Details of the Target

General Information of Target

Target ID LDTP13436
Target Name F-box only protein 3 (FBXO3)
Gene Name FBXO3
Gene ID 26273
Synonyms
FBX3; F-box only protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPDIIWVFPPQAEAEEDCHSDTVRADDDEENESPAETDLQAQLQMFRAQWMFELAPGVSS
SNLENRPCRAARGSLQKTSADTKGKQEQAKEEKARELFLKAVEEEQNGALYEAIKFYRRA
MQLVPDIEFKITYTRSPDGDGVGNSYIEDNDDDSKMADLLSYFQQQLTFQESVLKLCQPE
LESSQIHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLVCRGFYICARDPEIWRLACLKV
WGRSCIKLVPYTSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYI
RFFPDGHVMMLTTPEEPQSIVPRLRTRNTRTDAILLGHYRLSQDTDNQTKVFAVITKKKE
EKPLDYKYRYFRRVPVQEADQSFHVGLQLCSSGHQRFNKLIWIHHSCHITYKSTGETAVS
AFEIDKMYTPLFFARVRSYTAFSERPL
Target Type
Preclinical
Target Bioclass
Other
Subcellular location
Nucleus
Function
Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, SCF(FBXO3), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. The SCF(FBXO3) also acts as a regulator of inflammation by mediating ubiquitination and degradation of FBXL2 in response to lipopolysaccharide (LPS). The SCF(FBXO3) complex specifically recognizes FBXL2 phosphorylated at 'Thr-404' and promotes its ubiquitination.
TTD ID
T75819
Uniprot ID
Q9UK99
DrugMap ID
TTUX14L
Ensemble ID
ENST00000265651.8
HGNC ID
HGNC:13582

