Details of the Target

General Information of Target

Target ID LDTP13060
Target Name Myelin expression factor 2 (MYEF2)
Gene Name MYEF2
Gene ID 50804
Synonyms
KIAA1341; Myelin expression factor 2; MEF-2; MyEF-2; MST156
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRVGAEYQARIPEFDPGATKYTDKDNGGMLVWSPYHSIPDAKLDEYIAIAKEKHGYNVEQ
ALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTI
ASLVKYYYSWKKTRSRTSLMDRQARKLANRHNQGDSDDDVEETHPMDGNDSDYDPKKEAK
KEGNTEQPVQTSKIGLGRREYQSLQHRHHSQRSKCRPPKGMYLTQEDVVAVSCSPNAANT
ILRQLDMELISLKRQVQNAKQVNSALKQKMEGGIEEFKPPESNQKINARWTTEEQLLAVQ
GVRKYGKDFQAIADVIGNKTVGQVKNFFVNYRRRFNLEEVLQEWEAEQGTQASNGDASTL
GEETKSASNVPSGKSTDEEEEAQTPQAPRTLGPSPPAPSSTPTPTAPIATLNQPPPLLRP
TLPAAPALHRQPPPLQQQARFIQPRPTLNQPPPPLIRPANSMPPRLNPRPVLSTVGGQQP
PSLIGIQTDSQSSLH
Target Bioclass
Other
Subcellular location
Nucleus
Function Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA.
Uniprot ID
Q9P2K5
Ensemble ID
ENST00000561151.1
HGNC ID
HGNC:17940

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.19  LDD0402  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
DBIA
 Probe Info  		C143(1.27)  LDD3310  [3]
BTD
 Probe Info  		C143(1.51)  LDD2104  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C546(0.00); C143(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C546(0.00); C143(0.00)  LDD0036  [5]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [6]
Lodoacetamide azide
 Probe Info  		C143(0.00); C546(0.00)  LDD0037  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
NAIA_5
 Probe Info  		C546(0.00); C564(0.00); C143(0.00)  LDD2223  [7]
HHS-465
 Probe Info  		N.A.  LDD2240  [8]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C310
 Probe Info  		7.67  LDD1977  [9]
C338
 Probe Info  		10.56  LDD2001  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C143(0.52)  LDD1093  [10]
 LDCM0215  AC10 PaTu 8988t C143(0.78)  LDD1094  [10]
 LDCM0216  AC100 PaTu 8988t C143(0.93)  LDD1095  [10]
 LDCM0217  AC101 PaTu 8988t C143(0.76)  LDD1096  [10]
 LDCM0218  AC102 PaTu 8988t C143(0.86)  LDD1097  [10]
 LDCM0219  AC103 PaTu 8988t C143(0.98)  LDD1098  [10]
 LDCM0220  AC104 PaTu 8988t C143(0.89)  LDD1099  [10]
 LDCM0221  AC105 PaTu 8988t C143(0.89)  LDD1100  [10]
 LDCM0222  AC106 PaTu 8988t C143(1.09)  LDD1101  [10]
 LDCM0223  AC107 PaTu 8988t C143(0.57)  LDD1102  [10]
 LDCM0224  AC108 PaTu 8988t C143(0.82)  LDD1103  [10]
 LDCM0225  AC109 PaTu 8988t C143(1.22)  LDD1104  [10]
 LDCM0226  AC11 PaTu 8988t C143(0.72)  LDD1105  [10]
 LDCM0227  AC110 PaTu 8988t C143(0.71)  LDD1106  [10]
 LDCM0228  AC111 PaTu 8988t C143(1.29)  LDD1107  [10]
 LDCM0229  AC112 PaTu 8988t C143(0.65)  LDD1108  [10]
 LDCM0230  AC113 PaTu 8988t C143(0.98)  LDD1109  [10]
 LDCM0231  AC114 PaTu 8988t C143(1.08)  LDD1110  [10]
 LDCM0232  AC115 PaTu 8988t C143(0.88)  LDD1111  [10]
 LDCM0233  AC116 PaTu 8988t C143(1.13)  LDD1112  [10]
 LDCM0234  AC117 PaTu 8988t C143(0.94)  LDD1113  [10]
 LDCM0235  AC118 PaTu 8988t C143(0.87)  LDD1114  [10]
 LDCM0236  AC119 PaTu 8988t C143(0.90)  LDD1115  [10]
