Details of the Target

General Information of Target

Target ID LDTP15864
Target Name Proteasomal ATPase-associated factor 1 (PAAF1)
Gene Name PAAF1
Gene ID 80227
Synonyms
WDR71; Proteasomal ATPase-associated factor 1; Protein G-16; WD repeat-containing protein 71
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAPIPQGFSCLSRFLGWWFRQPVLVTQSAAIVPVRTKKRFTPPIYQPKFKTEKEFMQHA
RKAGLVIPPEKSDRSIHLACTAGIFDAYVPPEGDARISSLSKEGLIERTERMKKTMASQV
SIRRIKDYDANFKIKDFPEKAKDIFIEAHLCLNNSDHDRLHTLVTEHCFPDMTWDIKYKT
VRWSFVESLEPSHVVQVRCSSMMNQGNVYGQITVRMHTRQTLAIYDRFGRLMYGQEDVPK
DVLEYVVFEKQLTNPYGSWRMHTKIVPPWAPPKQPILKTVMIPGPQLKPEEEYEEAQGEA
QKPQLA
Target Bioclass
Other
Family
WD repeat PAAF1/RPN14 family
Function
Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation.
Uniprot ID
Q9BRP4
Ensemble ID
ENST00000310571.8
HGNC ID
HGNC:25687

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.S37R .
MDAMB157 SNV: p.C286S .
SUIT2 Deletion: p.D352TfsTer17 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C71(1.03)  LDD2109  [2]
HHS-465
 Probe Info  		Y84(6.39)  LDD2237  [3]
Acrolein
 Probe Info  		N.A.  LDD0221  [4]
DBIA
 Probe Info  		C139(1.12); C140(1.12)  LDD0532  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C265(0.00); C71(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C265(0.00); C71(0.00); C97(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C168(0.00); C265(0.00); C71(0.00); C97(0.00)  LDD0037  [7]
NAIA_5
 Probe Info  		C265(0.00); C168(0.00); C71(0.00); C97(0.00)  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C40(0.94)  LDD1507  [10]
 LDCM0215  AC10 HCT 116 C139(1.12); C140(1.12)  LDD0532  [5]
 LDCM0216  AC100 HEK-293T C140(1.25)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C140(0.96)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C140(1.02)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C140(1.06)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C140(1.03)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C140(1.25)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C140(0.92)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C140(1.17)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C140(0.98)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C140(1.05)  LDD0823  [5]
 LDCM0226  AC11 HCT 116 C139(1.05); C140(1.05)  LDD0543  [5]
 LDCM0227  AC110 HEK-293T C140(1.04)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C140(1.33)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C140(1.16)  LDD0827  [5]
 LDCM0230  AC113 HCT 116 C139(1.03); C140(1.03)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C139(1.07); C140(1.07)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C139(1.07); C140(1.07)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C139(1.20); C140(1.20)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C139(0.97); C140(0.97)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C139(0.95); C140(0.95)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C139(1.07); C140(1.07)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C139(1.28); C140(1.28)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C139(0.99); C140(0.99)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C139(1.03); C140(1.03)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C139(1.13); C140(1.13)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C139(0.90); C140(0.90)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C139(0.95); C140(0.95)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C139(0.98); C140(0.98)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C139(1.13); C140(1.13)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C139(0.98); C140(0.98)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C139(1.20); C140(1.20)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C139(1.38); C140(1.38)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C139(1.21); C140(1.21)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C139(1.02); C140(1.02)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C139(1.04); C140(1.04)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C139(1.26); C140(1.26)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C139(1.07); C140(1.07)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C139(1.02); C140(1.02)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C139(1.10); C140(1.10)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C139(0.95); C140(0.95)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C139(0.77); C140(0.77)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C139(1.05); C140(1.05)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C139(0.99); C140(0.99)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C139(0.88); C140(0.88)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C139(1.02); C140(1.02)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C139(1.36); C140(1.36)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C139(1.01); C140(1.01)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C139(0.93); C140(1.02)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C140(0.88); C139(0.89)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C140(0.87); C139(0.98)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C139(0.85); C140(0.97)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C140(0.90); C139(1.05)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C140(0.97); C139(1.14)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