Details of the Target

General Information of Target

Target ID LDTP16132
Target Name F-box/LRR-repeat protein 12 (FBXL12)
Gene Name FBXL12
Gene ID 54850
Synonyms
FBL12; F-box/LRR-repeat protein 12; F-box and leucine-rich repeat protein 12; F-box protein FBL12
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLSLKLPRLFSIDQIPQVFHEQGILFGYRHPQSSATACILSLFQMTNETLNIWTHLLPFW
FFAWRFVTALYMTDIKNDSYSWPMLVYMCTSCVYPLVSSCAHTFSSMSKNARHICYFLDY
GAVNLFSLGSAIAYSAYTFPDALMCTTFHDYYVALAVLNTILSTGLSCYSRFLEIQKPRL
CKVIRVLAFAYPYTWDSLPIFYRLFLFPGESAQNEATSYHQKHMIMTLLASFLYSAHLPE
RLAPGRFDYIGHSHQLFHVCVILATHMQMEAILLDKTLRKEWLLATSKPFSFSQIAGAIL
LCIIFSLSNIIYFSAALYRIPKPELHKKET
Target Bioclass
Enzyme
Function
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.
Uniprot ID
Q9NXK8
Ensemble ID
ENST00000247977.9
HGNC ID
HGNC:13611

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.L275I DBIA    Probe Info 
COLO792 SNV: p.T148I DBIA    Probe Info 
HCT15 SNV: p.D39N .
KYSE410 SNV: p.I223M .
MEWO SNV: p.P151L .
OVK18 SNV: p.P151S .
PF382 SNV: p.T148A DBIA    Probe Info 
SW1116 Substitution: p.V38W DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.78  LDD0403  [1]
DBIA
 Probe Info  		C134(7.18)  LDD0209  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C108(0.00); C155(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [4]
Lodoacetamide azide
 Probe Info  		C310(0.00); C108(0.00); C155(0.00)  LDD0037  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
IPM
 Probe Info  		N.A.  LDD2156  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C310(0.82); C134(0.95); C108(1.12); C212(1.13)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C310(0.96); C134(1.00); C108(1.10); C212(1.04)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C310(1.00); C134(0.96); C108(0.98); C212(0.76)  LDD1509  [9]
 LDCM0230  AC113 HCT 116 C310(1.00)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C310(1.06)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C310(0.92)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C310(0.98)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C310(0.92)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C310(0.97)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C310(0.95)  LDD0553  [10]
 LDCM0237  AC12 HEK-293T C134(0.93); C108(1.10); C212(0.99)  LDD1510  [9]
 LDCM0238  AC120 HCT 116 C310(0.94)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C310(1.02)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C310(1.12)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C310(1.04)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C310(1.28)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C310(1.22)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C310(1.06)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C310(0.97)  LDD0562  [10]
 LDCM0259  AC14 HEK-293T C134(0.99); C108(1.09); C212(0.84)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C310(0.98); C134(0.92); C212(1.07)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C310(0.87); C134(0.98); C108(0.80); C212(1.10)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C310(0.91); C134(0.90); C108(0.99); C212(0.96)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C310(1.03); C134(0.92); C108(1.05); C212(0.77)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C310(0.95); C134(0.90); C108(1.04); C212(1.07)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C134(0.99); C108(0.83); C212(1.01)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C310(0.93); C134(0.99); C108(0.98); C212(0.99)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C134(1.03); C108(1.07); C212(1.01)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C310(1.02); C134(1.00); C212(1.10)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C310(1.08); C134(1.00); C108(1.03); C212(1.06)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C310(0.87); C134(0.97); C108(0.95); C212(1.18)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C310(1.05); C134(0.93); C108(0.96); C212(0.94)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C310(1.11); C134(0.97); C108(1.01); C212(1.08)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C134(0.97); C108(0.94); C212(0.96)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C310(0.91); C134(0.95); C108(1.07); C212(0.92)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C310(0.98); C134(0.94); C108(1.01); C212(0.82)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C134(0.91); C108(1.01); C212(0.88)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C310(0.93); C134(1.01); C212(0.97)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C310(0.93); C134(0.99); C108(1.09); C212(1.00)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C310(0.87); C134(0.97); C108(1.13); C212(0.88)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C310(1.01); C134(0.88); C108(1.17); C212(1.07)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C310(0.90); C134(0.90); C108(0.94); C212(0.76)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C134(0.92); C108(1.02); C212(0.84)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C310(0.94); C134(1.02); C108(1.11); C212(0.93)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C134(0.95); C108(1.12); C212(1.00)