Details of the Target

General Information of Target

Target ID LDTP15317
Target Name Proline and serine-rich protein 1 (PROSER1)
Gene Name PROSER1
Gene ID 80209
Synonyms
C13orf23; KIAA2032; Proline and serine-rich protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMAVDIEYRYNCMAPSLRQERFAFKISPKPSKPLRPCIQLSSKNEASGMVAPAVQEKKVK
KRVSFADNQGLALTMVKVFSEFDDPLDMPFNITELLDNIVSLTTAESESFVLDFSQPSAD
YLDFRNRLQADHVCLENCVLKDKAIAGTVKVQNLAFEKTVKIRMTFDTWKSYTDFPCQYV
KDTYAGSDRDTFSFDISLPEKIQSYERMEFAVYYECNGQTYWDSNRGKNYRIIRAELKST
QGMTKPHSGPDLGISFDQFGSPRCSYGLFPEWPSYLGYEKLGPYY
Target Bioclass
Other
Function Mediates OGT interaction with and O-GlcNAcylation of TET2 to control TET2 stabilization at enhancers and CpG islands (CGIs).
Uniprot ID
Q86XN7
Ensemble ID
ENST00000352251.8
HGNC ID
HGNC:20291

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.H325R .
HUH28 SNV: p.S664F .
LS180 SNV: p.S191L .
MCC13 SNV: p.S577F .
MDAMB157 Substitution: p.S321V .
OVCAR5 SNV: p.Ter945SextTer16 .
TKKK SNV: p.T243A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C518(1.10)  LDD0532  [1]
IA-alkyne
 Probe Info  		C171(0.00); C139(0.00)  LDD0165  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]
m-APA
 Probe Info  		N.A.  LDD0404  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
NAIA_5
 Probe Info  		C129(0.00); C76(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C518(4.24)  LDD0371  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C139(2.48)  LDD0372  [9]
 LDCM0214  AC1 HEK-293T C518(1.51)  LDD0812  [1]
 LDCM0215  AC10 HCT 116 C518(1.10)  LDD0532  [1]
 LDCM0216  AC100 HEK-293T C518(0.88)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C518(0.97)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C518(0.96)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C518(0.85)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C518(1.06)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C518(0.86)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C518(0.96)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C518(0.91)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C518(1.00)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C518(1.00)  LDD0823  [1]
 LDCM0226  AC11 HCT 116 C518(1.19)  LDD0543  [1]
 LDCM0227  AC110 HEK-293T C518(0.92)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C518(0.86)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C518(0.97)  LDD0827  [1]
 LDCM0230  AC113 HEK-293T C518(1.59)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C518(1.49)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C518(1.57)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C518(1.17)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C518(1.79)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C518(1.20)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C518(1.52)  LDD0834  [1]
 LDCM0237  AC12 HCT 116 C518(0.79)  LDD0554  [1]
 LDCM0238  AC120 HEK-293T C518(1.35)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C518(1.69)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C518(2.17)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C518(1.55)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C518(1.62)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C518(1.82)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C518(2.54)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C518(2.42)  LDD0843  [1]
 LDCM0246  AC128 HEK-293T C518(0.89)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C518(1.04)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C518(0.85)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C518(0.76)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C518(1.30)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C518(0.69)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C518(0.97)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C518(0.76)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C518(0.90)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C518(1.16)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C518(1.07)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C518(0.87)  LDD0856  [1]
 LDCM0259  AC14 HCT 116 C518(1.16)  LDD0576  [1]
 LDCM0260  AC140 HEK-293T C518(1.21)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C518(1.02)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C518(1.00)  LDD0860  [1]
 LDCM0263  AC143 HCT 116 C518(1.63)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C518(1.46)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C518(1.36)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C518(1.50)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C518(2.48)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C518(2.34)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C518(2.63)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C518(1.30)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C518(1.00)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C518(1.38)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C518(1.45)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C518(3.79)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C518(1.78)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C518(1.97)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C518(1.12)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C518(1.69)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C518(0.87)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C518(0.95)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C518(0.79)  LDD0595  [1]
 LDCM0279  AC2 HEK-293T C518(1.48)  LDD0877  [1]
 LDCM0280  AC20 HCT 116 C518(0.59)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C518(0.71)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C518(0.66)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C518(1.17)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C518(0.95)  LDD0601  [1]
 LDCM0285  AC25 HEK-293T C518(0.92); C76(1.01)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C76(0.98); C139(1.09); C171(1.10)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C518(1.15); C76(1.00); C139(1.01); C171(0.87)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C518(0.92); C76(0.98); C171(0.95)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C518(0.90); C76(0.98); C171(1.08)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C518(1.12)  LDD0888  [1]
 LDCM0291  AC30 HEK-293T C76(0.99); C171(0.97)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C76(0.96); C139(0.86); C171(0.99)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C76(1.08); C171(1.09)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C518(0.82); C76(1.01)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C76(0.98); C139(1.05); C171(1.26)  LDD1534  [10]
