Details of the Target

General Information of Target

Target ID LDTP18349
Target Name Zinc finger CCHC domain-containing protein 2 (ZCCHC2)
Gene Name ZCCHC2
Gene ID 54877
Synonyms
C18orf49; KIAA1744; Zinc finger CCHC domain-containing protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAARQAVGSGAQETCGLDRILEALKLLLSPGGSGSSSLQVTKHDVLLATLKSNLSALEDK
FLKDPQWKNLKLLRDEIADKAEWPQNSVDVTWSFTSQTLLLLLCLKETMIRLAANFNPGK
PNPRTPEVAPALSPDALSISQQKTVQFVLQFVVTLGICPYLMPGVGVPLRYRTEFGAVVQ
DVVCFDAAPDATRRLYTSCKALLNVAQHTSLGSLIFCHHFGDIAAGLCQLGFCPTKRKLL
TPAEEVLTEEERTLSRGALRDMLDQVYQPLAVRELLILQGGPPQSCTDVKTQMRCRAPAW
LRRLCGQLLSERLMRPNGVQAVVRGILEGAGAGAAGGSDAEVTAADWKKCDLIAKILASC
PQQSLSPENYYRDICPQVLDLFHFQDKLTARQFQRVATTTFITLSRERPHLAAKYLLQPV
LAPLHRCLNTAELSESDMVPGTILVTEEELSRCIEDVFKVYVVGNEPLTVLMDSLLPVLG
VLFLLYCFTKQSVSHIRSLCQEILLWILGKLERKKAIASLKGFAGLDKAVPSLHSLCQFR
VATQGGIMITIKEAISDEDEDEALYQKVSSEQGRVEHLGDLLSHCQECGLAGDFFIFCLK
ELTHVASENETELKTEPFSSKSLLELEQHQTLLVEGQERKLLVLQLMAVLCERMSEQIFT
NVTQVVDFVAATLQRACASLAHQAESTVESQTLSMSMGLVAVMLGGAVQLKSSDFAVLKQ
LLPLLEKVSNTYPDPVIQELAVDLRITISTHGAFATEAVSMAAQSTLNRKDLEGKIEEQQ
QTSHERPTDVAHSHLEQQQSHETAPQTGLQSNAPIIPQGVNEPSTTTSQKSGSVTTEQLQ
EVLLSAYDPQIPTRAAALRTLSHWIEQREAKALEMQEKLLKIFLENLEHEDTFVYLSAIQ
GVALLSDVYPEKILPDLLAQYDSSKDKHTPETRMKVGEVLMRIVRALGDMVSKYREPLIH
TFLRGVRDPDGAHRASSLANLGELCQRLDFLLGSVVHEVTACLIAVAKTDGEVQVRRAAI
HVVVLLLRGLSQKATEVLSAVLKDLYHLLKHVVCLEPDDVAKLHAQLALEELDDIMKNFL
FPPQKLEKKIMVLP
Target Bioclass
Other
Uniprot ID
Q9C0B9
Ensemble ID
ENST00000269499.10
HGNC ID
HGNC:22916

