Details of the Target

General Information of Target

Target ID LDTP00146
Target Name PHD finger protein 20-like protein 1 (PHF20L1)
Gene Name PHF20L1
Gene ID 51105
Synonyms
PHD finger protein 20-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSKKPPNRPGITFEIGARLEALDYLQKWYPSRIEKIDYEEGKMLVHFERWSHRYDEWIYW
DSNRLRPLERPALRKEGLKDEEDFFDFKAGEEVLARWTDCRYYPAKIEAINKEGTFTVQF
YDGVIRCLKRMHIKAMPEDAKGQVKSQHPLSWCCPIDPAGSCNQSMGSEDWIALVKAAAA
AAAKNKTGSKPRTSANSNKDKDKDERKWFKVPSKKEETSTCIATPDVEKKEDLPTSSETF
GLHVENVPKMVFPQPESTLSNKRKNNQGNSFQAKRARLNKITGLLASKAVGVDGAEKKED
YNETAPMLEQAISPKPQSQKKNEADISSSANTQKPALLSSTLSSGKARSKKCKHESGDSS
GCIKPPKSPLSPELIQVEDLTLVSQLSSSVINKTSPPQPVNPPRPFKHSERRRRSQRLAT
LPMPDDSVEKVSSPSPATDGKVFSISSQNQQESSVPEVPDVAHLPLEKLGPCLPLDLSRG
SEVTAPVASDSSYRNECPRAEKEDTQMLPNPSSKAIADGRGAPAAAGISKTEKKVKLEDK
SSTAFGKRKEKDKERREKRDKDHYRPKQKKKKKKKKKSKQHDYSDYEDSSLEFLERCSSP
LTRSSGSSLASRSMFTEKTTTYQYPRAILSVDLSGENLSDVDFLDDSSTESLLLSGDEYN
QDFDSTNFEESQDEDDALNEIVRCICEMDEENGFMIQCEECLCWQHSVCMGLLEESIPEQ
YICYICRDPPGQRWSAKYRYDKEWLNNGRMCGLSFFKENYSHLNAKKIVSTHHLLADVYG
VTEVLHGLQLKIGILKNKHHPDLHLWACSGKRKDQDQIIAGVEKKIAQDTVNREEKKYVQ
NHKEPPRLPLKMEGTYITSEHSYQKPQSFGQDCKSLADPGSSDDDDVSSLEEEQEFHMRS
KNSLQYSAKEHGMPEKNPAEGNTVFVYNDKKGTEDPGDSHLQWQLNLLTHIENVQNEVTS
RMDLIEKEVDVLESWLDFTGELEPPDPLARLPQLKRHIKQLLIDMGKVQQIATLCSV
Target Bioclass
Other
Subcellular location
Nucleus
Function
Is a negative regulator of proteasomal degradation of a set of methylated proteins, including DNMT1 and SOX2. Involved in the maintainance of embryonic stem cells pluripotency, through the regulation of SOX2 levels.
Uniprot ID
A8MW92
Ensemble ID
ENST00000337920.8
HGNC ID
HGNC:24280

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
G415 SNV: p.S903T DBIA    Probe Info 
HCC1954 SNV: p.P248S DBIA    Probe Info 
HCT116 Deletion: p.K574RfsTer28 .
HCT15 SNV: p.A989V .
HSC4 SNV: p.Q720K DBIA    Probe Info 
HT SNV: p.T959A .
HT1376 SNV: p.P155T .
IM95 Deletion: p.I826Ter DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER Deletion: p.N322MfsTer42 .
J82 Deletion: p.D552EfsTer27 .
KATOIII SNV: p.F545S .
LNCaP clone FGC Deletion: p.V535Ter DBIA    Probe Info 
MCC13 SNV: p.P30S .
MEC1 Deletion: p.E957DfsTer13 .
MFE319 Deletion: p.K4SfsTer70; p.N322MfsTer42 .
MOLT4 SNV: p.R683Ter .
NALM6 Deletion: p.K298RfsTer66 DBIA    Probe Info 
NCIH1975 Deletion: p.N322MfsTer42
SNV: p.S313L		 .
RCC10RGB SNV: p.C684F .
RKO Deletion: p.N322MfsTer42 .
SG231 SNV: p.A877G .