C139(0.97); C140(0.97)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C140(0.99); C139(1.12)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C140(1.15); C139(1.23)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C140(0.93); C139(1.07)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C140(1.07); C139(1.40)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C139(1.05); C140(0.97)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C139(1.22); C140(1.14)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C139(1.13); C140(0.95)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C139(1.06); C140(1.07)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C139(1.13); C140(1.13)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C139(1.20); C140(1.20)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C139(1.11); C140(1.11)  LDD0595  [5]
 LDCM0279  AC2 HEK-293T C97(0.95)  LDD1518  [10]
 LDCM0280  AC20 HCT 116 C139(0.85); C140(0.85)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C139(0.71); C140(0.71)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C139(1.06); C140(1.06)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C139(0.94); C140(0.94)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C139(1.39); C140(1.39)  LDD0601  [5]
 LDCM0285  AC25 HEK-293T C40(0.81)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C97(0.94)  LDD1525  [10]
 LDCM0288  AC28 HEK-293T C168(0.83)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C168(1.05)  LDD1528  [10]
 LDCM0291  AC30 HEK-293T C168(0.92); C40(0.96); C210(0.83)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C168(1.03)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C40(1.00)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C40(0.86)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C97(0.96)  LDD1534  [10]
 LDCM0297  AC36 HEK-293T C168(1.00)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C168(1.10)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C168(0.93); C40(0.97); C210(1.03)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C168(1.10)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C168(0.88)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C40(1.08)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C40(0.83)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C97(0.95)  LDD1543  [10]
 LDCM0306  AC44 HEK-293T C168(0.98)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C168(0.95)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C139(0.86); C140(0.86)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C139(0.90); C140(0.90)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C139(0.89); C140(0.89)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C139(0.96); C140(0.96)  LDD0909  [5]
 LDCM0312  AC5 HEK-293T C168(1.14)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C139(0.88); C140(0.88)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C139(0.88); C140(0.88)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C139(0.86); C140(0.86)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C139(0.80); C140(0.80)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C139(0.95); C140(0.95)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C139(0.91); C140(0.91)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C139(0.82); C140(0.82)  LDD0917  [5]
 LDCM0320  AC57 HCT 116 C139(0.86); C140(0.86)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C139(0.80); C140(0.80)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C139(0.97); C140(0.97)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C139(1.20); C140(1.20)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C139(0.92); C140(0.92)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C139(0.97); C140(0.97)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C139(0.93); C140(0.93)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C139(1.05); C140(1.05)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C139(0.93); C140(0.93)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C139(0.89); C140(0.89)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C139(1.02); C140(1.02)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C139(0.92); C140(0.92)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C139(0.93); C140(0.93)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C139(1.02); C140(1.02)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C139(1.01); C140(1.01)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C139(1.15); C140(1.15)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C139(1.26); C140(1.26)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C139(1.16); C140(1.16)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C139(1.16); C140(1.16)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C139(1.09); C140(1.09)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C139(1.16); C140(1.16)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C139(1.13); C140(1.13)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C139(1.08); C140(1.08)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C139(1.04); C140(1.04)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C139(0.87); C140(0.87)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C139(1.03); C140(1.03)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C139(1.20); C140(1.20)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C139(1.15); C140(1.15)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C139(1.02); C140(1.02)  LDD0665  [5]