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C310(1.05); C134(1.04); C212(0.90)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C134(1.03); C108(0.85); C212(0.88)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C310(1.05); C134(0.97); C108(0.94); C212(0.98)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C310(0.90); C134(0.93); C108(0.95); C212(0.99)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C310(1.08); C134(0.89); C108(1.06); C212(0.97)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C310(1.03); C134(0.96); C108(0.91); C212(0.79)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C134(0.94); C108(1.08); C212(0.89)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C310(0.96); C134(0.98); C108(1.05); C212(0.99)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C134(1.10); C108(1.07); C212(0.92)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C310(0.99); C134(0.92); C212(1.12)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C310(1.04); C134(1.00); C108(1.10); C212(1.04)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C310(0.91); C134(0.96); C108(0.86); C212(1.16)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C310(1.02); C134(1.00); C108(1.11); C212(0.92)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C310(0.95); C134(0.87); C108(1.05); C212(0.99)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C310(1.11); C134(0.97); C108(0.98); C212(0.87)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C134(1.00); C108(0.84); C212(1.01)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C310(1.02); C134(0.94); C108(1.01); C212(1.14)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C134(0.95); C108(1.19); C212(0.78)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C310(0.97); C134(1.02); C212(1.03)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C310(0.99); C134(0.95); C108(1.03); C212(1.08)  LDD1558  [9]
 LDCM0320  AC57 HCT 116 C310(0.95)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C310(1.24)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C310(1.16)  LDD0639  [10]
 LDCM0323  AC6 HEK-293T C134(0.95); C108(0.88); C212(0.98)  LDD1562  [9]
 LDCM0324  AC60 HCT 116 C310(1.10)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C310(1.45)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C310(1.22)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C310(1.08)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C310(1.03)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C310(1.09)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C310(1.06)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C310(1.01)  LDD0648  [10]
 LDCM0334  AC7 HEK-293T C310(0.99); C134(0.99); C212(1.18)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C310(1.05); C134(1.13); C108(1.07); C212(0.94)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C310(0.98); C134(0.93); C108(1.05); C212(0.94)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C310(0.86); C134(0.94); C108(0.76); C212(0.96)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C310(1.08); C134(1.05); C108(1.16); C212(0.94)  LDD1514  [9]
 LDCM0156  Aniline NCI-H1299 11.78  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C310(1.11); C134(1.03); C212(1.02)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C134(1.19); C108(1.07); C212(0.97)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C310(0.88); C134(0.99); C108(0.94); C212(0.92)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C310(1.06); C134(0.94); C212(1.06)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C310(0.94); C134(0.99); C108(1.23); C212(0.91)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C310(1.12); C134(0.97); C108(0.98); C212(0.92)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C310(0.75); C134(0.95); C108(0.83); C212(0.88)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C310(1.03); C134(0.95); C212(1.06)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C310(0.90); C134(0.94); C108(0.86); C212(0.89)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C310(1.01); C134(1.02); C108(0.83); C212(0.88)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C310(1.18); C134(0.95); C108(0.88); C212(1.04)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C310(1.02); C134(0.98); C212(1.16)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C310(0.83); C134(1.19); C212(1.14)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C310(0.97); C134(0.94); C108(0.88); C212(1.10)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C310(1.07); C134(1.08); C108(0.88); C212(0.90)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C310(0.92); C134(0.99); C108(0.87); C212(0.94)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C310(1.13); C134(0.95); C212(0.97)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C310(1.00); C134(0.93); C108(1.21); C212(0.90)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C310(1.10); C134(0.99); C108(0.79); C212(0.75)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C310(0.98); C134(1.01); C108(0.98); C212(0.96)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C310(1.07); C134(0.95); C212(1.05)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C310(0.98); C134(0.84); C108(1.18); C212(1.04)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C310(1.04); C134(0.94); C108(0.84); C212(0.87)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C310(1.20); C134(1.20); C108(0.98); C212(1.03)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C310(0.89); C134(0.96); C108(0.83); C212(0.99)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C310(1.06); C134(1.01); C212(1.06)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C310(1.03); C134(0.90); C108(0.99); C212(0.97)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C310(0.99); C134(0.99); C108(0.79); C212(0.93)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C310(0.93); C134(0.89); C108(0.76); C212(1.06)  LDD1599  [9]
