Details of the Target

General Information of Target

Target ID LDTP12017
Target Name Inactive tyrosine-protein kinase PEAK1 (PEAK1)
Gene Name PEAK1
Gene ID 79834
Synonyms
KIAA2002; Inactive tyrosine-protein kinase PEAK1; Pseudopodium-enriched atypical kinase 1; Sugen kinase 269; Tyrosine-protein kinase SgK269
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAETREEETVSAEASGFSDLSDSEFLEFLDLEDAQESKALVNMPGPSSESLGKDDKPISL
QNWKRGLDILSPMERFHLKYLYVTDLATQNWCELQTAYGKELPGFLAPEKAAVLDTGASI
HLARELELHDLVTVPVTTKEDAWAIKFLNILLLIPTLQSEGHIREFPVFGEGEGVLLVGV
IDELHYTAKGELELAELKTRRRPMLPLEAQKKKDCFQVSLYKYIFDAMVQGKVTPASLIH
HTKLCLEKPLGPSVLRHAQQGGFSVKSLGDLMELVFLSLTLSDLPVIDILKIEYIHQETA
TVLGTEIVAFKEKEVRAKVQHYMAYWMGHREPQGVDVEEAWKCRTCTYADICEWRKGSGV
LSSTLAPQVKKAK
Target Bioclass
Enzyme
Family
Protein kinase superfamily
Subcellular location
Cytoplasm, cytoskeleton
Function
Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics. Acts as a scaffold for mediating EGFR signaling.
Uniprot ID
Q9H792
Ensemble ID
ENST00000312493.5
HGNC ID
HGNC:29431
ChEMBL ID
CHEMBL3627585

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K1698(5.26)  LDD0277  [1]
BTD
 Probe Info  		C1437(0.84)  LDD2092  [2]
AHL-Pu-1
 Probe Info  		C1681(2.80)  LDD0169  [3]
DBIA
 Probe Info  		C712(2.86)  LDD0080  [4]
IA-alkyne
 Probe Info  		C712(0.00); C1468(0.00); C1665(0.00); C993(0.00)  LDD0165  [5]
NAIA_4
 Probe Info  		C712(0.00); C1073(0.00)  LDD2226  [6]
NAIA_5
 Probe Info  		N.A.  LDD2225  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
IPM
 Probe Info  		C685(0.00); C712(0.00)  LDD0147  [7]
VSF
 Probe Info  		C1437(0.00); C993(0.00)  LDD0007  [8]
Phosphinate-6
 Probe Info  		C712(0.00); C1262(0.00)  LDD0018  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C1681(7.21)  LDD0170  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1681(2.80)  LDD0169  [3]
 LDCM0214  AC1 HEK-293T C685(1.12); C712(0.97); C365(1.15); C472(1.10)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C1665(1.09)  LDD0813  [4]
 LDCM0226  AC11 HEK-293T C1665(1.06)  LDD0824  [4]
 LDCM0230  AC113 HEK-293T C1665(0.85)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C1665(1.13)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C1665(1.00)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C1665(1.33)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C1665(1.20)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C1665(0.86)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C1665(1.02)  LDD0834  [4]
 LDCM0237  AC12 HEK-293T C1665(1.07)  LDD0835  [4]
 LDCM0238  AC120 HEK-293T C1665(0.92)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C1665(1.20)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C1665(1.14)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C1665(1.37)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C1665(1.27)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C1665(0.91)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C1665(1.27)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C1665(1.35)  LDD0843  [4]
 LDCM0259  AC14 HEK-293T C1665(1.00)  LDD0857  [4]
 LDCM0263  AC143 HCT 116 C1665(1.03)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C1665(0.78)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C1665(0.91)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C1665(0.86)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C1665(0.86)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C1665(0.99)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C1665(0.90)  LDD0586  [4]
 LDCM0270  AC15 HEK-293T C1665(0.99)  LDD0868  [4]
 LDCM0271  AC150 HCT 116 C1665(0.84)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C1665(0.92)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C1665(0.90)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C1665(1.02)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C1665(0.88)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C1665(0.80)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C1665(0.89)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C1665(1.00)  LDD2161  [4]
 LDCM0276  AC17 PaTu 8988t C1665(0.97)  LDD1155  [4]
 LDCM0277  AC18 PaTu 8988t C1665(1.07)  LDD1156  [4]
 LDCM0278  AC19 PaTu 8988t C1665(1.07)  LDD1157  [4]
 LDCM0279  AC2 HEK-293T C685(0.96); C712(0.95); C365(1.09); C472(1.00)  LDD1518  [11]
 LDCM0280  AC20 PaTu 8988t C1665(0.93)  LDD1159  [4]
 LDCM0281  AC21 PaTu 8988t C1665(1.01)  LDD1160  [4]
 LDCM0282  AC22 PaTu 8988t C1665(1.31)  LDD1161  [4]
 LDCM0283  AC23 PaTu 8988t C1665(1.13)  LDD1162  [4]
 LDCM0284  AC24 PaTu 8988t C1665(1.02)  LDD1163  [4]
