Details of the Target

General Information of Target

Target ID LDTP12026
Target Name Polyamine-transporting ATPase 13A3 (ATP13A3)
Gene Name ATP13A3
Gene ID 79572
Synonyms
AFURS1; Polyamine-transporting ATPase 13A3; ATPase family homolog up-regulated in senescence cells 1; Putrescine transporting ATPase; EC 7.6.2.16
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAALGHLAGEAAAAPGPGTPCASRGARLPGPVSSARNPSTVCLCPEQPTCSNADSRAHPL
GDEGGTASKKQKNKKKTRNRASVANGGEKASEKLAPEEVPLSAEAQAQQLAQELAWCVEQ
LELGLKRQKPTPKQKEQAIGAIRTLRSKRTPLPRKRQLMHSLFGDYRAQMEAEWREALRA
LRAAAYSAQVQPVDGATRKKSQRVCRPRSIWRAKATLDMPDEEFRFNFF
Target Bioclass
Enzyme
Family
Cation transport ATPase (P-type) (TC 3.A.3) family, Type V subfamily
Subcellular location
Recycling endosome membrane
Function ATP-driven pump involved in endocytosis-dependent polyamine transport. Uses ATP as an energy source to transfer polyamine precursor putrescine from the endosomal compartment to the cytosol.
Uniprot ID
Q9H7F0
Ensemble ID
ENST00000439040.6
HGNC ID
HGNC:24113

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K701(2.96)  LDD0277  [1]
BTD
 Probe Info  		C67(0.43)  LDD2096  [2]
AHL-Pu-1
 Probe Info  		C798(2.92)  LDD0168  [3]
DBIA
 Probe Info  		C529(32.76)  LDD0209  [4]
IPM
 Probe Info  		C168(0.46)  LDD1702  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [6]
TFBX
 Probe Info  		C762(0.00); C920(0.00); C529(0.00)  LDD0148  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C170
 Probe Info  		10.70  LDD1850  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C798(2.92)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C798(4.30)  LDD0169  [3]
 LDCM0214  AC1 PaTu 8988t C489(0.23); C496(0.23)  LDD1093  [9]
 LDCM0215  AC10 PaTu 8988t C937(1.00)  LDD1094  [9]
 LDCM0226  AC11 PaTu 8988t C937(1.12)  LDD1105  [9]
 LDCM0230  AC113 HCT 116 C489(0.97); C496(0.97)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C489(1.01); C496(1.01)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C489(0.89); C496(0.89)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C489(1.03); C496(1.03)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C489(0.97); C496(0.97)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C489(1.10); C496(1.10)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C489(1.38); C496(1.38)  LDD0553  [9]
 LDCM0237  AC12 PaTu 8988t C937(1.22)  LDD1116  [9]
 LDCM0238  AC120 HCT 116 C489(0.92); C496(0.92)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C489(1.31); C496(1.31)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C489(1.00); C496(1.00)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C489(0.98); C496(0.98)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C489(1.15); C496(1.15)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C489(1.16); C496(1.16)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C489(1.01); C496(1.01)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C489(0.95); C496(0.95)  LDD0562  [9]
