Details of the Target

General Information of Target

Target ID LDTP17563
Target Name Pleckstrin homology domain-containing family H member 3 (PLEKHH3)
Gene Name PLEKHH3
Gene ID 79990
Synonyms
Pleckstrin homology domain-containing family H member 3; PH domain-containing family H member 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLLDCNPEVDGLKHLLETGASVNAPPDPCKQSPVHLAAGSGLACFLLWQLQTGADLNQQ
DVLGEAPLHKAAKVGSLECLSLLVASDAQIDLCNKNGQTAEDLAWSCGFPDCAKFLTTIK
CMQTIKASEHPDRNDCVAVLRQKRSLGSVENTSGKRKC
Target Bioclass
Other
Uniprot ID
Q7Z736
Ensemble ID
ENST00000591022.6
HGNC ID
HGNC:26105

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FUOV1 SNV: p.E223Q DBIA    Probe Info 
G415 SNV: p.Y251C .
SNU1 Deletion: p.V192WfsTer6 .
TOV21G SNV: p.R126W DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C151(1.29)  LDD0531  [1]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C151(1.29)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C151(1.38)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C151(1.08)  LDD0543  [1]
 LDCM0237  AC12 HCT 116 C151(0.98)  LDD0554  [1]
 LDCM0259  AC14 HCT 116 C151(1.16)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C151(1.17)  LDD0587  [1]
 LDCM0276  AC17 HEK-293T C682(1.10); C656(0.85); C294(1.09)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C682(0.96); C656(1.01); C151(1.00); C294(0.93)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C682(1.26); C656(0.85); C151(0.94); C294(1.04)  LDD1517  [5]
 LDCM0279  AC2 HCT 116 C151(1.19)  LDD0596  [1]
 LDCM0280  AC20 HEK-293T C682(0.97); C656(1.09); C151(0.98)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C682(1.00); C656(1.00); C151(0.85); C294(1.05)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C682(0.99); C656(1.10); C151(1.13); C294(1.05)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C682(1.03); C656(0.96); C151(0.96)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C682(1.00); C656(1.11); C151(0.99)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C682(1.08); C656(0.91); C294(1.04)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C682(0.99); C656(0.87); C151(0.93); C294(0.99)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C682(0.98); C656(0.97); C151(0.97); C294(0.97)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C682(0.98); C656(0.97); C151(0.75)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C682(0.99); C656(0.91); C151(1.14); C294(0.92)  LDD1528  [5]
 LDCM0290  AC3 HCT 116 C151(1.62)  LDD0607  [1]
 LDCM0291  AC30 HEK-293T C682(0.97); C656(0.81); C151(0.99); C294(1.05)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C682(0.98); C656(1.32); C151(0.89)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C682(1.07); C656(0.99); C151(0.69)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C682(1.07); C656(0.98); C294(1.02)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C682(0.97); C656(0.81); C151(1.01); C294(1.05)  LDD1534  [5]
 LDCM0296  AC35 HCT 116 C682(1.07)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C682(1.18)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C682(1.09)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C682(1.20)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C682(1.12)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C151(1.38)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C682(1.33)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C682(1.29)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C682(1.18)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C682(1.30)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C682(1.35)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C682(1.42)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C151(1.25)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C151(1.22)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C151(0.87)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C151(1.07)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C151(1.25)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C151(1.29)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C151(0.98)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C151(1.06)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C151(1.30)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C151(1.23)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C151(1.59)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C151(1.58)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C682(0.97); C656(0.79); C294(0.97)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C682(0.96); C656(0.85); C151(1.19); C294(1.02)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C682(1.03); C656(1.01); C151(1.05); C294(1.05)  LDD1561  [5]
 LDCM0323  AC6 HCT 116 C151(1.47)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C682(1.03); C656(1.03); C151(1.03)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C682(1.06); C656(0.89); C151(1.14); C294(0.98)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C682(1.07); C656(0.85); C151(1.85); C294(1.01)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C682(1.05); C656(1.23); C151(0.82)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C682(1.04); C656(0.92); C151(0.65)  LDD1567  [5]
 LDCM0334  AC7 HCT 116 C151(1.08)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C151(0.93)  LDD0662  [1]
 LDCM0248  AKOS034007472 HCT 116 C151(1.25)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C151(1.19)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C151(1.79)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C406(0.94); C410(0.94); C416(0.94)  LDD2171  [1]
 LDCM0367  CL1 HCT 116 C682(0.94)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C682(0.81)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C151(1.76)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C151(1.79)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C151(1.15)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C151(0.99)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C151(1.48)  LDD0690  [1]
 LDCM0374  CL105 HEK-293T C682(0.91); C656(0.98); C151(0.95)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C682(1.12); C656(0.75); C151(0.59)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C682(1.05); C656(0.98); C151(0.87)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C682(1.01); C656(0.72); C151(0.90)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C682(0.96); C656(1.07); C151(0.85)  LDD1582  [5]
 LDCM0379  CL11 HCT 116 C682(0.90)  LDD0696  [1]
 LDCM0380  CL110 HEK-293T C682(1.33); C656(0.80); C151(0.82)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C682(1.13); C656(1.04); C151(0.77)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C682(1.05); C656(0.93); C151(0.92)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C682(0.96); C656(0.98); C151(0.95)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C682(0.99); C656(0.84); C151(1.01)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C682(0.89); C656(0.98); C151(0.96)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C682(0.98); C656(1.00); C151(1.00)  LDD1590  [5]
