Details of the Target

General Information of Target

Target ID LDTP14449
Target Name Trinucleotide repeat-containing gene 18 protein (TNRC18)
Gene Name TNRC18
Gene ID 84629
Synonyms
CAGL79; KIAA1856; Trinucleotide repeat-containing gene 18 protein; Long CAG trinucleotide repeat-containing gene 79 protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MTQNKLKLCSKANVYTEVPDGGWGWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESN
SRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVA
IGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWR
YSLLFVGLLQLNIVIFGALLRPIFIRGPASPKIVIQENRKEAQYMLENEKTRTSIDSIDS
GVELTTSPKNVPTHTNLELEPKADMQQVLVKTSPRPSEKKAPLLDFSILKEKSFICYALF
GLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIY
IELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEDDVVGIEKMSS
AAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALVRPCKMGLCQ
HHHSGETKVVSHRGKTLQDIPEDFLEMDLAKNEHRVHVQMEPV
Target Bioclass
Transcription factor
Uniprot ID
O15417
Ensemble ID
ENST00000430969.6
HGNC ID
HGNC:11962

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.S27N DBIA    Probe Info 
A3KAW SNV: p.A1971V .
AGS SNV: p.F1741Y DBIA    Probe Info 
AN3CA SNV: p.M778V; p.S2220P DBIA    Probe Info 
C32 SNV: p.R368H .
CAL33 SNV: p.G642S DBIA    Probe Info 
CAL51 Deletion: p.A350RfsTer240 DBIA    Probe Info 
CCK81 Deletion: p.R1786GfsTer3
SNV: p.P264H		 .
DANG SNV: p.H2183Q DBIA    Probe Info 
DEL SNV: p.H2005Q .
EFO27 Deletion: p.A1267GfsTer25; p.E2584RfsTer217 .
FTC133 SNV: p.R257C .
HCC15 SNV: p.D725V DBIA    Probe Info 
HCT116 SNV: p.S1028N DBIA    Probe Info 
HCT15 SNV: p.G1109S; p.A1723D .
HEC1 SNV: p.G234R DBIA    Probe Info 
IGR1 SNV: p.K1503N DBIA    Probe Info 
IGR37 Substitution: p.S1287F DBIA    Probe Info 
IGR39 Substitution: p.S1287F DBIA    Probe Info 
IGROV1 Insertion: p.R1786PfsTer37 .
IM95 Deletion: p.R1786GfsTer3 DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER Insertion: p.R1786PfsTer37 .
JURKAT SNV: p.P503H .
KMCH1 Substitution: p.S574I DBIA    Probe Info 
KNS81FD SNV: p.D2268H .
LN18 SNV: p.S1628N .
LNCaP clone FGC Deletion: p.K1655NfsTer12 DBIA    Probe Info 
LS180 SNV: p.A2408S .
MCC13 Deletion: p.P1040RfsTer119 .
MEC1 SNV: p.P568S .
MFE296 Deletion: p.K343RfsTer247 .
MFE319 SNV: p.T1913I .
NCIH1299 SNV: p.S2603I .
NCIH358 SNV: p.S1426R; p.D2171E .
OAW42 SNV: p.N2774S .
RKO SNV: p.L496M; p.R1969C DBIA    Probe Info 
RL952 SNV: p.N2774S DBIA    Probe Info 
RPMI8226 SNV: p.P2325A .
RVH421 SNV: p.P795L .
SISO SNV: p.G665W .
SKMEL28 SNV: p.G2593W .
SKNAS SNV: p.L2259F .
SNGM Deletion: p.S1028AfsTer131
Insertion: p.R1786PfsTer37
SNV: p.L1761M;p.Y2238C		 .
SW1271 SNV: p.G7V .
SW1573 SNV: p.P385L DBIA    Probe Info 
SW837 SNV: p.H2134P .
TE4 SNV: p.Y886S DBIA    Probe Info 
TOV21G SNV: p.P60T; p.E231Ter; p.E948D; p.K1065N; p.Q1072K; p.A2041E; p.P2047H; p.P2391Q .
UACC257 SNV: p.N1443S DBIA    Probe Info 
UACC62 SNV: p.A2610S .