 LDCM0246  AC128 PaTu 8988t C489(1.02); C496(1.02)  LDD1125  [9]
 LDCM0247  AC129 PaTu 8988t C489(0.98); C496(0.98)  LDD1126  [9]
 LDCM0249  AC130 PaTu 8988t C489(0.90); C496(0.90)  LDD1128  [9]
 LDCM0250  AC131 PaTu 8988t C489(0.88); C496(0.88)  LDD1129  [9]
 LDCM0251  AC132 PaTu 8988t C489(0.87); C496(0.87)  LDD1130  [9]
 LDCM0252  AC133 PaTu 8988t C489(1.00); C496(1.00)  LDD1131  [9]
 LDCM0253  AC134 PaTu 8988t C489(0.88); C496(0.88)  LDD1132  [9]
 LDCM0254  AC135 PaTu 8988t C489(0.93); C496(0.93)  LDD1133  [9]
 LDCM0255  AC136 PaTu 8988t C489(0.97); C496(0.97)  LDD1134  [9]
 LDCM0256  AC137 PaTu 8988t C489(0.96); C496(0.96)  LDD1135  [9]
 LDCM0257  AC138 PaTu 8988t C489(1.03); C496(1.03)  LDD1136  [9]
 LDCM0258  AC139 PaTu 8988t C489(1.01); C496(1.01)  LDD1137  [9]
 LDCM0259  AC14 PaTu 8988t C937(1.02)  LDD1138  [9]
 LDCM0260  AC140 PaTu 8988t C489(0.90); C496(0.90)  LDD1139  [9]
 LDCM0261  AC141 PaTu 8988t C489(0.98); C496(0.98)  LDD1140  [9]
 LDCM0262  AC142 PaTu 8988t C489(0.84); C496(0.84)  LDD1141  [9]
 LDCM0263  AC143 PaTu 8988t C489(1.01); C496(1.01)  LDD1142  [9]
 LDCM0264  AC144 PaTu 8988t C489(0.96); C496(0.96)  LDD1143  [9]
 LDCM0265  AC145 PaTu 8988t C489(1.00); C496(1.00)  LDD1144  [9]
 LDCM0266  AC146 PaTu 8988t C489(1.03); C496(1.03)  LDD1145  [9]
 LDCM0267  AC147 PaTu 8988t C489(1.09); C496(1.09)  LDD1146  [9]
 LDCM0268  AC148 PaTu 8988t C489(1.04); C496(1.04)  LDD1147  [9]
 LDCM0269  AC149 PaTu 8988t C489(1.16); C496(1.16)  LDD1148  [9]
 LDCM0270  AC15 PaTu 8988t C937(0.99)  LDD1149  [9]
 LDCM0271  AC150 PaTu 8988t C489(1.01); C496(1.01)  LDD1150  [9]
 LDCM0272  AC151 PaTu 8988t C489(1.08); C496(1.08)  LDD1151  [9]
 LDCM0273  AC152 PaTu 8988t C489(1.04); C496(1.04)  LDD1152  [9]
 LDCM0274  AC153 PaTu 8988t C489(1.01); C496(1.01)  LDD1153  [9]
 LDCM0621  AC154 PaTu 8988t C489(1.10); C496(1.10)  LDD2166  [9]
 LDCM0622  AC155 PaTu 8988t C489(1.04); C496(1.04)  LDD2167  [9]
 LDCM0623  AC156 PaTu 8988t C489(0.98); C496(0.98)  LDD2168  [9]
 LDCM0624  AC157 PaTu 8988t C489(1.05); C496(1.05)  LDD2169  [9]
 LDCM0276  AC17 PaTu 8988t C881(1.07); C888(1.07)  LDD1155  [9]
 LDCM0277  AC18 PaTu 8988t C881(1.12); C888(1.12)  LDD1156  [9]
 LDCM0278  AC19 PaTu 8988t C881(0.98); C888(0.98)  LDD1157  [9]
 LDCM0279  AC2 PaTu 8988t C489(0.21); C496(0.21)  LDD1158  [9]
 LDCM0280  AC20 PaTu 8988t C881(1.08); C888(1.08)  LDD1159  [9]
 LDCM0281  AC21 PaTu 8988t C881(1.03); C888(1.03)  LDD1160  [9]
 LDCM0282  AC22 PaTu 8988t C881(1.12); C888(1.12)  LDD1161  [9]
 LDCM0283  AC23 PaTu 8988t C881(1.13); C888(1.13)  LDD1162  [9]
 LDCM0284  AC24 PaTu 8988t C881(1.02); C888(1.02)  LDD1163  [9]
