
VDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQ
RVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKD
DTLFLKVAVDLTDLEDL
Target Bioclass
Other
Family
TNF receptor-associated factor family, A subfamily
Subcellular location
Cytoplasm
Function
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
Uniprot ID
O00463
Ensemble ID
ENST00000261464.10
HGNC ID
HGNC:12035

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO21 SNV: p.A230V .
HGC27 Deletion: p.I495del .
IGR1 SNV: p.R467Q .
NCIH2172 SNV: p.C116Y .
RPMI8226 SNV: p.R418T .
SUPT1 Deletion: p.S457HfsTer26 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C521(1.39)  LDD0531  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		C161(0.00); C229(0.00)  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		C161(0.00); C401(0.00)  LDD0037  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C521(1.39)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C521(1.15)  LDD0532  [1]
 LDCM0216  AC100 HEK-293T C215(1.05); C521(0.89)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C215(0.98); C521(1.06)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C215(1.07); C521(0.84)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C215(1.20); C521(0.81)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C215(1.12); C521(1.17)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C215(1.01); C521(1.19)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C215(1.01); C521(1.99)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C215(0.95); C521(1.02)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C215(0.95); C521(1.11)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C215(1.00); C521(1.05)  LDD0823  [1]
 LDCM0226  AC11 HCT 116 C521(0.89)  LDD0543  [1]
 LDCM0227  AC110 HEK-293T C215(1.40); C521(1.04)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C215(1.67); C521(1.76)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C215(1.44); C521(1.10)  LDD0827  [1]
 LDCM0230  AC113 HEK-293T C215(0.93)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C215(1.06)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C215(1.07)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C215(1.01)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C215(1.14)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C215(1.14)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C215(1.17)  LDD0834  [1]
 LDCM0237  AC12 HCT 116 C521(1.05)  LDD0554  [1]
 LDCM0238  AC120 HEK-293T C215(1.11)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C215(1.25)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C215(1.33)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C215(1.43)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C215(1.14)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C215(1.33)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C215(1.55)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C215(1.72)  LDD0843  [1]
 LDCM0259  AC14 HCT 116 C521(1.14)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C521(1.00)  LDD0587  [1]
 LDCM0276  AC17 HCT 116 C521(1.31)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C521(1.34)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C521(1.19)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C521(1.61)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C521(1.13)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C521(1.21)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C521(1.08)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C521(1.19)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C521(1.15)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C521(1.19)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C521(1.04)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C521(1.42)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C521(0.82)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C521(1.31)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C521(1.72)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C521(1.34)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C521(1.30)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C521(1.34)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C521(1.24)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C521(1.16)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C521(0.91)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C521(1.01)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C521(1.07)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C521(1.24)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C521(1.07)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C521(1.84)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C521(1.13)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C521(1.12)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C521(1.00)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C521(1.23)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C521(1.02)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C521(0.98)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C521(1.21)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C521(1.35)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C521(1.48)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C521(1.29)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C521(1.74)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C521(1.73)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C521(1.10)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C521(1.00)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C521(1.02)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C521(1.46)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C521(1.21)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C521(1.08)  LDD0636  [1]
 LDCM0323  AC6 HCT 116 C521(1.12)  LDD0640  [1]
 LDCM0325  AC61 HEK-293T C229(0.93)  LDD1564  [3]
 LDCM0332  AC68 HCT 116 C521(0.72)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C521(0.63)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C521(1.31)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C521(0.71)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C521(0.75)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C521(0.73)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C521(0.83)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C521(0.74)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C521(0.80)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C521(0.64)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C521(0.72)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C521(0.97)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C521(0.72)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C521(1.06)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C521(0.67)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C521(0.71)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C521(0.64)  LDD0665  [1]
 LDCM0349  AC83 HEK-293T C215(1.08)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C215(0.92)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C215(0.87)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C215(1.00)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C215(0.97)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C215(0.94)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C215(0.97)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C215(0.97)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C215(0.94)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C215(0.85)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C215(0.87)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C215(0.98)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C215(1.00)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C215(0.88)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C215(1.42)  LDD0962  [1]
 LDCM0365  AC98 HEK-293T C215(1.01); C521(1.11)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C215(0.94); C521(1.38)  LDD0964  [1]
