Details of the Target

General Information of Target

Target ID LDTP12009
Target Name Zinc finger protein 552 (ZNF552)
Gene Name ZNF552
Gene ID 79818
Synonyms
Zinc finger protein 552
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPAPSLGCSLKDVKWSSVAVPLDLLVSTYRLPQIARLDNGECVEGLRENDYLLIHSCRQ
WTTITAHSLEEGHYVIGPKIEIPVHYAGQFKLLEQDRDIKEPVQYFNSVEEVAKAFPERV
YVMEDITFNVKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTFKEKSRLNTIFKK
IGKLNSISKLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLELQMQEGEHTIRNIV
EKTRLPVNVTVPSPPPRNPYDLHFIREGHRYKFVNIQTKTVVVCCVLRNNKILPMHFPLH
LTVPKFSLPEHLVKGESWPETLVHHWLGICQEQFDIDEYSRAVRDVKTDWNEECKSPKKG
RCSGHNHVPNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLGGDWAPFPHDI
LPYQDSGDSGSDYLFPEASEESAGIPGKSELPYEELWLEEGKPSHQPLTRSLSEKNRCDQ
FRGSVRSKCATSPLPIPGTLGAAVKSSDTALPPPPVPPKSEAVREECRLLNAPPVPPRSA
KPLSTSPSIPPRTVKPARQQTRSPSPTLSYYSSGLHNISVTKTDTNPSESTPVSCYPCNR
VKTDSVDLKSPFGSPSAEAVSSRLSWPNHYSGASESQTRSDFLLDPSRSYSYPRQKTPGT
PKRNCPAPFDFDGCELLASPTSPVTAEFSSSVSGCPKSASYSLESTDVKSLAAGVTKQST
SCPALPPRAPKLVEEKVASETSPLPLKIDGAEEDPKSGSPDLSEDQYFVKKGMQDIFSAS
YPFSSPLHLQLAPRSCGDGSPWQPPADLSGLSIEEVSKSLRFIGLSEDVISFFVTEKIDG
NLLVQLTEEILSEDFKLSKLQVKKIMQFINGWRPKI
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q9H707
Ensemble ID
ENST00000391701.1
HGNC ID
HGNC:26135