 LDCM0296  AC35 HCT 116 C518(1.42)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C518(0.96)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C518(1.12)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C518(1.31)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C518(1.44)  LDD0617  [1]
 LDCM0301  AC4 HEK-293T C518(1.17)  LDD0899  [1]
 LDCM0302  AC40 HCT 116 C518(1.95)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C518(1.32)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C518(2.55)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C518(1.54)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C518(1.49)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C518(1.57)  LDD0624  [1]
 LDCM0308  AC46 HEK-293T C518(0.87)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C518(0.90)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C518(0.86)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C518(1.24)  LDD0909  [1]
 LDCM0312  AC5 HEK-293T C518(1.16)  LDD0910  [1]
 LDCM0313  AC50 HEK-293T C518(1.18)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C518(0.91)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C518(1.10)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C518(0.97)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C518(1.00)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C518(0.86)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C518(0.95)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C518(0.97)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C518(1.22)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C518(1.17)  LDD0920  [1]
 LDCM0323  AC6 HCT 116 C518(1.44)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C518(1.01)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C518(1.00)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C518(1.25)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C518(1.18)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C518(1.30)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C518(1.06)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C518(1.13)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C518(1.12)  LDD0929  [1]
 LDCM0332  AC68 HEK-293T C518(0.71)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C518(0.79)  LDD0931  [1]
 LDCM0334  AC7 HCT 116 C518(1.08)  LDD0651  [1]
 LDCM0335  AC70 HEK-293T C518(0.74)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C518(0.61)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C518(0.97)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C518(0.60)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C518(0.71)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C518(0.54)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C518(0.75)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C518(1.09)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C518(0.89)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C518(0.92)  LDD0942  [1]
 LDCM0345  AC8 HCT 116 C518(1.34)  LDD0662  [1]
 LDCM0346  AC80 HEK-293T C518(0.91)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C518(0.77)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C518(1.05)  LDD0946  [1]
 LDCM0349  AC83 HEK-293T C518(1.16)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C518(1.23)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C518(1.20)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C518(1.32)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C518(1.03)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C518(0.93)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C518(1.38)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C518(1.12)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C518(1.22)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C518(1.17)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C518(1.33)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C518(1.06)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C518(1.41)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C518(1.47)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C518(1.31)  LDD0962  [1]
 LDCM0365  AC98 HEK-293T C518(0.95)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C518(0.95)  LDD0964  [1]
 LDCM0248  AKOS034007472 HCT 116 C518(1.10)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C518(1.33)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C518(2.62)  LDD0592  [1]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [6]
 LDCM0367  CL1 PaTu 8988t C518(1.60)  LDD1246  [1]
 LDCM0368  CL10 PaTu 8988t C518(1.37)  LDD1247  [1]
 LDCM0369  CL100 HEK-293T C518(0.97)  LDD0967  [1]
 LDCM0370  CL101 HCT 116 C518(1.22)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C518(0.82)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C518(1.70)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C518(0.83)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C518(0.86)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C518(1.12)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C518(0.84)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C518(1.57)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C518(1.13)  LDD0695  [1]
 LDCM0379  CL11 PaTu 8988t C518(0.68)  LDD1258  [1]
 LDCM0380  CL110 HCT 116 C518(0.89)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C518(1.08)  LDD0698  [1]
 LDCM0382  CL112 HEK-293T C518(1.14); C76(0.93); C171(1.13)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C518(0.92); C76(1.00)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C518(1.00); C76(1.12); C139(1.11)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C518(0.81); C76(0.96); C171(1.08)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C518(1.16); C76(0.98); C171(1.06)  LDD1590  [10]
 LDCM0387  CL117 HCT 116 C518(2.20)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C518(1.42)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C518(2.11)  LDD0706  [1]
 LDCM0390  CL12 PaTu 8988t C518(1.00)  LDD1269  [1]
 LDCM0391  CL120 HCT 116 C518(1.09)  LDD0708  [1]
 LDCM0392  CL121 HEK-293T C518(0.89)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C518(0.58)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C518(0.89)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C518(1.17)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C518(1.49)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C518(1.08)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C518(1.23)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C518(1.09)  LDD0997  [1]
 LDCM0400  CL13 PaTu 8988t C518(1.07)  LDD1279  [1]
 LDCM0401  CL14 PaTu 8988t C518(1.36)  LDD1280  [1]
 LDCM0402  CL15 PaTu 8988t C518(0.96)  LDD1281  [1]
 LDCM0403  CL16 HEK-293T C518(1.14)  LDD1001  [1]