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NCIH2286 Deletion: p.I396FfsTer15 .
REH Deletion: p.K59NfsTer4 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0230  [1]
DBIA
 Probe Info  		C403(1.14)  LDD0532  [2]
IA-alkyne
 Probe Info  		C324(0.00); C136(0.00); C403(0.00); C225(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
AOyne
 Probe Info  		15.00  LDD0443  [4]
NAIA_5
 Probe Info  		C199(0.00); C193(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C225(1.50)  LDD1507  [6]
 LDCM0215  AC10 HCT 116 C403(1.14)  LDD0532  [2]
 LDCM0216  AC100 HEK-293T C403(1.05)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C403(0.97)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C403(0.91)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C403(0.83)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C403(0.90)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C403(1.34)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C403(1.08)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C403(0.74)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C403(1.09)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C403(0.88)  LDD0823  [2]
 LDCM0226  AC11 HCT 116 C403(1.40)  LDD0543  [2]
 LDCM0227  AC110 HEK-293T C403(0.70)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C403(0.74)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C403(0.70)  LDD0827  [2]
 LDCM0230  AC113 HCT 116 C225(0.95)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C225(0.98)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C225(1.03)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C225(0.70)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C225(1.44)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C225(1.29)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C225(1.14)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C403(1.22)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C225(0.66)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C225(0.54)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C225(1.01)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C225(0.76)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C225(0.70)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C225(1.02)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C225(1.14)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C225(1.02)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C403(0.74)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C403(0.30)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C403(0.37)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C403(0.59)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C403(0.37)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C403(0.28)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C403(0.25)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C403(0.41)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C403(0.37)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C403(0.34)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C403(0.34)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C403(0.33)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C403(1.45)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C403(0.30)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C403(0.30)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C403(0.32)  LDD0860  [2]
 LDCM0263  AC143 HEK-293T C403(1.88)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C403(0.66)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C403(0.68)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C403(0.62)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C403(0.72)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C403(0.68)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C403(0.72)  LDD0867  [2]
 LDCM0270  AC15 HCT 116 C403(1.15)  LDD0587  [2]
 LDCM0271  AC150 HEK-293T C403(0.67)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C403(0.62)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C403(0.69)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C403(0.70)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C403(0.68)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C403(0.77)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C403(0.62)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C403(0.64)  LDD2165  [2]
 LDCM0276  AC17 HEK-293T C225(1.00)  LDD1515  [6]
 LDCM0278  AC19 HEK-293T C225(1.10)  LDD1517  [6]
 LDCM0280  AC20 HEK-293T C225(1.30)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C225(1.18); C324(1.04)  LDD1520  [6]
 LDCM0283  AC23 HEK-293T C324(0.91)  LDD1522  [6]
 LDCM0285  AC25 HEK-293T C225(1.17)  LDD1524  [6]
 LDCM0287  AC27 HEK-293T C225(1.18)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C225(1.19)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C225(1.08); C324(1.06)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C225(0.95)  LDD1529  [6]
 LDCM0292  AC31 HEK-293T C324(0.84)  LDD1531  [6]
 LDCM0294  AC33 HEK-293T C225(1.01)  LDD1533  [6]
 LDCM0296  AC35 HEK-293T C225(0.94)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C225(1.29)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C225(1.04); C324(1.05)  LDD1537  [6]
 LDCM0300  AC39 HEK-293T C324(0.94)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C225(0.89)  LDD1540  [6]
 LDCM0303  AC41 HEK-293T C225(1.19)  LDD1542  [6]
 LDCM0305  AC43 HEK-293T C225(1.39)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C225(1.19)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C225(1.06); C324(1.15)  LDD1546  [6]
 LDCM0308  AC46 HCT 116 C403(0.95); C225(1.05)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C403(1.11); C225(1.19)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C403(1.08); C225(1.39)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C225(0.88); C403(0.90)  LDD0628  [2]
 LDCM0312  AC5 HEK-293T C225(1.16); C324(1.37)  LDD1551  [6]
 LDCM0313  AC50 HCT 116 C403(0.82); C225(1.07)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C403(0.82); C225(1.43)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C403(0.89); C225(1.28)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C403(0.88); C225(1.06)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C403(1.05); C225(1.07)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C225(0.91); C403(1.00)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C403(0.72); C225(0.74)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C403(0.92)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C403(1.00)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C403(0.78)  LDD0920  [2]
 LDCM0323  AC6 HCT 116 C403(0.90)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C403(0.94)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C403(0.97)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C403(0.98)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C403(1.06)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C403(1.08)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C403(0.97)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C403(0.97)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C403(0.95)  LDD0929  [2]
