Details of the Target

General Information of Target

Target ID LDTP16650
Target Name Coiled-coil domain-containing protein 85C (CCDC85C)
Gene Name CCDC85C
Gene ID 317762
Synonyms
Coiled-coil domain-containing protein 85C
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRPEGSLTYRVPERLRQGSCGVGRAAQALVCASAKEGTAFRMEAVQEGAAGVESEQAALG
EEAVLLLDDIMAEVEVVAEEEGLVERREEAQRAQQAVPGPGPMTPESALEELLAVQVELE
PVNAQARKAFSRQREKMERRRKPHLDRRGAVIQSVPGFWANVIANHPQMSALITDEDEDM
LSYMVSLEVEEEKHRVHLCKIMLFFRSNPYFQNKVITKEYLVNITEYRASHSTPIEWYPD
YEVEAYRRRHHNSSLNFFNWFSDHNFAGSNKIAEILCKDLWRNPLQYYKRMKPPEEGTET
SGDSQLLS
Target Bioclass
Other
Family
CCDC85 family
Subcellular location
Cell junction, tight junction
Function
May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia.
Uniprot ID
A6NKD9
Ensemble ID
ENST00000380243.9
HGNC ID
HGNC:35459

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
C-Sul
 Probe Info  		2.15  LDD0066  [2]
AHL-Pu-1
 Probe Info  		C373(3.17)  LDD0169  [3]
DBIA
 Probe Info  		C389(1.16)  LDD0078  [4]
N1
 Probe Info  		N.A.  LDD0245  [5]
NAIA_5
 Probe Info  		N.A.  LDD2224  [6]
IPM
 Probe Info  		C373(0.00); C89(0.00)  LDD2156  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C373(3.17)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C88(0.62); C89(0.71)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C88(0.95); C89(0.82)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C88(0.73); C89(0.73)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C88(0.84); C89(0.84)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C88(0.76); C89(0.76)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C88(0.93); C89(0.93)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C88(0.79); C89(0.79)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C88(0.95); C89(0.95)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C88(0.96); C89(0.96)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C88(0.98); C89(0.98)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C88(0.76); C89(0.76)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C88(0.69); C89(0.69)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C88(1.01); C89(0.97)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C88(0.91); C89(0.91)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C88(0.86); C89(0.86)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C88(0.91); C89(0.91)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C88(1.14); C89(1.14)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C88(0.93); C89(0.93)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C88(1.06); C89(1.06)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C88(1.01); C89(1.01)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C88(1.04); C89(1.04)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C88(1.13); C89(1.13)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C88(1.13); C89(1.13)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C88(0.99); C89(0.95)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C88(0.90); C89(0.90)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C88(1.07); C89(1.07)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C88(1.13); C89(1.13)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C88(1.10); C89(1.10)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C88(1.24); C89(1.24)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C88(1.13); C89(1.13)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C88(0.94); C89(0.94)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C88(1.05); C89(1.05)  LDD0562  [4]
 LDCM0246  AC128 PaTu 8988t C88(1.14); C89(1.14)  LDD1125  [4]
 LDCM0247  AC129 PaTu 8988t C88(1.08); C89(1.08)  LDD1126  [4]
 LDCM0249  AC130 PaTu 8988t C88(1.03); C89(1.03)  LDD1128  [4]
 LDCM0250  AC131 PaTu 8988t C88(1.06); C89(1.06)  LDD1129  [4]
 LDCM0251  AC132 PaTu 8988t C88(1.11); C89(1.11)  LDD1130  [4]
 LDCM0252  AC133 PaTu 8988t C88(1.02); C89(1.02)  LDD1131  [4]
 LDCM0253  AC134 PaTu 8988t C88(1.23); C89(1.23)  LDD1132  [4]
 LDCM0254  AC135 PaTu 8988t C88(0.96); C89(0.96)  LDD1133  [4]
 LDCM0255  AC136 PaTu 8988t C88(0.83); C89(0.83)  LDD1134  [4]
 LDCM0256  AC137 PaTu 8988t C88(1.06); C89(1.06)  LDD1135  [4]
 LDCM0257  AC138 PaTu 8988t C88(1.22); C89(1.22)  LDD1136  [4]
 LDCM0258  AC139 PaTu 8988t C88(1.07); C89(1.07)  LDD1137  [4]
 LDCM0259  AC14 HCT 116 C88(0.59); C89(0.78)  LDD0576  [4]
 LDCM0260  AC140 PaTu 8988t C88(1.09); C89(1.09)  LDD1139  [4]
 LDCM0261  AC141 PaTu 8988t C88(1.09); C89(1.09)  LDD1140  [4]
 LDCM0262  AC142 PaTu 8988t C88(1.12); C89(1.12)  LDD1141  [4]
 LDCM0270  AC15 HCT 116 C88(0.86); C89(0.95)  LDD0587  [4]