 LDCM0285  AC25 HCT 116 C1665(1.49)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C1665(1.24)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C1665(1.24)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C1665(1.04)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C1665(1.00)  LDD0606  [4]
 LDCM0290  AC3 HEK-293T C712(1.09); C472(0.98); C1468(1.04); C1437(1.05)  LDD1529  [11]
 LDCM0291  AC30 HCT 116 C1665(1.13)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C1665(1.28)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C1665(1.03)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C1665(1.27)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C1665(1.15)  LDD0612  [4]
 LDCM0296  AC35 HEK-293T C1665(0.77)  LDD0894  [4]
 LDCM0297  AC36 HEK-293T C1665(0.78)  LDD0895  [4]
 LDCM0298  AC37 HEK-293T C1665(0.71)  LDD0896  [4]
 LDCM0299  AC38 HEK-293T C1665(0.62)  LDD0897  [4]
 LDCM0300  AC39 HEK-293T C1665(0.78)  LDD0898  [4]
 LDCM0301  AC4 HEK-293T C712(0.98); C365(1.03); C472(1.06); C1468(0.99)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C1665(0.81)  LDD0900  [4]
 LDCM0303  AC41 HEK-293T C1665(0.76)  LDD0901  [4]
 LDCM0304  AC42 HEK-293T C1665(0.71)  LDD0902  [4]
 LDCM0305  AC43 HEK-293T C1665(0.77)  LDD0903  [4]
 LDCM0306  AC44 HEK-293T C1665(0.80)  LDD0904  [4]
 LDCM0307  AC45 HEK-293T C1665(0.78)  LDD0905  [4]
 LDCM0308  AC46 HCT 116 C1665(1.07)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C1665(1.08)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C1665(1.04)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C1665(1.26)  LDD0628  [4]
 LDCM0312  AC5 HEK-293T C685(1.02); C712(0.93); C365(1.15); C472(0.99)  LDD1551  [11]
 LDCM0313  AC50 HCT 116 C1665(1.22)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C1665(1.15)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C1665(1.08)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C1665(1.16)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C1665(1.10)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C1665(1.24)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C1665(1.44)  LDD0636  [4]
 LDCM0320  AC57 HEK-293T C1665(1.04)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C1665(1.01)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C1665(1.01)  LDD0920  [4]
 LDCM0323  AC6 HEK-293T C1665(1.13)  LDD0921  [4]
 LDCM0324  AC60 HEK-293T C1665(0.75)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C1665(1.02)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C1665(1.10)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C1665(0.84)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C1665(0.80)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C1665(0.71)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C1665(0.91)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C1665(0.83)  LDD0929  [4]
 LDCM0332  AC68 HCT 116 C1665(0.93)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C1665(0.96)  LDD0650  [4]
 LDCM0334  AC7 HEK-293T C1665(1.03)  LDD0932  [4]
 LDCM0335  AC70 HCT 116 C1665(0.93)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C1665(1.02)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C1665(0.98)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C1665(1.23)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C1665(1.22)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C1665(1.34)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C1665(0.96)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C1665(0.95)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C1665(0.95)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C1665(1.04)  LDD0661  [4]
 LDCM0345  AC8 HEK-293T C1665(0.98)  LDD0943  [4]
 LDCM0346  AC80 HCT 116 C1665(0.96)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C1665(0.93)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C1665(1.28)  LDD0665  [4]
 LDCM0349  AC83 HEK-293T C1665(0.96)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C1665(0.81)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C1665(0.80)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C1665(0.85)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C1665(0.95)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C1665(0.73)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C1665(0.90)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C1665(0.88)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C1665(0.83)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C1665(0.84)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C1665(0.74)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C1665(0.64)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C1665(1.06)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C1665(0.74)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C1665(0.98)  LDD0962  [4]
