Details of the Target

General Information of Target

Target ID LDTP12453
Target Name Something about silencing protein 10 (UTP3)
Gene Name UTP3
Gene ID 57050
Synonyms
CRLZ1; SAS10; Something about silencing protein 10; Charged amino acid-rich leucine zipper 1; CRL1; Disrupter of silencing SAS10; UTP3 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSWIPFKIGQPKKQIVPKTVERDFEREYGKLQQLEEQTRRLQKDMKKSTDADLAMSKSAV
KISLDLLSNPLCEQDQDLLNMVTALDTAMKRMDAFNQEKVNQIQKTVIEPLKKFGSVFPS
LNMAVKRREQALQDYRRLQAKVEKYEEKEKTGPVLAKLHQAREELRPVREDFEAKNRQLL
EEMPRFYGSRLDYFQPSFESLIRAQVVYYSEMHKIFGDLSHQLDQPGHSDEQRERENEAK
LSELRALSIVADD
Target Bioclass
Other
Family
SAS10 family
Subcellular location
Nucleus, nucleolus
Function
Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Uniprot ID
Q9NQZ2
Ensemble ID
ENST00000254803.4
HGNC ID
HGNC:24477

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K310(10.00)  LDD0277  [1]
IA-alkyne
 Probe Info  		C359(5.72)  LDD2157  [2]
AHL-Pu-1
 Probe Info  		C359(2.66)  LDD0170  [3]
DBIA
 Probe Info  		C359(1.05)  LDD0580  [4]
IPM
 Probe Info  		N.A.  LDD0025  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
NAIA_5
 Probe Info  		N.A.  LDD2224  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
NHS
 Probe Info  		N.A.  LDD0010  [7]
SF
 Probe Info  		Y461(0.00); Y413(0.00)  LDD0028  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
AOyne
 Probe Info  		13.10  LDD0443  [10]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		8.27  LDD0476  [11]
FFF probe3
 Probe Info  		9.40  LDD0465  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C359(2.66)  LDD0170  [3]
 LDCM0026  4SU-RNA+native RNA DM93 C359(8.09)  LDD0171  [3]
 LDCM0237  AC12 HEK-293T C359(1.00)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C359(0.97)  LDD1512  [12]
 LDCM0263  AC143 HCT 116 C359(1.05)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C359(1.24)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C359(1.13)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C359(1.19)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C359(1.16)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C359(2.05)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C359(1.49)  LDD0586  [4]
 LDCM0270  AC15 HEK-293T C359(1.05)  LDD1513  [12]
 LDCM0271  AC150 HCT 116 C359(1.01)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C359(1.21)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C359(1.10)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C359(2.02)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C359(1.18)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C359(0.98)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C359(1.16)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C359(0.83)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C359(0.67)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C359(1.30)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C359(0.93)  LDD0595  [4]
 LDCM0280  AC20 HCT 116 C359(0.87)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C359(1.03)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C359(0.86)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C359(0.72)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C359(0.88)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C359(1.35)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C359(1.17)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C359(1.42)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C359(1.30)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C359(1.50)  LDD0606  [4]
 LDCM0291  AC30 HCT 116 C359(1.65)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C359(1.92)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C359(1.64)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C359(1.75)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C359(1.83)  LDD0612  [4]
 LDCM0297  AC36 HEK-293T C359(0.93)  LDD1536  [12]
 LDCM0299  AC38 HEK-293T C359(1.02)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C359(1.00)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C359(0.96)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C359(0.96)  LDD1541  [12]
 LDCM0306  AC44 HEK-293T C359(1.08)  LDD1545  [12]
 LDCM0308  AC46 HEK-293T C359(1.06)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C359(1.10)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C359(1.16)  LDD1549  [12]
 LDCM0315  AC52 HEK-293T C359(1.02)  LDD1554  [12]
 LDCM0317  AC54 HEK-293T C359(1.07)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C359(1.07)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C359(1.03)  LDD1558  [12]
 LDCM0323  AC6 HEK-293T C359(0.94)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C359(0.96)  LDD1563  [12]
 LDCM0326  AC62 HEK-293T C359(0.96)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C359(0.90)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C359(0.88)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C359(0.88)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C359(0.84)  LDD1569  [12]
 LDCM0349  AC83 HCT 116 C359(1.03)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C359(0.80)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C359(0.64)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C359(1.18)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C359(20.00)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C359(1.10)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C359(0.90)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C359(1.09)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C359(1.33)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C359(1.21)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C359(0.68)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C359(0.92)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C359(0.98)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C359(0.85)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C359(1.09)  LDD0681  [4]
 LDCM0275  AKOS034007705 HEK-293T C359(1.13)  LDD1514  [12]
 LDCM0108  Chloroacetamide HeLa C359(0.00); H293(0.00)  LDD0222  [9]
 LDCM0632  CL-Sc Hep-G2 C359(1.84)  LDD2227  [6]