 LDCM0276  AC17 HCT 116 C88(0.56); C89(0.56)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C88(0.65); C89(0.65)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C88(0.62); C89(0.62)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C88(0.72); C89(0.87)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C88(0.67); C89(0.67)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C88(0.68); C89(0.68)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C88(0.61); C89(0.61)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C88(0.61); C89(0.61)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C88(0.70); C89(0.70)  LDD0601  [4]
 LDCM0285  AC25 HEK-293T C89(1.08)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C89(0.96)  LDD1525  [10]
 LDCM0288  AC28 HEK-293T C89(0.89)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C89(0.82)  LDD1528  [10]
 LDCM0290  AC3 HCT 116 C88(0.80); C89(0.81)  LDD0607  [4]
 LDCM0291  AC30 HEK-293T C89(1.02)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C89(0.98)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C89(1.04)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C89(1.03)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C89(1.04)  LDD1534  [10]
 LDCM0296  AC35 PaTu 8988t C88(0.89); C89(0.89)  LDD1175  [4]
 LDCM0297  AC36 PaTu 8988t C88(0.94); C89(0.94)  LDD1176  [4]
 LDCM0298  AC37 PaTu 8988t C88(0.96); C89(0.96)  LDD1177  [4]
 LDCM0299  AC38 PaTu 8988t C88(1.03); C89(1.03)  LDD1178  [4]
 LDCM0300  AC39 PaTu 8988t C88(1.10); C89(1.10)  LDD1179  [4]
 LDCM0301  AC4 HCT 116 C89(0.73); C88(0.75)  LDD0618  [4]
 LDCM0302  AC40 PaTu 8988t C88(1.62); C89(1.62)  LDD1181  [4]
 LDCM0303  AC41 PaTu 8988t C88(1.00); C89(1.00)  LDD1182  [4]
 LDCM0304  AC42 PaTu 8988t C88(1.48); C89(1.48)  LDD1183  [4]
 LDCM0305  AC43 PaTu 8988t C88(1.17); C89(1.17)  LDD1184  [4]
 LDCM0306  AC44 PaTu 8988t C88(2.04); C89(2.04)  LDD1185  [4]
 LDCM0307  AC45 PaTu 8988t C88(1.15); C89(1.15)  LDD1186  [4]
 LDCM0308  AC46 HEK-293T C89(1.10)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C89(0.79)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C89(0.76)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C89(0.89)  LDD1550  [10]
 LDCM0312  AC5 HCT 116 C88(0.75); C89(0.75)  LDD0629  [4]
 LDCM0313  AC50 HEK-293T C89(0.87)  LDD1552  [10]
 LDCM0315  AC52 HEK-293T C89(0.96)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C89(0.84)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C89(0.87)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C89(0.89)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C89(0.96)  LDD1558  [10]
 LDCM0320  AC57 PaTu 8988t C88(1.17); C89(1.17)  LDD1199  [4]
 LDCM0321  AC58 PaTu 8988t C88(1.13); C89(1.13)  LDD1200  [4]
 LDCM0322  AC59 PaTu 8988t C88(1.02); C89(1.02)  LDD1201  [4]
 LDCM0323  AC6 HCT 116 C88(0.96); C89(0.98)  LDD0640  [4]
 LDCM0324  AC60 PaTu 8988t C88(1.34); C89(1.34)  LDD1203  [4]
 LDCM0325  AC61 PaTu 8988t C88(0.86); C89(0.86)  LDD1204  [4]
 LDCM0326  AC62 PaTu 8988t C88(0.90); C89(0.90)  LDD1205  [4]
 LDCM0327  AC63 PaTu 8988t C88(0.81); C89(0.81)  LDD1206  [4]
 LDCM0328  AC64 PaTu 8988t C88(0.90); C89(0.90)  LDD1207  [4]
 LDCM0329  AC65 PaTu 8988t C88(0.77); C89(0.77)  LDD1208  [4]
 LDCM0330  AC66 PaTu 8988t C88(0.89); C89(0.89)  LDD1209  [4]
 LDCM0331  AC67 PaTu 8988t C88(0.97); C89(0.97)  LDD1210  [4]
 LDCM0332  AC68 HCT 116 C88(1.31); C89(1.31)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C88(1.39); C89(1.39)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C88(0.89); C89(0.97)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C88(1.31); C89(1.31)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C88(1.16); C89(1.16)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C88(1.38); C89(1.38)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C88(1.89); C89(1.89)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C88(1.66); C89(1.66)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C88(2.02); C89(2.02)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C88(1.29); C89(1.29)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C88(1.24); C89(1.24)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C88(1.18); C89(1.18)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C88(1.27); C89(1.27)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C88(0.87); C89(0.92)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C88(1.26); C89(1.26)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C88(0.66); C89(0.66)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C88(1.11); C89(1.11)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C89(1.18)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C89(1.18)