 LDCM0237  AC12 PaTu 8988t C143(0.69)  LDD1116  [10]
 LDCM0238  AC120 PaTu 8988t C143(1.06)  LDD1117  [10]
 LDCM0239  AC121 PaTu 8988t C143(0.88)  LDD1118  [10]
 LDCM0240  AC122 PaTu 8988t C143(0.96)  LDD1119  [10]
 LDCM0241  AC123 PaTu 8988t C143(0.90)  LDD1120  [10]
 LDCM0242  AC124 PaTu 8988t C143(0.89)  LDD1121  [10]
 LDCM0243  AC125 PaTu 8988t C143(1.05)  LDD1122  [10]
 LDCM0244  AC126 PaTu 8988t C143(1.04)  LDD1123  [10]
 LDCM0245  AC127 PaTu 8988t C143(0.99)  LDD1124  [10]
 LDCM0246  AC128 PaTu 8988t C143(1.07)  LDD1125  [10]
 LDCM0247  AC129 PaTu 8988t C143(0.99)  LDD1126  [10]
 LDCM0249  AC130 PaTu 8988t C143(0.99)  LDD1128  [10]
 LDCM0250  AC131 PaTu 8988t C143(0.89)  LDD1129  [10]
 LDCM0251  AC132 PaTu 8988t C143(0.85)  LDD1130  [10]
 LDCM0252  AC133 PaTu 8988t C143(0.93)  LDD1131  [10]
 LDCM0253  AC134 PaTu 8988t C143(0.74)  LDD1132  [10]
 LDCM0254  AC135 PaTu 8988t C143(0.89)  LDD1133  [10]
 LDCM0255  AC136 PaTu 8988t C143(0.90)  LDD1134  [10]
 LDCM0256  AC137 PaTu 8988t C143(0.94)  LDD1135  [10]
 LDCM0257  AC138 PaTu 8988t C143(0.79)  LDD1136  [10]
 LDCM0258  AC139 PaTu 8988t C143(0.83)  LDD1137  [10]
 LDCM0259  AC14 PaTu 8988t C143(0.78)  LDD1138  [10]
 LDCM0260  AC140 PaTu 8988t C143(0.92)  LDD1139  [10]
 LDCM0261  AC141 PaTu 8988t C143(1.01)  LDD1140  [10]
 LDCM0262  AC142 PaTu 8988t C143(0.95)  LDD1141  [10]
 LDCM0263  AC143 PaTu 8988t C143(0.92)  LDD1142  [10]
 LDCM0264  AC144 PaTu 8988t C143(1.00)  LDD1143  [10]
 LDCM0265  AC145 PaTu 8988t C143(1.03)  LDD1144  [10]
 LDCM0266  AC146 PaTu 8988t C143(0.94)  LDD1145  [10]
 LDCM0267  AC147 PaTu 8988t C143(0.99)  LDD1146  [10]
 LDCM0268  AC148 PaTu 8988t C143(0.83)  LDD1147  [10]
 LDCM0269  AC149 PaTu 8988t C143(0.82)  LDD1148  [10]
 LDCM0270  AC15 PaTu 8988t C143(0.91)  LDD1149  [10]
 LDCM0271  AC150 PaTu 8988t C143(0.84)  LDD1150  [10]
 LDCM0272  AC151 PaTu 8988t C143(0.69)  LDD1151  [10]
 LDCM0273  AC152 PaTu 8988t C143(0.87)  LDD1152  [10]
 LDCM0274  AC153 PaTu 8988t C143(0.78)  LDD1153  [10]
 LDCM0621  AC154 PaTu 8988t C143(0.78)  LDD2166  [10]
 LDCM0622  AC155 PaTu 8988t C143(0.86)  LDD2167  [10]
 LDCM0623  AC156 PaTu 8988t C143(0.89)  LDD2168  [10]
 LDCM0624  AC157 PaTu 8988t C143(0.89)  LDD2169  [10]
 LDCM0276  AC17 PaTu 8988t C143(0.78)  LDD1155  [10]
 LDCM0277  AC18 PaTu 8988t C143(0.95)  LDD1156  [10]
 LDCM0278  AC19 PaTu 8988t C143(0.84)  LDD1157  [10]
 LDCM0279  AC2 PaTu 8988t C143(0.65)  LDD1158  [10]
 LDCM0280  AC20 PaTu 8988t C143(0.80)  LDD1159  [10]
 LDCM0281  AC21 PaTu 8988t C143(0.88)  LDD1160  [10]
 LDCM0282  AC22 PaTu 8988t C143(0.69)  LDD1161  [10]
 LDCM0283  AC23 PaTu 8988t C143(0.57)  LDD1162  [10]
 LDCM0284  AC24 PaTu 8988t C143(0.79)  LDD1163  [10]
 LDCM0285  AC25 PaTu 8988t C143(1.10)  LDD1164  [10]
 LDCM0286  AC26 PaTu 8988t C143(1.06)  LDD1165  [10]
 LDCM0287  AC27 PaTu 8988t C143(1.06)  LDD1166  [10]
 LDCM0288  AC28 PaTu 8988t C143(0.91)  LDD1167  [10]
 LDCM0289  AC29 PaTu 8988t C143(1.01)  LDD1168  [10]
 LDCM0290  AC3 PaTu 8988t C143(0.51)  LDD1169  [10]