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.T390PfsTer10 .
A498 SNV: p.G520V .
AU565 SNV: p.S89W .
EFO21 SNV: p.E651Q .
HT115 SNV: p.E654D; p.H964P .
IM95 SNV: p.Y373N .
KMS27 SNV: p.E404G .
LNCaP clone FGC SNV: p.C628Y .
MEWO Substitution: p.P922L .
SKN SNV: p.G252S .
SW756 SNV: p.S604F .
WM115 SNV: p.T413I .
WM2664 SNV: p.T413I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C133(0.93)  LDD0531  [1]
IA-alkyne
 Probe Info  		C314(0.00); C585(0.00)  LDD0161  [2]
TFBX
 Probe Info  		N.A.  LDD0148  [3]
W1
 Probe Info  		N.A.  LDD0236  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C133(0.93)  LDD0531  [1]
 LDCM0246  AC128 HCT 116 C133(0.97)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C133(0.93)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C133(1.09)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C133(1.02)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C133(1.10)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C133(0.92)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C133(0.97)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C133(0.93)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C133(0.87)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C133(0.98)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C133(1.02)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C133(0.99)  LDD0575  [1]
 LDCM0260  AC140 HCT 116 C133(1.03)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C133(0.96)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C133(1.02)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C133(0.92)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C133(1.31)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C133(1.17)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C133(1.50)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C133(1.03)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C133(1.53)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C133(1.76)  LDD0586  [1]
 LDCM0271  AC150 HCT 116 C133(1.28)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C133(1.29)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C133(1.65)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C133(2.09)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C133(1.35)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C133(1.67)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C133(1.43)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C133(1.44)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C133(1.28)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C133(1.07)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C133(1.09)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C133(0.97)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C133(1.07)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C133(1.04)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C133(1.32)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C133(1.12)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C133(1.02)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C133(0.60)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C133(0.62)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C133(0.55)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C133(0.86)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C133(0.53)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C133(1.04)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C133(0.69)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C133(0.56)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C133(0.61)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C133(0.77)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C133(0.61)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C133(0.89)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C133(1.16)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C133(0.98)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C133(1.01)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C133(1.07)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C133(0.99)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C133(1.10)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C133(1.06)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C133(1.01)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C133(0.94)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C133(0.94)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C133(1.11)  LDD0624  [1]
 LDCM0312  AC5 HCT 116 C133(1.02)  LDD0629  [1]
 LDCM0320  AC57 HCT 116 C133(0.79)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C133(1.01)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C133(0.82)  LDD0639  [1]
 LDCM0324  AC60 HCT 116 C133(1.05)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C133(0.78)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C133(0.46)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C133(0.74)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C133(0.60)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C133(0.83)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C133(0.60)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C133(0.98)  LDD0648  [1]
 LDCM0020  ARS-1620 HCC44 C547(1.19); C556(1.19)  LDD2171  [1]
 LDCM0369  CL100 HCT 116 C133(0.86)  LDD0686  [1]
 LDCM0374  CL105 HCT 116 C133(1.25)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C133(1.18)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C133(1.21)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C133(1.23)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C133(1.28)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C133(1.38)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C133(1.21)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C133(0.98)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C133(0.48)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C133(0.52)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C133(0.65)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C133(0.69)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C133(1.27)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C133(0.93)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C133(1.02)  LDD0706  [1]
 LDCM0391  CL120 HCT 116 C133(1.07)  LDD0708  [1]
 LDCM0396  CL125 HCT 116 C133(0.53)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C133(0.63)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C133(0.87)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C133(0.60)  LDD0716  [1]
 LDCM0403  CL16 HCT 116 C133(0.90)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C133(0.87)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C133(0.82)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C133(1.01)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C133(0.92)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C133(0.90)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C133(0.91)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C133(0.91)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C133(0.99)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C133(0.83)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C133(0.90)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C133(1.03)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C133(0.86)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C133(0.94)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C133(0.93)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C133(1.04)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C133(1.10)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C133(1.04)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C133(1.13)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C133(0.99)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C133(1.02)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C133(1.06)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C133(1.07)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C133(0.99)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C133(1.21)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C133(1.44)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C133(1.16)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C133(0.96)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C133(1.25)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C133(1.23)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C133(0.98)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C133(1.17)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C133(1.45)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C133(1.05)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C133(1.03)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C133(1.03)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C133(0.87)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C133(1.30)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C133(1.19)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C133(0.92)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C133(1.24)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C133(1.29)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C133(1.00)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C133(1.11)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C133(1.00)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C133(0.93)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C133(1.03)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C133(1.11)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C133(1.04)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C133(0.94)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C133(1.05)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C133(0.98)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C133(1.16)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C133(0.88)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C133(0.92)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C133(1.11)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C133(0.96)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C133(1.04)  LDD0784  [1]
 LDCM0486  CL91 HCT 116 C133(0.86)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C133(0.86)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C133(1.02)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C133(0.89)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C133(0.96)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C133(0.86)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C133(0.91)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C133(0.93)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C133(0.97)  LDD0811  [1]
 LDCM0468  Fragment33 HCT 116 C133(0.87)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C133(1.17)  LDD0744  [1]
 LDCM0022  KB02 T cell C305(7.20)  LDD1703  [5]
 LDCM0024  KB05 T cell-activated C305(5.07)  LDD1706  [5]
 LDCM0021  THZ1 HCT 116 C547(1.19); C556(1.19)  LDD2173  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.