YSCCC SNV: p.E912Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
IA-alkyne
 Probe Info  		C1801(7.94)  LDD1704  [2]
DBIA
 Probe Info  		C2595(1.03)  LDD0531  [3]
Acrolein
 Probe Info  		N.A.  LDD0233  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
IPM
 Probe Info  		C1662(0.00); C1801(0.00)  LDD0147  [6]
TFBX
 Probe Info  		C607(0.00); C1762(0.00)  LDD0148  [6]
YN-1
 Probe Info  		N.A.  LDD0447  [7]
Phosphinate-6
 Probe Info  		C607(0.00); C726(0.00)  LDD0018  [8]
AOyne
 Probe Info  		8.00  LDD0443  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C2595(1.03)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C475(1.13)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C607(1.10); C475(1.07)  LDD1509  [10]
 LDCM0230  AC113 HEK-293T C2595(0.90)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C2595(0.99)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C2595(0.80)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C2595(0.96)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C2595(0.85)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C2595(0.69)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C2595(0.65)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C475(1.01)  LDD1510  [10]
 LDCM0238  AC120 HEK-293T C2595(0.95)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C2595(0.72)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C2595(0.40)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C2595(0.41)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C2595(0.75)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C2595(0.50)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C2595(0.37)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C2595(0.38)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C2595(0.92)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C2595(1.04)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C2595(1.10)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C2595(0.86)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C2595(1.31)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C2595(0.85)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C2595(0.95)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C2595(0.97)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C2595(1.11)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C2595(0.54)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C2595(0.45)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C2595(0.56)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C607(0.94); C475(1.04)  LDD1512  [10]
 LDCM0260  AC140 HEK-293T C2595(0.84)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C2595(0.55)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C2595(0.91)  LDD0860  [3]
 LDCM0263  AC143 HCT 116 C2595(1.19)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C2595(1.50)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C2595(1.31)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C2595(1.73)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C2595(1.28)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C2595(4.00)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C2595(2.86)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C475(1.06)  LDD1513  [10]
 LDCM0271  AC150 HCT 116 C2595(1.42)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C2595(1.23)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C2595(1.60)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C2595(2.33)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C2595(1.14)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C2595(1.54)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C2595(1.21)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C2595(1.58)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C2595(0.88)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C2595(0.71)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C2595(0.75)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C2595(1.26)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C2595(0.85)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C2595(0.79)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C2595(0.77)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C2595(0.72)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C2595(0.73)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C2595(2.04)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C2595(1.45)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C2595(1.27)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C2595(2.51)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C2595(1.89)  LDD0887  [3]
 LDCM0290  AC3 HCT 116 C2595(1.48)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C2595(1.15)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C2595(1.82)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C2595(1.57)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C2595(2.12)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C2595(2.41)  LDD0893  [3]
 LDCM0296  AC35 HCT 116 C2595(1.29)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C2595(0.78)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C2595(1.04)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C2595(1.03)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C2595(0.71)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C2595(1.42)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C2595(0.70)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C2595(1.26)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C2595(1.10)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C2595(0.92)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C2595(1.31)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C2595(0.77)  LDD0624  [3]
 LDCM0308  AC46 HEK-293T C2595(1.16)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C2595(0.78)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C2595(1.02)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C2595(1.10)  LDD0909  [3]
 LDCM0312  AC5 HCT 116 C2595(1.28)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C2595(1.23)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C2595(1.15)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C2595(1.14)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C2595(0.93)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C2595(1.18)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C2595(1.00)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C2595(1.04)  LDD0917  [3]
 LDCM0320  AC57 HEK-293T C2595(1.01)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C2595(1.15)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C2595(1.28)  LDD0920  [3]
 LDCM0323  AC6 HEK-293T C607(1.04); C475(1.14)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C2595(0.90)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C2595(0.87)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C2595(1.15)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C2595(1.24)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C2595(1.08)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C2595(0.74)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C2595(1.01)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C2595(0.79)  LDD0929  [3]
 LDCM0332  AC68 HCT 116 C2595(1.37)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C2595(1.30)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C475(1.01)  LDD1568  [10]
 LDCM0335  AC70 HCT 116 C2595(1.15)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C2595(1.11)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C2595(1.16)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C2595(1.13)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C2595(1.11)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C2595(1.33)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C2595(1.44)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C2595(1.18)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C2595(1.43)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C2595(1.19)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C2288(0.92)  LDD1569  [10]
 LDCM0346  AC80 HCT 116 C2595(1.64)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C2595(1.36)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C2595(1.15)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C2595(1.88)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C2595(1.58)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C2595(1.47)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C2595(1.90)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C2595(1.42)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C2595(1.55)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C2595(2.41)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C2595(1.68)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C2595(1.98)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C2595(2.05)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C2595(1.25)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C2595(1.64)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C2595(1.80)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C2595(1.68)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C2595(1.47)  LDD0681  [3]
