Details of the Target

General Information of Target

Target ID LDTP12245
Target Name E3 ubiquitin-protein ligase MSL2 (MSL2)
Gene Name MSL2
Gene ID 55167
Synonyms
KIAA1585; MSL2L1; RNF184; E3 ubiquitin-protein ligase MSL2; EC 2.3.2.-; E3 ubiquitin-protein transferase MSL2; Male-specific lethal 2-like 1; MSL2-like 1; Male-specific lethal-2 homolog; MSL-2; Male-specific lethal-2 homolog 1; RING finger protein 184
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLVSQNSRRRRRRVAKATAHNSSWGEMQAPNAPGLPADVPGSDVPQGPSDSQILQGLCA
SEGPSTSVLPTSAEGPSTFVPPTISEASSASGQPTISEGPGTSVLPTPSEGLSTSGPPTI
SKGLCTSVTLAASEGRNTSRPPTSSEEPSTSVPPTASEVPSTSLPPTPGEGTSTSVPPTA
YEGPSTSVVPTPDEGPSTSVLPTPGEGPGTSVPLAATEGLSTSVQATPDEGPSTSVPPTA
TEGLSTPVPPTRDEGPSTSVPATPGEGPSTSVLPAASDGQSISLVPTRGKGSSTSVPPTA
TEGLSTSVQPTAGEGSSTSVPPTPGGGLSTSVPPTATEELSTSVPPTPGEGPSTSVLPIP
GEGLSTSVPPTASDGSDTSVPPTPGEGASTLVQPTAPDGPGSSVLPNPGEGPSTLFSSSA
SVDRNPSKCSLVLPSPRVTKASVDSDSEGPKGAEGPIEFEVLRDCESPNSISIMGLNTSR
VAITLKPQDPMEQNVAELLQFLLVKDQSKYPIRESEMREYIVKEYRNQFPEILRRAAAHL
ECIFRFELRELDPEAHTYILLNKLGPVPFEGLEESPNGPKMGLLMMILGQIFLNGNQAKE
AEIWEMLWRMGVQRERRLSIFGNPKRLLSVEFVWQRYLDYRPVTDCKPVEYEFFWGPRSH
LETTKMKILKFMAKIYNKDPMDWPEKYNEALEEDAARAFAEGWQALPHFRRPFFEEAAAE
VPSPDSEVSSYSSKYAPHSWPESRLESKARKLVQLFLLMDSTKLPIPKKGILYYIGRECS
KVFPDLLNRAARTLNHVYGTELVVLDPRNHSYTLYNRREMEETEEIVDSPNRPGNNFLMQ
VLSFIFIMGNHARESAVWAFLRGLGVQAGRKHVITCRYLSQRYIDSLRVPDSDPVQYEFV
WGPRARLETSKMKALRYVARIHRKEPQDWPQQYREAMEDEANRADVGHRQIFVHNFR
Target Bioclass
Enzyme
Family
MSL2 family
Function
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.
Uniprot ID
Q9HCI7
Ensemble ID
ENST00000309993.3
HGNC ID
HGNC:25544

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.R39Q DBIA    Probe Info 
HUPT3 SNV: p.P425R DBIA    Probe Info 
KMCH1 SNV: p.D252V DBIA    Probe Info 
MDAMB453 SNV: p.T543I .
NCIH716 SNV: p.C498W .
OVK18 SNV: p.R15H .
RBE Insertion: p.L267CfsTer3 .
