Details of the Target

General Information of Target

Target ID LDTP16801
Target Name Uncharacterized protein KIAA0513 (KIAA0513)
Gene Name KIAA0513
Gene ID 9764
Synonyms
Uncharacterized protein KIAA0513
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MNGDDAFARRPRDDAQISEKLRKAFDDIAKYFSKKEWEKMKSSEKIVYVYMKLNYEVMTK
LGFKVTLPPFMRSKRAADFHGNDFGNDRNHRNQVERPQMTFGSLQRIFPKIMPKKPAEEE
NGLKEVPEASGPQNDGKQLCPPGNPSTLEKINKTSGPKRGKHAWTHRLRERKQLVVYEEI
SDPEEDDE
Target Bioclass
Other
Subcellular location
Cytoplasm
Uniprot ID
O60268
Ensemble ID
ENST00000538274.6
HGNC ID
HGNC:29058

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.P267H .
NCIH1793 SNV: p.E85Q .
TOV21G SNV: p.E239Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K253(10.00)  LDD0277  [1]
Probe 1
 Probe Info  		Y278(11.47); Y398(12.67)  LDD3495  [2]
NAIA_5
 Probe Info  		C317(1.15)  LDD2227  [3]
DBIA
 Probe Info  		C317(1.13)  LDD0078  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0161  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
IPM
 Probe Info  		N.A.  LDD2156  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C317(2.82)  LDD0812  [4]
 LDCM0215  AC10 HCT 116 C317(1.19)  LDD0532  [4]
 LDCM0226  AC11 HCT 116 C317(1.49)  LDD0543  [4]
 LDCM0230  AC113 HCT 116 C317(0.86)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C317(0.88)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C317(1.01)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C317(0.92)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C317(0.89)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C317(0.98)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C317(0.86)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C317(2.02)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C317(0.85)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C317(0.89)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C317(0.84)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C317(0.78)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C317(0.71)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C317(0.88)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C317(0.76)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C317(0.79)  LDD0562  [4]
 LDCM0259  AC14 HCT 116 C317(1.83)  LDD0576  [4]
 LDCM0263  AC143 HCT 116 C317(0.98)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C317(0.97)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C317(1.01)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C317(0.99)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C317(1.53)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C317(0.85)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C317(1.13)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C317(2.08)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C317(1.26)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C317(1.20)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C317(0.96)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C317(0.68)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C317(0.97)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C317(0.82)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C317(0.98)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C317(0.89)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C317(0.98)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C317(1.17)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C317(1.19)  LDD0595  [4]
 LDCM0279  AC2 HEK-293T C317(1.17)  LDD0877  [4]
 LDCM0280  AC20 HCT 116 C317(1.27)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C317(1.21)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C317(1.32)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C317(1.22)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C317(1.14)  LDD0601  [4]
 LDCM0285  AC25 PaTu 8988t C317(0.79)  LDD1164  [4]
 LDCM0286  AC26 PaTu 8988t C317(0.82)  LDD1165  [4]
 LDCM0287  AC27 PaTu 8988t C317(1.02)  LDD1166  [4]
 LDCM0288  AC28 PaTu 8988t C317(1.00)  LDD1167  [4]
 LDCM0289  AC29 PaTu 8988t C317(0.88)  LDD1168  [4]
 LDCM0290  AC3 HEK-293T C317(0.91)  LDD0888  [4]
 LDCM0291  AC30 PaTu 8988t C317(0.67)  LDD1170  [4]
 LDCM0292  AC31 PaTu 8988t C317(0.69)  LDD1171  [4]
 LDCM0293  AC32 PaTu 8988t C317(1.26)  LDD1172  [4]
 LDCM0294  AC33 PaTu 8988t C317(1.01)  LDD1173  [4]
 LDCM0295  AC34 PaTu 8988t C317(1.25)  LDD1174  [4]
 LDCM0296  AC35 HCT 116 C317(0.49)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C317(0.79)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C317(0.98)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C317(0.72)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C317(0.72)  LDD0617  [4]
 LDCM0301  AC4 HEK-293T C317(1.32)  LDD0899  [4]
 LDCM0302  AC40 HCT 116 C317(0.90)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C317(0.79)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C317(0.84)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C317(0.91)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C317(0.87)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C317(1.02)  LDD0624  [4]
 LDCM0308  AC46 PaTu 8988t C317(1.16)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C317(0.88)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C317(1.26)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C317(1.87)  LDD1190  [4]
 LDCM0312  AC5 HEK-293T C317(1.22)  LDD0910  [4]
 LDCM0313  AC50 PaTu 8988t C317(1.66)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C317(0.88)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C317(1.30)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C317(1.22)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C317(1.40)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C317(1.16)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C317(1.91)  LDD1198  [4]
 LDCM0320  AC57 PaTu 8988t C317(1.10)  LDD1199  [4]
 LDCM0321  AC58 PaTu 8988t C317(0.66)  LDD1200  [4]
 LDCM0322  AC59 PaTu 8988t C317(0.88)  LDD1201  [4]
 LDCM0323  AC6 HCT 116 C317(1.54)  LDD0640  [4]
 LDCM0324  AC60 PaTu 8988t C317(0.84)  LDD1203  [4]
 LDCM0325  AC61 PaTu 8988t C317(0.94)  LDD1204  [4]
 LDCM0326  AC62 PaTu 8988t C317(1.29)  LDD1205  [4]
 LDCM0327  AC63 PaTu 8988t C317(0.98)  LDD1206  [4]
 LDCM0328  AC64 PaTu 8988t C317(1.17)  LDD1207  [4]
 LDCM0329  AC65 PaTu 8988t C317(0.88)  LDD1208  [4]
 LDCM0330  AC66 PaTu 8988t C317(0.75)  LDD1209  [4]
 LDCM0331  AC67 PaTu 8988t C317(0.87)  LDD1210  [4]