 LDCM0291  AC30 PaTu 8988t C143(1.10)  LDD1170  [10]
 LDCM0292  AC31 PaTu 8988t C143(1.20)  LDD1171  [10]
 LDCM0293  AC32 PaTu 8988t C143(0.99)  LDD1172  [10]
 LDCM0294  AC33 PaTu 8988t C143(1.01)  LDD1173  [10]
 LDCM0295  AC34 PaTu 8988t C143(0.80)  LDD1174  [10]
 LDCM0296  AC35 PaTu 8988t C143(0.90)  LDD1175  [10]
 LDCM0297  AC36 PaTu 8988t C143(1.00)  LDD1176  [10]
 LDCM0298  AC37 PaTu 8988t C143(1.00)  LDD1177  [10]
 LDCM0299  AC38 PaTu 8988t C143(1.12)  LDD1178  [10]
 LDCM0300  AC39 PaTu 8988t C143(1.14)  LDD1179  [10]
 LDCM0301  AC4 PaTu 8988t C143(0.59)  LDD1180  [10]
 LDCM0302  AC40 PaTu 8988t C143(1.00)  LDD1181  [10]
 LDCM0303  AC41 PaTu 8988t C143(1.00)  LDD1182  [10]
 LDCM0304  AC42 PaTu 8988t C143(1.08)  LDD1183  [10]
 LDCM0305  AC43 PaTu 8988t C143(0.92)  LDD1184  [10]
 LDCM0306  AC44 PaTu 8988t C143(0.95)  LDD1185  [10]
 LDCM0307  AC45 PaTu 8988t C143(1.01)  LDD1186  [10]
 LDCM0308  AC46 HEK-293T C143(1.14); C546(1.06)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C143(0.96); C546(1.01)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C143(1.13); C546(1.10)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C143(0.88); C546(1.04)  LDD1550  [11]
 LDCM0312  AC5 PaTu 8988t C143(0.52)  LDD1191  [10]
 LDCM0313  AC50 HEK-293T C143(0.92); C546(1.14)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C143(1.04); C546(1.00)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C143(0.79); C546(1.03)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C143(0.92); C546(1.02)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C143(1.03); C546(1.07)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C143(0.97); C546(0.93)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C143(1.02); C546(1.09)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C143(0.85); C546(0.92)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C143(0.92); C546(1.05)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C143(1.06); C546(1.04)  LDD1561  [11]
 LDCM0323  AC6 PaTu 8988t C143(0.90)  LDD1202  [10]
 LDCM0324  AC60 HEK-293T C143(0.86); C546(1.04)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C143(0.82); C546(0.96)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C143(0.98); C546(0.97)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C143(0.96); C546(0.95)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C143(0.97); C546(1.13)  LDD1567  [11]
 LDCM0332  AC68 PaTu 8988t C143(0.72)  LDD1211  [10]
 LDCM0333  AC69 PaTu 8988t C143(0.87)  LDD1212  [10]
 LDCM0334  AC7 PaTu 8988t C143(1.05)  LDD1213  [10]
 LDCM0335  AC70 PaTu 8988t C143(0.83)  LDD1214  [10]
 LDCM0336  AC71 PaTu 8988t C143(0.71)  LDD1215  [10]
 LDCM0337  AC72 PaTu 8988t C143(0.67)  LDD1216  [10]
 LDCM0338  AC73 PaTu 8988t C143(0.75)  LDD1217  [10]
 LDCM0339  AC74 PaTu 8988t C143(0.92)  LDD1218  [10]
 LDCM0340  AC75 PaTu 8988t C143(0.81)  LDD1219  [10]
 LDCM0341  AC76 PaTu 8988t C143(0.85)  LDD1220  [10]
 LDCM0342  AC77 PaTu 8988t C143(0.82)  LDD1221  [10]
