Details of the Target

General Information of Target

Target ID LDTP12235
Target Name Rho guanine nucleotide exchange factor 10-like protein (ARHGEF10L)
Gene Name ARHGEF10L
Gene ID 55160
Synonyms
GRINCHGEF; KIAA1626; Rho guanine nucleotide exchange factor 10-like protein; GrinchGEF
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSRLQEIRERQKLRRQLLAQQLGAESADSIGAVLNSKDEQREIAETRETCRASYDTSAP
NAKRKYLDEGETDEDKMEEYKDELEMQQDEENLPYEEEIYKDSSTFLKGTQSLNPHNDYC
QHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIR
ELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEG
LDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKRST
DGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV
GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGG
TSAGRGRERNRSNFRGERGGFRGGRGGAHRGGFPPR
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC.
Uniprot ID
Q9HCE6
Ensemble ID
ENST00000361221.8
HGNC ID
HGNC:25540

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO27 SNV: p.P57H .
HCT116 SNV: p.V665M DBIA    Probe Info 
HCT15 SNV: p.V611L; p.L941M .
IM95 Deletion: p.P650HfsTer34 .
Ishikawa (Heraklio) 02 ER Insertion: p.R651TfsTer80 DBIA    Probe Info 
MDST8 SNV: p.S854Y .
MEWO SNV: p.S205F; p.V839G .
NCIH1792 SNV: p.C136S .
ONS76 SNV: p.Y452H .
P31FUJ SNV: p.Q201K .
REH SNV: p.S374C .
RKO SNV: p.E879K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C444(0.70)  LDD0531  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C444(0.70)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C444(0.91)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C444(1.07)  LDD0543  [2]
 LDCM0237  AC12 HCT 116 C444(0.71)  LDD0554  [2]
 LDCM0246  AC128 HCT 116 C444(0.87)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C444(0.99)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C444(0.72)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C444(0.71)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C444(0.96)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C444(0.87)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C444(1.01)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C444(0.92)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C444(1.00)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C444(1.05)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C444(1.02)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C444(0.98)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C444(0.77)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C444(1.08)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C444(1.02)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C444(0.92)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C444(1.73)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C444(1.26)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C444(1.04)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C444(1.11)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C444(2.19)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C444(1.68)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C444(1.03)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C444(1.04)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C444(0.95)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C444(0.83)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C444(1.33)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C444(1.55)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C444(1.40)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C444(1.38)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C444(1.04)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C444(0.80)  LDD2161  [2]
 LDCM0279  AC2 HCT 116 C444(1.09)  LDD0596  [2]
 LDCM0285  AC25 HCT 116 C444(0.81)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C444(1.12)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C444(1.12)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C444(1.02)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C444(0.82)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C444(1.10)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C444(0.97)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C444(0.70)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C444(1.58)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C444(0.84)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C444(0.95)  LDD0612  [2]
 LDCM0301  AC4 HCT 116 C444(1.03)  LDD0618  [2]
 LDCM0312  AC5 HCT 116 C444(1.30)  LDD0629  [2]
 LDCM0320  AC57 HCT 116 C444(1.30)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C444(1.13)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C444(1.13)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C444(0.97)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C444(1.41)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C444(1.62)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C444(1.07)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C444(1.25)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C444(1.36)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C444(1.84)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C444(2.00)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C444(2.51)  LDD0648  [2]
 LDCM0334  AC7 HCT 116 C444(0.88)  LDD0651  [2]
 LDCM0345  AC8 HCT 116 C444(1.56)  LDD0662  [2]
 LDCM0349  AC83 HCT 116 C444(0.85)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C444(1.15)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C444(1.17)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C444(0.99)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C444(0.88)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C444(1.34)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C444(0.79)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C444(1.29)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C444(1.18)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C444(0.86)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C444(0.91)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C444(0.84)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C444(1.09)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C444(0.79)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C444(1.00)  LDD0681  [2]
 LDCM0248  AKOS034007472 HCT 116 C444(0.87)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C444(1.16)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C444(1.95)  LDD0592  [2]
 LDCM0367  CL1 HCT 116 C444(0.82)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C444(1.00)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C444(0.79)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C444(1.12)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C444(1.08)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C444(0.95)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C444(0.83)  LDD0690  [2]
 LDCM0379  CL11 HCT 116 C444(0.86)  LDD0696  [2]
 LDCM0382  CL112 HCT 116 C444(1.12)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C444(0.86)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C444(0.83)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C444(1.31)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C444(1.04)  LDD0703  [2]
 LDCM0390  CL12 HCT 116 C444(1.11)  LDD0707  [2]
 LDCM0396  CL125 HCT 116 C444(0.82)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C444(1.27)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C444(0.67)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C444(3.01)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C444(0.82)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C444(0.84)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C444(0.91)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C444(1.44)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C444(1.00)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C444(1.10)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C444(0.78)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C444(0.80)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C444(0.78)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C444(0.87)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C444(1.16)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C444(0.87)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C444(0.92)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C444(1.38)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C444(0.99)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C444(0.86)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C444(1.30)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C444(1.28)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C444(0.99)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C444(1.12)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C444(0.87)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C444(1.07)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C444(1.15)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C444(1.03)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C444(1.29)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C444(0.85)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C444(0.87)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C444(1.36)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C444(0.91)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C444(0.89)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C444(0.87)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C444(1.03)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C444(1.27)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C444(0.93)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C444(1.01)  LDD0752  [2]
 LDCM0440  CL5 HCT 116 C444(0.99)  LDD0757  [2]
 LDCM0451  CL6 HCT 116 C444(0.76)  LDD0768  [2]
 LDCM0462  CL7 HCT 116 C444(0.99)  LDD0779  [2]
 LDCM0469  CL76 HCT 116 C444(1.28)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C444(1.04)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C444(1.42)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C444(1.08)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C444(1.03)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C444(0.95)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C444(0.89)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C444(1.07)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C444(0.89)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C444(0.90)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C444(1.37)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C444(1.15)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C444(0.74)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C444(0.85)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C444(0.76)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C444(0.91)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C444(1.18)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C444(0.83)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C444(0.88)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C444(1.00)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C444(1.45)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C444(0.72)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C444(0.88)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C444(1.65)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C444(1.23)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C444(0.90)  LDD0811  [2]
 LDCM0427  Fragment51 HCT 116 C444(1.32)  LDD0744  [2]
 LDCM0022  KB02 769-P C359(2.79)  LDD2246  [3]
 LDCM0023  KB03 769-P C359(4.71)  LDD2663  [3]
 LDCM0024  KB05 MEL167 C444(1.12)  LDD3316  [3]

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840