 LDCM0396  CL125 HCT 116 C310(1.36)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C310(1.12)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C310(1.26)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C310(0.87)  LDD0716  [10]
 LDCM0400  CL13 HEK-293T C310(0.98); C134(0.87); C212(1.04)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C310(0.91); C134(0.80); C108(1.00); C212(1.09)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C310(1.02); C134(1.04); C108(0.79); C212(0.99)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C310(0.85); C134(0.91); C108(0.98); C212(0.98)  LDD1607  [9]
 LDCM0404  CL17 HCT 116 C310(0.78)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C310(1.03)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C310(0.94)  LDD0723  [10]
 LDCM0407  CL2 HEK-293T C310(0.92); C134(0.90); C108(0.97); C212(0.98)  LDD1611  [9]
 LDCM0408  CL20 HCT 116 C310(0.76)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C310(0.98)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C310(1.07)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C310(0.93)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C310(0.92)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C310(0.93)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C310(1.18)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C310(0.99)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C310(0.92)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C310(0.79)  LDD0734  [10]
 LDCM0418  CL3 HEK-293T C310(0.92); C134(1.03); C108(0.94); C212(0.91)  LDD1622  [9]
 LDCM0419  CL30 HCT 116 C310(0.88)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C310(1.06)  LDD0737  [10]
 LDCM0421  CL32 HEK-293T C134(1.08); C108(1.05); C212(1.02)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C310(0.76); C134(1.10); C108(1.05); C212(0.87)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C134(1.04); C108(1.09); C212(1.60)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C310(0.86); C134(1.19); C212(1.23)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C310(1.09); C134(1.23); C108(1.05); C212(0.90)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C310(1.12); C134(0.93); C212(1.26)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C310(1.01); C134(0.95); C108(0.90); C212(0.82)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C310(0.80); C134(1.01); C108(0.85); C212(1.03)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C310(0.81); C134(0.99); C108(0.83); C212(0.93)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C310(0.92); C134(0.99); C108(0.92); C212(0.94)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C310(1.08); C134(0.87); C108(1.03); C212(1.11)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C310(1.19); C134(1.03); C108(1.12); C212(0.96)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C134(1.01); C108(1.06); C212(1.06)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C310(0.75); C134(0.94); C108(1.09); C212(0.82)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C134(1.04); C108(1.28); C212(1.08)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C310(0.92); C134(1.03); C212(1.08)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C310(1.10); C134(1.05); C108(1.05); C212(1.12)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C310(1.10); C134(0.88); C212(1.22)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C310(0.79); C134(0.95); C108(0.92); C212(1.25)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C310(0.98); C134(0.88); C108(0.90); C212(0.88)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C310(0.87); C134(0.92); C108(0.79); C212(0.91)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C310(0.87); C134(0.96); C108(0.29); C212(1.04)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C310(0.85); C134(0.98); C108(0.99); C212(0.98)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C310(1.02); C134(0.92); C108(0.99); C212(0.95)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C134(1.00); C108(1.21); C212(1.16)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C310(0.73); C134(0.97); C108(1.13); C212(0.94)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C134(1.15); C108(0.47); C212(1.17)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C310(0.89); C134(1.00); C212(1.14)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C310(0.95); C134(0.98); C108(0.95); C212(1.08)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C310(1.11); C134(1.03); C108(1.07); C212(1.11)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C310(1.19); C134(0.93); C212(