 LDCM0285  AC25 PaTu 8988t C881(0.94); C888(0.94); C489(1.07); C496(1.07)  LDD1164  [9]
 LDCM0286  AC26 PaTu 8988t C881(0.83); C888(0.83); C489(0.91); C496(0.91)  LDD1165  [9]
 LDCM0287  AC27 PaTu 8988t C881(0.90); C888(0.90); C489(0.97); C496(0.97)  LDD1166  [9]
 LDCM0288  AC28 PaTu 8988t C881(0.78); C888(0.78); C489(0.99); C496(0.99)  LDD1167  [9]
 LDCM0289  AC29 PaTu 8988t C881(0.73); C888(0.73); C489(0.96); C496(0.96)  LDD1168  [9]
 LDCM0290  AC3 PaTu 8988t C489(0.24); C496(0.24)  LDD1169  [9]
 LDCM0291  AC30 PaTu 8988t C881(1.05); C888(1.05); C489(0.97); C496(0.97)  LDD1170  [9]
 LDCM0292  AC31 PaTu 8988t C881(1.09); C888(1.09); C489(0.92); C496(0.92)  LDD1171  [9]
 LDCM0293  AC32 PaTu 8988t C881(0.90); C888(0.90); C489(0.98); C496(0.98)  LDD1172  [9]
 LDCM0294  AC33 PaTu 8988t C881(0.95); C888(0.95); C489(0.95); C496(0.95)  LDD1173  [9]
 LDCM0295  AC34 PaTu 8988t C881(0.96); C888(0.96); C489(1.03); C496(1.03)  LDD1174  [9]
 LDCM0296  AC35 PaTu 8988t C489(0.89); C496(0.89)  LDD1175  [9]
 LDCM0297  AC36 PaTu 8988t C489(0.84); C496(0.84)  LDD1176  [9]
 LDCM0298  AC37 PaTu 8988t C489(0.82); C496(0.82)  LDD1177  [9]
 LDCM0299  AC38 PaTu 8988t C489(0.92); C496(0.92)  LDD1178  [9]
 LDCM0300  AC39 PaTu 8988t C489(0.97); C496(0.97)  LDD1179  [9]
 LDCM0301  AC4 PaTu 8988t C489(0.20); C496(0.20)  LDD1180  [9]
 LDCM0302  AC40 PaTu 8988t C489(0.81); C496(0.81)  LDD1181  [9]
 LDCM0303  AC41 PaTu 8988t C489(0.90); C496(0.90)  LDD1182  [9]
 LDCM0304  AC42 PaTu 8988t C489(0.83); C496(0.83)  LDD1183  [9]
 LDCM0305  AC43 PaTu 8988t C489(0.90); C496(0.90)  LDD1184  [9]
 LDCM0306  AC44 PaTu 8988t C489(0.93); C496(0.93)  LDD1185  [9]
 LDCM0307  AC45 PaTu 8988t C489(0.83); C496(0.83)  LDD1186  [9]
 LDCM0308  AC46 PaTu 8988t C881(0.83); C888(0.83); C489(0.82); C496(0.82)  LDD1187  [9]
 LDCM0309  AC47 PaTu 8988t C881(0.90); C888(0.90); C489(0.86); C496(0.86)  LDD1188  [9]
 LDCM0310  AC48 PaTu 8988t C881(0.79); C888(0.79); C489(0.93); C496(0.93)  LDD1189  [9]
 LDCM0311  AC49 PaTu 8988t C881(0.89); C888(0.89); C489(0.87); C496(0.87)  LDD1190  [9]
 LDCM0312  AC5 PaTu 8988t C489(0.19); C496(0.19)  LDD1191  [9]
 LDCM0313  AC50 PaTu 8988t C881(0.78); C888(0.78); C489(0.84); C496(0.84)  LDD1192  [9]
 LDCM0314  AC51 PaTu 8988t C881(0.27); C888(0.27); C489(0.96); C496(0.96)  LDD1193  [9]
 LDCM0315  AC52 PaTu 8988t C881(0.72); C888(0.72); C489(0.82); C496(0.82)  LDD1194  [9]
 LDCM0316  AC53 PaTu 8988t C881(0.84); C888(0.84); C489(0.88); C496(0.88)  LDD1195  [9]
 LDCM0317  AC54 PaTu 8988t C881(0.70); C888(0.70); C489(0.91); C496(0.91)  LDD1196  [9]
 LDCM0318  AC55 PaTu 8988t C881(0.75); C888(0.75); C489(0.82); C496(0.82)  LDD1197  [9]
 LDCM0319  AC56 PaTu 8988t C881(0.74); C888(0.74); C489(0.90); C496(0.90)  LDD1198  [9]
