Details of the Target

General Information of Target

Target ID LDTP12841
Target Name Very long chain fatty acid elongase 5 (ELOVL5)
Gene Name ELOVL5
Gene ID 60481
Synonyms
ELOVL2; Very long chain fatty acid elongase 5; EC 2.3.1.199; 3-keto acyl-CoA synthase ELOVL5; ELOVL fatty acid elongase 5; ELOVL FA elongase 5; Elongation of very long chain fatty acids protein 5; Fatty acid elongase 1; hELO1; Very long chain 3-ketoacyl-CoA synthase 5; Very long chain 3-oxoacyl-CoA synthase 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALSVPGYSPGFRKPPEVVRLRRKRARSRGAAASPPRELTEPAARRAALVAGLPLRPFPA
AGGRGGGSGGGPAAARRNPFARLDNRPRVAAEPPDGPAREQPEAPVPFLDSNQENDLLWE
EKFPERTTVTELPQTSHVSFSEPDIPSSKSTELPVDWSIKTRLLFTSSQPFTWADHLKAQ
EEAQGLVQHCRATEVTLPKSIQDPKLSSELRCTFQQSLIYWLHPALSWLPLFPRIGADRK
MAGKTSPWSNDATLQHVLMSDWSVSFTSLYNLLKTKLCPYFYVCTYQFTVLFRAAGLAGS
DLITALISPTTRGLREAMRNEGIEFSLPLIKESGHKKETASGTSLGYGEEQAISDEDEEE
SFSWLEEMGVQDKIKKPDILSIKLRKEKHEVQMDHRPESVVLVKGINTFTLLNFLINSKS
LVATSGPQAGLPPTLLSPVAFRGATMQMLKARSVNVKTQALSGYRDQFSLEITGPIMPHS
LHSLTMLLKSSQSGSFSAVLYPHEPTAVFNICLQMDKVLDMEVVHKELTNCGLHPNTLEQ
LSQIPLLGKSSLRNVVLRDYIYNWRS
Target Bioclass
Enzyme
Family
ELO family, ELOVL5 subfamily
Subcellular location
Endoplasmic reticulum membrane
Function
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid. {|HAMAP-Rule:MF_03205}.
Uniprot ID
Q9NYP7
Ensemble ID
ENST00000304434.11
HGNC ID
HGNC:21308
ChEMBL ID
CHEMBL5937

