Details of the Target

General Information of Target

Target ID LDTP17017
Target Name Dystrophia myotonica WD repeat-containing protein (DMWD)
Gene Name DMWD
Gene ID 1762
Synonyms
DM9; Dystrophia myotonica WD repeat-containing protein; Dystrophia myotonica-containing WD repeat motif protein; Protein 59; Protein DMR-N9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATQGHLTFKDVAIEFSQEEWKCLEPVQKALYKDVMLENYRNLVFLGISPKCVIKELPPT
ENSNTGERFQTVALERHQSYDIENLYFREIQKHLHDLEFQWKDGETNDKEVPVPHENNLT
GKRDQHSQGDVENNHIENQLTSNFESRLAELQKVQTEGRLYECNETEKTGNNGCLVSPHI
REKTYVCNECGKAFKASSSLINHQRIHTTEKPYKCNECGKAFHRASLLTVHKVVHTRGKS
YQCDVCGKIFRKNSYFVRHQRSHTGQKPYICNECGKSFSKSSHLAVHQRIHTGEKPYKCN
LCGKSFSQRVHLRLHQTVHTGERPFKCNECGKTFKRSSNLTVHQVIHAGKKPYKCDVCGK
AFRHRSNLVCHRRIHSGEKQYKCNECGKVFSKRSSLAVHRRIHTVEKPCKCNECGKVFSK
RSSLAVHQRIHTGQKTYKCNKCGKVYSKHSHLAVHWRIHTGEKAYKCNECGKVFSIHSRL
AAHQRIHTGEKPYKCNECGKVFSQHSRLAVHRRIHTGEKPYKCKECGKVFSDRSAFARHR
RIHTGEKPYKCKECGKVFSQCSRLTVHRRIHSGEKPYKCNECGKVYSQYSHLVGHRRVHT
GEKPYKCHECGKAFNQGSTLNRHQRIHTGEKPYKCNQCGNSFSQRVHLRLHQTVHTGDRP
YKCNECGKTFKRSSNLTAHQIIHAGKKPYKCDECGKVFRHSSHLVSHQRIHTGEKRYKCI
ECGKAFGRLFSLSKHQRIHSGKKPYKCNECGKSFICRSGLTKHRIRHTGESLTTKLNVTR
P
Target Bioclass
Other
Subcellular location
Perikaryon
Function Regulator of the deubiquitinating USP12/DMWD/WDR48 complex. Functions as a cofactor that promotes USP12 enzymatic activity.
Uniprot ID
Q09019
Ensemble ID
ENST00000270223.7
HGNC ID
HGNC:2936

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C140(1.00); C141(1.00)  LDD0078  [2]
IA-alkyne
 Probe Info  		C261(0.00); C137(0.00); C278(0.00); C1204(0.00)  LDD0161  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
IPM
 Probe Info  		N.A.  LDD0147  [5]
AOyne
 Probe Info  		14.50  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C301(0.95); C307(0.95)  LDD0812  [2]
 LDCM0215  AC10 HCT 116 C140(0.93); C141(0.93)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C140(1.43); C141(1.43)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C140(0.85); C141(0.85)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C140(0.82); C141(0.82)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C140(1.38); C141(1.38)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C140(1.04); C141(1.04)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C140(1.33); C141(1.33)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C140(1.36); C141(1.36)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C140(0.78); C141(0.76)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C140(3.36); C141(1.34)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C140(1.10); C141(1.82)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C140(1.17); C141(1.17)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C140(1.40); C141(1.17)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C140(1.10); C141(1.04)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C140(0.88); C141(1.00)  LDD0546  [2]
 LDCM0237  AC12 HCT 116 C140(0.91); C141(0.91)  LDD0554  [2]
 LDCM0246  AC128 HEK-293T C140(0.87)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C140(0.80)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C140(0.92)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C140(0.81)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C140(0.88)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C140(0.88)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C140(0.82)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C140(0.86)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C140(0.88)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C140(1.01)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C140(1.01)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C140(1.01)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C140(0.97); C141(0.97)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C140(0.85)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C140(0.98)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C140(0.89)  LDD0860  [2]
 LDCM0263  AC143 HCT 116 C301(1.04); C307(1.04)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C301(1.07); C307(1.07)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C301(0.84); C307(0.84)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C301(0.89); C307(0.89)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C301(1.00); C307(1.00)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C301(0.91); C307(0.91)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C301(0.86); C307(0.86)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C140(0.83); C141(0.83)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C301(1.09); C307(1.09)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C301(1.63); C307(1.63)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C301(0.91); C307(0.91)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C301(1.02); C307(1.02)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C301(1.05); C307(1.05)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C301(1.09); C307(1.09)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C301(1.26); C307(1.26)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C301(1.00); C307(1.00)  LDD2161  [2]
 LDCM0276  AC17 HEK-293T C140(1.80); C141(1.80)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C140(1.69); C141(1.69)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C140(1.39); C141(1.39)  LDD0876  [2]
 LDCM0279  AC2 HEK-293T C301(1.09); C307(1.09)  LDD0877  [2]
