Details of the Target

General Information of Target

Target ID LDTP00063
Target Name WD repeat-containing protein 91 (WDR91)
Gene Name WDR91
Gene ID 29062
Synonyms
WD repeat-containing protein 91
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEAVERTDELVREYLLFRGFTHTLRQLDAEIKADKEKGFRVDKIVDQLQQLMQVYDLAA
LRDYWSYLERRLFSRLEDIYRPTIHKLKTSLFRFYLVYTIQTNRNDKAQEFFAKQATELQ
NQAEWKDWFVLPFLPSPDTNPTFATYFSRQWADTFIVSLHNFLSVLFQCMPVPVILNFDA
ECQRTNQVQEENEVLRQKLFALQAEIHRLKKEEQQPEEEEALVQHKLPPYVSNMDRLGDS
ELAMVCSQRNASLSQSPRVGFLSSLLPQSKKSPSRLSPAQGPPQPQSSAKKESFGGQGTK
GKDPTSGAKDGKSLLSGLATGESGWSQHRQRRLQDHGKERKELFSTTTSQCAEKKPEASG
PEAEPCPELHTEPVEPLTRASSAGPEGGGVRPEQPFIVLGQEEYGEHHSSIMHCRVDCSG
RRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLLLLGSGVGTVRLYDT
EAKKNLCEININDNMPRILSLACSPNGASFVCSAAAPSLTSQVDFSAPDIGSKGMNQVPG
RLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSW
RAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIHKSGLKVSEYSLPSDATGPFVLSGYSG
YKQVQVPRGRLFAFDSEGNYMLTCSATGGVIYKLGGDEKVLESCLSLGGHRAPVVTVDWS
TAMDCGTCLTASMDGKIKLTTLLAHKA
Target Bioclass
Other
Family
WD repeat WDR91 family
Subcellular location
Early endosome membrane
Function
Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May play a role in meiosis.
Uniprot ID
A4D1P6
Ensemble ID
ENST00000354475.5
HGNC ID
HGNC:24997

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.G389E DBIA    Probe Info 
DU145 SNV: p.T347S DBIA    Probe Info 
HCT15 SNV: p.R476S .
HEC1B SNV: p.R476C .
HKGZCC SNV: p.P528R .
HT SNV: p.S306A .
HT115 SNV: p.R75H .
HUH28 SNV: p.G307R .
LNCaP clone FGC SNV: p.D138Y DBIA    Probe Info 
MELJUSO SNV: p.M550R DBIA    Probe Info 
OVK18 SNV: p.V619M DBIA    Probe Info 
PATU8988T SNV: p.E403G .
PC14 SNV: p.R75H .
PC9 SNV: p.R75H .
SBC5 SNV: p.S518R .
SKMEL24 SNV: p.W435G DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.33  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C366(2.17)  LDD0168  [2]
DBIA
 Probe Info  		C246(2.32)  LDD0080  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
ENE
 Probe Info  		N.A.  LDD0006  [6]
IPM
 Probe Info  		C366(0.00); C246(0.00); C351(0.00)  LDD2156  [7]
VSF
 Probe Info  		C351(0.00); C246(0.00)  LDD0007  [6]
AOyne
 Probe Info  		15.00  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C366(2.17)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C366(2.65); C351(3.79); C246(2.25)  LDD0169  [2]
 LDCM0214  AC1 HCT 116 C246(1.06)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C246(0.89)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C246(1.04)  LDD0543  [3]
 LDCM0237  AC12 HCT 116 C246(1.12)  LDD0554  [3]
 LDCM0259  AC14 HCT 116 C246(0.88)  LDD0576  [3]
 LDCM0263  AC143 HCT 116 C246(1.63)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C246(1.60)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C246(1.09)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C246(1.37)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C246(1.12)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C246(0.76)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C246(0.85)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C246(0.90)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C246(1.05)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C246(1.12)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C246(1.39)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C246(0.84)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C246(1.10)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C246(0.74)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C246(1.20)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C246(0.83)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C366(1.02); C487(1.10); C351(1.02); C246(1.02)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C366(1.08); C487(1.11); C351(0.98); C246(0.84)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C366(1.52); C487(1.07); C351(1.69); C246(0.82)  LDD1517  [9]
 LDCM0279  AC2 HCT 116 C246(1.08)  LDD0596  [3]
 LDCM0280  AC20 HEK-293T C366(1.01); C487(0.99); C351(1.07); C246(0.79)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C366(0.96); C487(1.12); C351(1.05); C246(1.00)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C366(1.09); C487(0.97); C351(1.00); C246(1.00)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C366(0.89); C487(0.98); C351(0.96); C246(1.05)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C487(0.87); C351(0.95); C246(0.94); C596(1.06)  LDD1523  [9]
 LDCM0285  AC25 HCT 116 C246(1.00)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C246(1.20)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C246(1.15)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C246(1.15)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C246(1.28)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C246(1.06)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C246(1.26)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C246(1.05)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C246(1.29)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C246(1.07)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C246(1.22)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C246(1.25)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C246(1.28)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C246(1.30)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C246(1.17)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C246(0.97)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C246(1.27)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C246(1.14)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C246(1.35)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C246(0.94)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C246(1.01)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C246(1.16)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C246(1.30)  LDD0624  [3]
 LDCM0308  AC46 HEK-293T C366(0.91); C487(1.06); C351(1.00); C246(1.02)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C366(0.88); C487(1.00); C351(0.99); C246(1.02)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C487(1.04); C351(0.87); C246(1.02); C596(1.06)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C366(1.04); C487(1.06); C351(1.00); C246(0.94)  LDD1550  [9]
 LDCM0312  AC5 HCT 116 C246(1.21)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C366(1.03); C487(0.96); C351(1.00); C246(0.97)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C366(0.97); C487(1.16); C351(0.93); C246(0.92)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C366(0.99); C487(1.01); C351(1.07); C246(0.99)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C366(0.98); C487(1.03); C351(1.01); C246(0.95)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C366(1.01); C487(0.99); C351(1.02); C246(1.11)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C366(0.89); C487(0.92); C351(0.98); C246(0.97)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C487(1.09); C351(0.93); C246(1.04); C596(0.98)  LDD1558  [9]