SNU1 SNV: p.G392D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K463(8.33)  LDD0277  [1]
DBIA
 Probe Info  		C490(1.11); C493(1.11); C495(1.11)  LDD0078  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C476(0.00); C107(0.00)  LDD0037  [3]
AOyne
 Probe Info  		14.50  LDD0443  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C81(1.00); C84(1.00)  LDD0812  [2]
 LDCM0215  AC10 HCT 116 C102(1.17)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C102(0.83); C490(0.72); C493(0.72); C495(0.72)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C102(0.87); C490(0.88); C493(0.88); C495(0.88)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C102(0.81); C490(0.91); C493(0.91); C495(0.91)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C102(0.84); C490(0.78); C493(0.78); C495(0.78)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C102(0.87); C490(0.76); C493(0.76); C495(0.76)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C102(0.94); C490(0.91); C493(0.91); C495(0.91)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C102(0.89); C490(0.88); C493(0.88); C495(0.88)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C102(0.60); C490(1.23); C493(0.82); C495(0.86)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C102(0.63); C490(0.62); C493(0.76); C495(0.82)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C102(0.65); C490(0.66); C493(0.70); C495(0.74)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C102(1.27)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C102(0.71); C490(0.61); C493(0.76); C495(0.79)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C102(0.65); C490(0.73); C493(0.73); C495(0.77)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C102(0.63); C490(0.81); C493(0.75); C495(0.84)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C102(1.01); C490(1.20); C493(1.20); C495(1.20)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C102(1.08); C490(1.24); C493(1.24); C495(1.24)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C102(1.14); C490(1.48); C493(1.48); C495(1.48)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C102(1.22); C490(1.43); C493(1.43); C495(1.43)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C102(1.07); C490(1.14); C493(1.14); C495(1.14)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C102(1.16); C490(1.65); C493(1.65); C495(1.65)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C102(1.00); C490(1.13); C493(1.13); C495(1.13)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C102(1.02)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C102(1.24); C490(1.24); C493(1.24); C495(1.24)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C102(1.05); C490(1.21); C493(1.21); C495(1.21)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C102(0.87); C490(1.05); C493(1.05); C495(1.05)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C102(1.12); C490(1.18); C493(1.18); C495(1.18)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C102(1.13); C490(1.49); C493(1.49); C495(1.49)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C102(1.22); C490(1.09); C493(1.09); C495(1.09)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C102(1.07); C490(1.50); C493(1.50); C495(1.50)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C102(1.12); C490(1.61); C493(1.61); C495(1.61)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C81(1.22); C84(1.22)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C81(1.07); C84(1.07)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C81(0.99); C84(0.99)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C81(1.16); C84(1.16)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C81(1.07); C84(1.07)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C81(0.99); C84(0.99)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C81(1.09); C84(1.09)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C81(1.20); C84(1.20)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C81(1.10); C84(1.10)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C81(1.30); C84(1.30)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C81(1.21); C84(1.21)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C81(1.37); C84(1.37)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C102(1.09)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C81(1.30); C84(1.30)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C81(1.31); C84(1.31)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C81(1.10); C84(1.10)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C493(0.80); C490(0.92); C495(0.92); C81(1.14)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C81(1.20); C84(1.20); C493(1.26); C490(1.33)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C81(1.06); C84(1.06); C490(1.11); C495(1.11)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C81(1.09); C84(1.09); C493(1.22); C490(1.35)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C81(0.91); C84(0.91); C493(1.16); C498(1.28)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C81(0.98); C84(0.98); C493(1.47); C490(1.53)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C81(1.13); C84(1.13); C493(1.30); C498(1.38)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C102(1.05)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C493(0.95); C498(1.04); C81(1.06); C84(1.06)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C81(0.93); C84(0.93); C498(1.05); C493(1.09)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C493(1.11); C81(1.13); C84(1.13); C490(1.15)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C81(1.04); C84(1.04); C493(1.19); C490(1.39)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C490(1.56); C493(1.38); C495(1.56); C498(1.37)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C490(1.43); C493(1.47); C495(1.43); C498(1.20)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C490(1.24); C493(1.48); C495(1.24); C498(1.14)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C490(1.12); C493(1.07); C495(1.12); C498(1.24)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C498(0.92); C102(1.06); C490(1.17); C493(1.17)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C490(0.93); C493(0.93); C495(0.93); C102(1.19)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C498(0.94); C102(0.97); C490(1.80); C493(1.80)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C81(1.10); C84(1.10)  LDD0877  [2]
 LDCM0280  AC20 HCT 116 C498(0.92); C102(0.93); C490(1.41); C493(1.41)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C102(1.05); C498(1.08); C490(1.31); C493(1.31)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C498(0.91); C102(0.98); C490(1.16); C493(1.16)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C102(0.86); C498(0.88); C490(1.02); C493(1.02)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C102(0.88); C498(0.92); C490(1.39); C493(1.39)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C81(1.23)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C81(1.31)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C81(1.33)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C81(1.25)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C81(1.29)  LDD0606  [2]
 LDCM0290  AC3 HEK-293T C81(1.10); C84(1.10)  LDD0888  [2]