 LDCM0387  CL117 HCT 116 C682(1.32)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C682(1.03)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C682(1.22)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C682(0.88)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C682(1.20)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C151(0.82)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C151(1.22)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C151(1.17)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C151(1.40)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C682(0.95); C656(0.92); C151(0.77)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C682(1.04); C656(1.04); C151(0.68)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C682(1.06); C656(0.97); C151(0.95)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C682(1.03); C656(0.97); C151(0.92)  LDD1603  [5]
 LDCM0400  CL13 HCT 116 C682(0.91)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C682(0.93)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C682(1.18)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C151(0.82)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C151(1.18)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C151(1.40)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C151(1.01)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C682(0.84)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C151(0.96)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C151(1.24)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C151(1.68)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C151(1.47)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C151(1.11)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C151(1.45)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C151(1.16)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C151(1.36)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C151(1.03)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C151(1.95)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C682(0.74)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C151(0.88)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C682(1.22)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C682(0.99)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C682(0.96)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C682(1.15)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C682(1.09)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C682(1.13)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C682(1.01)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C682(0.98)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C682(1.41)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C682(1.40)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C682(1.01)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C682(1.00)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C682(1.07)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C682(1.13)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C682(1.27)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C682(1.10)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C682(1.01)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C682(0.99)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C682(1.01)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C682(0.90)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C682(1.00)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C682(1.25)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C682(1.13)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C682(1.04)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C682(1.09)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C682(0.89)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C682(0.98)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C682(1.24)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C682(1.08)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C682(1.02)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C682(0.95)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C682(1.04)  LDD0769  [1]
 LDCM0453  CL61 HEK-293T C682(0.93); C656(1.12); C151(0.78)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C682(0.92); C656(0.83); C151(0.75)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C682(0.96); C656(0.94); C151(0.92)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C682(1.10); C656(1.14); C151(0.94)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C682(0.92); C656(1.02); C294(1.06)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C682(0.99); C656(1.00); C151(1.00); C294(1.15)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C682(1.01); C656(0.92); C151(1.11); C294(0.99)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C682(1.03); C656(1.06); C151(0.82)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C682(1.07); C656(1.03); C151(1.04); C294(1.03)  LDD1664  [5]
 LDCM0462  CL7 HCT 116 C682(0.99)  LDD0779  [1]
 LDCM0463  CL70 HEK-293T C682(0.98); C656(0.89); C151(1.13); C294(1.02)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C682(0.96); C656(0.81); C151(0.94)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C682(1.06); C656(1.26); C151(0.68)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C682(0.88); C656(0.88); C151(0.78)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C682(0.93); C656(0.81); C151(0.68)  LDD1670  [5]
 LDCM0469  CL76 HCT 116 C682(0.80)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C682(1.16)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C682(1.10)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C682(0.90)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C682(0.94)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C682(0.92)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C682(0.94)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C682(1.07)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C682(0.93)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C682(0.95)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C682(0.97)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C682(1.04)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C682(1.01)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C682(0.99)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C682(1.06)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C682(1.05)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C682(1.40)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C151(1.19)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C151(1.46)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C151(1.31)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C151(1.05)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C151(1.36)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C151(1.24)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C151(1.71)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C151(1.48)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C151(1.21)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C682(1.11); C656(1.00); C151(0.93)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C682(0.94); C656(0.98); C151(1.01)  LDD1671  [5]
 LDCM0427  Fragment51 HCT 116 C682(1.87)  LDD0744  [1]
 LDCM0022  KB02 HEK-293T C682(0.98); C656(1.22)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C682(1.00); C656(1.03)  LDD1497  [5]
 LDCM0024  KB05 HMCB C682(3.62)  LDD3312  [6]
 LDCM0021  THZ1 HCT 116 C406(0.94); C410(0.94); C416(0.94)  LDD2173  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840