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL88 SNV: p.W26Ter .
YSCCC SNV: p.F12L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y92(20.00)  LDD0260  [1]
STPyne
 Probe Info  		K263(7.49); K56(3.91)  LDD0277  [2]
BTD
 Probe Info  		C61(4.40)  LDD1699  [3]
DBIA
 Probe Info  		C61(1,120.86)  LDD0209  [4]
ATP probe
 Probe Info  		K199(0.00); K200(0.00)  LDD0199  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C96(0.00); C61(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C61(0.00); C96(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C61(0.00); C96(0.00)  LDD0037  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
WYneO
 Probe Info  		N.A.  LDD0022  [9]
Compound 10
 Probe Info  		N.A.  LDD2216  [10]
ENE
 Probe Info  		N.A.  LDD0006  [9]
IPM
 Probe Info  		C61(0.00); C96(0.00)  LDD0005  [9]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [11]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OEA-DA
 Probe Info  		16.25  LDD0046  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C61(1.26)  LDD2142  [3]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C61(1.62)  LDD2112  [3]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C61(0.49)  LDD2095  [3]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C61(0.56)  LDD2130  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C61(1.01); C96(0.93)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C61(1.37)  LDD2152  [3]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C61(1.03)  LDD2103  [3]
 LDCM0214  AC1 HEK-293T C96(1.05)  LDD1507  [13]
 LDCM0226  AC11 HEK-293T C96(1.01)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C96(0.96)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C96(1.01)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C96(1.03)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C96(1.08)  LDD1515  [13]
 LDCM0278  AC19 HEK-293T C96(1.12)  LDD1517  [13]
 LDCM0280  AC20 HEK-293T C96(0.93)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C96(0.93)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C96(0.97)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C96(0.94)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C96(0.86)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C96(1.05)  LDD1524  [13]
 LDCM0287  AC27 HEK-293T C96(0.95)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C96(0.98)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C96(0.86)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C96(0.97)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C96(0.96)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C96(0.95)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C96(0.92)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C96(1.11)  LDD1533  [13]
 LDCM0296  AC35 HEK-293T C96(1.00)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C96(0.97)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C96(0.91)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C96(0.97)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C96(0.99)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C96(1.02)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C96(0.98)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C96(1.12)  LDD1542  [13]
 LDCM0305  AC43 HEK-293T C96(1.01)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C96(0.93)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C96(0.97)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C96(1.02)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C96(1.01)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C96(0.93)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C96(1.05)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C96(0.92)  LDD1551  [13]
 LDCM0314  AC51 HEK-293T C96(0.93)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C96(0.99)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C96(0.93)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C96(1.01)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C96(1.10)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C96(1.00)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C96(1.10)  LDD1559  [13]
 LDCM0322  AC59 HEK-293T C96(1.06)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C96(1.01)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C96(1.00)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C96(0.96)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C96(1.01)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C96(1.12)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C96(0.96)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C96(0.95)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C96(0.93)  LDD1569  [13]
 LDCM0520  AKOS000195272 MDA-MB-231 C96(1.18)  LDD2113  [3]
 LDCM0248  AKOS034007472 HEK-293T C96(0.93)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C96(1.12)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C96(0.97)  LDD1514  [13]
 LDCM0199  BPK-21 T cell C61(7.08)  LDD0530  [14]
 LDCM0368  CL10 HEK-293T C96(1.36)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C61(1.52); C96(0.94)  LDD1573  [13]
 LDCM0371  CL102 HEK-293T C96(1.33)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C96(1.08)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C61(1.62); C96(1.00)  LDD1577  [13]
 LDCM0375  CL106 HEK-293T C96(0.99)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C96(0.98)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C61(1.21); C96(0.88)  LDD1581  [13]
 LDCM0379  CL11 HEK-293T C96(1.50)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C96(1.41)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C96(1.08)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C61(1.37); C96(0.92)  LDD1586  [13]
 LDCM0384  CL114 HEK-293T C96(1.60)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C96(1.05)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C61(1.22); C96(1.01)  LDD1590  [13]
 LDCM0388  CL118 HEK-293T C96(1.05)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C96(1.15)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C96(1.33)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C61(1.09); C96(0.98)  LDD1595  [13]
 LDCM0393  CL122 HEK-293T C96(1.23)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C96(1.18)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C61(2.04); C96(1.02)  LDD1599  [13]
 LDCM0397  CL126 HEK-293T C96(1.36)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C96(1.05)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C61(1.17); C96(1.01)  LDD1603  [13]
 LDCM0401  CL14 HEK-293T C96(1.17)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C96(1.26)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C61(1.00); C96(1.07)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C96(1.32)  LDD1608  [13]
 LDCM0406  CL19 HEK-293T C96(1.10)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C96(1.10)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C96(1.17)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C96(1.72)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C96(1.18)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C96(1.26)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C96(1.30)  LDD1616  [13]
 LDCM0414  CL26 HEK-293T C96(1.01)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C96(1.05)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C61(1.44); C96(1.00)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C96(1.03)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C96(1.21)  LDD1622  [13]
 LDCM0420  CL31 HEK-293T C96(1.14)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C96(1.08)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C96(2.62)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C96(1.20)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C96(1.46)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C96(1.43)  LDD1629  [13]
 LDCM0428  CL39 HEK-293T C96(1.06)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C61(2.10); C96(1.15)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C61(0.91); C96(1.01)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C96(1.12)  LDD1635  [13]