 LDCM0320  AC57 HCT 116 C489(0.79); C496(0.79)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C489(0.79); C496(0.79)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C489(0.88); C496(0.88)  LDD0639  [9]
 LDCM0323  AC6 PaTu 8988t C937(0.95)  LDD1202  [9]
 LDCM0324  AC60 HCT 116 C489(0.74); C496(0.74)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C489(0.83); C496(0.83)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C489(0.77); C496(0.77)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C489(0.73); C496(0.73)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C489(0.88); C496(0.88)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C489(0.92); C496(0.92)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C489(0.93); C496(0.93)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C489(0.95); C496(0.95)  LDD0648  [9]
 LDCM0332  AC68 PaTu 8988t C489(0.93); C496(0.93)  LDD1211  [9]
 LDCM0333  AC69 PaTu 8988t C489(0.85); C496(0.85)  LDD1212  [9]
 LDCM0334  AC7 PaTu 8988t C937(1.01)  LDD1213  [9]
 LDCM0335  AC70 PaTu 8988t C489(0.94); C496(0.94)  LDD1214  [9]
 LDCM0336  AC71 PaTu 8988t C489(0.87); C496(0.87)  LDD1215  [9]
 LDCM0337  AC72 PaTu 8988t C489(1.01); C496(1.01)  LDD1216  [9]
 LDCM0338  AC73 PaTu 8988t C489(0.96); C496(0.96)  LDD1217  [9]
 LDCM0339  AC74 PaTu 8988t C489(0.95); C496(0.95)  LDD1218  [9]
 LDCM0340  AC75 PaTu 8988t C489(0.91); C496(0.91)  LDD1219  [9]
 LDCM0341  AC76 PaTu 8988t C489(0.97); C496(0.97)  LDD1220  [9]
 LDCM0342  AC77 PaTu 8988t C489(0.82); C496(0.82)  LDD1221  [9]
 LDCM0343  AC78 PaTu 8988t C489(0.89); C496(0.89)  LDD1222  [9]
 LDCM0344  AC79 PaTu 8988t C489(0.85); C496(0.85)  LDD1223  [9]
 LDCM0345  AC8 PaTu 8988t C937(0.99)  LDD1224  [9]
 LDCM0346  AC80 PaTu 8988t C489(0.94); C496(0.94)  LDD1225  [9]
 LDCM0347  AC81 PaTu 8988t C489(0.80); C496(0.80)  LDD1226  [9]
 LDCM0348  AC82 PaTu 8988t C489(0.85); C496(0.85)  LDD1227  [9]
 LDCM0349  AC83 PaTu 8988t C881(0.94); C888(0.94)  LDD1228  [9]
 LDCM0350  AC84 PaTu 8988t C881(0.89); C888(0.89)  LDD1229  [9]
 LDCM0351  AC85 PaTu 8988t C881(1.26); C888(1.26)  LDD1230  [9]
 LDCM0352  AC86 PaTu 8988t C881(1.26); C888(1.26)  LDD1231  [9]
 LDCM0353  AC87 PaTu 8988t C881(1.05); C888(1.05)  LDD1232  [9]
 LDCM0354  AC88 PaTu 8988t C881(0.84); C888(0.84)  LDD1233  [9]
 LDCM0355  AC89 PaTu 8988t C881(1.22); C888(1.22)  LDD1234  [9]
 LDCM0357  AC90 PaTu 8988t C881(1.26); C888(1.26)  LDD1236  [9]
 LDCM0358  AC91 PaTu 8988t C881(0.96); C888(0.96)  LDD1237  [9]
 LDCM0359  AC92 PaTu 8988t C881(0.89); C888(0.89)  LDD1238  [9]
 LDCM0360  AC93 PaTu 8988t C881(1.00); C888(1.00)  LDD1239  [9]
 LDCM0361  AC94 PaTu 8988t C881(1.05); C888(1.05)  LDD1240  [9]
 LDCM0362  AC95 PaTu 8988t C881(1.40); C888(1.40)  LDD1241  [9]
 LDCM0363  AC96 PaTu 8988t C881(1.34); C888(1.34)  LDD1242  [9]
 LDCM0364  AC97 PaTu 8988t C881(1.08); C888(1.08)  LDD1243  [9]
