Details of the Target

General Information of Target

Target ID LDTP12840
Target Name Protein downstream neighbor of Son (DONSON)
Gene Name DONSON
Gene ID 29980
Synonyms
C21orf60; Protein downstream neighbor of Son; B17
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MVPHLLLLCLLPLVRATEPHEGRADEQSAEAALAVPNASHFFSWNNYTFSDWQNFVGRRR
YGAESQNPTVKALLIVAYSFIIVFSLFGNVLVCHVIFKNQRMHSATSLFIVNLAVADIMI
TLLNTPFTLVRFVNSTWIFGKGMCHVSRFAQYCSLHVSALTLTAIAVDRHQVIMHPLKPR
ISITKGVIYIAVIWTMATFFSLPHAICQKLFTFKYSEDIVRSLCLPDFPEPADLFWKYLD
LATFILLYILPLLIISVAYARVAKKLWLCNMIGDVTTEQYFALRRKKKKTIKMLMLVVVL
FALCWFPLNCYVLLLSSKVIRTNNALYFAFHWFAMSSTCYNPFIYCWLNENFRIELKALL
SMCQRPPKPQEDRPPSPVPSFRVAWTEKNDGQRAPLANNLLPTSQLQSGKTDLSSVEPIV
TMS
Target Bioclass
Other
Family
DONSON family
Subcellular location
Nucleus
Function
Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability.
Uniprot ID
Q9NYP3
Ensemble ID
ENST00000303071.10
HGNC ID
HGNC:2993

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.A48S .
KMRC3 SNV: p.N554H .
ONS76 SNV: p.F12L DBIA    Probe Info 
YSCCC SNV: p.E358K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C190(9.06)  LDD0209  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C190(1.24)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C190(1.31); C512(0.83)  LDD1508  [6]
 LDCM0216  AC100 HEK-293T C190(0.80)  LDD0814  [7]
 LDCM0217  AC101 HEK-293T C190(0.64)  LDD0815  [7]
 LDCM0218  AC102 HEK-293T C190(0.62)  LDD0816  [7]
 LDCM0219  AC103 HEK-293T C190(0.89)  LDD0817  [7]
 LDCM0220  AC104 HEK-293T C190(0.84)  LDD0818  [7]
 LDCM0221  AC105 HEK-293T C190(0.74)  LDD0819  [7]
 LDCM0222  AC106 HEK-293T C190(0.63)  LDD0820  [7]
 LDCM0223  AC107 HEK-293T C190(0.73)  LDD0821  [7]
 LDCM0224  AC108 HEK-293T C190(0.67)  LDD0822  [7]
 LDCM0225  AC109 HEK-293T C190(0.66)  LDD0823  [7]
 LDCM0226  AC11 HEK-293T C190(1.03); C512(0.99)  LDD1509  [6]
 LDCM0227  AC110 HEK-293T C190(0.64)  LDD0825  [7]
 LDCM0228  AC111 HEK-293T C190(0.82)  LDD0826  [7]
 LDCM0229  AC112 HEK-293T C190(0.73)  LDD0827  [7]
 LDCM0237  AC12 HEK-293T C190(1.03)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C190(0.97)  LDD1512  [6]
 LDCM0263  AC143 HEK-293T C190(1.05)  LDD0861  [7]
 LDCM0264  AC144 HEK-293T C190(1.16)  LDD0862  [7]
 LDCM0265  AC145 HEK-293T C190(1.39)  LDD0863  [7]
 LDCM0266  AC146 HEK-293T C190(1.07)  LDD0864  [7]
 LDCM0267  AC147 HEK-293T C190(1.15)  LDD0865  [7]
 LDCM0268  AC148 HEK-293T C190(1.19)  LDD0866  [7]
 LDCM0269  AC149 HEK-293T C190(1.14)  LDD0867  [7]
 LDCM0270  AC15 HEK-293T C190(0.88)  LDD1513  [6]
 LDCM0271  AC150 HEK-293T C190(1.06)  LDD0869  [7]
 LDCM0272  AC151 HEK-293T C190(1.05)  LDD0870  [7]
 LDCM0273  AC152 HEK-293T C190(0.87)  LDD0871  [7]
 LDCM0274  AC153 HEK-293T C190(0.81)  LDD0872  [7]
 LDCM0621  AC154 HEK-293T C190(1.00)  LDD2162  [7]
 LDCM0622  AC155 HEK-293T C190(0.97)  LDD2163  [7]
 LDCM0623  AC156 HEK-293T C190(1.02)  LDD2164  [7]
 LDCM0624  AC157 HEK-293T C190(0.88)  LDD2165  [7]
 LDCM0276  AC17 HEK-293T C190(1.01)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C190(1.07); C512(0.77)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C190(1.35); C512(0.94)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C190(1.00); C512(0.79)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C190(1.11)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C190(1.09); C512(0.93)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C190(1.25)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C190(0.96)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C190(0.97); C512(0.86)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C190(1.08)  LDD0883  [7]
 LDCM0286  AC26 HEK-293T C190(1.00)  LDD0884  [7]
 LDCM0287  AC27 HEK-293T C190(1.22)  LDD0885  [7]
 LDCM0288  AC28 HEK-293T C190(1.00)  LDD0886  [7]
 LDCM0289  AC29 HEK-293T C190(0.87)  LDD0887  [7]
 LDCM0290  AC3 HEK-293T C190(1.09); C512(1.07)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C190(1.11)  LDD0889  [7]
 LDCM0292  AC31 HEK-293T C190(1.11)  LDD0890  [7]
 LDCM0293  AC32 HEK-293T C190(1.00)  LDD0891  [7]
 LDCM0294  AC33 HEK-293T C190(0.78)  LDD0892  [7]
 LDCM0295  AC34 HEK-293T C190(0.64)  LDD0893  [7]
 LDCM0296  AC35 HEK-293T C190(0.99); C512(0.95)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C190(1.11)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C190(0.97); C512(1.13)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C190(0.97)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C190(0.95)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C190(1.13)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C190(0.97); C512(0.90)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C190(1.09)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C190(1.08); C512(1.06)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C190(1.23); C512(0.93)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C190(1.09)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C190(1.18); C512(1.03)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C190(1.09)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C190(1.12)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C190(1.04); C512(0.93)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C190(1.00)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C190(1.17); C512(0.91)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C190(1.07); C512(0.91)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C190(1.09); C512(1.01)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C190(1.14)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C190(0.99); C512(0.98)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C190(1.00)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C190(0.88)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C190(0.95); C512(0.86)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C190(1.33)  LDD0918  [7]