 LDCM0248  AKOS034007472 HEK-293T C607(0.97); C475(1.05); C2288(0.96); C1662(1.06)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C607(1.01); C475(1.11); C1239(0.91); C2288(1.03)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C2288(0.98)  LDD1514  [10]
 LDCM0020  ARS-1620 HCC44 C1662(1.05)  LDD2171  [3]
 LDCM0367  CL1 HCT 116 C2595(0.90)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C2595(0.87)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C2595(1.24)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C607(1.14)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C475(1.08)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C607(1.01); C475(1.10)  LDD1576  [10]
 LDCM0374  CL105 HCT 116 C2595(0.72)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C2595(0.81)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C2595(0.76)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C2595(0.81)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C2595(0.95)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C2595(0.88)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C2595(0.82)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C2595(0.81)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C2595(1.08)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C2595(1.99)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C2595(1.58)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C2595(1.84)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C2595(1.64)  LDD0984  [3]
 LDCM0387  CL117 HCT 116 C2595(0.46)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C2595(1.09)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C2595(1.14)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C2595(1.04)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C2595(0.86)  LDD0708  [3]
 LDCM0392  CL121 HEK-293T C2595(0.80)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C2595(1.11)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C2595(1.09)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C2595(1.00)  LDD0993  [3]
 LDCM0396  CL125 HEK-293T C2595(1.06)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C2595(0.59)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C2595(0.98)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C2595(0.90)  LDD0997  [3]
 LDCM0400  CL13 HCT 116 C2595(0.79)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C2595(0.84)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C2595(1.00)  LDD0719  [3]
 LDCM0404  CL17 HCT 116 C2595(1.04)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C2595(1.54)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C2595(0.80)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C2595(1.12)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C2595(1.18)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C2595(1.11)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C2595(1.43)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C2595(0.54)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C2595(1.04)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C2595(1.59)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C2595(0.80)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C2595(1.37)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C2595(1.91)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C2595(1.03)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C2595(0.82)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C2595(0.90)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C2595(0.93)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C2595(0.99)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C2595(1.18)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C2595(0.97)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C2595(1.19)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C2595(1.31)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C2595(1.28)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C2595(1.22)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C2595(1.35)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C2595(1.17)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C2595(1.19)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C2595(1.24)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C2595(1.36)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C2595(1.14)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C2595(0.86)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C607(0.90); C475(1.11)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C475(1.09)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C2288(0.89)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C607(1.11)  LDD1643  [10]
 LDCM0440  CL5 HCT 116 C2595(1.52)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C475(1.08)  LDD1645  [10]
 LDCM0444  CL53 HEK-293T C607(1.01); C475(1.11); C1239(1.06); C2288(0.98)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C475(0.96)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C607(0.99); C475(1.11)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C475(1.09)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C607(1.15); C475(1.17); C2288(1.11); C1662(1.07)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C607(0.95); C475(1.13)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C475(1.09)  LDD1653  [10]
 LDCM0451  CL6 HCT 116 C2595(0.74)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C2288(0.99)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C607(1.06)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C475(1.17)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C607(1.05); C475(1.11)  LDD1658  [10]
 LDCM0457  CL65 HEK-293T C607(1.03); C475(1.15); C1239(1.15); C2288(0.92)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C475(1.08)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C607(1.04); C475(1.17)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C475(0.98)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C607(0.91); C475(1.15); C2288(1.10); C1662(1.03)  LDD1664  [10]
 LDCM0462  CL7 HCT 116 C2595(0.57)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C607(1.00); C475(1.11)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C475(0.99)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C2288(0.99)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C607(1.11)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C475(1.12)  LDD1670  [10]
 LDCM0470  CL77 HEK-293T C607(1.12); C475(1.16); C1239(0.99); C2288(1.05)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C475(1.04)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C607(1.02); C475(1.02)  LDD1675  [10]
 LDCM0473  CL8 HCT 116 C2595(1.07)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C475(1.02)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C607(0.96); C475(1.08); C2288(0.92); C1662(1.00)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C607(0.97); C475(1.06)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C475(1.04)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C2288(0.91)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C607(1.13)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C475(1.47)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C607(1.04); C475(1.47)  LDD1684  [10]
 LDCM0483  CL89 HEK-293T C607(1.11); C475(1.20); C1239(0.89); C2288(1.19)  LDD1686  [10]
 LDCM0484  CL9 HCT 116 C2595(1.18)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C475(1.17)  LDD1688  [10]
 LDCM0486  CL91 HCT 116 C2595(1.46)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C2595(1.09)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C2595(0.90)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C2595(1.32)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C2595(1.42)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C2595(1.22)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C2595(1.37)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C2595(1.47)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C2595(1.11)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C607(1.13); C475(1.07)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C607(1.17); C475(1.13)  LDD1671  [10]
 LDCM0427  Fragment51 HCT 116 C2595(1.00)  LDD0744  [3]
 LDCM0022  KB02 HEK-293T C726(0.82); C475(0.96)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C726(1.12); C475(1.09)  LDD1497  [10]
 LDCM0024  KB05 HMCB C2240(1.56)  LDD3312  [11]
 LDCM0109  NEM HeLa N.A.  LDD0233  [4]
 LDCM0021  THZ1 HCT 116 C1662(1.05)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase NEDD4 (NEDD4) . P46934
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcriptional coactivator YAP1 (YAP1) YAP1 family P46937

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840