Details of the Target

General Information of Target

Target ID LDTP18350
Target Name Zinc finger protein 518B (ZNF518B)
Gene Name ZNF518B
Gene ID 85460
Synonyms
KIAA1729; Zinc finger protein 518B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLRMKLPLKPTHPAEPPPEAEEPEADARPGAKAPSRRRRDCRPPPPPPPPAGPSRGPLPP
PPPPRGLGPPVAGGAAAGAGMPGGGGGPSAALREQERVYEWFGLVLGSAQRLEFMCGLLD
LCNPLELRFLGSCLEDLARKDYHYLRDSEAKANGLSDPGPLADFREPAVRSRLIVYLALL
GSENREAAGRLHRLLPQVDSVLKSLRAARGEGSRGGAEDERGEDGDGEQDAEKDGSGPEG
GIVEPRVGGGLGSRAQEELLLLFTMASLHPAFSFHQRVTLREHLERLRAALRGGPEDAEV
EVEPCKFAGPRAQNNSAHGDYMQNNESSLIEQAPIPQDGLTVAPHRAQREAVHIEKIMLK
GVQRKRADKYWEYTFKVNWSDLSVTTVTKTHQELQEFLLKLPKELSSETFDKTILRALNQ
GSLKREERRHPDLEPILRQLFSSSSQAFLQSQKVHSFFQSISSDSLHSINNLQSSLKTSK
ILEHLKEDSSEASSQEEDVLQHAIIHKKHTGKSPIVNNIGTSCSPLDGLTMQYSEQNGIV
DWRKQSCTTIQHPEHCVTSADQHSAEKRSLSSINKKKGKPQTEKEKIKKTDNRLNSRING
IRLSTPQHAHGGTVKDVNLDIGSGHDTCGETSSESYSSPSSPRHDGRESFESEEEKDRDT
DSNSEDSGNPSTTRFTGYGSVNQTVTVKPPVQIASLGNENGNLLEDPLNSPKYQHISFMP
TLHCVMHNGAQKSEVVVPAPKPADGKTIGMLVPSPVAISAIRESANSTPVGILGPTACTG
ESEKHLELLASPLPIPSTFLPHSSTPALHLTVQRLKLPPPQGSSESCTVNIPQQPPGSLS
IASPNTAFIPIHNPGSFPGSPVATTDPITKSASQVVGLNQMVPQIEGNTGTVPQPTNVKV
VLPAAGLSAAQPPASYPLPGSPLAAGVLPSQNSSVLSTAATSPQPASAGISQAQATVPPA
VPTHTPGPAPSPSPALTHSTAQSDSTSYISAVGNTNANGTVVPPQQMGSGPCGSCGRRCS
CGTNGNLQLNSYYYPNPMPGPMYRVPSFFTLPSICNGSYLNQAHQSNGNQLPFFLPQTPY
ANGLVHDPVMGSQANYGMQQMAGFGRFYPVYPAPNVVANTSGSGPKKNGNVSCYNCGVSG
HYAQDCKQSSMEANQQGTYRLRYAPPLPPSNDTLDSAD
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function
Through its association with the EHMT1-EHMT2/G9A and PRC2/EED-EZH2 histone methyltransferase complexes may function in gene silencing, regulating repressive post-translational methylation of histone tails at promoters of target genes.
Uniprot ID
Q9C0D4
Ensemble ID
ENST00000326756.4
HGNC ID
HGNC:29365

