Details of the Target

General Information of Target

Target ID LDTP12888
Target Name WW domain-containing oxidoreductase (WWOX)
Gene Name WWOX
Gene ID 51741
Synonyms
FOR; SDR41C1; WOX1; WW domain-containing oxidoreductase; EC 1.1.1.-; Fragile site FRA16D oxidoreductase; Short chain dehydrogenase/reductase family 41C member 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MILEGGGVMNLNPGNNLLHQPPAWTDSYSTCNVSSGFFGGQWHEIHPQYWTKYQVWEWLQ
HLLDTNQLDANCIPFQEFDINGEHLCSMSLQEFTRAAGTAGQLLYSNLQHLKWNGQCSSD
LFQSTHNVIVKTEQTEPSIMNTWKDENYLYDTNYGSTVDLLDSKTFCRAQISMTTTSHLP
VAESPDMKKEQDPPAKCHTKKHNPRGTHLWEFIRDILLNPDKNPGLIKWEDRSEGVFRFL
KSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNARGWRENEN
Target Bioclass
Enzyme
Family
Short-chain dehydrogenases/reductases (SDR) family
Subcellular location
Cytoplasm
Function
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
Uniprot ID
Q9NZC7
Ensemble ID
ENST00000355860.7
HGNC ID
HGNC:12799

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A101D SNV: p.D58H .
AN3CA SNV: p.A145V .
JURKAT SNV: p.P101S .
KU1919 SNV: p.V321G .
KYSE410 SNV: p.N285K; p.A289S DBIA    Probe Info 
NCIH1944 SNV: p.Q244R .
OCIAML2 SNV: p.P217S DBIA    Probe Info 
RKO SNV: p.A394V .
WM793 SNV: p.D270N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C382(5.72)  LDD0204  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [2]
NAIA_5
 Probe Info  		C382(0.00); C299(0.00); C155(0.00)  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C382(0.96)  LDD1093  [4]
 LDCM0215  AC10 HEK-293T C382(0.95)  LDD0813  [4]
 LDCM0216  AC100 PaTu 8988t C382(1.20)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C382(1.14)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C382(0.94)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C382(1.20)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C382(0.95)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C382(1.37)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C382(1.26)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C382(1.10)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C382(1.26)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C382(1.33)  LDD1104  [4]
 LDCM0226  AC11 HEK-293T C382(0.92)  LDD0824  [4]
 LDCM0227  AC110 PaTu 8988t C382(1.21)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C382(1.39)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C382(1.00)  LDD1108  [4]
 LDCM0230  AC113 HEK-293T C382(1.16)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C382(0.82)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C382(0.96)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C382(0.93)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C382(0.83)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C382(1.03)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C382(0.92)  LDD0834  [4]
 LDCM0237  AC12 HEK-293T C382(0.96)  LDD0835  [4]
 LDCM0238  AC120 HEK-293T C382(0.82)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C382(0.97)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C382(0.82)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C382(0.82)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C382(1.01)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C382(0.90)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C382(0.72)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C382(0.91)  LDD0843  [4]
 LDCM0246  AC128 PaTu 8988t C382(1.44)  LDD1125  [4]
 LDCM0247  AC129 PaTu 8988t C382(1.33)  LDD1126  [4]
 LDCM0249  AC130 PaTu 8988t C382(1.34)  LDD1128  [4]
 LDCM0250  AC131 PaTu 8988t C382(1.31)  LDD1129  [4]
 LDCM0251  AC132 PaTu 8988t C382(1.10)  LDD1130  [4]
 LDCM0252  AC133 PaTu 8988t C382(1.06)  LDD1131  [4]
 LDCM0253  AC134 PaTu 8988t C382(1.08)  LDD1132  [4]
 LDCM0254  AC135 PaTu 8988t C382(1.39)  LDD1133  [4]