 LDCM0343  AC78 PaTu 8988t C143(0.90)  LDD1222  [10]
 LDCM0344  AC79 PaTu 8988t C143(0.68)  LDD1223  [10]
 LDCM0345  AC8 PaTu 8988t C143(1.18)  LDD1224  [10]
 LDCM0346  AC80 PaTu 8988t C143(0.83)  LDD1225  [10]
 LDCM0347  AC81 PaTu 8988t C143(0.64)  LDD1226  [10]
 LDCM0348  AC82 PaTu 8988t C143(0.84)  LDD1227  [10]
 LDCM0365  AC98 PaTu 8988t C143(0.73)  LDD1244  [10]
 LDCM0366  AC99 PaTu 8988t C143(0.94)  LDD1245  [10]
 LDCM0248  AKOS034007472 PaTu 8988t C143(0.74)  LDD1127  [10]
 LDCM0356  AKOS034007680 PaTu 8988t C143(0.87)  LDD1235  [10]
 LDCM0275  AKOS034007705 PaTu 8988t C143(1.20)  LDD1154  [10]
 LDCM0156  Aniline NCI-H1299 12.76  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C564(0.63)  LDD2227  [7]
 LDCM0367  CL1 PaTu 8988t C143(1.03)  LDD1246  [10]
 LDCM0368  CL10 PaTu 8988t C143(0.89)  LDD1247  [10]
 LDCM0369  CL100 PaTu 8988t C143(0.52)  LDD1248  [10]
 LDCM0370  CL101 PaTu 8988t C143(0.90)  LDD1249  [10]
 LDCM0371  CL102 PaTu 8988t C143(0.85)  LDD1250  [10]
 LDCM0372  CL103 PaTu 8988t C143(0.77)  LDD1251  [10]
 LDCM0373  CL104 PaTu 8988t C143(0.95)  LDD1252  [10]
 LDCM0374  CL105 PaTu 8988t C143(0.74)  LDD1253  [10]
 LDCM0375  CL106 PaTu 8988t C143(0.70)  LDD1254  [10]
 LDCM0376  CL107 PaTu 8988t C143(0.74)  LDD1255  [10]
 LDCM0377  CL108 PaTu 8988t C143(0.60)  LDD1256  [10]
 LDCM0378  CL109 PaTu 8988t C143(0.64)  LDD1257  [10]
 LDCM0379  CL11 PaTu 8988t C143(1.08)  LDD1258  [10]
 LDCM0380  CL110 PaTu 8988t C143(0.71)  LDD1259  [10]
 LDCM0381  CL111 PaTu 8988t C143(0.62)  LDD1260  [10]
 LDCM0382  CL112 PaTu 8988t C143(1.11)  LDD1261  [10]
 LDCM0383  CL113 PaTu 8988t C143(1.05)  LDD1262  [10]
 LDCM0384  CL114 PaTu 8988t C143(1.07)  LDD1263  [10]
 LDCM0385  CL115 PaTu 8988t C143(1.12)  LDD1264  [10]
 LDCM0386  CL116 PaTu 8988t C143(1.24)  LDD1265  [10]
 LDCM0387  CL117 PaTu 8988t C143(1.12)  LDD1266  [10]
 LDCM0388  CL118 PaTu 8988t C143(0.92)  LDD1267  [10]
 LDCM0389  CL119 PaTu 8988t C143(1.01)  LDD1268  [10]
 LDCM0390  CL12 PaTu 8988t C143(1.00)  LDD1269  [10]
 LDCM0391  CL120 PaTu 8988t C143(0.96)  LDD1270  [10]
 LDCM0392  CL121 HEK-293T C143(0.93); C546(0.92)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C143(1.06); C546(1.01)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C143(0.92); C546(1.03)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C143(1.00); C546(1.07)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C143(0.85); C546(0.88)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C143(1.06); C546(0.87)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C143(1.06); C546(0.98)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C143(0.98); C546(0.92)  LDD1603  [11]
 LDCM0400  CL13 PaTu 8988t C143(0.90)  LDD1279  [10]
 LDCM0401  CL14 PaTu 8988t C143(0.88)  LDD1280  [10]
 LDCM0402  CL15 PaTu 8988t C143(0.79)  LDD1281  [10]
 LDCM0403  CL16 PaTu 8988t C143(0.91)  LDD1282  [10]
 LDCM0404  CL17 PaTu 8988t C143(0.94)  LDD1283  [10]
 LDCM0405  CL18 PaTu 8988t C143(0.92)  LDD1284  [10]
 LDCM0406  CL19 PaTu 8988t C143(0.96)  LDD1285  [10]
