Details of the Target

General Information of Target

Target ID LDTP13465
Target Name Phosphatidylcholine transfer protein (PCTP)
Gene Name PCTP
Gene ID 58488
Synonyms
STARD2; Phosphatidylcholine transfer protein; PC-TP; START domain-containing protein 2; StARD2; StAR-related lipid transfer protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE
ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK
TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR
AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN
EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES
KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS
QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD
KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK
EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM
KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV
KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL
VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD
VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE
DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN
SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK
SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS
ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS
SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI
KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD
YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE
DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS
TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG
SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS
LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL
AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD
NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM
MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ
TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP
NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL
TQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE
SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK
TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK
KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK
CR
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule.
Uniprot ID
Q9UKL6
Ensemble ID
ENST00000268896.10
HGNC ID
HGNC:8752
ChEMBL ID
CHEMBL4523490

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MOLT4 SNV: p.S147F IA-alkyne    Probe Info 
SW1573 SNV: p.K55E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y54(11.29); Y84(23.06)  LDD3495  [1]
BTD
 Probe Info  		C207(0.51)  LDD2137  [2]
DBIA
 Probe Info  		C207(1.08)  LDD0532  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C93(1.23)  LDD0812  [3]
 LDCM0215  AC10 HCT 116 C207(1.08)  LDD0532  [3]
 LDCM0216  AC100 HEK-293T C207(0.99); C93(1.00)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C207(1.11); C93(1.04)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C207(1.04); C93(1.09)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C207(1.14); C93(1.17)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C207(1.06); C93(1.04)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C207(1.20); C93(0.97)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C207(1.36); C93(0.95)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C207(1.03); C93(0.86)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C207(1.03); C93(0.92)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C207(1.15); C93(0.92)  LDD0823  [3]
 LDCM0226  AC11 HCT 116 C207(1.03)  LDD0543  [3]
 LDCM0227  AC110 HEK-293T C207(1.30); C93(1.33)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C207(1.63); C93(1.59)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C207(1.35); C93(1.43)  LDD0827  [3]
 LDCM0230  AC113 HCT 116 C207(0.92)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C207(0.92)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C207(0.87)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C207(0.81)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C207(0.87)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C207(0.98)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C207(0.91)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C207(1.16)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C207(0.97)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C207(1.04)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C207(0.99)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C207(1.13)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C207(1.12)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C207(0.93)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C207(0.98)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C207(1.07)  LDD0562  [3]
 LDCM0246  AC128 HEK-293T C207(1.19); C93(0.93)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C207(0.90); C93(1.07)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C207(1.01); C93(1.20)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C207(1.29); C93(0.99)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C207(0.87); C93(1.05)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C207(0.95); C93(1.24)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C207(0.99); C93(1.16)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C207(0.96); C93(1.22)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C207(0.88); C93(1.10)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C207(1.02); C93(1.21)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C207(1.05); C93(1.49)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C207(1.05); C93(1.25)  LDD0856  [3]
 LDCM0259  AC14 HCT 116 C207(0.93)  LDD0576  [3]
 LDCM0260  AC140 HEK-293T C207(0.96); C93(1.17)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C207(1.08); C93(1.30)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C207(0.92); C93(1.12)  LDD0860  [3]
 LDCM0263  AC143 HCT 116 C207(0.71)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C207(0.90)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C207(0.79)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C207(1.08)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C207(0.99)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C207(0.75)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C207(0.97)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C207(1.03)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C207(1.10)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C207(0.97)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C207(1.19)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C207(0.81)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C207(0.87)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C207(0.90)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C207(1.13)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C207(0.90)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C93(1.50)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C93(1.28)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C93(1.25)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C93(1.19)  LDD0877  [3]