SKOV3 Deletion: p.V535Ter DBIA    Probe Info 
TOV21G Deletion: p.V535Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C221(2.43)  LDD0170  [1]
IA-alkyne
 Probe Info  		C751(6.83)  LDD1704  [2]
DBIA
 Probe Info  		C751(1.01)  LDD0531  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
NAIA_5
 Probe Info  		C497(0.00); C472(0.00)  LDD2224  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C221(2.43)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C472(2.08); C221(2.10)  LDD0171  [1]
 LDCM0214  AC1 HCT 116 C751(1.01)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C751(1.19)  LDD1508  [7]
 LDCM0216  AC100 HEK-293T C751(1.10)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C751(1.03)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C751(0.98)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C751(1.22)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C751(0.93)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C751(1.18)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C751(0.92)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C751(0.98)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C751(1.03)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C751(1.06)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C221(1.09); C751(1.05)  LDD1509  [7]
 LDCM0227  AC110 HEK-293T C751(1.11)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C751(1.03)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C751(0.96)  LDD0827  [3]
 LDCM0230  AC113 HCT 116 C751(0.99)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C751(0.97)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C751(0.86)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C751(1.04)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C751(0.90)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C751(0.95)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C751(0.99)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C221(1.12); C751(1.07)  LDD1510  [7]
 LDCM0238  AC120 HCT 116 C751(0.91)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C751(0.83)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C751(0.99)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C751(0.79)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C751(0.85)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C751(0.85)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C751(0.88)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C751(0.87)  LDD0562  [3]
 LDCM0259  AC14 HEK-293T C221(1.07); C751(1.06)  LDD1512  [7]
 LDCM0263  AC143 HEK-293T C751(1.19)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C751(1.04)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C751(1.00)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C751(1.01)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C751(1.07)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C751(1.08)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C751(1.00)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C751(1.09); C873(1.17)  LDD1513  [7]
 LDCM0271  AC150 HEK-293T C751(0.98)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C751(0.90)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C751(1.03)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C751(1.13)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C751(1.20)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C751(1.11)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C751(1.12)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C751(1.07)  LDD2165  [3]
 LDCM0276  AC17 HEK-293T C751(1.00)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C751(1.00)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C751(0.80)  LDD0876  [3]
 LDCM0279  AC2 HCT 116 C751(0.92)  LDD0596  [3]
 LDCM0280  AC20 HEK-293T C751(1.02)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C751(1.00)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C751(1.00)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C751(1.03)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C751(1.00)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C221(0.91); C751(1.04); C472(1.03)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C751(1.15)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C221(1.02); C751(1.14)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C221(0.98); C751(0.87)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C873(1.12)  LDD1528  [7]
 LDCM0290  AC3 HCT 116 C751(1.07)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C221(0.96); C751(1.06)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C751(0.95); C873(0.99)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C751(0.82)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C221(1.08); C751(1.23); C472(1.14)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C751(1.10)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C221(1.07); C751(0.97)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C221(1.10); C751(1.06)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C873(1.04)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C221(1.11); C751(1.16)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C751(0.93); C873(1.00)  LDD1539  [7]
 LDCM0301  AC4 HCT 116 C751(1.18)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C751(0.79)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C221(0.95); C751(1.26); C472(1.15)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C751(1.36)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C221(1.05); C751(0.95)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C221(1.15); C751(1.26)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C873(0.97)  LDD1546  [7]
 LDCM0308  AC46 HCT 116 C751(1.05)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C751(1.01)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C751(1.11)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C751(0.91)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C751(1.16)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C751(0.99)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C751(0.99)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C751(0.94)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C751(1.07)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C751(0.97)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C751(0.94)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C751(1.19)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C751(0.99)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C751(0.95)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C751(1.03)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C221(0.94); C751(1.10)  LDD1562  [7]
 LDCM0324  AC60 HCT 116 C751(1.06)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C751(0.94)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C751(1.16)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C751(1.11)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C751(1.10)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C751(0.96)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C751(0.86)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C751(1.08)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C751(0.89)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C751(1.00)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C751(1.07); C873(0.95)  LDD1568  [7]
 LDCM0335  AC70 HCT 116 C751(1.09)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C751(0.99)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C751(1.18)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C751(1.12)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C751(0.98)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C751(1.04)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C751(0.94)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C751(1.02)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C751(1.04)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C751(1.01)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C751(0.83)  LDD1569  [7]
 LDCM0346  AC80 HCT 116 C751(0.90)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C751(0.89)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C751(0.84)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C751(1.14)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C751(1.16)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C751(1.02)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C751(1.05)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C751(0.97)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C751(0.94)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C751(0.94)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C751(1.02)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C751(1.13)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C751(1.16)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C751(1.00)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C751(1.22)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C751(0.90)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C751(1.03)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C751(1.19)  LDD0681  [3]
 LDCM0365  AC98 HEK-293T C751(0.88)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C751(0.93)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C873(0.94)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C221(0.92); C751(1.04); C472(1.20)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C751(0.96)  LDD1514  [7]