 LDCM0248  AKOS034007472 PaTu 8988t C937(0.93)  LDD1127  [9]
 LDCM0356  AKOS034007680 PaTu 8988t C937(1.14)  LDD1235  [9]
 LDCM0275  AKOS034007705 PaTu 8988t C937(1.10)  LDD1154  [9]
 LDCM0367  CL1 HCT 116 C489(1.20); C496(1.20)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C489(1.09); C496(1.09)  LDD0685  [9]
 LDCM0369  CL100 PaTu 8988t C489(0.22); C496(0.22)  LDD1248  [9]
 LDCM0370  CL101 PaTu 8988t C937(1.11)  LDD1249  [9]
 LDCM0371  CL102 PaTu 8988t C937(0.98)  LDD1250  [9]
 LDCM0372  CL103 PaTu 8988t C937(1.05)  LDD1251  [9]
 LDCM0373  CL104 PaTu 8988t C937(1.09)  LDD1252  [9]
 LDCM0374  CL105 PaTu 8988t C881(1.09); C888(1.09)  LDD1253  [9]
 LDCM0375  CL106 PaTu 8988t C881(1.10); C888(1.10)  LDD1254  [9]
 LDCM0376  CL107 PaTu 8988t C881(0.89); C888(0.89)  LDD1255  [9]
 LDCM0377  CL108 PaTu 8988t C881(0.88); C888(0.88)  LDD1256  [9]
 LDCM0378  CL109 PaTu 8988t C881(1.18); C888(1.18)  LDD1257  [9]
 LDCM0379  CL11 HCT 116 C489(1.09); C496(1.09)  LDD0696  [9]
 LDCM0380  CL110 PaTu 8988t C881(1.07); C888(1.07)  LDD1259  [9]
 LDCM0381  CL111 PaTu 8988t C881(1.01); C888(1.01)  LDD1260  [9]
 LDCM0382  CL112 PaTu 8988t C881(0.82); C888(0.82); C489(0.93); C496(0.93)  LDD1261  [9]
 LDCM0383  CL113 PaTu 8988t C881(1.03); C888(1.03); C489(0.96); C496(0.96)  LDD1262  [9]
 LDCM0384  CL114 PaTu 8988t C881(0.86); C888(0.86); C489(0.90); C496(0.90)  LDD1263  [9]
 LDCM0385  CL115 PaTu 8988t C881(0.76); C888(0.76); C489(0.97); C496(0.97)  LDD1264  [9]
 LDCM0386  CL116 PaTu 8988t C881(0.76); C888(0.76); C489(0.83); C496(0.83)  LDD1265  [9]
 LDCM0387  CL117 PaTu 8988t C489(0.86); C496(0.86)  LDD1266  [9]
 LDCM0388  CL118 PaTu 8988t C489(0.67); C496(0.67)  LDD1267  [9]
 LDCM0389  CL119 PaTu 8988t C489(0.82); C496(0.82)  LDD1268  [9]
 LDCM0390  CL12 HCT 116 C489(1.04); C496(1.04)  LDD0707  [9]
 LDCM0391  CL120 PaTu 8988t C489(0.96); C496(0.96)  LDD1270  [9]
 LDCM0392  CL121 PaTu 8988t C881(0.85); C888(0.85); C489(0.92); C496(0.92)  LDD1271  [9]
 LDCM0393  CL122 PaTu 8988t C881(0.63); C888(0.63); C489(0.76); C496(0.76)  LDD1272  [9]
 LDCM0394  CL123 PaTu 8988t C881(0.71); C888(0.71); C489(0.82); C496(0.82)  LDD1273  [9]
 LDCM0395  CL124 PaTu 8988t C881(0.70); C888(0.70); C489(0.80); C496(0.80)  LDD1274  [9]
 LDCM0396  CL125 HCT 116 C489(1.10); C496(1.10)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C489(0.79); C496(0.79)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C489(1.20); C496(1.20)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C489(1.04); C496(1.04)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C489(1.03); C496(1.03)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C489(1.11); C496(1.11)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C489(1.07); C496(1.07)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C489(0.95); C496(0.95)