 LDCM0255  AC136 PaTu 8988t C382(1.46)  LDD1134  [4]
 LDCM0256  AC137 PaTu 8988t C382(1.43)  LDD1135  [4]
 LDCM0257  AC138 PaTu 8988t C382(1.23)  LDD1136  [4]
 LDCM0258  AC139 PaTu 8988t C382(1.42)  LDD1137  [4]
 LDCM0259  AC14 HEK-293T C382(0.94)  LDD0857  [4]
 LDCM0260  AC140 PaTu 8988t C382(1.35)  LDD1139  [4]
 LDCM0261  AC141 PaTu 8988t C382(1.41)  LDD1140  [4]
 LDCM0262  AC142 PaTu 8988t C382(1.41)  LDD1141  [4]
 LDCM0263  AC143 HEK-293T C382(0.98)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C382(0.67)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C382(0.53)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C382(0.53)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C382(0.71)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C382(0.92)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C382(0.81)  LDD0867  [4]
 LDCM0270  AC15 HEK-293T C382(0.81)  LDD0868  [4]
 LDCM0271  AC150 HEK-293T C382(0.86)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C382(0.87)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C382(0.71)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C382(0.71)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C382(0.78)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C382(0.73)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C382(0.59)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C382(0.68)  LDD2165  [4]
 LDCM0276  AC17 PaTu 8988t C382(0.96)  LDD1155  [4]
 LDCM0277  AC18 PaTu 8988t C382(1.06)  LDD1156  [4]
 LDCM0278  AC19 PaTu 8988t C382(1.02)  LDD1157  [4]
 LDCM0279  AC2 PaTu 8988t C382(0.96)  LDD1158  [4]
 LDCM0280  AC20 PaTu 8988t C382(1.15)  LDD1159  [4]
 LDCM0281  AC21 PaTu 8988t C382(1.00)  LDD1160  [4]
 LDCM0282  AC22 PaTu 8988t C382(0.98)  LDD1161  [4]
 LDCM0283  AC23 PaTu 8988t C382(1.07)  LDD1162  [4]
 LDCM0284  AC24 PaTu 8988t C382(0.93)  LDD1163  [4]
 LDCM0285  AC25 PaTu 8988t C382(0.97)  LDD1164  [4]
 LDCM0286  AC26 PaTu 8988t C382(0.97)  LDD1165  [4]
 LDCM0287  AC27 PaTu 8988t C382(1.14)  LDD1166  [4]
 LDCM0288  AC28 PaTu 8988t C382(1.19)  LDD1167  [4]
 LDCM0289  AC29 PaTu 8988t C382(1.12)  LDD1168  [4]
 LDCM0290  AC3 PaTu 8988t C382(0.99)  LDD1169  [4]
 LDCM0291  AC30 PaTu 8988t C382(1.16)  LDD1170  [4]
 LDCM0292  AC31 PaTu 8988t C382(0.92)  LDD1171  [4]
 LDCM0293  AC32 PaTu 8988t C382(1.11)  LDD1172  [4]
 LDCM0294  AC33 PaTu 8988t C382(1.20)  LDD1173  [4]
 LDCM0295  AC34 PaTu 8988t C382(1.21)  LDD1174  [4]
 LDCM0296  AC35 HEK-293T C382(1.41)  LDD0894  [4]
 LDCM0297  AC36 HEK-293T C382(1.17)  LDD0895  [4]
 LDCM0298  AC37 HEK-293T C382(1.23)  LDD0896  [4]
 LDCM0299  AC38 HEK-293T C382(1.23)  LDD0897  [4]
 LDCM0300  AC39 HEK-293T C382(1.24)  LDD0898  [4]
 LDCM0301  AC4 PaTu 8988t C382(0.85)  LDD1180  [4]
 LDCM0302  AC40 HEK-293T C382(1.13)  LDD0900  [4]
 LDCM0303  AC41 HEK-293T C382(1.13)  LDD0901  [4]
 LDCM0304  AC42 HEK-293T C382(1.05)  LDD0902  [4]
 LDCM0305  AC43 HEK-293T C382(1.08)  LDD0903  [4]
 LDCM0306  AC44 HEK-293T C382(0.97)  LDD0904  [4]
 LDCM0307  AC45 HEK-293T C382(1.03)  LDD0905  [4]
 LDCM0308  AC46 PaTu 8988t C382(1.45)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C382(1.64)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C382(1.39)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C382(1.53)  LDD1190  [4]
 LDCM0312  AC5 PaTu 8988t C382(0.83)  LDD1191  [4]
 LDCM0313  AC50 PaTu 8988t C382(1.68)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C382(0.47)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C382(1.32)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C382(1.97)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C382(2.06)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C382(1.29)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C382(1.32)  LDD1198  [4]