 LDCM0280  AC20 HEK-293T C140(1.23); C141(1.23)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C140(1.12); C141(1.12)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C140(1.17); C141(1.17)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C140(1.71); C141(1.71)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C140(1.30); C141(1.30)  LDD0882  [2]
 LDCM0285  AC25 HEK-293T C301(0.78); C307(0.78)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C301(0.83); C307(0.83)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C301(0.95); C307(0.95)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C301(0.77); C307(0.77)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C301(0.95); C307(0.95)  LDD0887  [2]
 LDCM0290  AC3 HEK-293T C301(0.95); C307(0.95)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C301(0.84); C307(0.84)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C301(0.82); C307(0.82)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C301(0.89); C307(0.89)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C301(0.82); C307(0.82)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C301(0.82); C307(0.82)  LDD0893  [2]
 LDCM0296  AC35 HCT 116 C140(0.75); C141(0.75)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C140(1.28); C141(1.28)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C140(0.85); C141(0.85)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C140(0.55); C141(0.55)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C140(0.85); C141(0.85)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C301(1.10); C307(1.10)  LDD0899  [2]
 LDCM0302  AC40 HCT 116 C140(0.81); C141(0.81)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C140(0.54); C141(0.54)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C140(0.81); C141(0.81)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C140(0.86); C141(0.86)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C140(0.83); C141(0.83)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C140(0.96); C141(0.96)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C140(0.98); C141(1.05)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C140(0.99); C141(1.10)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C140(1.01); C141(1.09)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C140(0.95); C141(1.01)  LDD0909  [2]
 LDCM0312  AC5 HEK-293T C301(1.03); C307(1.03)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C140(1.01); C141(1.04)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C140(1.02); C141(1.22)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C140(1.09); C141(1.27)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C140(1.22); C141(1.57)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C140(1.06); C141(1.22)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C140(1.14); C141(1.51)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C140(1.03); C141(1.27)  LDD0917  [2]
 LDCM0320  AC57 HEK-293T C141(1.57)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C141(1.20)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C141(1.10)  LDD0920  [2]
 LDCM0323  AC6 HCT 116 C140(0.98); C141(0.98)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C141(1.59)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C141(1.40)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C141(0.99)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C141(1.23)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C141(1.57)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C141(1.29)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C141(1.19)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C141(1.17)  LDD0929  [2]
 LDCM0332  AC68 HCT 116 C140(0.99); C141(0.99); C301(1.00); C307(1.00)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C301(0.94); C307(0.94); C140(1.31); C141(1.31)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C140(1.01); C141(1.01)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C301(1.29); C307(1.29); C140(1.44); C141(1.44)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C140(0.95); C141(0.95); C301(0.98); C307(0.98)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C301(1.08); C307(1.08); C140(1.46); C141(1.46)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C301(1.15); C307(1.15); C140(2.10); C141(2.10)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C301(1.09); C307(1.09); C140(1.83); C141(1.83)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C301(0.90); C307(0.90); C140(2.61); C141(2.61)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C301(0.97); C307(0.97); C140(1.40); C141(1.40)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C301(1.01); C307(1.01); C140(1.22); C141(1.22)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C140(1.08); C141(1.08); C301(1.09); C307(1.09)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C140(1.19); C141(1.19); C301(1.24); C307(1.24)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C140(0.95); C141(0.95)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C301(1.19); C307(1.19); C140(1.36); C141(1.36)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C301(0.99); C307(0.99); C140(1.19); C141(1.19)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C301(1.13); C307(1.13); C140(2.00); C141(2.00)  LDD0665  [2]