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C489(0.87); C496(0.87)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C489(0.82); C496(0.82)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C489(0.89); C496(0.89)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C489(1.14); C496(1.14)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C489(0.89); C496(0.89)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C489(0.95); C496(0.95)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C489(1.07); C496(1.07)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C489(0.85); C496(0.85)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C489(0.99); C496(0.99)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C489(0.97); C496(0.97)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C489(0.87); C496(0.87)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C489(0.92); C496(0.92)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C489(0.89); C496(0.89)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C489(0.96); C496(0.96)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C489(1.04); C496(1.04)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C489(1.08); C496(1.08)  LDD0736  [9]
 LDCM0420  CL31 PaTu 8988t C881(1.02); C888(1.02); C489(0.78); C496(0.78)  LDD1299  [9]
 LDCM0421  CL32 PaTu 8988t C881(0.77); C888(0.77); C489(0.75); C496(0.75)  LDD1300  [9]
 LDCM0422  CL33 PaTu 8988t C881(1.06); C888(1.06); C489(0.97); C496(0.97)  LDD1301  [9]
 LDCM0423  CL34 PaTu 8988t C881(1.03); C888(1.03); C489(0.90); C496(0.90)  LDD1302  [9]
 LDCM0424  CL35 PaTu 8988t C489(0.87); C496(0.87); C881(0.94); C888(0.94)  LDD1303  [9]
 LDCM0425  CL36 PaTu 8988t C881(0.57); C888(0.57); C489(0.31); C496(0.31)  LDD1304  [9]
 LDCM0426  CL37 PaTu 8988t C881(0.95); C888(0.95); C489(0.74); C496(0.74)  LDD1305  [9]
 LDCM0428  CL39 PaTu 8988t C881(0.94); C888(0.94); C489(1.02); C496(1.02)  LDD1307  [9]
 LDCM0429  CL4 HCT 116 C489(1.00); C496(1.00)  LDD0746  [9]
 LDCM0430  CL40 PaTu 8988t C881(1.05); C888(1.05); C489(0.90); C496(0.90)  LDD1309  [9]
 LDCM0431  CL41 PaTu 8988t C881(0.95); C888(0.95); C489(0.94); C496(0.94)  LDD1310  [9]
 LDCM0432  CL42 PaTu 8988t C881(1.00); C888(1.00); C489(0.90); C496(0.90)  LDD1311  [9]
 LDCM0433  CL43 PaTu 8988t C881(0.89); C888(0.89); C489(0.76); C496(0.76)  LDD1312  [9]
 LDCM0434  CL44 PaTu 8988t C881(0.89); C888(0.89); C489(0.69); C496(0.69)  LDD1313  [9]
 LDCM0435  CL45 PaTu 8988t C881(0.84); C888(0.84); C489(0.67); C496(0.67)  LDD1314  [9]
 LDCM0436  CL46 PaTu 8988t C881(0.96); C888(0.96); C489(0.80); C496(0.80)  LDD1315  [9]
 LDCM0437  CL47 PaTu 8988t C881(1.12); C888(1.12); C489(0.79); C496(0.79)  LDD1316  [9]
 LDCM0438  CL48 PaTu 8988t C881(1.12); C888(1.12); C489(0.79); C496(0.79)  LDD1317  [9]
 LDCM0439  CL49 PaTu 8988t C881(1.08); C888(1.08); C489(0.82); C496(0.82)  LDD1318  [9]