 LDCM0320  AC57 HEK-293T C382(0.95); C209(0.96); C380(0.84)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C382(0.93); C209(1.04); C299(0.98)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C382(0.78); C209(0.88)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C382(0.77)  LDD0921  [4]
 LDCM0324  AC60 HEK-293T C382(0.89); C380(1.02)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C382(1.18); C209(0.93); C380(0.80)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C382(0.91); C209(1.04); C380(1.29)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C382(1.03); C209(1.13); C380(0.98)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C382(1.03); C209(1.12)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C382(0.95)  LDD0932  [4]
 LDCM0345  AC8 HEK-293T C382(0.71)  LDD0943  [4]
 LDCM0365  AC98 PaTu 8988t C382(1.15)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C382(1.34)  LDD1245  [4]
 LDCM0248  AKOS034007472 HEK-293T C382(1.01)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C382(0.83)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C382(0.84)  LDD0873  [4]
 LDCM0102  BDHI 8 Jurkat C382(5.72)  LDD0204  [1]
 LDCM0367  CL1 HEK-293T C382(1.04); C209(0.98); C299(1.04)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C382(1.26); C209(0.81); C380(1.26)  LDD1572  [5]
 LDCM0369  CL100 PaTu 8988t C382(0.72)  LDD1248  [4]
 LDCM0370  CL101 HEK-293T C382(0.70)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C382(0.86)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C382(0.76)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C382(0.77)  LDD0971  [4]
 LDCM0374  CL105 PaTu 8988t C382(0.84)  LDD1253  [4]
 LDCM0375  CL106 PaTu 8988t C382(0.78)  LDD1254  [4]
 LDCM0376  CL107 PaTu 8988t C382(0.89)  LDD1255  [4]
 LDCM0377  CL108 PaTu 8988t C382(0.92)  LDD1256  [4]
 LDCM0378  CL109 PaTu 8988t C382(1.06)  LDD1257  [4]
 LDCM0379  CL11 HEK-293T C382(1.12); C209(0.73); C380(0.92)  LDD1583  [5]
 LDCM0380  CL110 PaTu 8988t C382(1.00)  LDD1259  [4]
 LDCM0381  CL111 PaTu 8988t C382(1.02)  LDD1260  [4]
 LDCM0382  CL112 PaTu 8988t C382(0.91)  LDD1261  [4]
 LDCM0383  CL113 PaTu 8988t C382(0.91)  LDD1262  [4]
 LDCM0384  CL114 PaTu 8988t C382(0.97)  LDD1263  [4]
 LDCM0385  CL115 PaTu 8988t C382(1.00)  LDD1264  [4]
 LDCM0386  CL116 PaTu 8988t C382(0.92)  LDD1265  [4]
 LDCM0387  CL117 HEK-293T C382(1.32)  LDD0985  [4]
 LDCM0388  CL118 HEK-293T C382(1.39)  LDD0986  [4]
 LDCM0389  CL119 HEK-293T C382(0.93)  LDD0987  [4]
 LDCM0390  CL12 HEK-293T C382(1.06); C209(0.95)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C382(1.09)  LDD0989  [4]
 LDCM0392  CL121 PaTu 8988t C382(1.56)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C382(1.43)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C382(1.52)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C382(1.55)  LDD1274  [4]
 LDCM0396  CL125 HEK-293T C382(0.94); C209(1.00); C299(1.16)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C382(0.94); C209(1.16)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C382(0.94); C209(1.16); C299(1.11)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C382(1.03)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C382(0.88); C209(1.04); C299(1.01)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C382(1.06); C209(1.14)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C382(1.42); C209(1.11); C299(1.34)  LDD1606  [5]
 LDCM0403  CL16 PaTu 8988t C382(1.00)  LDD1282  [4]
 LDCM0404  CL17 PaTu 8988t C382(1.05)  LDD1283  [4]
 LDCM0405  CL18 PaTu 8988t C382(0.89)  LDD1284  [4]
 LDCM0406  CL19 PaTu 8988t C382(0.94)  LDD1285  [4]
 LDCM0407  CL2 HEK-293T C382(0.79); C209(1.20)  LDD1611  [5]
 LDCM0408  CL20 PaTu 8988t C382(1.06)  LDD1287  [4]
 LDCM0409  CL21 PaTu 8988t C382(1.04)  LDD1288  [4]
 LDCM0410  CL22 PaTu 8988t C382(1.00)  LDD1289  [4]
 LDCM0411  CL23 PaTu 8988t C382(1.07)  LDD1290  [4]