 LDCM0349  AC83 HEK-293T C140(1.02)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C140(0.92)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C140(0.70)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C140(0.72)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C140(0.91)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C140(0.91)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C140(0.89)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C140(0.93)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C140(0.92)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C140(0.95)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C140(0.78)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C140(0.82)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C140(0.82)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C140(0.76)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C140(1.03)  LDD0962  [2]
 LDCM0365  AC98 HCT 116 C140(1.28); C141(1.28)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C140(1.02); C141(1.02)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C140(0.91); C141(0.91)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C140(1.16); C141(1.16)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C140(0.86); C141(0.86)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C140(1.00); C141(1.00)  LDD0078  [2]
 LDCM0367  CL1 HCT 116 C301(0.75); C307(0.75)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C301(0.78); C307(0.78)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C301(0.58); C307(0.58)  LDD0967  [2]
 LDCM0370  CL101 HCT 116 C140(1.19); C141(1.19)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C140(2.72); C141(2.72)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C140(1.11); C141(1.11)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C140(1.11); C141(1.11)  LDD0690  [2]
 LDCM0374  CL105 HEK-293T C140(1.65); C141(1.65)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C140(1.90); C141(1.90)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C140(1.16); C141(1.16)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C140(1.73); C141(1.73)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C140(2.69); C141(2.69)  LDD0976  [2]
 LDCM0379  CL11 HCT 116 C301(0.97); C307(0.97)  LDD0696  [2]
 LDCM0380  CL110 HEK-293T C140(3.81); C141(3.81)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C140(3.37); C141(3.37)  LDD0979  [2]
 LDCM0382  CL112 HEK-293T C301(0.61); C307(0.61)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C301(0.83); C307(0.83)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C301(0.60); C307(0.60)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C301(0.62); C307(0.62)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C301(0.85); C307(0.85)  LDD0984  [2]
 LDCM0387  CL117 HCT 116 C140(1.44); C141(1.44)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C140(0.93); C141(0.93)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C140(0.93); C141(0.93)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C301(0.90); C307(0.90)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C140(0.69); C141(0.69)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C140(1.50); C141(2.22)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C140(1.47); C141(2.15)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C140(2.09); C141(3.48)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C140(1.37); C141(1.89)  LDD0993  [2]
 LDCM0396  CL125 HEK-293T C141(0.89)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C141(1.08)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C141(1.06)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C141(0.72)  LDD0997  [2]
 LDCM0400  CL13 HCT 116 C301(0.89); C307(0.89)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C301(0.77); C307(0.77)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C301(1.06); C307(1.06)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C301(1.30); C307(1.30)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C301(0.96); C307(0.96)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C301(1.34); C307(1.34)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C301(1.46); C307(1.46)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C301(0.76); C307(0.76)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C301(1.19); C307(1.19)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C301(1.05); C307(1.05)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C301(1.07); C307(1.07)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C301(1.09); C307(1.09)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C301(1.18); C307(1.18)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C301(1.10); C307(1.10)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C301(1.10); C307(1.10)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C301(1.22); C307(1.22)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C301(1.19); C307(1.19)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C301(1.25); C307(1.25)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C301(0.93); C307(0.93)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C301(1.15); C307(1.15)  LDD0736  [2]
 LDCM0420  CL31 HEK-293T C598(0.97)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C441(0.91)  LDD1625  [7]
 LDCM0423  CL34 HEK-293T C598(1.09)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C598(1.14)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C598(1.01)  LDD1629  [7]
 LDCM0428  CL39 HEK-293T C598(0.96)  LDD1632  [7]
 LDCM0429  CL4 HCT 116 C301(0.78); C307(0.78)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C598(0.96)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C598(0.99)  LDD1635  [7]