 LDCM0407  CL2 PaTu 8988t C143(0.84)  LDD1286  [10]
 LDCM0408  CL20 PaTu 8988t C143(1.01)  LDD1287  [10]
 LDCM0409  CL21 PaTu 8988t C143(0.89)  LDD1288  [10]
 LDCM0410  CL22 PaTu 8988t C143(0.86)  LDD1289  [10]
 LDCM0411  CL23 PaTu 8988t C143(0.96)  LDD1290  [10]
 LDCM0412  CL24 PaTu 8988t C143(1.07)  LDD1291  [10]
 LDCM0413  CL25 PaTu 8988t C143(1.12)  LDD1292  [10]
 LDCM0414  CL26 PaTu 8988t C143(0.86)  LDD1293  [10]
 LDCM0415  CL27 PaTu 8988t C143(0.94)  LDD1294  [10]
 LDCM0416  CL28 PaTu 8988t C143(1.10)  LDD1295  [10]
 LDCM0417  CL29 PaTu 8988t C143(0.88)  LDD1296  [10]
 LDCM0418  CL3 PaTu 8988t C143(1.04)  LDD1297  [10]
 LDCM0419  CL30 PaTu 8988t C143(0.96)  LDD1298  [10]
 LDCM0420  CL31 PaTu 8988t C143(0.93)  LDD1299  [10]
 LDCM0421  CL32 PaTu 8988t C143(1.06)  LDD1300  [10]
 LDCM0422  CL33 PaTu 8988t C143(0.83)  LDD1301  [10]
 LDCM0423  CL34 PaTu 8988t C143(1.02)  LDD1302  [10]
 LDCM0424  CL35 PaTu 8988t C143(1.07)  LDD1303  [10]
 LDCM0425  CL36 PaTu 8988t C143(0.28)  LDD1304  [10]
 LDCM0426  CL37 PaTu 8988t C143(0.86)  LDD1305  [10]
 LDCM0428  CL39 PaTu 8988t C143(1.05)  LDD1307  [10]
 LDCM0429  CL4 PaTu 8988t C143(1.08)  LDD1308  [10]
 LDCM0430  CL40 PaTu 8988t C143(0.94)  LDD1309  [10]
 LDCM0431  CL41 PaTu 8988t C143(0.93)  LDD1310  [10]
 LDCM0432  CL42 PaTu 8988t C143(1.01)  LDD1311  [10]
 LDCM0433  CL43 PaTu 8988t C143(0.98)  LDD1312  [10]
 LDCM0434  CL44 PaTu 8988t C143(1.05)  LDD1313  [10]
 LDCM0435  CL45 PaTu 8988t C143(0.84)  LDD1314  [10]
 LDCM0436  CL46 PaTu 8988t C143(0.99)  LDD1315  [10]
 LDCM0437  CL47 PaTu 8988t C143(0.99)  LDD1316  [10]
 LDCM0438  CL48 PaTu 8988t C143(0.93)  LDD1317  [10]
 LDCM0439  CL49 PaTu 8988t C143(1.06)  LDD1318  [10]
 LDCM0440  CL5 PaTu 8988t C143(0.81)  LDD1319  [10]
 LDCM0441  CL50 PaTu 8988t C143(0.92)  LDD1320  [10]
 LDCM0442  CL51 PaTu 8988t C143(1.07)  LDD1321  [10]
 LDCM0443  CL52 PaTu 8988t C143(0.98)  LDD1322  [10]
 LDCM0444  CL53 PaTu 8988t C143(1.04)  LDD1323  [10]
 LDCM0445  CL54 PaTu 8988t C143(0.95)  LDD1324  [10]
 LDCM0446  CL55 PaTu 8988t C143(0.97)  LDD1325  [10]
 LDCM0447  CL56 PaTu 8988t C143(0.72)  LDD1326  [10]
 LDCM0448  CL57 PaTu 8988t C143(0.81)  LDD1327  [10]
 LDCM0449  CL58 PaTu 8988t C143(0.90)  LDD1328  [10]
 LDCM0450  CL59 PaTu 8988t C143(0.83)  LDD1329  [10]
 LDCM0451  CL6 PaTu 8988t C143(0.82)  LDD1330  [10]
 LDCM0452  CL60 PaTu 8988t C143(0.85)  LDD1331  [10]
 LDCM0453  CL61 PaTu 8988t C143(1.13)  LDD1332  [10]
 LDCM0454  CL62 PaTu 8988t C143(1.17)  LDD1333  [10]
 LDCM0455  CL63 PaTu 8988t C143(1.10)  LDD1334  [10]
 LDCM0456  CL64 PaTu 8988t C143(0.96)  LDD1335  [10]
 LDCM0457  CL65 PaTu 8988t C143(1.27)  LDD1336  [10]
 LDCM0458  CL66 PaTu 8988t C143(1.02)  LDD1337  [10]
 LDCM0459  CL67 PaTu 8988t C143(0.98)  LDD1338  [10]
 LDCM0460  CL68 PaTu 8988t C143(1.17)  LDD1339  [10]
 LDCM0461  CL69 PaTu 8988t C143(0.96)  LDD1340  [10]
 LDCM0462  CL7 PaTu 8988t C143(0.83)  LDD1341  [10]
 LDCM0463  CL70 PaTu 8988t C143(1.16)  LDD1342  [10]
