Details of the Target

General Information of Target

Target ID LDTP12008
Target Name GRB2-associated and regulator of MAPK protein 1 (GAREM1)
Gene Name GAREM1
Gene ID 64762
Synonyms
C18orf11; FAM59A; GAREM; GRB2-associated and regulator of MAPK protein 1; GRB2-associated and regulator of MAPK1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHCTGALRDGQ
LAGPRAGVSKRHLRGDQITWIGGNEEGCEAISFLLSLIDRLVLYCGSRLGKYYVKERSKA
MVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEP
IFDRLLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTRKTESALTED
Target Bioclass
Other
Family
GAREM family
Function
[Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation.
Uniprot ID
Q9H706
Ensemble ID
ENST00000269209.7
HGNC ID
HGNC:26136

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A101D Substitution: p.S780F .
A2780 SNV: p.Q861Ter .
COLO829 SNV: p.T235I .
GB2 SNV: p.P196L .
JURKAT Insertion: p.D412RfsTer8 .
MDAMB157 SNV: p.R341W .
MOLT4 SNV: p.K864T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C595(1.03); C598(1.03)  LDD0078  [1]
NAIA_5
 Probe Info  		N.A.  LDD2225  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
AOyne
 Probe Info  		14.40  LDD0443  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C595(0.88); C598(0.88)  LDD0812  [1]
 LDCM0215  AC10 HEK-293T C595(1.13); C598(1.13)  LDD0813  [1]
 LDCM0216  AC100 HCT 116 C595(1.00); C598(1.00)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C595(1.12); C598(1.12)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C595(0.79); C598(0.79)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C595(1.72); C598(1.72)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C595(1.02); C598(1.02)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C595(1.44); C598(1.44)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C595(1.64); C598(1.64)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C595(1.32); C598(1.44)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C595(1.02); C598(0.80)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C595(0.78); C598(0.81)  LDD0542  [1]
 LDCM0226  AC11 HEK-293T C595(0.99); C598(0.99)  LDD0824  [1]
 LDCM0227  AC110 HCT 116 C595(0.84); C598(0.81)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C595(1.10); C598(1.16)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C595(1.03); C598(1.14)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C595(1.21); C598(1.21)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C595(1.63); C598(1.63)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C595(1.64); C598(1.64)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C595(1.80); C598(1.80)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C595(1.48); C598(1.48)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C595(1.12); C598(1.12)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C595(1.26); C598(1.26)  LDD0553  [1]
 LDCM0237  AC12 HEK-293T C595(1.05); C598(1.05)  LDD0835  [1]
 LDCM0238  AC120 HCT 116 C595(0.81); C598(0.81)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C595(1.15); C598(1.15)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C595(1.18); C598(1.18)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C595(1.20); C598(1.20)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C595(1.70); C598(1.70)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C595(1.36); C598(1.36)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C595(1.89); C598(1.89)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C595(2.03); C598(2.03)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C595(1.43); C598(1.43)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C595(1.30); C598(1.30)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C595(1.17); C598(1.17)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C595(0.99); C598(0.99)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C595(0.71); C598(0.71)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C595(1.18); C598(1.18)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C595(1.20); C598(1.20)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C595(0.91); C598(0.91)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C595(0.60); C598(0.60)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C595(0.75); C598(0.75)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C595(0.58); C598(0.58)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C595(0.74); C598(0.74)  LDD0575  [1]
 LDCM0259  AC14 HEK-293T C595(1.34); C598(1.34)  LDD0857  [1]
 LDCM0260  AC140 HCT 116 C595(0.94); C598(0.94)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C595(0.73); C598(0.73)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C595(0.66); C598(0.66)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C595(1.24); C598(1.24)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C595(1.66); C598(1.66)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C595(1.30); C598(1.30)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C595(1.93); C598(1.93)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C595(1.84); C598(1.84)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C595(2.26); C598(2.26)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C595(1.84); C598(1.84)  LDD0586  [1]
 LDCM0270  AC15 HEK-293T C595(1.23); C598(1.23)  LDD0868  [1]
 LDCM0271  AC150 HCT 116 C595(1.25); C598(1.25)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C595(1.40); C598(1.40)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C595(1.49); C598(1.49)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C595(3.39); C598(3.39)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C595(2.03); C598(2.03)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C595(1.97); C598(1.97)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C595(1.39); C598(1.39)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C595(1.93); C598(1.93)  LDD2161  [1]
 LDCM0276  AC17 HEK-293T C595(1.30); C598(1.30)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C595(1.61); C598(1.61)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C595(1.69); C598(1.69)  LDD0876  [1]
 LDCM0279  AC2 HEK-293T C595(1.54); C598(1.54)  LDD0877  [1]
 LDCM0280  AC20 HEK-293T C595(1.33); C598(1.33)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C595(1.12); C598(1.12)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C595(1.35); C598(1.35)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C595(1.40); C598(1.40)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C595(1.63); C598(1.63)  LDD0882  [1]