 LDCM0280  AC20 HEK-293T C93(1.56)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C93(1.49)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C93(1.51)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C93(1.81)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C93(1.21)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C93(1.26)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C93(1.33)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C93(1.21)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C93(1.48)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C93(1.26)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C93(1.04)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C93(1.19)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C93(1.03)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C93(1.26)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C93(1.16)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C93(1.09)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C93(1.05)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C93(1.15)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C93(1.13)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C93(1.14)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C93(1.17)  LDD0898  [3]
 LDCM0301  AC4 HEK-293T C93(1.13)  LDD0899  [3]
 LDCM0302  AC40 HEK-293T C93(1.07)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C93(1.24)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C93(1.07)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C93(1.21)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C93(1.26)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C93(1.16)  LDD0905  [3]
 LDCM0308  AC46 HCT 116 C207(1.05)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C207(0.93)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C207(0.98)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C207(0.97)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C93(1.08)  LDD0910  [3]
 LDCM0313  AC50 HCT 116 C207(0.92)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C207(0.94)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C207(1.03)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C207(1.02)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C207(0.97)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C207(1.15)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C207(0.96)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C207(1.13); C93(1.00)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C207(1.09); C93(1.00)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C207(0.98); C93(0.91)  LDD0920  [3]
 LDCM0323  AC6 HCT 116 C207(1.14)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C207(0.91); C93(0.98)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C207(0.76); C93(1.28)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C207(0.87); C93(1.07)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C207(0.72); C93(1.27)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C207(0.82); C93(1.00)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C207(0.80); C93(1.18)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C207(0.87); C93(0.98)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C207(0.76); C93(1.14)  LDD0929  [3]
 LDCM0332  AC68 HEK-293T C207(0.91); C93(1.01)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C207(0.82); C93(1.13)  LDD0931  [3]
 LDCM0334  AC7 HCT 116 C207(1.11)  LDD0651  [3]
 LDCM0335  AC70 HEK-293T C207(0.99); C93(1.45)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C207(1.00); C93(1.16)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C207(0.88); C93(1.18)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C207(0.99); C93(1.36)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C207(1.29); C93(1.23)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C207(1.04); C93(1.28)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C207(0.93); C93(1.20)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C207(0.89); C93(1.33)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C207(0.85); C93(1.39)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C207(0.88); C93(1.16)  LDD0942  [3]
 LDCM0345  AC8 HCT 116 C207(1.14)  LDD0662  [3]
 LDCM0346  AC80 HEK-293T C207(0.84); C93(1.32)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C207(0.82); C93(1.27)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C207(0.79); C93(1.76)  LDD0946  [3]
 LDCM0349  AC83 HCT 116 C207(1.17)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C207(1.06)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C207(1.14)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C207(1.16)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C207(1.17)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C207(1.06)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C207(1.07)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C207(1.19)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C207(0.96)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C207(1.03)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C207(1.13)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C207(1.47)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C207(1.21)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C207(1.16)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C207(1.12)  LDD0681  [3]
 LDCM0365  AC98 HEK-293T C207(1.13); C93(0.94)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C207(1.28); C93(0.90)  LDD0964  [3]
 LDCM0248  AKOS034007472 HCT 116 C207(1.02)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C207(1.07)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C207(1.10)  LDD0592  [3]
 LDCM0367  CL1 HEK-293T C93(0.93)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C93(1.85)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C93(1.40)  LDD0967  [3]
 LDCM0370  CL101 HCT 116 C207(1.09)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C207(1.21)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C207(1.11)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C207(1.05)  LDD0690  [3]
 LDCM0374  CL105 HEK-293T C93(1.22)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C93(1.41)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C93(1.32)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C93(1.30)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C93(1.15)  LDD0976  [3]
 LDCM0379  CL11 HEK-293T C93(2.03)  LDD0977  [3]
 LDCM0380  CL110 HEK-293T C93(1.19)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C93(1.09)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C93(1.26)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C93(1.09)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C93(1.53)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C93(1.29)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C93(1.39)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C93(1.10)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C93(1.12)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C93(1.21)  LDD0987  [3]
 LDCM0390  CL12 HEK-293T C93(1.13)  LDD0988  [3]
 LDCM0391  CL120 HEK-293T C93(1.21)  LDD0989  [3]
 LDCM0392  CL121 HCT 116 C207(1.02)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C207(1.05)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C207(0.91)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C207(1.04)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C207(0.93); C93(1.05)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C207(0.92); C93(1.21)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C207(1.08); C93(1.06)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C207(1.07); C93(0.99)  LDD0997  [3]