 LDCM0248  AKOS034007472 HCT 116 C521(1.34)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C521(0.97)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C521(1.12)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C521(1.15)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C521(1.07)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C521(1.33)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C521(0.93)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C521(1.27)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C521(1.40)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C521(1.16)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C521(1.05)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C521(1.14)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C521(1.05)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C521(1.02)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C521(1.09)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C521(0.87)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C521(1.24)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C521(1.24)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C521(1.04)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C521(1.30)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C521(1.16)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C521(1.15)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C521(1.21)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C521(1.12)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C521(0.94)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C521(1.07)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C521(1.08)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C521(1.07)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C521(1.07)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C521(1.09)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C521(0.91)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C521(1.19)  LDD0712  [1]
 LDCM0400  CL13 HCT 116 C521(0.89)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C521(1.19)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C521(1.09)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C521(0.99)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C521(1.18)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C521(1.50)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C521(1.09)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C521(0.94)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C521(1.17)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C521(1.26)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C521(1.14)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C521(1.05)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C521(1.10)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C521(1.06)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C521(1.06)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C521(1.33)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C521(1.21)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C521(1.10)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C521(0.97)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C521(1.04)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C521(1.03)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C521(0.98)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C521(1.27)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C521(0.80)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C521(0.87)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C521(0.93)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C521(0.89)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C521(0.90)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C521(1.21)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C521(0.97)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C521(1.03)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C521(0.92)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C521(0.91)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C521(1.18)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C521(0.97)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C521(0.73)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C521(0.94)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C521(0.82)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C521(0.83)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C521(0.85)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C521(0.78)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C521(0.77)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C521(1.05)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C521(0.90)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C521(0.76)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C521(0.84)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C521(0.73)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C521(0.83)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C521(0.80)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C521(0.91)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C521(1.17)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C521(1.03)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C521(1.03)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C521(1.11)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C521(1.08)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C521(1.00)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C521(1.01)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C521(1.05)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C521(0.98)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C521(0.98)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C521(1.05)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C521(1.08)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C521(0.87)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C521(0.93)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C521(1.13)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C521(0.96)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C521(1.15)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C521(1.20)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C521(0.86)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C521(0.92)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C521(1.23)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C521(1.54)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C521(0.88)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C521(1.22)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C521(1.12)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C521(1.08)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C521(1.09)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C521(0.85)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C521(1.04)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C521(1.00)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C521(0.87)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C521(1.05)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C521(1.08)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C521(0.94)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C521(1.55)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C521(0.87)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C521(0.96)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C521(0.96)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C521(1.13)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C521(1.11)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C521(1.74)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C521(1.94)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C521(1.65)  LDD0811  [1]
 LDCM0468  Fragment33 HCT 116 C521(0.85)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C521(0.90)  LDD0744  [1]
 LDCM0022  KB02 697 C240(1.56)  LDD2245  [4]
 LDCM0023  KB03 697 C240(2.34)  LDD2662  [4]
 LDCM0024  KB05 MOLM-13 C532(1.63)  LDD3333  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Phytanoyl-CoA dioxygenase, peroxisomal (PHYH) PhyH family O14832
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
TNF receptor-associated factor 3 (TRAF3) TNF receptor-associated factor family Q13114
TNF receptor-associated factor 6 (TRAF6) TNF receptor-associated factor family Q9Y4K3
Protein yippee-like 5 (YPEL5) Yippee family P62699
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Protein SEC13 homolog (SEC13) WD repeat SEC13 family P55735
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
THAP domain-containing protein 7 (THAP7) . Q9BT49
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor receptor superfamily member 14 (TNFRSF14) Tumor necrosis factor receptor superfamily Q92956
Other
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Protein FAM9A (FAM9A) FAM9 family Q8IZU1
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Homer protein homolog 1 (HOMER1) Homer family Q86YM7
N-myc-interactor (NMI) NMI family Q13287
UV excision repair protein RAD23 homolog A (RAD23A) RAD23 family P54725
Serpin B9 (SERPINB9) Serpin family P50453
Serine/arginine-rich splicing factor 1 (SRSF1) Splicing factor SR family Q07955
TNF receptor-associated factor 5 (TRAF5) TNF receptor-associated factor family O00463
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165
AN1-type zinc finger protein 6 (ZFAND6) . Q6FIF0
Calcium and integrin-binding family member 3 (CIB3) . Q96Q77
Coiled-coil domain-containing protein 184 (CCDC184) . Q52MB2
F-box only protein 28 (FBXO28) . Q9NVF7
Heat shock factor 2-binding protein (HSF2BP) . O75031
LIM domain transcription factor LMO4 (LMO4) . P61968
PRKCA-binding protein (PICK1) . Q9NRD5
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Stress-induced-phosphoprotein 1 (STIP1) . P31948

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840