 LDCM0440  CL5 HCT 116 C489(1.12); C496(1.12)  LDD0757  [9]
 LDCM0441  CL50 PaTu 8988t C881(1.39); C888(1.39); C489(0.84); C496(0.84)  LDD1320  [9]
 LDCM0442  CL51 PaTu 8988t C881(1.31); C888(1.31); C489(0.80); C496(0.80)  LDD1321  [9]
 LDCM0443  CL52 PaTu 8988t C881(1.01); C888(1.01); C489(0.77); C496(0.77)  LDD1322  [9]
 LDCM0444  CL53 PaTu 8988t C881(1.00); C888(1.00); C489(0.69); C496(0.69)  LDD1323  [9]
 LDCM0445  CL54 PaTu 8988t C881(0.84); C888(0.84); C489(0.73); C496(0.73)  LDD1324  [9]
 LDCM0446  CL55 PaTu 8988t C881(0.89); C888(0.89); C489(0.72); C496(0.72)  LDD1325  [9]
 LDCM0447  CL56 PaTu 8988t C881(1.01); C888(1.01); C489(0.52); C496(0.52)  LDD1326  [9]
 LDCM0448  CL57 PaTu 8988t C881(1.07); C888(1.07); C489(0.89); C496(0.89)  LDD1327  [9]
 LDCM0449  CL58 PaTu 8988t C881(1.04); C888(1.04); C489(0.84); C496(0.84)  LDD1328  [9]
 LDCM0450  CL59 PaTu 8988t C881(0.99); C888(0.99); C489(0.88); C496(0.88)  LDD1329  [9]
 LDCM0451  CL6 HCT 116 C489(0.94); C496(0.94)  LDD0768  [9]
 LDCM0452  CL60 PaTu 8988t C881(1.10); C888(1.10); C489(0.81); C496(0.81)  LDD1331  [9]
 LDCM0453  CL61 HCT 116 C489(0.96); C496(0.96)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C489(0.99); C496(0.99)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C489(1.10); C496(1.10)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C489(0.98); C496(0.98)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C489(1.03); C496(1.03)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C489(1.09); C496(1.09)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C489(1.03); C496(1.03)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C489(0.97); C496(0.97)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C489(1.06); C496(1.06)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C489(1.04); C496(1.04)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C489(0.93); C496(0.93)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C489(0.83); C496(0.83)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C489(0.88); C496(0.88)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C489(0.94); C496(0.94)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C489(0.91); C496(0.91)  LDD0784  [9]
 LDCM0469  CL76 PaTu 8988t C937(0.71); C881(0.91); C888(0.91); C489(0.86)  LDD1348  [9]
 LDCM0470  CL77 PaTu 8988t C937(0.85); C881(0.83); C888(0.83); C489(0.88)  LDD1349  [9]
 LDCM0471  CL78 PaTu 8988t C937(0.80); C881(0.87); C888(0.87); C489(0.75)  LDD1350  [9]
 LDCM0472  CL79 PaTu 8988t C937(1.00); C881(0.87); C888(0.87); C489(0.85)  LDD1351  [9]
 LDCM0473  CL8 HCT 116 C489(1.00); C496(1.00)  LDD0790  [9]
 LDCM0474  CL80 PaTu 8988t C937(0.82); C881(0.85); C888(0.85); C489(0.69)  LDD1353  [9]
 LDCM0475  CL81 PaTu 8988t C937(0.83); C881(0.87); C888(0.87); C489(0.65)  LDD1354  [9]