 LDCM0367  CL1 HEK-293T C359(0.85)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C359(0.96)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C359(0.90)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C359(1.01)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C359(0.85)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C359(1.10)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C359(1.06)  LDD1577  [12]
 LDCM0374  CL105 HCT 116 C359(0.85)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C359(1.59)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C359(0.99)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C359(1.16)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C359(0.85)  LDD0695  [4]
 LDCM0379  CL11 HEK-293T C359(1.08)  LDD1583  [12]
 LDCM0380  CL110 HCT 116 C359(1.06)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C359(0.88)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C359(0.81)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C359(1.36)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C359(1.14)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C359(1.27)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C359(1.46)  LDD0703  [4]
 LDCM0387  CL117 HEK-293T C359(1.06)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C359(1.47)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C359(1.04)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C359(1.04)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C359(0.96)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C359(0.99)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C359(1.02)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C359(1.03)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C359(1.11)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C359(0.83)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C359(1.26)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C359(1.01)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C359(0.99)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C359(0.93)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C359(1.03)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C359(0.89)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C359(0.96)  LDD1607  [12]
 LDCM0407  CL2 HEK-293T C359(0.79)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C359(1.04)  LDD1612  [12]
 LDCM0410  CL22 HEK-293T C359(1.25)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C359(1.20)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C359(1.23)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C359(0.76)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C359(0.95)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C359(1.04)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C359(0.93)  LDD1620  [12]
 LDCM0418  CL3 HEK-293T C359(1.02)  LDD1622  [12]
 LDCM0421  CL32 HEK-293T C359(1.08)  LDD1625  [12]
 LDCM0423  CL34 HEK-293T C359(1.11)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C359(1.17)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C359(1.11)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C359(1.02)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C359(0.96)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C359(0.99)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C359(0.95)  LDD1634  [12]
 LDCM0434  CL44 HEK-293T C359(1.12)  LDD1638  [12]
 LDCM0436  CL46 HEK-293T C359(1.09)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C359(1.21)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C359(1.05)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C359(0.85)  LDD1643  [12]
 LDCM0441  CL50 HEK-293T C359(1.37)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C359(0.95)  LDD1646  [12]
 LDCM0447  CL56 HEK-293T C359(1.07)  LDD1650  [12]
 LDCM0449  CL58 HEK-293T C359(1.19)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C359(1.14)  LDD1653  [12]
 LDCM0452  CL60 HEK-293T C359(1.06)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C359(0.80)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C359(1.05)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C359(0.97)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C359(0.93)  LDD1659  [12]
 LDCM0460  CL68 HEK-293T C359(1.05)  LDD1663  [12]
 LDCM0463  CL70 HEK-293T C359(1.10)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C359(1.16)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C359(1.07)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C359(1.02)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C359(1.10)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C359(0.99)  LDD1672  [12]
 LDCM0473  CL8 HEK-293T C359(0.85)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C359(1.01)  LDD1677  [12]
 LDCM0476  CL82 HEK-293T C359(1.23)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C359(1.20)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C359(1.09)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C359(0.79)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C359(0.78)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C359(1.00)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C359(0.89)  LDD1685  [12]
 LDCM0487  CL92 HEK-293T C359(1.01)  LDD1690  [12]
 LDCM0489  CL94 HEK-293T C359(1.11)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C359(1.06)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C359(1.22)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C359(0.86)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C359(0.90)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C359(0.89)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C359(1.05)  LDD1698  [12]
 LDCM0468  Fragment33 HEK-293T C359(1.03)  LDD1671  [12]
 LDCM0427  Fragment51 HEK-293T C359(0.94)  LDD1631  [12]
 LDCM0107  IAA HeLa N.A.  LDD0221  [9]
 LDCM0022  KB02 HEK-293T C359(0.95)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C359(0.92)  LDD1497  [12]
 LDCM0024  KB05 HEK-293T C359(0.84)  LDD1502  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Cell division cycle-associated 7-like protein (CDCA7L) . Q96GN5
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
PRKCA-binding protein (PICK1) . Q9NRD5

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402