 LDCM0404  CL17 HEK-293T C518(1.27)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C518(1.02)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C518(1.22)  LDD1004  [1]
 LDCM0407  CL2 PaTu 8988t C518(0.63)  LDD1286  [1]
 LDCM0408  CL20 HEK-293T C518(1.14)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C518(1.04)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C518(1.15)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C518(0.95)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C518(1.28)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C518(1.40)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C518(1.23)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C518(0.90)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C518(1.14)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C518(1.22)  LDD1015  [1]
 LDCM0418  CL3 PaTu 8988t C518(1.28)  LDD1297  [1]
 LDCM0419  CL30 HEK-293T C518(1.22)  LDD1017  [1]
 LDCM0420  CL31 HEK-293T C518(1.26)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C518(1.04)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C518(1.91)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C518(1.07)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C518(0.99)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C518(1.03)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C518(0.95)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C518(1.02)  LDD1026  [1]
 LDCM0429  CL4 PaTu 8988t C518(0.72)  LDD1308  [1]
 LDCM0430  CL40 HEK-293T C518(1.01)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C518(0.97)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C518(1.36)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C518(1.02)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C518(1.22)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C518(1.02)  LDD1033  [1]
 LDCM0436  CL46 HEK-293T C518(1.32)  LDD1034  [1]
 LDCM0437  CL47 HEK-293T C518(1.00)  LDD1035  [1]
 LDCM0438  CL48 HEK-293T C518(1.13)  LDD1036  [1]
 LDCM0439  CL49 HEK-293T C518(1.01)  LDD1037  [1]
 LDCM0440  CL5 PaTu 8988t C518(0.92)  LDD1319  [1]
 LDCM0441  CL50 HEK-293T C518(0.91)  LDD1039  [1]
 LDCM0442  CL51 HEK-293T C518(0.87)  LDD1040  [1]
 LDCM0443  CL52 HEK-293T C518(0.88)  LDD1041  [1]
 LDCM0444  CL53 HEK-293T C518(0.87)  LDD1042  [1]
 LDCM0445  CL54 HEK-293T C518(0.92)  LDD1043  [1]
 LDCM0446  CL55 HEK-293T C518(1.13)  LDD1044  [1]
 LDCM0447  CL56 HEK-293T C518(0.94)  LDD1045  [1]
 LDCM0448  CL57 HEK-293T C518(1.18)  LDD1046  [1]
 LDCM0449  CL58 HEK-293T C518(0.93)  LDD1047  [1]
 LDCM0450  CL59 HEK-293T C518(1.01)  LDD1048  [1]
 LDCM0451  CL6 PaTu 8988t C518(1.00)  LDD1330  [1]
 LDCM0452  CL60 HEK-293T C518(1.00)  LDD1050  [1]
 LDCM0453  CL61 HEK-293T C518(0.98)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C518(1.00)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C518(0.98)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C518(0.54)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C518(1.12)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C518(1.25)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C518(0.72)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C518(0.88)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C518(0.82)  LDD1059  [1]
 LDCM0462  CL7 PaTu 8988t C518(0.98)  LDD1341  [1]
 LDCM0463  CL70 HEK-293T C518(1.05)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C518(0.92)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C518(1.11)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C518(0.87)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C518(1.33)  LDD1065  [1]
 LDCM0469  CL76 HEK-293T C518(0.52)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C518(0.54)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C518(0.57)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C518(0.63)  LDD1070  [1]
 LDCM0473  CL8 PaTu 8988t C518(1.04)  LDD1352  [1]
 LDCM0474  CL80 HEK-293T C518(0.49)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C518(0.58)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C518(0.80)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C518(0.58)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C518(0.46)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C518(0.48)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C518(0.43)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C518(0.55)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C518(0.64)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C518(0.65)  LDD1081  [1]
 LDCM0484  CL9 PaTu 8988t C518(1.21)  LDD1363  [1]
 LDCM0485  CL90 HEK-293T C518(0.51)  LDD1083  [1]
 LDCM0486  CL91 HEK-293T C518(1.32)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C518(0.81)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C518(0.98)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C518(1.64)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C518(1.54)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C518(1.19)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C518(1.37)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C518(1.15)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C518(1.04)  LDD1092  [1]
 LDCM0495  E2913 HEK-293T C518(0.90); C76(1.02); C171(0.99)  LDD1698  [10]
 LDCM0625  F8 Ramos C171(1.32); C139(1.49)  LDD2187  [11]
 LDCM0572  Fragment10 Ramos C171(1.55)  LDD2189  [11]
 LDCM0574  Fragment12 Ramos C171(1.06)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C171(1.25)  LDD2192  [11]
 LDCM0576  Fragment14 Ramos C171(1.25)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C171(0.67)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C171(0.94)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C171(0.93)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C171(0.83)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C171(0.46); C139(1.61)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C171(1.80)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C171(0.98)  LDD2200  [11]
 LDCM0468  Fragment33 HEK-293T C518(1.34)  LDD1066  [1]
 LDCM0596  Fragment38 Ramos C171(0.68)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C171(0.93); C139(1.37)  LDD2184  [11]
 LDCM0427  Fragment51 HEK-293T C518(1.00)  LDD1025  [1]
 LDCM0610  Fragment52 Ramos C171(1.55)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C171(1.27)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C171(1.30); C139(4.03)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C171(1.02)  LDD2188  [11]
 LDCM0022  KB02 HEK-293T C171(0.84); C76(1.00)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C171(1.11); C76(0.90)  LDD1497  [10]
 LDCM0024  KB05 HEK-293T C171(0.98); C76(0.70)  LDD1502  [10]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578