 LDCM0476  CL82 PaTu 8988t C937(0.69); C881(1.02); C888(1.02); C489(0.74)  LDD1355  [9]
 LDCM0477  CL83 PaTu 8988t C937(0.78); C881(0.90); C888(0.90); C489(0.72)  LDD1356  [9]
 LDCM0478  CL84 PaTu 8988t C937(0.85); C881(1.05); C888(1.05); C489(0.85)  LDD1357  [9]
 LDCM0479  CL85 PaTu 8988t C937(0.95); C881(0.86); C888(0.86); C489(0.89)  LDD1358  [9]
 LDCM0480  CL86 PaTu 8988t C937(0.91); C881(0.92); C888(0.92); C489(0.99)  LDD1359  [9]
 LDCM0481  CL87 PaTu 8988t C937(0.78); C881(0.84); C888(0.84); C489(0.78)  LDD1360  [9]
 LDCM0482  CL88 PaTu 8988t C937(0.84); C881(0.88); C888(0.88); C489(0.79)  LDD1361  [9]
 LDCM0483  CL89 PaTu 8988t C937(0.93); C881(0.96); C888(0.96); C489(0.82)  LDD1362  [9]
 LDCM0484  CL9 HCT 116 C489(1.00); C496(1.00)  LDD0801  [9]
 LDCM0485  CL90 PaTu 8988t C937(0.88); C881(0.91); C888(0.91); C489(0.79)  LDD1364  [9]
 LDCM0486  CL91 PaTu 8988t C489(0.24); C496(0.24)  LDD1365  [9]
 LDCM0487  CL92 PaTu 8988t C489(0.20); C496(0.20)  LDD1366  [9]
 LDCM0488  CL93 PaTu 8988t C489(0.19); C496(0.19)  LDD1367  [9]
 LDCM0489  CL94 PaTu 8988t C489(0.23); C496(0.23)  LDD1368  [9]
 LDCM0490  CL95 PaTu 8988t C489(0.19); C496(0.19)  LDD1369  [9]
 LDCM0491  CL96 PaTu 8988t C489(0.22); C496(0.22)  LDD1370  [9]
 LDCM0492  CL97 PaTu 8988t C489(0.19); C496(0.19)  LDD1371  [9]
 LDCM0493  CL98 PaTu 8988t C489(0.19); C496(0.19)  LDD1372  [9]
 LDCM0494  CL99 PaTu 8988t C489(0.20); C496(0.20)  LDD1373  [9]
 LDCM0495  E2913 HEK-293T C920(0.97); C113(1.06); C762(1.12); C529(1.04)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C168(0.46)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C489(0.98); C496(0.98)  LDD0785  [9]
 LDCM0427  Fragment51 PaTu 8988t C881(0.92); C888(0.92); C489(0.92); C496(0.92)  LDD1306  [9]
 LDCM0022  KB02 HEK-293T C529(0.91); C762(1.06); C920(0.92)  LDD1492  [10]
 LDCM0023  KB03 Jurkat C529(32.76)  LDD0209  [4]
 LDCM0024  KB05 HMCB C529(1.40)  LDD3312  [11]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C67(0.43)  LDD2096  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C67(0.98)  LDD2104  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C920(0.85)  LDD2107  [2]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C920(0.54)  LDD2115  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C920(0.84)  LDD2123  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C920(1.06)  LDD2127  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C920(0.37)  LDD2134  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C920(0.94)  LDD2137  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C920(1.60)  LDD2140  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C920(1.43)  LDD2146  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C920(0.95)  LDD2148  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840