 LDCM0400  CL13 HEK-293T C93(1.17)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C93(1.09)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C93(1.28)  LDD1000  [3]
 LDCM0403  CL16 HEK-293T C93(0.94)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C93(0.94)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C93(0.98)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C93(1.05)  LDD1004  [3]
 LDCM0407  CL2 HEK-293T C93(1.19)  LDD1005  [3]
 LDCM0408  CL20 HEK-293T C93(0.99)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C93(1.18)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C93(1.05)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C93(1.02)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C93(1.04)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C93(1.08)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C93(1.12)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C93(1.01)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C93(0.93)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C93(1.01)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C93(1.20)  LDD1016  [3]
 LDCM0419  CL30 HEK-293T C93(1.38)  LDD1017  [3]
 LDCM0420  CL31 HEK-293T C93(1.14)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C93(1.41)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C93(1.29)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C93(1.20)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C93(1.31)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C93(1.39)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C93(1.28)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C93(1.96)  LDD1026  [3]
 LDCM0429  CL4 HEK-293T C93(1.08)  LDD1027  [3]
 LDCM0430  CL40 HEK-293T C93(1.28)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C93(1.90)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C93(1.81)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C93(1.83)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C93(1.39)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C93(1.68)  LDD1033  [3]
 LDCM0436  CL46 HEK-293T C93(1.15)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C93(1.31)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C93(1.07)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C93(1.08)  LDD1037  [3]
 LDCM0440  CL5 HEK-293T C93(1.33)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C93(1.56)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C93(1.22)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C93(0.91)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C93(1.08)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C93(1.09)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C93(1.03)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C93(0.99)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C93(1.08)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C93(0.99)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C93(1.24)  LDD1048  [3]
 LDCM0451  CL6 HEK-293T C93(1.19)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C93(1.57)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C93(1.09)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C93(1.32)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C93(1.39)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C93(1.02)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C93(1.22)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C93(1.21)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C93(1.19)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C93(1.28)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C93(1.11)  LDD1059  [3]
 LDCM0462  CL7 HEK-293T C93(1.26)  LDD1060  [3]
 LDCM0463  CL70 HEK-293T C93(1.08)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C93(1.42)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C93(1.00)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C93(1.14)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C93(1.88)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C93(1.14)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C93(1.13)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C93(1.12)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C93(1.22)  LDD1070  [3]
 LDCM0473  CL8 HEK-293T C93(1.02)  LDD1071  [3]
 LDCM0474  CL80 HEK-293T C93(1.16)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C93(1.17)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C93(1.07)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C93(1.20)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C93(1.18)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C93(1.15)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C93(1.28)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C93(1.13)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C93(1.18)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C93(1.18)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C93(0.87)  LDD1082  [3]
 LDCM0485  CL90 HEK-293T C93(1.04)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C93(1.11)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C93(1.14)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C93(1.19)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C93(1.52)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C93(1.50)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C93(1.23)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C93(1.11)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C93(1.29)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C93(1.16)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C93(0.90)  LDD1698  [6]
 LDCM0625  F8 Ramos C207(0.60)  LDD2187  [7]
 LDCM0572  Fragment10 Ramos C207(0.48)  LDD2189  [7]
 LDCM0573  Fragment11 Ramos C207(11.92)  LDD2190  [7]
 LDCM0574  Fragment12 Ramos C207(0.38)  LDD2191  [7]
 LDCM0575  Fragment13 Ramos C207(0.58)  LDD2192  [7]
 LDCM0576  Fragment14 Ramos C207(0.58)  LDD2193  [7]
 LDCM0579  Fragment20 Ramos C207(0.32)  LDD2194  [7]
 LDCM0580  Fragment21 Ramos C207(0.95)  LDD2195  [7]
 LDCM0582  Fragment23 Ramos C207(0.76)  LDD2196  [7]
 LDCM0578  Fragment27 Ramos C207(0.68)  LDD2197  [7]
 LDCM0586  Fragment28 Ramos C207(0.31)  LDD2198  [7]
 LDCM0588  Fragment30 Ramos C207(0.15)  LDD2199  [7]
 LDCM0590  Fragment32 Ramos C207(0.47)  LDD2201  [7]
 LDCM0468  Fragment33 HEK-293T C93(1.73)  LDD1066  [3]
 LDCM0596  Fragment38 Ramos C207(1.67)  LDD2203  [7]
 LDCM0566  Fragment4 Ramos C207(0.41)  LDD2184  [7]
 LDCM0427  Fragment51 HEK-293T C93(1.49)  LDD1025  [3]
 LDCM0610  Fragment52 Ramos C207(0.44)  LDD2204  [7]
 LDCM0614  Fragment56 Ramos C207(0.91)  LDD2205  [7]
 LDCM0569  Fragment7 Ramos C207(0.30)  LDD2186  [7]
 LDCM0571  Fragment9 Ramos C207(0.36)  LDD2188  [7]
 LDCM0022  KB02 HEK-293T C207(0.87); C93(0.94)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C207(0.95); C93(0.93)  LDD1497  [6]
 LDCM0024  KB05 OAW-42 C207(4.70)  LDD3369  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C207(0.51)  LDD2137  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Type-1 angiotensin II receptor-associated protein (AGTRAP) . Q6RW13

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Omega-3-carboxylic Acids . DB09568
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
L-dilinoleoyllecithin . DB04372
Palmitoyl-linoleoyl Phosphatidylcholine . DB02306

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840