 LDCM0464  CL71 PaTu 8988t C143(1.04)  LDD1343  [10]
 LDCM0465  CL72 PaTu 8988t C143(1.21)  LDD1344  [10]
 LDCM0466  CL73 PaTu 8988t C143(1.08)  LDD1345  [10]
 LDCM0467  CL74 PaTu 8988t C143(1.15)  LDD1346  [10]
 LDCM0469  CL76 HEK-293T C143(1.04); C546(1.20)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C143(0.84); C546(0.85)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C143(1.13); C546(1.06)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C143(1.28); C546(1.01)  LDD1675  [11]
 LDCM0473  CL8 PaTu 8988t C143(0.93)  LDD1352  [10]
 LDCM0474  CL80 HEK-293T C143(1.10); C546(0.96)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C143(1.43); C546(0.92)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C143(1.00); C546(0.97)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C143(1.45); C546(0.85)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C143(1.55); C546(0.86)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C143(0.86); C546(0.89)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C143(1.11); C546(0.94)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C143(1.12); C546(1.04)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C143(1.02); C546(0.93)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C143(0.89); C546(0.86)  LDD1686  [11]
 LDCM0484  CL9 PaTu 8988t C143(0.86)  LDD1363  [10]
 LDCM0485  CL90 HEK-293T C143(0.76); C546(0.79)  LDD1688  [11]
 LDCM0486  CL91 PaTu 8988t C143(0.55)  LDD1365  [10]
 LDCM0487  CL92 PaTu 8988t C143(0.52)  LDD1366  [10]
 LDCM0488  CL93 PaTu 8988t C143(0.53)  LDD1367  [10]
 LDCM0489  CL94 PaTu 8988t C143(0.25)  LDD1368  [10]
 LDCM0490  CL95 PaTu 8988t C143(0.44)  LDD1369  [10]
 LDCM0491  CL96 PaTu 8988t C143(0.67)  LDD1370  [10]
 LDCM0492  CL97 PaTu 8988t C143(0.64)  LDD1371  [10]
 LDCM0493  CL98 PaTu 8988t C143(0.58)  LDD1372  [10]
 LDCM0494  CL99 PaTu 8988t C143(0.61)  LDD1373  [10]
 LDCM0495  E2913 HEK-293T C143(1.09); C546(1.20)  LDD1698  [11]
 LDCM0468  Fragment33 PaTu 8988t C143(0.90)  LDD1347  [10]
 LDCM0427  Fragment51 PaTu 8988t C143(1.10)  LDD1306  [10]
 LDCM0022  KB02 HEK-293T C143(0.94); C546(1.07)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C143(1.03); C546(1.06)  LDD1497  [11]
 LDCM0024  KB05 COLO792 C143(1.27)  LDD3310  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C143(1.51)  LDD2104  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C564(0.91)  LDD2120  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C564(0.78)  LDD2128  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C564(1.01)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C564(1.29)  LDD2144  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Conserved oligomeric Golgi complex subunit 8 (COG8) COG8 family Q96MW5
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Protein Mis18-beta (OIP5) Mis18 family O43482
Testis-expressed protein 11 (TEX11) SPO22 family Q8IYF3
Puratrophin-1 (PLEKHG4) . Q58EX7
TNF receptor-associated factor 1 (TRAF1) . Q13077

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402