 LDCM0332  AC68 HCT 116 C317(0.69)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C317(0.82)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C317(1.47)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C317(0.89)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C317(0.88)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C317(0.77)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C317(0.95)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C317(0.87)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C317(1.06)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C317(0.90)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C317(0.90)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C317(0.71)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C317(0.69)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C317(1.12)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C317(0.88)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C317(0.90)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C317(0.77)  LDD0665  [4]
 LDCM0248  AKOS034007472 HCT 116 C317(1.69)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C317(1.48)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C317(1.71)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C317(1.13)  LDD0078  [4]
 LDCM0632  CL-Sc Hep-G2 C317(1.15)  LDD2227  [3]
 LDCM0369  CL100 HEK-293T C317(1.76)  LDD0967  [4]
 LDCM0370  CL101 HCT 116 C317(1.33)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C317(1.36)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C317(1.32)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C317(1.59)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C317(1.16)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C317(1.30)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C317(1.15)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C317(1.13)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C317(1.06)  LDD0695  [4]
 LDCM0380  CL110 HCT 116 C317(1.08)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C317(1.05)  LDD0698  [4]
 LDCM0382  CL112 PaTu 8988t C317(0.81)  LDD1261  [4]
 LDCM0383  CL113 PaTu 8988t C317(0.85)  LDD1262  [4]
 LDCM0384  CL114 PaTu 8988t C317(0.90)  LDD1263  [4]
 LDCM0385  CL115 PaTu 8988t C317(0.78)  LDD1264  [4]
 LDCM0386  CL116 PaTu 8988t C317(0.93)  LDD1265  [4]
 LDCM0387  CL117 HCT 116 C317(0.94)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C317(0.86)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C317(0.84)  LDD0706  [4]
 LDCM0391  CL120 HCT 116 C317(0.79)  LDD0708  [4]
 LDCM0392  CL121 PaTu 8988t C317(0.96)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C317(1.74)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C317(1.28)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C317(1.10)  LDD1274  [4]
 LDCM0396  CL125 PaTu 8988t C317(0.73)  LDD1275  [4]
 LDCM0397  CL126 PaTu 8988t C317(0.67)  LDD1276  [4]
 LDCM0398  CL127 PaTu 8988t C317(0.92)  LDD1277  [4]
 LDCM0399  CL128 PaTu 8988t C317(0.85)  LDD1278  [4]
 LDCM0403  CL16 HEK-293T C317(0.93)  LDD1001  [4]
 LDCM0404  CL17 HCT 116 C317(0.95)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C317(0.95)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C317(0.91)  LDD0723  [4]
 LDCM0408  CL20 HCT 116 C317(1.03)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C317(1.04)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C317(0.88)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C317(0.79)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C317(1.00)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C317(0.89)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C317(0.93)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C317(1.00)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C317(0.96)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C317(1.12)  LDD0734  [4]
 LDCM0419  CL30 HCT 116 C317(0.83)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C317(1.03)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C317(0.94)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C317(0.98)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C317(1.28)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C317(1.31)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C317(0.94)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C317(0.87)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C317(0.80)  LDD0745  [4]
 LDCM0430  CL40 HCT 116 C317(1.36)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C317(0.93)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C317(0.82)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C317(1.03)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C317(1.12)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C317(1.01)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C317(0.88)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C317(0.95)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C317(1.03)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C317(1.11)  LDD0756  [4]
 LDCM0441  CL50 HCT 116 C317(0.97)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C317(0.99)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C317(1.08)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C317(1.06)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C317(0.90)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C317(0.85)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C317(0.87)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C317(0.94)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C317(1.08)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C317(1.02)  LDD0767  [4]
 LDCM0452  CL60 HCT 116 C317(1.01)  LDD0769  [4]
 LDCM0486  CL91 HEK-293T C317(0.78)  LDD1084  [4]
 LDCM0487  CL92 HEK-293T C317(1.10)  LDD1085  [4]
 LDCM0488  CL93 HEK-293T C317(1.02)  LDD1086  [4]
 LDCM0489  CL94 HEK-293T C317(1.61)  LDD1087  [4]
 LDCM0490  CL95 HEK-293T C317(2.01)  LDD1088  [4]
 LDCM0491  CL96 HEK-293T C317(1.11)  LDD1089  [4]
 LDCM0492  CL97 HEK-293T C317(1.34)  LDD1090  [4]
 LDCM0493  CL98 HEK-293T C317(1.38)  LDD1091  [4]
 LDCM0494  CL99 HEK-293T C317(1.38)  LDD1092  [4]
 LDCM0427  Fragment51 HCT 116 C317(0.88)  LDD0744  [4]
 LDCM0022  KB02 HCT 116 C317(1.98)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C317(1.97)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C317(2.38)  LDD0082  [4]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019