 LDCM0291  AC30 HCT 116 C81(1.14)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C81(1.35)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C81(1.65)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C81(1.44)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C81(1.59)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C498(0.88); C102(0.96)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C102(0.82); C498(0.83)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C498(0.85); C102(0.87)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C102(0.95); C498(1.03)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C498(0.80); C102(0.99)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C81(1.11); C84(1.11)  LDD0899  [2]
 LDCM0302  AC40 HCT 116 C498(0.94); C102(1.15)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C498(0.81); C102(1.06)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C498(0.99); C102(1.12)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C498(0.92); C102(1.09)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C498(1.01); C102(1.02)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C498(0.99); C102(1.05)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C102(1.01)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C102(1.03)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C102(0.97)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C102(1.19)  LDD0628  [2]
 LDCM0312  AC5 HEK-293T C81(1.07); C84(1.07)  LDD0910  [2]
 LDCM0313  AC50 HCT 116 C102(1.14)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C102(0.89)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C102(1.07)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C102(1.14)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C102(1.27)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C102(1.26)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C102(1.43)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C498(1.10); C102(1.23)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C102(1.26); C498(1.26)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C102(1.26); C498(1.41)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C102(0.99)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C102(1.14); C498(1.17)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C498(1.09); C102(1.33)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C498(1.03); C102(1.49)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C498(1.10); C102(1.22)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C498(1.29); C102(1.39)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C498(1.05); C102(1.41)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C498(1.09); C102(1.34)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C498(1.00); C102(1.44)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C490(1.00); C493(1.02); C495(1.02); C498(1.17)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C490(1.05); C493(1.15); C495(1.15); C498(1.25)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C102(0.96)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C498(1.36); C490(1.89); C493(1.92); C495(1.92)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C490(0.73); C493(0.83); C495(0.83); C498(0.94)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C490(0.94); C493(0.97); C495(0.97); C498(1.12)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C490(1.02); C493(1.19); C495(1.19); C498(1.33)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C490(1.15); C493(1.35); C495(1.35); C498(1.38)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C490(1.18); C493(1.27); C495(1.27); C498(1.68)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C490(0.83); C493(0.98); C495(0.98); C498(1.06)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C490(0.92); C493(1.03); C495(1.03); C498(1.17)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C490(0.75); C493(0.85); C495(0.85); C498(0.89)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C490(0.75); C493(0.86); C495(0.86); C498(0.88)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C102(1.26)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C490(0.83); C493(0.90); C495(0.90); C498(1.04)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C490(0.85); C493(0.89); C495(0.89); C498(1.19)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C490(1.19); C493(1.33); C495(1.33); C498(1.34)  LDD0665  [2]
 LDCM0349  AC83 HEK-293T C107(1.02)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C107(2.00)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C107(1.34)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C107(1.43)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C107(1.46)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C107(1.34)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C107(1.83)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C107(2.15)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C107(1.46)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C107(1.55)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C107(1.52)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C107(1.86)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C107(1.89)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C107(2.02)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C107(3.65)  LDD0962  [2]
 LDCM0365  AC98 HCT 116 C490(0.94); C493(0.94); C495(0.94); C102(1.03)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C490(0.66); C493(0.66); C495(0.66); C102(0.78)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C102(1.12)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C102(1.08)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C102(1.38)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C490(1.11); C493(1.11); C495(1.11)  LDD0078  [2]
 LDCM0367  CL1 HCT 116 C81(0.88)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C81(0.89)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C81(1.13); C84(1.13)  LDD0967  [2]
 LDCM0370  CL101 HCT 116 C102(1.17)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C102(1.03)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C102(0.86)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C102(1.04)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C498(1.08); C102(1.10); C490(1.55); C493(1.55)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C498(1.25); C102(1.26); C490(1.65); C493(1.65)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C498(1.09); C102(1.17); C490(1.26); C493(1.26)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C490(1.26); C493(1.26); C495(1.26); C498(1.32)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C498(1.00); C102(1.11); C490(1.26); C493(1.26)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C81(0.86)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C498(1.14); C102(1.19); C490(1.41); C493(1.41)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C498(0.93); C102(0.97); C490(1.11); C493(1.11)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C81(1.05)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C81(1.63)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C81(1.21)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C81(1.20)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C81(1.32)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C102(1.32); C498(1.44)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C498(0.88); C102(1.06)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C498(0.95); C102(1.07)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C81(0.82)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C498(0.70); C102(0.96)