 LDCM0248  AKOS034007472 HEK-293T C1665(0.97)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C1665(0.98)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C1665(0.99)  LDD0873  [4]
 LDCM0632  CL-Sc Hep-G2 C1468(20.00)  LDD2227  [6]
 LDCM0367  CL1 HEK-293T C1665(0.75)  LDD0965  [4]
 LDCM0368  CL10 HEK-293T C1665(1.11)  LDD0966  [4]
 LDCM0369  CL100 HEK-293T C685(1.00); C712(1.02); C472(1.04); C1468(1.01)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C1665(0.94)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C1665(0.93)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C1665(0.94)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C1665(1.04)  LDD0971  [4]
 LDCM0374  CL105 PaTu 8988t C1665(0.93)  LDD1253  [4]
 LDCM0375  CL106 PaTu 8988t C1665(1.05)  LDD1254  [4]
 LDCM0376  CL107 PaTu 8988t C1665(1.00)  LDD1255  [4]
 LDCM0377  CL108 PaTu 8988t C1665(0.95)  LDD1256  [4]
 LDCM0378  CL109 PaTu 8988t C1665(0.93)  LDD1257  [4]
 LDCM0379  CL11 HEK-293T C1665(0.97)  LDD0977  [4]
 LDCM0380  CL110 PaTu 8988t C1665(1.08)  LDD1259  [4]
 LDCM0381  CL111 PaTu 8988t C1665(1.14)  LDD1260  [4]
 LDCM0382  CL112 HCT 116 C1665(1.12)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C1665(1.05)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C1665(1.03)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C1665(1.03)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C1665(1.06)  LDD0703  [4]
 LDCM0387  CL117 HEK-293T C1665(0.78)  LDD0985  [4]
 LDCM0388  CL118 HEK-293T C1665(0.61)  LDD0986  [4]
 LDCM0389  CL119 HEK-293T C1665(0.70)  LDD0987  [4]
 LDCM0390  CL12 HEK-293T C1665(0.89)  LDD0988  [4]
 LDCM0391  CL120 HEK-293T C1665(0.80)  LDD0989  [4]
 LDCM0392  CL121 HCT 116 C1665(1.09)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C1665(1.15)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C1665(1.05)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C1665(1.24)  LDD0712  [4]
 LDCM0396  CL125 HEK-293T C1665(1.03)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C1665(1.03)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C1665(1.04)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C1665(1.05)  LDD0997  [4]
 LDCM0400  CL13 HEK-293T C1665(0.87)  LDD0998  [4]
 LDCM0401  CL14 HEK-293T C1665(0.76)  LDD0999  [4]
 LDCM0402  CL15 HEK-293T C1665(0.83)  LDD1000  [4]
 LDCM0403  CL16 HEK-293T C1665(0.94)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C1665(1.04)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C1665(0.91)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C1665(1.15)  LDD1004  [4]
 LDCM0407  CL2 HEK-293T C1665(0.84)  LDD1005  [4]
 LDCM0408  CL20 HEK-293T C1665(1.01)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C1665(0.90)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C1665(1.16)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C1665(0.91)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C1665(0.89)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C1665(1.06)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C1665(1.11)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C1665(0.82)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C1665(0.89)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C1665(1.02)  LDD1015  [4]
 LDCM0418  CL3 HEK-293T C1665(0.90)  LDD1016  [4]
 LDCM0419  CL30 HEK-293T C1665(1.02)  LDD1017  [4]
 LDCM0420  CL31 HEK-293T C1665(0.93)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C1665(0.91)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C1665(0.84)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C1665(0.85)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C1665(0.95)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C1665(0.82)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C1665(0.86)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C1665(0.91)  LDD1026  [4]
 LDCM0429  CL4 HEK-293T C1665(0.87)  LDD1027  [4]
 LDCM0430  CL40 HEK-293T C1665(0.74)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C1665(0.86)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C1665(0.80)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C1665(0.81)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C1665(0.89)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C1665(0.75)  LDD1033  [4]
 LDCM0436  CL46 HEK-293T C1665(0.87)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C1665(0.91)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C1665(0.87)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C1665(0.85)  LDD1037  [4]
 LDCM0440  CL5 HEK-293T C1665(0.89)  LDD1038  [4]