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C121(1.05); C243(0.72); C245(0.72)  LDD0532  [1]
AOyne
 Probe Info  		12.90  LDD0443  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C121(1.05); C243(0.72); C245(0.72)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C243(0.63); C245(0.63)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C243(0.73); C245(0.73)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C243(0.76); C245(0.76)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C243(1.02); C245(1.02)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C243(0.77); C245(0.77)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C243(0.84); C245(0.84)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C243(1.00); C245(1.00)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C243(1.06); C245(1.06)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C243(0.86); C245(0.86)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C243(0.67); C245(0.67)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C121(1.32); C243(0.80); C245(0.80)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C243(0.72); C245(0.72)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C243(0.90); C245(0.90)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C243(0.90); C245(0.90)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C243(0.99); C245(0.99)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C243(0.75); C245(0.75)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C243(1.04); C245(1.04)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C243(1.23); C245(1.23)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C243(0.88); C245(0.88)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C243(0.74); C245(0.74)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C243(0.85); C245(0.85)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C121(1.04); C243(0.71); C245(0.71)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C243(1.02); C245(1.02)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C243(0.80); C245(0.80)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C243(1.11); C245(1.11)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C243(0.83); C245(0.83)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C243(0.82); C245(0.82)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C243(0.95); C245(0.95)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C243(1.04); C245(1.04)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C243(1.10); C245(1.10)  LDD0562  [1]
 LDCM0259  AC14 HCT 116 C121(1.03); C243(0.71); C245(0.71)  LDD0576  [1]
 LDCM0263  AC143 HCT 116 C243(1.06); C245(1.06)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C243(1.29); C245(1.29)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C243(1.30); C245(1.30)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C243(1.71); C245(1.71)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C243(1.29); C245(1.29)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C243(1.43); C245(1.43)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C243(1.59); C245(1.59)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C243(0.80); C245(0.80); C121(0.94)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C243(1.13); C245(1.13)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C243(0.96); C245(0.96)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C243(1.04); C245(1.04)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C243(2.02); C245(2.02)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C243(1.38); C245(1.38)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C243(1.35); C245(1.35)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C243(1.09); C245(1.09)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C243(0.81); C245(0.81)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C121(0.93); C243(1.00); C245(1.00)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C121(0.79); C243(1.28); C245(1.28)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C121(0.83); C243(1.05); C245(1.05)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C121(0.94); C243(0.99); C245(0.99)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C121(0.83); C243(1.15); C245(1.15)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C121(1.07); C243(1.18); C245(1.18)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C121(0.78); C243(0.88); C245(0.88)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C121(0.71); C243(0.99); C245(0.99)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C243(0.87); C245(0.87)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C243(0.92); C245(0.92)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C243(1.02); C245(1.02)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C243(1.03); C245(1.03)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C243(0.94); C245(0.94)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C243(1.05); C245(1.05)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C243(1.19); C245(1.19)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C243(1.17); C245(1.17)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C243(1.07); C245(1.07)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C243(1.30); C245(1.30)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C243(1.40); C245(1.40)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C243(1.22); C245(1.22)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C243(1.29); C245(1.29)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C243(1.30); C245(1.30)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C243(1.01); C245(1.01)  LDD0617  [1]
 LDCM0302  AC40 HCT 116 C243(1.49); C245(1.49)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C243(2.08); C245(2.08)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C243(1.37); C245(1.37)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C243(1.71); C245(1.71)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C243(1.79); C245(1.79)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C243(1.65); C245(1.65)  LDD0624  [1]
 LDCM0320  AC57 HCT 116 C121(1.49)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C121(1.19)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C121(1.37)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C121(0.80); C243(0.97); C245(0.97)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C121(1.37)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C121(1.38)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C121(1.64)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C121(1.61)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C121(1.88)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C121(1.51)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C121(1.23)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C121(1.53)  LDD0648  [1]
 LDCM0334  AC7 HCT 116 C121(0.76); C243(0.77); C245(0.77)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C243(0.72); C245(0.72); C121(0.82)  LDD0662  [1]
 LDCM0365  AC98 HCT 116 C243(1.08); C245(1.08)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C243(0.73); C245(0.73)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C121(0.96); C243(0.68); C245(0.68)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C243(0.91); C245(0.91); C121(1.15)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C121(0.92); C243(0.97); C245(0.97)  LDD0592  [1]
 LDCM0370  CL101 HCT 116 C121(0.60); C243(0.80); C245(0.80)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C243(0.64); C245(0.64); C121(0.81)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C243(0.70); C245(0.70); C121(0.85)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C243(0.79); C245(0.79); C121(0.80)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C121(1.11); C243(1.26); C245(1.26)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C121(0.88); C243(1.37); C245(1.37)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C121(0.85); C243(1.10); C245(1.10)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C121(0.82); C243(1.21); C245(1.21)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C243(1.11); C245(1.11); C121(1.17)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C121(0.85); C243(1.17); C245(1.17)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C243(0.93); C245(0.93); C121(1.12)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C243(0.88); C245(0.88)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C243(1.07); C245(1.07)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C243(0.81); C245(0.81)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C243(1.07); C245(1.07)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C243(1.07); C245(1.07)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C243(1.75); C245(1.75)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C243(1.17); C245(1.17)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C243(1.04); C245(1.04)  LDD0706  [1]
 LDCM0391  CL120 HCT 116 C243(1.38); C245(1.38)  LDD0708  [1]
 LDCM0396  CL125 HCT 116 C121(1.20)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C121(1.16)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C121(1.33)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C121(1.32)  LDD0716  [1]
 LDCM0403  CL16 HCT 116 C243(0.98); C245(0.98); C121(1.17)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C121(1.27)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C121(1.00)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C121(1.33)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C121(1.34)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C121(1.21)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C121(1.04)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C121(1.37)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C121(1.27)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C121(1.46)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C121(1.45)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C121(1.37)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C121(1.49)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C121(1.29)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C121(1.30)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C121(1.10)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C121(0.77); C243(1.13); C245(1.13)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C121(0.85); C243(0.93); C245(0.93)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C121(0.63); C243(0.89); C245(0.89)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C121(0.92); C243(0.96); C245(0.96)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C121(0.93); C243(1.04); C245(1.04)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C121(0.84); C243(1.01); C245(1.01)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C121(0.90); C243(1.08); C245(1.08)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C121(0.91); C243(1.15); C245(1.15)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C121(0.85); C243(1.06); C245(1.06)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C121(0.59); C243(0.88); C245(0.88)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C121(0.94); C243(0.98); C245(0.98)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C121(0.90); C243(0.90); C245(0.90)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C121(0.85); C243(0.86); C245(0.86)  LDD0752  [1]
 LDCM0427  Fragment51 HCT 116 C121(0.73); C243(0.95); C245(0.95)  LDD0744  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glycogen [starch] synthase, muscle (GYS1) Glycosyltransferase 3 family P13807
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
GTP-binding protein GEM (GEM) RGK family P55040
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B5 (HOXB5) Antp homeobox family P09067
Zinc finger and BTB domain-containing protein 16 (ZBTB16) Krueppel C2H2-type zinc-finger protein family Q05516
Zinc finger protein 648 (ZNF648) Krueppel C2H2-type zinc-finger protein family Q5T619
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Zinc finger protein 792 (ZNF792) Krueppel C2H2-type zinc-finger protein family Q3KQV3
Zinc finger protein 835 (ZNF835) Krueppel C2H2-type zinc-finger protein family Q9Y2P0
Zinc finger protein 837 (ZNF837) Krueppel C2H2-type zinc-finger protein family Q96EG3
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-D1-binding protein 1 (CCNDBP1) CCNDBP1 family O95273
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin-associated protein 4-11 (KRTAP4-11) KRTAP type 4 family Q9BYQ6
Keratin-associated protein 4-5 (KRTAP4-5) KRTAP type 4 family Q9BYR2
Tektin-4 (TEKT4) Tektin family Q8WW24
Calcium and integrin-binding family member 3 (CIB3) . Q96Q77
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Coiled-coil domain-containing protein 125 (CCDC125) . Q86Z20
Fibroblast growth factor receptor substrate 3 (FRS3) . O43559
INO80 complex subunit B (INO80B) . Q9C086
PHD finger protein 24 (PHF24) . Q9UPV7

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.