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C89(1.13)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C89(1.21)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C89(1.23)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C89(1.28)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C89(1.14)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C89(1.11)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C89(0.92)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C89(0.96)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C89(0.96)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C89(0.87)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C89(1.02)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C89(0.84)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C89(1.12)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C88(1.35); C89(1.35)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C88(0.65); C89(0.65)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C88(1.00); C89(1.06)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C88(0.94); C89(0.97)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C89(0.98); C88(1.04)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C389(1.16)  LDD0078  [4]
 LDCM0367  CL1 PaTu 8988t C89(1.05)  LDD1246  [4]
 LDCM0368  CL10 PaTu 8988t C89(1.36)  LDD1247  [4]
 LDCM0369  CL100 HCT 116 C88(0.69); C89(0.79)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C88(0.56); C89(0.67)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C88(0.49); C89(0.74)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C88(0.74); C89(0.96)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C88(0.63); C89(0.75)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C88(0.56); C89(0.56)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C88(0.55); C89(0.55)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C88(0.60); C89(0.60)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C88(0.52); C89(0.52)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C88(0.57); C89(0.57)  LDD0695  [4]
 LDCM0379  CL11 PaTu 8988t C89(1.34)  LDD1258  [4]
 LDCM0380  CL110 HCT 116 C88(0.75); C89(0.75)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C88(0.70); C89(0.70)  LDD0698  [4]
 LDCM0384  CL114 HEK-293T C89(1.05)  LDD1588  [10]
 LDCM0387  CL117 PaTu 8988t C88(1.04); C89(1.04)  LDD1266  [4]
 LDCM0388  CL118 PaTu 8988t C88(0.94); C89(0.94)  LDD1267  [4]
 LDCM0389  CL119 PaTu 8988t C88(1.15); C89(1.15)  LDD1268  [4]
 LDCM0390  CL12 PaTu 8988t C89(1.11)  LDD1269  [4]
 LDCM0391  CL120 PaTu 8988t C88(0.97); C89(0.97)  LDD1270  [4]
 LDCM0393  CL122 HEK-293T C89(0.81)  LDD1597  [10]
 LDCM0396  CL125 PaTu 8988t C88(0.95); C89(0.95)  LDD1275  [4]
 LDCM0397  CL126 PaTu 8988t C88(0.99); C89(0.99)  LDD1276  [4]
 LDCM0398  CL127 PaTu 8988t C88(0.94); C89(0.94)  LDD1277  [4]
 LDCM0399  CL128 PaTu 8988t C88(1.06); C89(1.06)  LDD1278  [4]
 LDCM0400  CL13 PaTu 8988t C89(1.24)  LDD1279  [4]
 LDCM0401  CL14 PaTu 8988t C89(1.69)  LDD1280  [4]
 LDCM0402  CL15 PaTu 8988t C89(1.10)  LDD1281  [4]
 LDCM0403  CL16 HCT 116 C89(1.38); C88(1.78)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C89(0.92); C88(0.96)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C89(1.16); C88(1.32)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C89(1.06); C88(1.15)  LDD0723  [4]
 LDCM0407  CL2 PaTu 8988t C89(1.08)  LDD1286  [4]
 LDCM0408  CL20 HCT 116 C89(1.30); C88(1.47)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C89(1.05); C88(1.12)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C89(1.35); C88(1.68)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C89(0.99); C88(1.16)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C89(1.37); C88(1.73)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C88(1.74); C89(1.48)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C88(1.48); C89(1.65)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C88(1.87); C89(1.39)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C88(1.45); C89(1.29)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C88(2.22); C89(1.80)  LDD0734  [4]
 LDCM0418  CL3 PaTu 8988t C89(1.04)  LDD1297  [4]
 LDCM0419  CL30 HCT 116 C88(1.68); C89(1.51)  LDD0736  [4]
 LDCM0420  CL31 PaTu 8988t C88(0.99); C89(0.99)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C88(1.25); C89(1.25)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C88(1.31); C89(1.31)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C88(1.86); C89(1.86)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C88(1.81); C89(1.81)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C88(1.55); C89(1.55)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C88(2.30); C89(2.30)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C88(1.59); C89(1.59)  LDD1307  [4]