 LDCM0441  CL50 HEK-293T C1665(1.05)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C1665(0.91)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C1665(1.06)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C1665(1.02)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C1665(0.78)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C1665(0.98)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C1665(0.94)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C1665(0.93)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C1665(0.96)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C1665(0.89)  LDD1048  [4]
 LDCM0451  CL6 HEK-293T C1665(0.91)  LDD1049  [4]
 LDCM0452  CL60 HEK-293T C1665(0.96)  LDD1050  [4]
 LDCM0453  CL61 HEK-293T C1665(0.94)  LDD1051  [4]
 LDCM0454  CL62 HEK-293T C1665(0.82)  LDD1052  [4]
 LDCM0455  CL63 HEK-293T C1665(0.84)  LDD1053  [4]
 LDCM0456  CL64 HEK-293T C1665(0.85)  LDD1054  [4]
 LDCM0457  CL65 HEK-293T C1665(0.91)  LDD1055  [4]
 LDCM0458  CL66 HEK-293T C1665(0.90)  LDD1056  [4]
 LDCM0459  CL67 HEK-293T C1665(0.96)  LDD1057  [4]
 LDCM0460  CL68 HEK-293T C1665(0.74)  LDD1058  [4]
 LDCM0461  CL69 HEK-293T C1665(0.81)  LDD1059  [4]
 LDCM0462  CL7 HEK-293T C1665(0.90)  LDD1060  [4]
 LDCM0463  CL70 HEK-293T C1665(0.91)  LDD1061  [4]
 LDCM0464  CL71 HEK-293T C1665(0.79)  LDD1062  [4]
 LDCM0465  CL72 HEK-293T C1665(0.75)  LDD1063  [4]
 LDCM0466  CL73 HEK-293T C1665(0.77)  LDD1064  [4]
 LDCM0467  CL74 HEK-293T C1665(0.80)  LDD1065  [4]
 LDCM0469  CL76 HCT 116 C1665(0.88)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C1665(0.93)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C1665(0.87)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C1665(0.95)  LDD0789  [4]
 LDCM0473  CL8 HEK-293T C1665(1.06)  LDD1071  [4]
 LDCM0474  CL80 HCT 116 C1665(0.90)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C1665(0.99)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C1665(1.05)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C1665(1.04)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C1665(1.17)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C1665(1.02)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C1665(1.04)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C1665(1.01)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C1665(1.06)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C1665(1.47)  LDD0800  [4]
 LDCM0484  CL9 HEK-293T C1665(0.93)  LDD1082  [4]
 LDCM0485  CL90 HCT 116 C1665(1.35)  LDD0802  [4]
 LDCM0486  CL91 HEK-293T C712(0.98); C472(0.95); C1468(0.89); C1437(1.08)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C712(1.09); C365(1.10); C472(1.07); C1468(1.13)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C685(0.95); C712(1.01); C365(1.05); C472(1.00)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C685(0.79); C712(1.02); C365(1.02); C472(0.97)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C685(1.02); C712(0.96); C365(0.91); C472(1.02)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C685(0.97); C712(1.05); C365(0.98); C472(1.00)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C685(1.04); C712(0.96); C365(1.00); C472(1.01)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C685(0.96); C712(0.91); C365(0.98); C472(1.00)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C685(0.94); C712(1.00); C472(1.09); C1468(0.93)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C685(0.86); C712(1.22); C472(1.05); C1468(0.97)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1437(1.59)  LDD1702  [2]
 LDCM0468  Fragment33 HEK-293T C1665(0.76)  LDD1066  [4]
 LDCM0427  Fragment51 HEK-293T C1665(0.96)  LDD1025  [4]
 LDCM0022  KB02 HCT 116 C712(2.86)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C712(1.34)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C712(1.99)  LDD0082  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1437(0.84)  LDD2092  [2]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C1437(1.24)  LDD2106  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1437(0.98)  LDD2109  [2]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C1437(1.81)  LDD2118  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1437(0.81)  LDD2123  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1437(1.23)  LDD2127  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1437(0.40)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1437(0.84)  LDD2136  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1437(0.70)  LDD2140  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1437(1.02)  LDD2144  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Breast cancer anti-estrogen resistance protein 1 (BCAR1) CAS family P56945

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402