 LDCM0320  AC57 HCT 116 C246(1.66)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C246(1.64)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C246(1.44)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C246(1.08)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C246(1.54)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C246(1.22)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C246(1.57)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C246(1.39)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C246(1.63)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C246(1.80)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C246(1.84)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C246(1.78)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C246(0.76)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C246(0.76)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C246(0.86)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C246(0.67)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C246(0.88)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C246(0.71)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C246(0.73)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C246(0.99)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C246(0.63)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C246(0.82)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C246(0.70)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C246(0.73)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C246(0.65)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C246(0.98)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C246(0.97)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C246(0.74)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C246(0.93)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C246(1.28)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C246(1.51)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C246(1.32)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C246(1.50)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C246(1.21)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C246(1.34)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C246(1.38)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C246(1.26)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C246(1.01)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C246(1.52)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C246(1.46)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C246(0.94)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C246(1.40)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C246(0.99)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C246(1.57)  LDD0681  [3]
 LDCM0248  AKOS034007472 HCT 116 C246(0.97)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C246(1.00)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C246(0.98)  LDD0592  [3]
 LDCM0367  CL1 HCT 116 C246(1.07)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C246(1.03)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C246(1.20)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C246(0.74)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C246(0.79)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C246(0.92)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C246(0.91)  LDD0690  [3]
 LDCM0374  CL105 HEK-293T C366(0.97); C487(0.93); C351(0.98); C246(0.95)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C366(1.00); C487(1.05); C351(1.04); C246(0.96)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C366(0.97); C487(1.04); C351(0.96); C246(0.78)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C366(1.10); C487(1.06); C351(1.04); C246(1.11)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C366(0.91); C487(0.89); C351(0.92); C246(1.15)  LDD1582  [9]
 LDCM0379  CL11 HCT 116 C246(1.09)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C366(0.93); C487(1.03); C351(1.05); C246(1.02)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C366(1.00); C487(1.04); C351(1.07); C246(0.96)  LDD1585  [9]
 LDCM0382  CL112 HCT 116 C246(1.01)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C246(1.09)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C246(1.20)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C246(1.09)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C246(1.13)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C246(0.96)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C246(1.24)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C246(1.37)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C246(1.20)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C246(1.45)  LDD0708  [3]
 LDCM0392  CL121 HEK-293T C366(0.93); C487(0.94); C351(0.97); C246(1.03)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C366(1.04); C487(1.04); C351(0.97); C246(0.99)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C366(0.87); C487(0.90); C351(0.88); C246(0.84)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C366(0.84); C487(0.95); C351(1.03); C246(1.05)  LDD1599  [9]
 LDCM0396  CL125 HCT 116 C246(0.94)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C246(1.14)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C246(1.22)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C246(1.51)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C246(1.15)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C246(1.14)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C246(1.28)  LDD0719  [3]
 LDCM0403  CL16 HEK-293T C366(1.02); C487(0.95); C351(0.97); C246(1.04)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C366(1.01); C487(0.91); C351(1.00); C246(1.10)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C366(1.01); C487(1.08); C351(1.03); C246(0.88)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C366(1.03); C487(1.15); C351(0.94); C246(0.94)  LDD1610  [9]
 LDCM0407  CL2 HCT 116 C246(1.02)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C366(1.03); C487(1.17); C351(1.12); C246(0.97)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C366(1.06); C487(0.91); C351(0.93); C246(1.10)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C366(1.07); C487(1.09); C351(1.03); C246(1.17)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C366(1.05); C487(0.97); C351(1.02); C246(1.01)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C487(0.94); C351(0.99); C246(1.19); C596(1.42)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C366(0.90); C487(0.90); C351(0.89); C246(0.93)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C366(0.96); C487(0.96); C351(0.92); C246(1.04)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C366(1.09); C487(0.95); C351(0.95); C246(0.88)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C366(0.91); C487(1.01); C351(0.96); C246(1.02)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C366(1.01); C487(1.07); C351(0.86); C246(0.92)  LDD1621  [9]