 LDCM0332  AC68 HCT 116 C225(0.81)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C225(1.10)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C403(0.94)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C225(1.07)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C225(1.08)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C225(1.41)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C225(1.19)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C225(1.28)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C225(1.07)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C225(1.13)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C225(1.04)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C225(1.21)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C225(1.07)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C403(0.93)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C225(1.23)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C225(1.15)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C225(0.95)  LDD0665  [2]
 LDCM0365  AC98 HEK-293T C403(0.99)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C403(1.34)  LDD0964  [2]
 LDCM0248  AKOS034007472 HCT 116 C403(1.28)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C403(1.26)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C403(0.97)  LDD0592  [2]
 LDCM0370  CL101 HCT 116 C403(0.95)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C403(1.02)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C403(1.20)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C403(0.92)  LDD0690  [2]
 LDCM0375  CL106 HEK-293T C225(0.94)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C324(0.95)  LDD1580  [6]
 LDCM0379  CL11 HEK-293T C324(0.86)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C225(0.95)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C324(1.21)  LDD1585  [6]
 LDCM0384  CL114 HEK-293T C225(1.00)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C324(0.93)  LDD1589  [6]
 LDCM0388  CL118 HEK-293T C225(1.01)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C324(1.05)  LDD1593  [6]
 LDCM0392  CL121 HCT 116 C225(0.82); C403(0.94)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C403(0.94); C225(1.24)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C403(0.79); C225(1.06)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C403(0.89); C225(1.07)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C403(0.96)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C403(0.83)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C403(0.79)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C403(0.82)  LDD0997  [2]
 LDCM0401  CL14 HEK-293T C225(1.16)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C324(0.79)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C403(1.08)  LDD1001  [2]
 LDCM0404  CL17 HCT 116 C403(0.71)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C403(0.81)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C403(0.86)  LDD0723  [2]
 LDCM0407  CL2 HEK-293T C225(0.99)  LDD1611  [6]
 LDCM0408  CL20 HCT 116 C403(0.88)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C403(0.65)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C403(0.72)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C403(0.84)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C403(0.90)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C403(0.70)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C403(0.88)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C403(0.90)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C403(0.78)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C403(0.80)  LDD0734  [2]
 LDCM0418  CL3 HEK-293T C324(0.97)  LDD1622  [6]
 LDCM0419  CL30 HCT 116 C403(0.87)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C225(0.58); C403(0.88)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C225(0.82); C403(1.14)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C225(0.95); C403(0.95)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C225(0.82); C403(0.94)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C225(0.86); C403(0.78)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C225(0.78); C403(0.88)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C225(0.79); C403(0.72)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C225(0.97); C403(0.88)  LDD0745  [2]
 LDCM0430  CL40 HCT 116 C225(0.60); C403(0.82)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C225(0.78); C403(0.94)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C225(0.80); C403(0.41)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C225(0.93); C403(0.70)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C225(0.76); C403(0.91)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C225(0.68); C403(0.80)  LDD0752  [2]
 LDCM0437  CL47 HEK-293T C324(0.77)  LDD1641  [6]
 LDCM0440  CL5 HEK-293T C225(0.72)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C225(0.97)  LDD1645  [6]
 LDCM0444  CL53 HEK-293T C225(0.95)  LDD1647  [6]
 LDCM0446  CL55 HEK-293T C225(1.22)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C225(1.44)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C225(0.97); C324(1.02)  LDD1651  [6]
 LDCM0450  CL59 HEK-293T C324(1.02)  LDD1653  [6]
 LDCM0454  CL62 HEK-293T C225(1.09)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C324(0.81)  LDD1658  [6]
 LDCM0457  CL65 HEK-293T C225(0.97)  LDD1660  [6]
 LDCM0459  CL67 HEK-293T C225(1.24)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C225(0.95)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C225(1.36); C324(1.08)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C225(1.13)  LDD1665  [6]
 LDCM0464  CL71 HEK-293T C324(0.89)  LDD1667  [6]
 LDCM0467  CL74 HEK-293T C225(1.03)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C403(0.72)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C403(0.56)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C403(0.44)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C403(0.40)  LDD1070  [2]
 LDCM0473  CL8 HEK-293T C225(0.75)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C403(0.71)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C403(0.41)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C403(0.56)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C403(0.63)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C403(0.40)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C403(0.45)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C403(0.42)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C403(0.47)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C403(0.51)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C403(0.61)  LDD1081  [2]
 LDCM0484  CL9 HEK-293T C225(0.99); C324(1.01)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C403(0.60)  LDD1083  [2]
 LDCM0486  CL91 HEK-293T C225(1.31)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C225(1.09)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C225(1.24); C324(1.09)  LDD1691  [6]
 LDCM0490  CL95 HEK-293T C324(0.78)  LDD1693  [6]
 LDCM0493  CL98 HEK-293T C225(1.25)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C324(0.86)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C324(0.96)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C324(0.99)  LDD1671  [6]
 LDCM0427  Fragment51 HCT 116 C225(0.62); C403(0.52)  LDD0744  [2]
 LDCM0022  KB02 697 C324(2.55)  LDD2245  [7]
 LDCM0023  KB03 697 C324(3.46)  LDD2662  [7]
 LDCM0024  KB05 G361 C324(4.04)  LDD3311  [7]
 LDCM0109  NEM HeLa N.A.  LDD0230  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cullin-1 (CUL1) Cullin family Q13616
S-phase kinase-associated protein 1 (SKP1) SKP1 family P63208

The Drug(s) Related To This Target

Preclinical
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bc-1215 Small molecular drug DA5RC6

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840