 LDCM0349  AC83 HEK-293T C139(0.99); C140(0.99)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C139(0.96); C140(0.96)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C139(1.13); C140(1.13)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C139(1.17); C140(1.17)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C139(1.03); C140(1.03)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C139(1.26); C140(1.26)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C139(1.23); C140(1.23)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C139(1.15); C140(1.15)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C139(0.98); C140(0.98)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C139(1.11); C140(1.11)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C139(1.10); C140(1.10)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C139(1.13); C140(1.13)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C139(0.97); C140(0.97)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C139(1.03); C140(1.03)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C139(1.02); C140(1.02)  LDD0962  [5]
 LDCM0365  AC98 HEK-293T C140(0.99)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C140(1.41)  LDD0964  [5]
 LDCM0248  AKOS034007472 HCT 116 C139(0.97); C140(0.97)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C139(1.12); C140(1.12)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C139(1.01); C140(1.01)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 9.84  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C139(0.86); C140(0.86)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C139(1.61); C140(1.61)  LDD0685  [5]
 LDCM0369  CL100 HEK-293T C40(1.25); C97(1.19)  LDD1573  [10]
 LDCM0370  CL101 HCT 116 C139(0.94); C140(0.94)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C139(1.02); C140(1.02)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C139(0.84); C140(0.84)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C139(0.85); C140(0.85)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C139(0.94); C140(0.94)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C139(1.01); C140(1.01)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C139(1.32); C140(1.32)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C139(1.36); C140(1.36)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C139(1.21); C140(1.21)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C139(1.22); C140(1.22)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C139(1.47); C140(1.47)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C139(1.30); C140(1.30)  LDD0698  [5]
 LDCM0382  CL112 HEK-293T C40(0.90); C97(1.03)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C168(0.86); C210(1.42)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C40(0.52)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C40(1.16)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C40(0.99); C97(1.09)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C168(0.77); C210(0.96)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C40(0.95)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C40(1.10)  LDD1593  [10]
 LDCM0390  CL12 HCT 116 C139(1.69); C140(1.69)  LDD0707  [5]
 LDCM0391  CL120 HEK-293T C40(1.04); C97(1.01)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C139(0.82); C140(0.82)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C139(0.84); C140(0.84)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C139(1.18); C140(1.18)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C139(0.94); C140(0.94)  LDD0993  [5]
 LDCM0396  CL125 HCT 116 C139(0.89); C140(0.89)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C139(0.89); C140(0.89)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C139(0.86); C140(0.86)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C139(0.82); C140(0.82)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C139(1.99); C140(1.99)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C139(1.55); C140(1.55)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C139(1.71); C140(1.71)  LDD0719  [5]
 LDCM0403  CL16 HEK-293T C139(0.86); C140(0.86)  LDD1001  [5]
 LDCM0404  CL17 HEK-293T C139(1.08); C140(1.08)  LDD1002  [5]
 LDCM0405  CL18 HEK-293T C139(1.12); C140(1.12)  LDD1003  [5]
 LDCM0406  CL19 HEK-293T C139(0.93); C140(0.93)  LDD1004  [5]
 LDCM0407  CL2 HCT 116 C139(1.03); C140(1.03)  LDD0724  [5]
 LDCM0408  CL20 HEK-293T C139(0.92); C140(0.92)  LDD1006  [5]
 LDCM0409  CL21 HEK-293T C139(1.05); C140(1.05)  LDD1007  [5]
 LDCM0410  CL22 HEK-293T C139(0.93); C140(0.93)  LDD1008  [5]
 LDCM0411  CL23 HEK-293T C139(0.83); C140(0.83)  LDD1009  [5]
 LDCM0412  CL24 HEK-293T C139(1.07); C140(1.07)  LDD1010  [5]
 LDCM0413  CL25 HEK-293T C139(0.77); C140(0.77)  LDD1011  [5]
 LDCM0414  CL26 HEK-293T C139(0.92); C140(0.92)  LDD1012  [5]
 LDCM0415  CL27 HEK-293T C139(0.86); C140(0.86)  LDD1013  [5]
 LDCM0416  CL28 HEK-293T C139(1.10); C140(1.10)  LDD1014  [5]
 LDCM0417  CL29 HEK-293T C139(1.13); C140(1.13)  LDD1015  [5]
 LDCM0418  CL3 HCT 116 C139(1.07); C140(1.07)  LDD0735  [5]
 LDCM0419  CL30 HEK-293T C139(1.15); C140(1.15)  LDD1017  [5]