 LDCM0433  CL43 HEK-293T C96(1.08)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C96(1.08)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C96(1.44)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C96(1.17)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C96(1.22)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C96(1.37)  LDD1642  [13]
 LDCM0440  CL5 HEK-293T C96(1.14)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C96(1.19)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C61(1.12); C96(1.04)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C96(1.39)  LDD1647  [13]
 LDCM0446  CL55 HEK-293T C96(1.17)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C96(1.13)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C96(1.68)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C96(1.26)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C96(1.31)  LDD1653  [13]
 LDCM0452  CL60 HEK-293T C96(1.38)  LDD1655  [13]
 LDCM0454  CL62 HEK-293T C96(0.94)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C96(1.14)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C61(3.10); C96(1.10)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C96(1.06)  LDD1660  [13]
 LDCM0459  CL67 HEK-293T C96(1.12)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C96(1.13)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C96(1.33)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C96(1.16)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C96(1.16)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C96(1.27)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C96(1.23)  LDD1668  [13]
 LDCM0467  CL74 HEK-293T C96(0.97)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C61(1.06); C96(0.95)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C96(1.24)  LDD1673  [13]
 LDCM0472  CL79 HEK-293T C96(1.03)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C96(1.74)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C96(1.03)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C96(1.08)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C96(1.03)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C96(1.44)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C96(1.57)  LDD1681  [13]
 LDCM0480  CL86 HEK-293T C96(1.06)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C96(1.18)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C61(0.99); C96(1.02)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C96(1.21)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C96(1.29)  LDD1687  [13]
 LDCM0486  CL91 HEK-293T C96(1.09)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C96(1.19)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C96(1.75)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C96(1.14)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C96(1.88)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C96(1.78)  LDD1694  [13]
 LDCM0493  CL98 HEK-293T C96(1.16)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C96(1.10)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C96(1.10)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C96(43.75)  LDD1702  [3]
 LDCM0625  F8 Ramos C96(1.55)  LDD2187  [15]
 LDCM0573  Fragment11 Ramos C96(1.48)  LDD2190  [15]
 LDCM0575  Fragment13 Ramos C96(1.42)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C96(1.75)  LDD2193  [15]
 LDCM0580  Fragment21 Ramos C96(1.56)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C96(0.88)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C96(0.93)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C96(1.42)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C96(1.52)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C96(1.42)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C96(2.93)  LDD2201  [15]
 LDCM0468  Fragment33 HEK-293T C96(1.12)  LDD1671  [13]
 LDCM0596  Fragment38 Ramos C96(3.50)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C96(3.58)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C96(1.05)  LDD1631  [13]
 LDCM0610  Fragment52 Ramos C96(2.18)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C96(1.16)  LDD2205  [15]
 LDCM0022  KB02 T cell-activated C61(20.00)  LDD1704  [14]
 LDCM0023  KB03 Jurkat C61(1,120.86)  LDD0209  [4]
 LDCM0024  KB05 COLO792 C61(14.75)  LDD3310  [16]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C61(2.07)  LDD2102  [3]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C61(1.37); C96(1.04)  LDD2090  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C61(1.16)  LDD2092  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C61(1.01)  LDD2093  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C61(1.00)  LDD2094  [3]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C61(0.78)  LDD2097  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C61(2.45)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C61(0.91); C96(1.06)  LDD2099  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C61(0.97)  LDD2101  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C61(1.27)  LDD2104  [3]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C61(1.54)  LDD2106  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C61(0.93); C96(1.13)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C61(1.00)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C61(1.19)  LDD2109  [3]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C61(3.67)  LDD2110  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C61(1.04)  LDD2111  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C61(0.56)  LDD2115  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C61(2.53)  LDD2119  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C61(0.93); C96(1.05)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C61(0.98); C96(0.77)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C61(1.58)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C61(1.17); C96(0.97)  LDD2129  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C61(0.60)  LDD2133  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C96(0.47)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C61(1.13); C96(1.30)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C61(1.62); C96(1.69)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C61(1.04); C96(1.35)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C61(2.94)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C61(1.01)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C61(0.93); C96(0.58)  LDD2141  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C61(2.51)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C61(0.89)  LDD2146  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C61(1.20); C96(0.67)  LDD2148  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C61(1.49)  LDD2150  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C61(0.07)  LDD2206  [17]
 LDCM0628  OTUB2-COV-1 HEK-293T C61(0.64)  LDD2207  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heme oxygenase 1 (HMOX1) Heme oxygenase family P09601
Heme oxygenase 2 (HMOX2) Heme oxygenase family P30519
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc transporter ZIP9 (SLC39A9) ZIP transporter (TC 2.A.5) family Q9NUM3
Phospholipid transfer protein C2CD2L (C2CD2L) . O14523
Proteolipid protein 2 (PLP2) . Q04941
Synaptojanin-2-binding protein (SYNJ2BP) . P57105
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgi SNAP receptor complex member 2 (GOSR2) GOSR2 family O14653
Ninjurin-2 (NINJ2) Ninjurin family Q9NZG7
Syntaxin-7 (STX7) Syntaxin family O15400
Protein SYS1 homolog (SYS1) SYS1 family Q8N2H4
Transmembrane protein 243 (TMEM243) TMEM243 family Q9BU79
Insulin-like growth factor-binding protein 5 (IGFBP5) . P24593
Thrombospondin type-1 domain-containing protein 7A (THSD7A) . Q9UPZ6

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alpha-linolenic Acid Small molecular drug DB00132

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
17 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.