 LDCM0429  CL4 PaTu 8988t C89(1.14)  LDD1308  [4]
 LDCM0430  CL40 PaTu 8988t C88(1.42); C89(1.42)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C88(2.72); C89(2.72)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C88(2.52); C89(2.52)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C88(4.38); C89(4.38)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C88(1.96); C89(1.96)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C88(1.39); C89(1.39)  LDD1314  [4]
 LDCM0436  CL46 HCT 116 C88(0.92); C89(0.92)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C88(0.90); C89(0.90)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C88(0.83); C89(0.83)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C88(0.98); C89(0.98)  LDD0756  [4]
 LDCM0440  CL5 PaTu 8988t C89(1.29)  LDD1319  [4]
 LDCM0441  CL50 HCT 116 C88(0.88); C89(0.88)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C88(1.01); C89(1.01)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C88(0.98); C89(0.98)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C88(0.81); C89(0.81)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C88(0.89); C89(0.89)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C88(0.77); C89(0.77)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C88(0.71); C89(0.71)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C88(0.80); C89(0.80)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C88(0.84); C89(0.84)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C88(0.86); C89(0.86)  LDD0767  [4]
 LDCM0451  CL6 PaTu 8988t C89(1.25)  LDD1330  [4]
 LDCM0452  CL60 HCT 116 C88(0.77); C89(0.77)  LDD0769  [4]
 LDCM0453  CL61 PaTu 8988t C89(0.85)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C89(1.74)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C89(1.84)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C89(1.22)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C89(2.03)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C89(1.73)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C89(1.51)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C89(1.93)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C89(1.80)  LDD1340  [4]
 LDCM0462  CL7 PaTu 8988t C89(1.43)  LDD1341  [4]
 LDCM0463  CL70 PaTu 8988t C89(2.15)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C89(1.00)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C89(2.18)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C89(2.39)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C89(2.08)  LDD1346  [4]
 LDCM0469  CL76 PaTu 8988t C89(1.94)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C89(1.54)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C89(2.08)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C89(2.40)  LDD1351  [4]
 LDCM0473  CL8 PaTu 8988t C89(1.25)  LDD1352  [4]
 LDCM0474  CL80 PaTu 8988t C89(2.52)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C89(2.07)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C89(2.44)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C89(2.60)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C89(1.33)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C89(1.74)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C89(1.98)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C89(2.10)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C89(2.55)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C89(1.41)  LDD1362  [4]
 LDCM0484  CL9 PaTu 8988t C89(0.99)  LDD1363  [4]
 LDCM0485  CL90 PaTu 8988t C89(1.78)  LDD1364  [4]
 LDCM0486  CL91 HCT 116 C88(0.78); C89(0.99)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C88(0.93); C89(1.02)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C88(0.97); C89(0.79)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C88(0.95); C89(0.88)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C88(0.89); C89(0.77)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C88(0.94); C89(0.90)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C88(0.79); C89(0.80)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C88(0.78); C89(0.82)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C88(0.66); C89(0.69)  LDD0811  [4]
 LDCM0468  Fragment33 PaTu 8988t C89(1.58)  LDD1347  [4]
 LDCM0427  Fragment51 PaTu 8988t C88(2.57); C89(2.57)  LDD1306  [4]
 LDCM0022  KB02 HEK-293T C89(0.96)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C89(0.96)  LDD1497  [10]
 LDCM0024  KB05 HEK-293T C89(0.92)  LDD1502  [10]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402