 LDCM0321  AC58 HEK-293T C190(1.11)  LDD0919  [7]
 LDCM0322  AC59 HEK-293T C190(0.78)  LDD0920  [7]
 LDCM0323  AC6 HEK-293T C190(1.13)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C190(1.29)  LDD0922  [7]
 LDCM0325  AC61 HEK-293T C190(1.18)  LDD0923  [7]
 LDCM0326  AC62 HEK-293T C190(1.15)  LDD0924  [7]
 LDCM0327  AC63 HEK-293T C190(1.03)  LDD0925  [7]
 LDCM0328  AC64 HEK-293T C190(1.03)  LDD0926  [7]
 LDCM0329  AC65 HEK-293T C190(0.93)  LDD0927  [7]
 LDCM0330  AC66 HEK-293T C190(1.37)  LDD0928  [7]
 LDCM0331  AC67 HEK-293T C190(1.06)  LDD0929  [7]
 LDCM0332  AC68 HCT 116 C190(0.94)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C190(0.89)  LDD0650  [7]
 LDCM0334  AC7 HEK-293T C190(1.02)  LDD1568  [6]
 LDCM0335  AC70 HCT 116 C190(1.08)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C190(0.97)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C190(1.12)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C190(1.03)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C190(0.75)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C190(1.16)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C190(1.10)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C190(0.88)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C190(0.90)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C190(1.16)  LDD0661  [7]
 LDCM0345  AC8 HEK-293T C190(1.03); C512(0.97)  LDD1569  [6]
 LDCM0346  AC80 HCT 116 C190(0.93)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C190(1.01)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C190(0.95)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C190(1.27)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C190(1.72)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C190(1.69)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C190(1.20)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C190(1.40)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C190(1.32)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C190(1.24)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C190(1.33)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C190(1.13)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C190(1.51)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C190(1.10)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C190(1.17)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C190(1.21)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C190(1.12)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C190(1.38)  LDD0681  [7]
 LDCM0365  AC98 HEK-293T C190(0.77)  LDD0963  [7]
 LDCM0366  AC99 HEK-293T C190(0.75)  LDD0964  [7]
 LDCM0248  AKOS034007472 HEK-293T C190(1.16); C512(1.03)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C190(0.91)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C190(0.93); C512(0.89)  LDD1514  [6]
 LDCM0367  CL1 HEK-293T C190(0.82)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C190(0.80)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C190(1.19); C512(0.79)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C190(1.03)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C190(1.05); C512(1.01)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C190(1.19); C512(0.97)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C190(1.09); C512(0.90)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C190(0.76)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C190(1.08); C512(1.19)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C190(0.78); C512(0.90)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C190(1.10); C512(1.01)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C190(1.06)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C190(0.74)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C190(1.02); C512(0.98)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C190(0.83); C512(0.81)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C190(0.92)  LDD0980  [7]
 LDCM0383  CL113 HEK-293T C190(0.84)  LDD0981  [7]
 LDCM0384  CL114 HEK-293T C190(1.09)  LDD0982  [7]
 LDCM0385  CL115 HEK-293T C190(0.91)  LDD0983  [7]
 LDCM0386  CL116 HEK-293T C190(0.71)  LDD0984  [7]
 LDCM0387  CL117 HEK-293T C190(1.14)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C190(1.19); C512(1.08)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C190(0.98); C512(0.83)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C190(0.81); C512(1.01)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C190(1.14); C512(0.78)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C190(0.90)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C190(1.04); C512(0.90)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C190(0.87); C512(0.92)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C190(1.03); C512(0.88)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C190(1.09)  LDD0994  [7]
 LDCM0397  CL126 HEK-293T C190(1.31)  LDD0995  [7]
 LDCM0398  CL127 HEK-293T C190(1.32)  LDD0996  [7]
 LDCM0399  CL128 HEK-293T C190(1.17)  LDD0997  [7]
 LDCM0400  CL13 HEK-293T C190(0.89)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C190(0.88); C512(0.92)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C190(0.88); C512(1.08)  LDD1606  [6]
 LDCM0403  CL16 HCT 116 C190(1.24)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C190(1.07)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C190(1.01)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C190(1.24)  LDD0723  [7]
 LDCM0407  CL2 HEK-293T C190(1.04); C512(1.08)  LDD1611  [6]