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C102(1.44)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C102(1.30)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C102(1.20)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C102(1.31)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C498(0.93); C102(0.94)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C102(0.95); C498(1.06)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C498(0.96); C102(1.01)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C498(1.14); C102(1.23)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C81(1.04)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C81(0.88)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C81(1.24)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C81(0.81); C84(0.81); C490(1.23); C493(1.23)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C81(1.03); C84(1.03); C490(1.07); C493(1.07)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C490(0.88); C493(0.88); C495(0.88); C81(1.02)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C81(1.04); C84(1.04); C490(1.05); C493(1.05)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C81(0.99)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C81(1.33); C84(1.33); C490(1.77); C493(1.77)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C490(1.16); C493(1.16); C495(1.16); C81(1.16)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C81(1.20); C84(1.20); C490(1.30); C493(1.30)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C81(0.73); C84(0.73); C490(0.99); C493(0.99)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C81(0.84); C84(0.84); C490(1.03); C493(1.03)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C490(1.24); C493(1.24); C495(1.24); C81(0.84)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C490(1.22); C493(1.22); C495(1.22); C81(0.91)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C490(1.75); C493(1.75); C495(1.75); C81(0.83)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C490(1.14); C493(1.14); C495(1.14); C81(0.80)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C490(1.14); C493(1.14); C495(1.14); C81(0.97)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C81(0.86)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C490(1.27); C493(1.27); C495(1.27); C81(0.87)  LDD0736  [2]
 LDCM0420  CL31 HEK-293T C107(1.64); C81(1.07); C84(1.07)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C107(1.41); C81(1.10); C84(1.10)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C107(1.33); C81(1.11); C84(1.11)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C107(1.37); C81(1.11); C84(1.11)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C107(1.45); C81(1.06); C84(1.06)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C107(1.25); C81(0.95); C84(0.95)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C107(1.94); C81(1.06); C84(1.06)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C107(3.02); C81(1.05); C84(1.05)  LDD1026  [2]
 LDCM0429  CL4 HCT 116 C81(0.93)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C107(1.46); C81(1.03); C84(1.03)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C107(2.26); C81(0.95); C84(0.95)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C107(2.28); C81(1.08); C84(1.08)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C107(1.78); C81(0.92); C84(0.92)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C107(1.49); C81(1.06); C84(1.06)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C107(2.07); C81(1.01); C84(1.01)  LDD1033  [2]
 LDCM0436  CL46 HEK-293T C84(1.15)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C84(1.22)  LDD1641  [5]
 LDCM0440  CL5 HCT 116 C81(0.84)  LDD0757  [2]
 LDCM0449  CL58 HEK-293T C84(1.03)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C84(1.23)  LDD1653  [5]
 LDCM0451  CL6 HCT 116 C81(0.91)  LDD0768  [2]
 LDCM0453  CL61 HCT 116 C498(1.01); C81(0.98); C84(0.98)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C498(0.96); C81(0.87); C84(0.87)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C498(1.11); C81(0.88); C84(0.88)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C498(1.08); C81(0.92); C84(0.92)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C498(0.95); C81(0.82); C84(0.82)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C498(1.26); C81(0.87); C84(0.87)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C498(1.28); C81(0.91); C84(0.91)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C498(1.29); C81(1.04); C84(1.04)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C498(1.20); C81(0.85); C84(0.85)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C81(0.94)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C498(1.28); C81(0.94); C84(0.94)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C498(1.06); C81(0.84); C84(0.84)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C498(1.00); C81(0.90); C84(0.90)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C498(0.88); C81(0.91); C84(0.91)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C498(1.07); C81(0.80); C84(0.80)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C81(0.85); C84(0.85)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C81(1.06); C84(1.06)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C81(1.07); C84(1.07)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C81(0.96); C84(0.96)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C81(1.08)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C81(0.97); C84(0.97)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C81(1.02); C84(1.02)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C81(1.05); C84(1.05)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C81(0.81); C84(0.81)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C81(0.92); C84(0.92)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C81(0.81); C84(0.81)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C81(0.93); C84(0.93)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C81(0.88); C84(0.88)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C81(0.88); C84(0.88)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C81(0.90); C84(0.90)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C81(0.92)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C81(0.95); C84(0.95)  LDD0802  [2]
 LDCM0486  CL91 HEK-293T C81(1.03); C84(1.03)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C81(1.18); C84(1.18)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C81(1.11); C84(1.11)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C81(1.13); C84(1.13)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C81(1.12); C84(1.12)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C81(1.14); C84(1.14)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C81(1.02); C84(1.02)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C81(1.06); C84(1.06)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C81(1.03); C84(1.03)  LDD1092  [2]
 LDCM0468  Fragment33 HCT 116 C498(1.17); C81(0.91); C84(0.91)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C107(1.88); C81(0.99); C84(0.99)  LDD1025  [2]
 LDCM0022  KB02 HCT 116 C476(1.01)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C476(0.98)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C476(1.09)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Male-specific lethal 1 homolog (MSL1) Msl-1 family Q68DK7

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402