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C814(10.63)  LDD1704  [1]
DBIA
 Probe Info  		C512(0.86)  LDD0531  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C512(0.86)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C512(1.10)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C512(2.32)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C512(0.87)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C512(0.90)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C512(1.32)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C512(1.06)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C512(1.12)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C512(1.69)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C512(1.60)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C512(0.95)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C512(1.02)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C512(1.02)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C512(0.77)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C512(0.82)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C512(1.28)  LDD0546  [2]
 LDCM0237  AC12 HCT 116 C512(0.82)  LDD0554  [2]
 LDCM0259  AC14 HCT 116 C512(1.00)  LDD0576  [2]
 LDCM0263  AC143 HCT 116 C512(1.21)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C512(0.96)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C512(0.92)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C512(1.36)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C512(0.97)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C512(1.11)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C512(1.51)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C512(1.13)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C512(0.86)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C512(0.78)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C512(0.94)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C512(1.44)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C512(0.97)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C512(1.05)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C512(1.05)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C512(1.05)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C512(1.07)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C512(1.05)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C512(0.94)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C512(0.87)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C512(1.13)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C512(1.09)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C512(1.21)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C512(0.98)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C512(0.93)  LDD0601  [2]
 LDCM0290  AC3 HCT 116 C512(0.82)  LDD0607  [2]
 LDCM0296  AC35 HCT 116 C512(1.30)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C512(0.99)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C512(0.98)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C512(1.35)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C512(1.25)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C512(0.82)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C512(1.00)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C512(0.87)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C512(1.04)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C512(1.10)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C512(0.95)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C512(1.71)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C512(0.96)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C512(1.02)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C512(0.87)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C512(0.85)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C512(0.86)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C512(0.98)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C512(1.00)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C512(0.82)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C512(0.93)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C512(0.87)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C512(1.37)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C512(1.05)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C512(1.04)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C512(0.92)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C512(1.22)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C512(0.93)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C512(0.82)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C512(0.70)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C512(0.87)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C512(0.91)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C512(1.00)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C512(1.02)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C512(0.67)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C512(0.95)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C512(1.23)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C512(1.16)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C512(1.07)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C512(1.12)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C512(1.12)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C512(1.23)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C512(1.44)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C512(1.40)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C512(1.50)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C512(1.49)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C512(1.13)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C512(1.01)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C512(1.14)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C512(1.04)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C512(1.21)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C512(1.41)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C512(1.54)  LDD0665  [2]
 LDCM0365  AC98 HCT 116 C512(1.27)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C512(1.27)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C512(1.13)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C512(0.95)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C512(1.19)  LDD0592  [2]
 LDCM0367  CL1 HCT 116 C512(0.72)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C512(1.18)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C512(0.75)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C512(1.01)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C512(1.05)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C512(1.18)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C512(0.89)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C512(1.14)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C512(0.98)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C512(0.98)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C512(0.90)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C512(1.42)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C512(1.57)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C512(1.25)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C512(1.41)  LDD0698  [2]
 LDCM0387  CL117 HCT 116 C512(1.74)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C512(0.96)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C512(1.28)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C512(1.25)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C512(1.23)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C512(0.93)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C512(0.79)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C512(0.84)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C512(0.81)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C512(0.69)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C512(0.78)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C512(0.64)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C512(0.75)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C512(1.08)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C512(1.05)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C512(1.18)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C512(1.04)  LDD0720  [2]
 LDCM0407  CL2 HCT 116 C512(1.04)  LDD0724  [2]
 LDCM0418  CL3 HCT 116 C512(0.75)  LDD0735  [2]
 LDCM0420  CL31 HCT 116 C512(1.06)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C512(1.15)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C512(0.98)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C512(1.31)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C512(1.28)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C512(1.13)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C512(1.27)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C512(1.56)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C512(0.79)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C512(1.05)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C512(1.05)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C512(1.37)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C512(1.26)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C512(1.15)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C512(1.36)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C512(1.08)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C512(0.98)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C512(1.20)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C512(1.02)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C512(1.08)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C512(1.10)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C512(1.06)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C512(1.26)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C512(1.00)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C512(1.49)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C512(1.15)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C512(1.11)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C512(1.24)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C512(1.29)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C512(1.42)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C512(1.14)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C512(1.58)  LDD0769  [2]
 LDCM0462  CL7 HCT 116 C512(1.20)  LDD0779  [2]
 LDCM0473  CL8 HCT 116 C512(1.77)  LDD0790  [2]
 LDCM0484  CL9 HCT 116 C512(1.17)  LDD0801  [2]
 LDCM0486  CL91 HCT 116 C512(0.89)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C512(0.93)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C512(0.78)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C512(0.83)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C512(1.08)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C512(0.93)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C512(0.91)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C512(0.78)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C512(0.79)  LDD0811  [2]
 LDCM0427  Fragment51 HCT 116 C512(1.23)  LDD0744  [2]
 LDCM0022  KB02 T cell-activated C814(10.63)  LDD1704  [1]
 LDCM0024  KB05 T cell-activated C814(8.18)  LDD1706  [1]

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019