 LDCM0412  CL24 PaTu 8988t C382(0.98)  LDD1291  [4]
 LDCM0413  CL25 PaTu 8988t C382(1.01)  LDD1292  [4]
 LDCM0414  CL26 PaTu 8988t C382(1.03)  LDD1293  [4]
 LDCM0415  CL27 PaTu 8988t C382(1.11)  LDD1294  [4]
 LDCM0416  CL28 PaTu 8988t C382(1.02)  LDD1295  [4]
 LDCM0417  CL29 PaTu 8988t C382(0.90)  LDD1296  [4]
 LDCM0418  CL3 HEK-293T C382(1.08); C209(1.16); C299(1.42)  LDD1622  [5]
 LDCM0419  CL30 PaTu 8988t C382(1.00)  LDD1298  [4]
 LDCM0420  CL31 PaTu 8988t C382(1.24)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C382(1.13)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C382(1.25)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C382(1.24)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C382(1.19)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C382(0.83)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C382(1.22)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C382(1.22)  LDD1307  [4]
 LDCM0429  CL4 HEK-293T C382(1.12)  LDD1633  [5]
 LDCM0430  CL40 PaTu 8988t C382(1.15)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C382(1.14)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C382(1.30)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C382(1.45)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C382(1.36)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C382(1.08)  LDD1314  [4]
 LDCM0436  CL46 HEK-293T C382(0.85)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C382(0.91)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C382(0.86)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C382(1.07)  LDD1037  [4]
 LDCM0440  CL5 HEK-293T C382(1.04); C209(1.41); C380(0.79)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C382(0.90)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C382(1.12)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C382(1.09)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C382(1.13)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C382(1.16)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C382(0.91)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C382(1.16)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C382(0.84)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C382(1.09)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C382(0.88)  LDD1048  [4]
 LDCM0451  CL6 HEK-293T C382(0.99); C209(0.98); C299(1.20)  LDD1654  [5]
 LDCM0452  CL60 HEK-293T C382(0.82)  LDD1050  [4]
 LDCM0453  CL61 PaTu 8988t C382(1.00)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C382(1.06)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C382(0.92)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C382(1.05)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C382(1.03)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C382(1.13)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C382(1.34)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C382(1.40)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C382(1.27)  LDD1340  [4]
 LDCM0462  CL7 HEK-293T C382(0.84); C209(0.82)  LDD1665  [5]
 LDCM0463  CL70 PaTu 8988t C382(1.29)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C382(0.93)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C382(0.91)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C382(1.25)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C382(0.98)  LDD1346  [4]
 LDCM0469  CL76 PaTu 8988t C382(1.24)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C382(1.13)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C382(1.39)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C382(1.30)  LDD1351  [4]
 LDCM0473  CL8 HEK-293T C382(1.68); C380(0.77)  LDD1676  [5]