 LDCM0632  CL-Sc Hep-G2 C472(0.62)  LDD2227  [4]
 LDCM0367  CL1 HEK-293T C221(1.00); C751(1.08); C472(0.96)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C221(1.09); C751(1.28)  LDD1572  [7]
 LDCM0369  CL100 HCT 116 C751(1.04)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C221(1.01); C751(0.96); C472(1.08)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C221(1.15); C751(1.04)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C221(1.04); C751(0.94)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C221(0.77); C751(1.27); C472(1.01)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C751(0.91)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C751(0.96)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C751(0.90)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C751(0.99)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C751(1.31)  LDD0976  [3]
 LDCM0379  CL11 HEK-293T C751(1.51); C873(1.11)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C751(0.95)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C751(1.00)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C221(0.74); C751(1.50); C472(1.02)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C221(1.00); C751(1.10); C472(1.01)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C221(1.15); C751(1.38)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C221(1.33); C751(1.03)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C221(0.71); C751(1.01); C472(0.93)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C221(1.02); C751(0.82); C472(1.00)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C221(1.11); C751(0.98)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C221(1.03); C751(1.39)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C751(1.08)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C221(0.63); C751(0.97); C472(0.94)  LDD1595  [7]
 LDCM0392  CL121 HCT 116 C751(0.99)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C751(1.13)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C751(1.39)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C751(1.23)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C751(1.04)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C751(0.96)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C751(0.98)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C751(1.08)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C221(1.04); C751(0.88); C472(1.01)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C221(1.11); C751(0.96)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C221(0.95); C751(1.49)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C751(0.98)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C751(1.28)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C751(0.90)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C751(1.11)  LDD1004  [3]
 LDCM0407  CL2 HEK-293T C221(1.02); C751(0.98)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C751(1.10)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C751(0.99)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C751(1.11)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C751(1.16)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C751(1.13)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C751(1.23)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C751(1.16)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C751(1.11)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C751(1.14)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C751(1.14)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C221(1.11); C751(0.95)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C751(1.11)  LDD1017  [3]
 LDCM0420  CL31 HEK-293T C221(1.21); C751(1.07)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C221(1.09); C751(1.11)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C873(1.15)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C221(1.07); C751(1.41)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C751(1.04); C873(0.98)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C751(0.93)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C221(0.95); C751(0.90); C472(0.91)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C221(1.06); C751(1.29)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C221(0.59); C751(1.26); C472(0.92)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C221(0.61); C751(1.06); C472(0.90)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C221(0.90); C751(1.31); C472(1.10)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C751(1.09)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C221(1.31); C751(1.07)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C221(1.12); C751(0.92)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C873(1.04)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C221(1.00); C751(1.29)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C751(1.19); C873(1.01)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C751(1.09)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C221(1.01); C751(0.80); C472(0.79)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C221(0.90); C751(1.30); C472(1.23)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C221(1.05); C751(0.90)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C221(0.82); C751(1.29); C472(1.04)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C221(0.97); C751(1.28); C472(1.07)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C751(1.22)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C221(1.03); C751(0.89)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C221(1.12); C751(1.00)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C873(1.26)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C221(1.01); C751(1.10)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C751(1.10); C873(1.16)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C751(1.19)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C751(1.08)  LDD1655  [7]
 LDCM0453  CL61 HCT 116 C751(1.06)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C751(1.17)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C751(1.08)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C751(1.15)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C751(1.08)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C751(1.33)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C751(1.32)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C751(2.37)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C751(1.69)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C221(1.10); C751(0.99)  LDD1665  [7]
 LDCM0463  CL70 HCT 116 C751(1.13)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C751(1.19)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C751(1.17)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C751(1.13)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C751(1.08)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C751(1.16)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C751(1.09)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C751(1.18)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C751(1.47)  LDD0789  [3]
 LDCM0473  CL8 HEK-293T C221(1.02); C751(1.32)  LDD1676  [7]
 LDCM0474  CL80 HCT 116 C751(1.27)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C751(1.40)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C751(1.71)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C751(1.74)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C751(1.81)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C751(1.26)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C751(1.16)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C751(1.24)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C751(1.52)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C751(2.10)  LDD0800  [3]
 LDCM0484  CL9 HEK-293T C873(1.22)  LDD1687  [7]
 LDCM0485  CL90 HCT 116 C751(1.08)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C751(1.14)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C751(1.86)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C751(1.41)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C751(1.20)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C751(1.12)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C751(1.03)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C751(0.27)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C751(2.00)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C751(1.17)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C221(0.95); C751(1.08)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C751(1.15)  LDD0785  [3]
 LDCM0427  Fragment51 HEK-293T C221(1.18); C751(0.86)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C873(0.92); C472(1.04)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C873(1.03); C472(1.22)  LDD1497  [7]
 LDCM0024  KB05 MEWO C751(2.21)  LDD3319  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone H3.1 (H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12) Histone H3 family P68431
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) Histone H4 family P62805

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840