 LDCM0421  CL32 HEK-293T C168(1.25)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C168(1.06)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C168(1.08); C40(1.31); C210(1.01)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C168(1.49)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C40(1.33)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C168(0.99); C210(1.17)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C40(1.03)  LDD1632  [10]
 LDCM0429  CL4 HCT 116 C139(1.06); C140(1.06)  LDD0746  [5]
 LDCM0430  CL40 HEK-293T C40(0.80); C97(1.12)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C40(1.38)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C97(0.99)  LDD1636  [10]
 LDCM0434  CL44 HEK-293T C168(0.99)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C168(1.04)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C139(0.85); C140(0.85)  LDD1034  [5]
 LDCM0437  CL47 HEK-293T C139(0.91); C140(0.91)  LDD1035  [5]
 LDCM0438  CL48 HEK-293T C139(0.81); C140(0.81)  LDD1036  [5]
 LDCM0439  CL49 HEK-293T C139(0.84); C140(0.84)  LDD1037  [5]
 LDCM0440  CL5 HCT 116 C139(1.21); C140(1.21)  LDD0757  [5]
 LDCM0441  CL50 HEK-293T C139(0.90); C140(0.90)  LDD1039  [5]
 LDCM0442  CL51 HEK-293T C139(1.04); C140(1.04)  LDD1040  [5]
 LDCM0443  CL52 HEK-293T C139(0.86); C140(0.86)  LDD1041  [5]
 LDCM0444  CL53 HEK-293T C139(1.02); C140(1.02)  LDD1042  [5]
 LDCM0445  CL54 HEK-293T C139(1.16); C140(1.16)  LDD1043  [5]
 LDCM0446  CL55 HEK-293T C139(0.91); C140(0.91)  LDD1044  [5]
 LDCM0447  CL56 HEK-293T C139(0.81); C140(0.81)  LDD1045  [5]
 LDCM0448  CL57 HEK-293T C139(1.05); C140(1.05)  LDD1046  [5]
 LDCM0449  CL58 HEK-293T C139(0.94); C140(0.94)  LDD1047  [5]
 LDCM0450  CL59 HEK-293T C139(0.80); C140(0.80)  LDD1048  [5]
 LDCM0451  CL6 HCT 116 C139(1.27); C140(1.27)  LDD0768  [5]
 LDCM0452  CL60 HEK-293T C139(0.85); C140(0.85)  LDD1050  [5]
 LDCM0453  CL61 HCT 116 C139(1.10); C140(1.10)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C139(1.06); C140(1.06)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C139(1.03); C140(1.03)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C139(1.59); C140(1.59)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C139(1.42); C140(1.42)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C139(1.41); C140(1.41)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C139(1.47); C140(1.47)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C139(1.41); C140(1.41)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C139(1.27); C140(1.27)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C139(1.78); C140(1.78)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C139(1.55); C140(1.55)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C139(1.47); C140(1.47)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C139(1.26); C140(1.26)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C139(1.02); C140(1.02)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C139(1.35); C140(1.35)  LDD0784  [5]
 LDCM0469  CL76 HEK-293T C139(1.23); C140(1.23)  LDD1067  [5]
 LDCM0470  CL77 HEK-293T C139(1.15); C140(1.15)  LDD1068  [5]
 LDCM0471  CL78 HEK-293T C139(1.38); C140(1.38)  LDD1069  [5]
 LDCM0472  CL79 HEK-293T C139(1.15); C140(1.15)  LDD1070  [5]
 LDCM0473  CL8 HCT 116 C139(0.97); C140(0.97)  LDD0790  [5]
 LDCM0474  CL80 HEK-293T C139(1.43); C140(1.43)  LDD1072  [5]
 LDCM0475  CL81 HEK-293T C139(1.08); C140(1.08)  LDD1073  [5]
 LDCM0476  CL82 HEK-293T C139(1.22); C140(1.22)  LDD1074  [5]
 LDCM0477  CL83 HEK-293T C139(1.01); C140(1.01)  LDD1075  [5]
 LDCM0478  CL84 HEK-293T C139(1.24); C140(1.24)  LDD1076  [5]
 LDCM0479  CL85 HEK-293T C139(1.22); C140(1.22)  LDD1077  [5]
 LDCM0480  CL86 HEK-293T C139(1.24); C140(1.24)  LDD1078  [5]
 LDCM0481  CL87 HEK-293T C139(1.04); C140(1.04)  LDD1079  [5]
 LDCM0482  CL88 HEK-293T C139(1.41); C140(1.41)  LDD1080  [5]
 LDCM0483  CL89 HEK-293T C139(1.11); C140(1.11)  LDD1081  [5]
 LDCM0484  CL9 HCT 116 C139(1.12); C140(1.12)  LDD0801  [5]
 LDCM0485  CL90 HEK-293T C139(1.31); C140(1.31)  LDD1083  [5]
 LDCM0487  CL92 HEK-293T C168(1.02)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C168(0.96)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C168(0.97); C40(1.18); C210(0.90)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C168(1.09)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C40(1.44)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C168(0.80); C210(1.24)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C40(1.01)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C40(1.14)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C40(1.09)  LDD1698  [10]
 LDCM0468  Fragment33 HCT 116 C139(1.37); C140(1.37)  LDD0785  [5]
 LDCM0427  Fragment51 HEK-293T C40(0.95)  LDD1631  [10]
 LDCM0107  IAA HeLa N.A.  LDD0221  [4]
 LDCM0022  KB02 42-MG-BA C53(1.10)  LDD2244  [11]
 LDCM0023  KB03 8305C C53(1.19)  LDD2665  [11]
 LDCM0024  KB05 UACC257 C265(1.91)  LDD3325  [11]
 LDCM0109  NEM HeLa N.A.  LDD0230  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C71(1.03)  LDD2109  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C71(1.35)  LDD2129  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C71(1.46)  LDD2135  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C71(1.06)  LDD2137  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C71(0.99)  LDD2140  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C71(2.01)  LDD2144  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
26S proteasome regulatory subunit 8 (PSMC5) AAA ATPase family P62195

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840