 LDCM0474  CL80 PaTu 8988t C382(1.37)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C382(1.33)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C382(1.60)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C382(1.52)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C382(1.27)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C382(1.18)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C382(1.28)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C382(1.38)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C382(1.40)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C382(1.31)  LDD1362  [4]
 LDCM0484  CL9 HEK-293T C382(1.20); C209(0.92); C380(0.70)  LDD1687  [5]
 LDCM0485  CL90 PaTu 8988t C382(1.51)  LDD1364  [4]
 LDCM0486  CL91 PaTu 8988t C382(0.63)  LDD1365  [4]
 LDCM0487  CL92 PaTu 8988t C382(0.73)  LDD1366  [4]
 LDCM0488  CL93 PaTu 8988t C382(0.85)  LDD1367  [4]
 LDCM0489  CL94 PaTu 8988t C382(0.77)  LDD1368  [4]
 LDCM0490  CL95 PaTu 8988t C382(0.73)  LDD1369  [4]
 LDCM0491  CL96 PaTu 8988t C382(0.69)  LDD1370  [4]
 LDCM0492  CL97 PaTu 8988t C382(0.68)  LDD1371  [4]
 LDCM0493  CL98 PaTu 8988t C382(0.96)  LDD1372  [4]
 LDCM0494  CL99 PaTu 8988t C382(0.86)  LDD1373  [4]
 LDCM0495  E2913 HEK-293T C382(0.95); C209(1.16); C299(1.53)  LDD1698  [5]
 LDCM0625  F8 Ramos C382(1.30)  LDD2187  [6]
 LDCM0573  Fragment11 Ramos C299(0.55)  LDD2190  [6]
 LDCM0575  Fragment13 Ramos C299(0.86); C382(1.01)  LDD2192  [6]
 LDCM0576  Fragment14 Ramos C299(0.71); C382(0.54)  LDD2193  [6]
 LDCM0580  Fragment21 Ramos C382(0.92)  LDD2195  [6]
 LDCM0582  Fragment23 Ramos C382(0.98)  LDD2196  [6]
 LDCM0578  Fragment27 Ramos C299(1.04); C382(0.91)  LDD2197  [6]
 LDCM0586  Fragment28 Ramos C382(0.72)  LDD2198  [6]
 LDCM0588  Fragment30 Ramos C382(1.22)  LDD2199  [6]
 LDCM0589  Fragment31 Ramos C382(0.99)  LDD2200  [6]
 LDCM0590  Fragment32 Ramos C382(1.79)  LDD2201  [6]
 LDCM0468  Fragment33 PaTu 8988t C382(1.14)  LDD1347  [4]
 LDCM0596  Fragment38 Ramos C299(0.86); C382(1.13)  LDD2203  [6]
 LDCM0566  Fragment4 Ramos C382(1.64)  LDD2184  [6]
 LDCM0427  Fragment51 PaTu 8988t C382(1.32)  LDD1306  [4]
 LDCM0610  Fragment52 Ramos C382(1.59)  LDD2204  [6]
 LDCM0614  Fragment56 Ramos C382(1.17)  LDD2205  [6]
 LDCM0571  Fragment9 Ramos C382(4.53)  LDD2188  [6]
 LDCM0022  KB02 HEK-293T C382(0.91); C299(1.02)  LDD1492  [5]
 LDCM0023  KB03 Jurkat C382(13.07)  LDD0209  [1]
 LDCM0024  KB05 IGR39 C382(1.18)  LDD3315  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C382(0.42)  LDD2206  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Casein kinase II subunit beta (CSNK2B) Casein kinase 2 subunit beta family P67870
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Peptidyl-prolyl cis-trans isomerase B (PPIB) Cyclophilin-type PPIase family P23284
MYG1 exonuclease (MYG1) MYG1 family Q9HB07
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Nitric oxide synthase 3 (NOS3) NOS family P29474
Inactive Ufm1-specific protease 1 (UFSP1) Peptidase C78 family Q6NVU6
Aminoacylase-1 (ACY1) Peptidase M20A family Q03154
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Protein kinase C alpha type (PRKCA) AGC Ser/Thr protein kinase family P17252
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
GTP-binding protein GEM (GEM) RGK family P55040
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) Thiolase family Q9BWD1
Coagulation factor XIII A chain (F13A1) Transglutaminase family P00488
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (CTDSP1) . Q9GZU7
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Transporter and channel
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Metal transporter CNNM3 (CNNM3) ACDP family Q8NE01
Annexin A11 (ANXA11) Annexin family P50995
Arrestin domain-containing protein 3 (ARRDC3) Arrestin family Q96B67
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Solute carrier family 15 member 2 (SLC15A2) Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family Q16348
Cellular tumor antigen p53 (TP53) P53 family P04637