 LDCM0433  CL43 HEK-293T C598(1.08)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C441(0.73)  LDD1638  [7]
 LDCM0436  CL46 HCT 116 C140(1.81); C141(1.81)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C140(1.02); C141(1.02)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C140(1.23); C141(1.23)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C140(1.15); C141(1.15)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C301(1.05); C307(1.05)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C140(1.20); C141(1.20)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C140(1.43); C141(1.43)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C140(2.42); C141(2.42)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C140(1.28); C141(1.28)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C140(1.17); C141(1.17)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C140(1.83); C141(1.83)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C140(1.03); C141(1.03)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C140(1.29); C141(1.29)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C140(2.04); C141(2.04)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C140(1.03); C141(1.03)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C301(0.81); C307(0.81)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C140(1.08); C141(1.08)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C140(1.06); C301(0.87); C307(0.87)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C140(0.98); C301(0.81); C307(0.81)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C140(0.96); C301(0.64); C307(0.64)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C140(0.81); C301(1.30); C307(1.30)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C140(0.98); C301(0.93); C307(0.93)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C140(0.89); C301(0.90); C307(0.90)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C140(1.15); C301(0.98); C307(0.98)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C140(0.88); C301(0.92); C307(0.92)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C140(0.95); C301(1.20); C307(1.20)  LDD1059  [2]
 LDCM0462  CL7 HCT 116 C301(1.09); C307(1.09)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C140(1.08); C301(1.00); C307(1.00)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C140(1.03); C301(0.65); C307(0.65)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C140(1.28); C301(0.88); C307(0.88)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C140(0.81); C301(1.13); C307(1.13)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C140(1.00); C301(0.75); C307(0.75)  LDD1065  [2]
 LDCM0469  CL76 HCT 116 C140(1.21); C141(1.21); C301(0.93); C307(0.93)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C140(0.88); C141(0.88); C301(1.43); C307(1.43)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C140(2.04); C141(2.04); C301(1.03); C307(1.03)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C140(0.90); C141(0.90); C301(1.18); C307(1.18)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C301(0.80); C307(0.80)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C140(0.93); C141(0.93); C301(1.16); C307(1.16)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C140(0.90); C141(0.90); C301(1.25); C307(1.25)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C140(0.93); C141(0.93); C301(1.32); C307(1.32)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C140(1.12); C141(1.12); C301(0.88); C307(0.88)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C140(1.71); C141(1.71); C301(0.62); C307(0.62)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C140(1.21); C141(1.21); C301(0.98); C307(0.98)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C140(1.09); C141(1.09); C301(1.13); C307(1.13)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C140(1.11); C141(1.11); C301(0.80); C307(0.80)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C140(0.93); C141(0.93); C301(0.89); C307(0.89)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C140(0.99); C141(0.99); C301(1.12); C307(1.12)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C301(0.77); C307(0.77)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C140(4.36); C141(4.36); C301(0.80); C307(0.80)  LDD0802  [2]
 LDCM0486  CL91 HEK-293T C301(0.65); C307(0.65)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C301(1.19); C307(1.19)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C301(1.06); C307(1.06)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C301(0.86); C307(0.86)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C301(1.13); C307(1.13)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C301(0.76); C307(0.76)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C301(0.95); C307(0.95)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C301(0.91); C307(0.91)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C301(0.78); C307(0.78)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C598(1.02)  LDD1698  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C584(2.05)  LDD1702  [8]
 LDCM0468  Fragment33 HEK-293T C140(0.79); C301(1.38); C307(1.38)  LDD1066  [2]
 LDCM0427  Fragment51 HEK-293T C598(0.93)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C441(0.75)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C441(1.14)  LDD1497  [7]
 LDCM0024  KB05 HEK-293T C441(1.20)  LDD1502  [7]
 LDCM0021  THZ1 HCT 116 C140(1.20); C141(1.20)  LDD2173  [2]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761