 LDCM0408  CL20 HCT 116 C190(1.33)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C190(1.09)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C190(1.04)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C190(1.05)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C190(1.44)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C190(0.86)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C190(0.90)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C190(1.17)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C190(1.21)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C190(1.70)  LDD0734  [7]
 LDCM0418  CL3 HEK-293T C190(0.89); C512(0.94)  LDD1622  [6]
 LDCM0419  CL30 HCT 116 C190(1.51)  LDD0736  [7]
 LDCM0420  CL31 HEK-293T C190(0.92); C512(0.91)  LDD1624  [6]
 LDCM0421  CL32 HCT 116 C190(1.56)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C190(0.72)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C190(0.85)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C190(1.25)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C190(0.74)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C190(1.34)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C190(1.27)  LDD0745  [7]
 LDCM0429  CL4 HEK-293T C190(1.05); C512(0.89)  LDD1633  [6]
 LDCM0430  CL40 HCT 116 C190(0.91)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C190(0.70)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C190(0.75)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C190(1.25)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C190(1.67)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C190(1.55)  LDD0752  [7]
 LDCM0436  CL46 HEK-293T C190(0.87)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C190(0.74)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C190(0.76); C512(0.98)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C190(1.01)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C190(0.97)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C190(1.05); C512(0.95)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C190(1.14); C512(0.84)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C190(0.88)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C190(0.81); C512(0.76)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C190(1.01); C512(0.95)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C190(1.01)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C190(0.88); C512(1.02)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C190(0.89)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C190(0.89)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C190(0.92); C512(0.89)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C190(0.81); C512(0.97)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C190(0.94)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C190(0.99); C512(1.09)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C190(0.90); C512(1.36)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C190(1.03); C512(0.81)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C190(0.88)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C190(1.33); C512(1.04)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C190(0.94); C512(1.09)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C190(0.86)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C190(0.92); C512(1.05)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C190(0.97); C512(0.97)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C190(0.91)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C190(0.81)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C190(0.86); C512(1.06)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C190(0.94)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C190(1.02); C512(0.89)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C190(1.14)  LDD1067  [7]
 LDCM0470  CL77 HEK-293T C190(1.07)  LDD1068  [7]
 LDCM0471  CL78 HEK-293T C190(0.96)  LDD1069  [7]
 LDCM0472  CL79 HEK-293T C190(0.94)  LDD1070  [7]
 LDCM0473  CL8 HEK-293T C190(0.81)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C190(0.90)  LDD1072  [7]
 LDCM0475  CL81 HEK-293T C190(0.98)  LDD1073  [7]
 LDCM0476  CL82 HEK-293T C190(0.87)  LDD1074  [7]
 LDCM0477  CL83 HEK-293T C190(1.05)  LDD1075  [7]
 LDCM0478  CL84 HEK-293T C190(1.24)  LDD1076  [7]
 LDCM0479  CL85 HEK-293T C190(1.05)  LDD1077  [7]
 LDCM0480  CL86 HEK-293T C190(1.19)  LDD1078  [7]
 LDCM0481  CL87 HEK-293T C190(1.20)  LDD1079  [7]
 LDCM0482  CL88 HEK-293T C190(0.96)  LDD1080  [7]
 LDCM0483  CL89 HEK-293T C190(1.09)  LDD1081  [7]
 LDCM0484  CL9 HEK-293T C190(0.96); C512(1.04)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C190(1.20)  LDD1083  [7]
 LDCM0486  CL91 HEK-293T C190(0.90); C512(0.93)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C190(0.99)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C190(0.84); C512(0.91)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C190(0.85)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C190(0.82)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C190(0.79); C512(0.99)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C190(1.02)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C190(1.02); C512(1.08)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C190(1.00); C512(1.17)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C190(0.83); C512(1.02)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C190(0.90); C512(1.13)  LDD1671  [6]
 LDCM0427  Fragment51 HCT 116 C190(1.19)  LDD0744  [7]
 LDCM0022  KB02 HEK-293T C190(1.05)  LDD1492  [6]
 LDCM0023  KB03 Jurkat C190(9.06)  LDD0209  [1]
 LDCM0024  KB05 SKMEL24 C190(1.35)  LDD3323  [8]

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840