1.09)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C310(0.98); C134(0.84); C108(1.05); C212(0.89)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C310(1.03); C134(0.97); C108(0.98); C212(0.91)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C310(0.96); C134(0.99); C108(0.78); C212(0.89)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C310(0.90); C134(0.90); C108(0.92); C212(1.03)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C310(0.89); C134(0.81); C108(1.33); C212(1.13)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C310(1.08); C134(0.97); C108(1.05); C212(0.88)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C134(0.98); C108(0.95); C212(1.14)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C310(0.78); C134(0.99); C108(1.05); C212(1.09)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C310(1.06); C134(1.15); C108(1.25); C212(0.94)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C134(1.03); C108(1.19); C212(0.98)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C310(0.91); C134(1.03); C212(1.02)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C310(1.19); C134(1.02); C108(1.06); C212(1.36)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C310(1.10); C134(0.98); C212(1.26)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C310(1.00); C134(0.86); C108(1.20); C212(0.97)  LDD1670  [9]
 LDCM0469  CL76 HCT 116 C310(0.97)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C310(0.69)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C310(0.90)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C310(0.79)  LDD0789  [10]
 LDCM0473  CL8 HEK-293T C134(1.22); C108(0.89); C212(1.01)  LDD1676  [9]
 LDCM0474  CL80 HCT 116 C310(0.85)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C310(0.78)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C310(0.82)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C310(0.98)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C310(1.05)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C310(0.76)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C310(0.93)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C310(0.82)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C310(0.90)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C310(1.17)  LDD0800  [10]
 LDCM0484  CL9 HEK-293T C310(0.68); C134(1.04); C108(1.14); C212(0.94)  LDD1687  [9]
 LDCM0485  CL90 HCT 116 C310(0.72)  LDD0802  [10]
 LDCM0486  CL91 HEK-293T C310(1.03); C134(0.96); C108(0.99); C212(0.94)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C134(1.03); C108(1.02); C212(0.83)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C310(0.87); C134(1.01); C108(0.93); C212(0.90)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C134(1.05); C108(1.11); C212(1.05)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C310(0.86); C134(1.16); C212(1.16)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C310(1.03); C134(1.02); C108(1.01); C212(1.03)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C310(0.98); C134(1.02); C212(1.15)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C310(0.98); C134(1.00); C108(1.25); C212(1.01)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C310(1.06); C134(0.99); C108(0.84); C212(0.93)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C310(1.11); C134(0.96); C108(0.87); C212(1.03)  LDD1698  [9]
 LDCM0625  F8 Ramos C310(1.36); C108(0.75)  LDD2187  [11]
 LDCM0572  Fragment10 Ramos C108(1.21)  LDD2189  [11]
 LDCM0573  Fragment11 Ramos C310(2.59); C108(2.78)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C310(1.16)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C108(0.89)  LDD2192  [11]
 LDCM0576  Fragment14 Ramos C310(0.73); C108(0.76)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C310(1.53)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C310(0.63); C108(1.07)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C310(0.79)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C310(0.76); C108(1.00)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C310(1.68); C108(1.04)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C310(0.69); C108(1.00)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C310(0.60); C108(0.80)  LDD2200  [11]
 LDCM0590  Fragment32 Ramos C310(0.40)  LDD2201  [11]
 LDCM0468  Fragment33 HEK-293T C310(0.95); C134(0.92); C108(0.91); C212(1.00)  LDD1671  [9]
 LDCM0596  Fragment38 Ramos C310(0.87); C108(1.19)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C310(0.98)  LDD2184  [11]
 LDCM0427  Fragment51 HEK-293T C310(1.04); C134(0.96); C108(1.02); C212(1.00)  LDD1631  [9]
 LDCM0610  Fragment52 Ramos C108(0.60)  LDD2204  [11]
 LDCM0569  Fragment7 Ramos C108(0.46)  LDD2186  [11]
 LDCM0022  KB02 HEK-293T C134(0.90); C108(1.28)  LDD1492  [9]
 LDCM0023  KB03 Jurkat C134(7.18)  LDD0209  [2]
 LDCM0024  KB05 MKN-1 C55(2.78); C212(2.04); C155(2.08)  LDD3331  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
S-phase kinase-associated protein 1 (SKP1) SKP1 family P63208
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-dependent kinase inhibitor 1C (CDKN1C) CDI family P49918
Gem-associated protein 4 (GEMIN4) . P57678
RING finger protein 32 (RNF32) . Q9H0A6

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840