Phospholipid scramblase 3 (PLSCR3) Phospholipid scramblase family Q9NRY6
Protein shisa-5 (SHISA5) Shisa family Q8N114
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C8 (HOXC8) Antp homeobox family P31273
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Doublesex- and mab-3-related transcription factor 3 (DMRT3) DMRT family Q9NQL9
Zinc finger protein GLIS2 (GLIS2) GLI C2H2-type zinc-finger protein family Q9BZE0
Zinc finger protein ZIC 1 (ZIC1) GLI C2H2-type zinc-finger protein family Q15915
Vascular endothelial zinc finger 1 (VEZF1) Krueppel C2H2-type zinc-finger protein family Q14119
Zinc finger protein 135 (ZNF135) Krueppel C2H2-type zinc-finger protein family P52742
Zinc finger protein 414 (ZNF414) Krueppel C2H2-type zinc-finger protein family Q96IQ9
Homeobox protein OTX1 (OTX1) Paired homeobox family P32242
Pre-B-cell leukemia transcription factor 4 (PBX4) TALE/PBX homeobox family Q9BYU1
Chorion-specific transcription factor GCMb (GCM2) . O75603
Forkhead box protein D4-like 1 (FOXD4L1) . Q9NU39
Homeobox protein VENTX (VENTX) . O95231
Oligodendrocyte transcription factor 3 (OLIG3) . Q7RTU3
Paired box protein Pax-9 (PAX9) . P55771
Zinc finger protein 581 (ZNF581) . Q9P0T4
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-2C adrenergic receptor (ADRA2C) G-protein coupled receptor 1 family P18825
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) CEA family P40199
Other
Click To Hide/Show 44 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) CDIP1/LITAF family Q99732
Cancer/testis antigen 1 (CTAG1A; CTAG1B) CTAG/PCC1 family P78358
Protein ENTREP3 (ENTREP3) ENTREP family P81408
Stabilizer of axonemal microtubules 1 (SAXO1) FAM154 family Q8IYX7
Protein FAM222B (FAM222B) FAM222 family Q8WU58
Protein fem-1 homolog A (FEM1A) Fem-1 family Q9BSK4
Progranulin (GRN) Granulin family P28799
Protein INCA1 (INCA1) INCA family Q0VD86
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type II cytoskeletal 3 (KRT3) Intermediate filament family P12035
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Mediator of RNA polymerase II transcription subunit 25 (MED25) Mediator complex subunit 25 family Q71SY5
Myozenin-1 (MYOZ1) Myozenin family Q9NP98
Myozenin-2 (MYOZ2) Myozenin family Q9NPC6
Protein PAT1 homolog 1 (PATL1) PAT1 family Q86TB9
Keratin-associated protein 11-1 (KRTAP11-1) PMG family Q8IUC1
Submaxillary gland androgen-regulated protein 3A (SMR3A) PROL1/PROL3 family Q99954
RNA guanine-N7 methyltransferase activating subunit (RAMAC) RAM family Q9BTL3
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Heat shock protein beta-2 (HSPB2) Small heat shock protein (HSP20) family Q16082
Trichoplein keratin filament-binding protein (TCHP) TCHP family Q9BT92
Tektin-3 (TEKT3) Tektin family Q9BXF9
U1 small nuclear ribonucleoprotein C (SNRPC) U1 small nuclear ribonucleoprotein C family P09234
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
AP-4 complex accessory subunit RUSC1 (RUSC1) . Q9BVN2
Coiled-coil domain-containing protein 24 (CCDC24) . Q8N4L8
DAZ-associated protein 2 (DAZAP2) . Q15038
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Fibroblast growth factor receptor substrate 3 (FRS3) . O43559
Kelch domain-containing protein 7B (KLHDC7B) . Q96G42
Kelch-like protein 38 (KLHL38) . Q2WGJ6
Peflin (PEF1) . Q9UBV8
Protein SPMIP9 (SPMIP9) . Q96LM6
Protein TFG (TFG) . Q92734
RING finger protein 11 (RNF11) . Q9Y3C5
SH2 domain-containing protein 4A (SH2D4A) . Q9H788
SHC-transforming protein 3 (SHC3) . Q92529
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00
Uncharacterized protein C10orf55 (C10orf55) . Q5SWW7
Uncharacterized protein C11orf87 (C11orf87) . Q6NUJ2
WW domain-binding protein 1 (WBP1) . Q96G27

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
8 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.