 LDCM0418  CL3 HCT 116 C246(0.91)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C366(0.98); C487(1.01); C351(1.01); C246(0.86)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C366(1.02); C487(0.94); C351(0.93); C246(1.02)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C366(1.07); C487(1.02); C351(1.06); C246(1.04)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C366(0.96); C487(0.97); C351(1.00); C246(1.02)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C366(1.05); C487(0.97); C351(0.87); C246(1.24)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C366(1.17); C487(0.94); C351(1.04); C246(1.00)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C487(1.12); C351(0.94); C246(1.27); C596(0.97)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C366(0.96); C487(0.92); C351(0.84); C246(0.99)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C366(0.97); C487(0.86); C351(0.93); C246(0.94)  LDD1632  [9]
 LDCM0429  CL4 HCT 116 C246(1.36)  LDD0746  [3]
 LDCM0430  CL40 HEK-293T C366(1.09); C487(0.91); C351(1.07); C246(0.97)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C366(0.83); C487(0.89); C351(0.99); C246(0.96)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C366(1.04); C487(0.99); C351(1.00); C246(0.95)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C366(0.99); C487(1.06); C351(0.93); C246(1.11)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C366(1.07); C487(1.00); C351(1.17); C246(1.11)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C366(0.98); C487(0.88); C351(0.98); C246(1.14)  LDD1639  [9]
 LDCM0436  CL46 HCT 116 C246(1.03)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C246(0.89)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C246(0.64)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C246(0.89)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C246(1.10)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C246(0.97)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C246(0.96)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C246(1.16)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C246(0.90)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C246(0.89)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C246(0.84)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C246(0.86)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C246(0.85)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C246(0.92)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C246(0.84)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C246(1.12)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C246(0.95)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C596(0.78)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C596(0.81)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C596(0.64)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C596(0.72)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C596(0.84)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C596(0.85)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C596(0.96)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C596(1.31)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C596(1.01)  LDD1059  [3]
 LDCM0462  CL7 HCT 116 C246(0.98)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C596(1.04)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C596(1.38)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C596(1.01)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C596(1.41)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C596(1.66)  LDD1065  [3]
 LDCM0469  CL76 HCT 116 C246(1.02)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C246(0.92)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C246(1.11)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C246(1.20)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C246(1.12)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C246(1.14)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C246(1.33)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C246(1.20)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C246(1.29)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C246(1.25)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C246(1.01)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C246(1.05)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C246(1.22)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C246(1.30)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C246(1.27)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C246(1.31)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C246(1.00)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C246(1.01)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C246(1.09)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C246(0.90)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C246(1.16)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C246(1.35)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C246(0.87)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C246(1.03)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C246(1.18)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C246(1.37)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C366(0.94); C487(0.92); C351(0.88); C246(0.80)  LDD1698  [9]
 LDCM0625  F8 Ramos C246(1.17)  LDD2187  [10]
 LDCM0572  Fragment10 Ramos C246(1.06)  LDD2189  [10]
 LDCM0573  Fragment11 Ramos C246(0.71)  LDD2190  [10]
 LDCM0574  Fragment12 Ramos C246(1.53)  LDD2191  [10]
 LDCM0575  Fragment13 Ramos C246(1.16)  LDD2192  [10]
 LDCM0576  Fragment14 Ramos C246(1.03)  LDD2193  [10]
 LDCM0579  Fragment20 Ramos C246(1.43)  LDD2194  [10]
 LDCM0580  Fragment21 Ramos C246(1.16)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C246(1.44)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C246(1.37)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C246(0.89)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C246(1.31)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C246(1.17)  LDD2200  [10]
 LDCM0590  Fragment32 Ramos C246(1.36)  LDD2201  [10]
 LDCM0468  Fragment33 HEK-293T C596(1.28)  LDD1066  [3]
 LDCM0596  Fragment38 Ramos C246(1.21)  LDD2203  [10]
 LDCM0566  Fragment4 Ramos C246(1.14)  LDD2184  [10]
 LDCM0427  Fragment51 HEK-293T C366(0.96); C487(1.00); C351(1.00); C246(0.98)  LDD1631  [9]
 LDCM0610  Fragment52 Ramos C246(1.12)  LDD2204  [10]
 LDCM0614  Fragment56 Ramos C246(1.11)  LDD2205  [10]
 LDCM0569  Fragment7 Ramos C246(1.26)  LDD2186  [10]
 LDCM0571  Fragment9 Ramos C246(1.49)  LDD2188  [10]
 LDCM0022  KB02 HCT 116 C246(2.32)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C246(1.57)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C246(2.78)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
WD repeat-containing protein 81 (WDR81) WD repeat WDR81 family Q562E7

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578