 LDCM0285  AC25 HEK-293T C595(1.20); C598(1.20)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C595(0.98); C598(0.98)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C595(1.14); C598(1.14)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C595(1.01); C598(1.01)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C595(1.08); C598(1.08)  LDD0887  [1]
 LDCM0290  AC3 HEK-293T C595(0.89); C598(0.89)  LDD0888  [1]
 LDCM0291  AC30 HEK-293T C595(0.87); C598(0.87)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C595(0.83); C598(0.83)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C595(1.25); C598(1.25)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C595(1.10); C598(1.10)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C595(1.38); C598(1.38)  LDD0893  [1]
 LDCM0296  AC35 HEK-293T C595(1.22); C598(1.22)  LDD0894  [1]
 LDCM0297  AC36 HEK-293T C595(0.74); C598(0.74)  LDD0895  [1]
 LDCM0298  AC37 HEK-293T C595(1.10); C598(1.10)  LDD0896  [1]
 LDCM0299  AC38 HEK-293T C595(1.26); C598(1.26)  LDD0897  [1]
 LDCM0300  AC39 HEK-293T C595(1.34); C598(1.34)  LDD0898  [1]
 LDCM0301  AC4 HEK-293T C595(1.18); C598(1.18)  LDD0899  [1]
 LDCM0302  AC40 HEK-293T C595(0.86); C598(0.86)  LDD0900  [1]
 LDCM0303  AC41 HEK-293T C595(1.13); C598(1.13)  LDD0901  [1]
 LDCM0304  AC42 HEK-293T C595(1.03); C598(1.03)  LDD0902  [1]
 LDCM0305  AC43 HEK-293T C595(1.00); C598(1.00)  LDD0903  [1]
 LDCM0306  AC44 HEK-293T C595(0.90); C598(0.90)  LDD0904  [1]
 LDCM0307  AC45 HEK-293T C595(1.31); C598(1.31)  LDD0905  [1]
 LDCM0308  AC46 HEK-293T C595(1.00); C598(1.00)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C595(1.05); C598(1.05)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C595(1.38); C598(1.38)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C595(1.40); C598(1.40)  LDD0909  [1]
 LDCM0312  AC5 HEK-293T C595(0.86); C598(0.86)  LDD0910  [1]
 LDCM0313  AC50 HEK-293T C595(1.05); C598(1.05)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C595(1.10); C598(1.10)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C595(1.34); C598(1.34)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C595(1.24); C598(1.24)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C595(1.07); C598(1.07)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C595(1.10); C598(1.10)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C595(1.25); C598(1.25)  LDD0917  [1]
 LDCM0320  AC57 HCT 116 C595(1.15); C598(1.15)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C595(1.46); C598(1.46)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C595(1.03); C598(1.03)  LDD0639  [1]
 LDCM0323  AC6 HEK-293T C595(0.98); C598(0.98)  LDD0921  [1]
 LDCM0324  AC60 HCT 116 C595(1.06); C598(1.06)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C595(0.93); C598(0.93)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C595(1.56); C598(1.56)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C595(1.17); C598(1.17)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C595(1.23); C598(1.23)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C595(0.32); C598(0.32)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C595(0.26); C598(0.26)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C595(0.33); C598(0.33)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C595(1.20); C598(1.20)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C595(1.37); C598(1.37)  LDD0650  [1]
 LDCM0334  AC7 HEK-293T C595(0.72); C598(0.72)  LDD0932  [1]
 LDCM0335  AC70 HCT 116 C595(1.19); C598(1.19)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C595(1.06); C598(1.06)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C595(1.40); C598(1.40)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C595(2.39); C598(2.39)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C595(1.76); C598(1.76)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C595(2.90); C598(2.90)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C595(1.53); C598(1.53)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C595(1.79); C598(1.79)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C595(1.36); C598(1.36)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C595(1.25); C598(1.25)  LDD0661  [1]
 LDCM0345  AC8 HEK-293T C595(1.19); C598(1.19)  LDD0943  [1]
 LDCM0346  AC80 HCT 116 C595(1.52); C598(1.52)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C595(1.12); C598(1.12)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C595(2.61); C598(2.61)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C595(1.51); C598(1.51)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C595(1.21); C598(1.21)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C595(1.00); C598(1.00)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C595(1.74); C598(1.74)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C595(2.32); C598(2.32)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C595(1.43); C598(1.43)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C595(1.98); C598(1.98)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C595(1.16); C598(1.16)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C595(2.71); C598(2.71)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C595(2.67); C598(2.67)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C595(1.34); C598(1.34)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C595(1.29); C598(1.29)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C595(1.21); C598(1.21)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C595(2.19); C598(2.19)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C595(1.77); C598(1.77)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C595(1.76); C598(1.76)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C595(0.78); C598(0.78)  LDD0683  [1]
 LDCM0248  AKOS034007472 HEK-293T C595(1.21); C598(1.21)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C595(0.90); C598(0.90)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C595(0.99); C598(0.99)  LDD0873  [1]
 LDCM0020  ARS-1620 HCC44 C595(1.03); C598(1.03)  LDD0078  [1]
 LDCM0632  CL-Sc Hep-G2 C9(1.35)  LDD2227  [2]
 LDCM0369  CL100 HEK-293T C595(0.98); C598(0.98)  LDD0967  [1]
 LDCM0370  CL101 HEK-293T C595(1.08); C598(1.08)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C595(0.83); C598(0.83)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C595(0.76); C598(0.76)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C595(0.98); C598(0.98)  LDD0971  [1]
 LDCM0374  CL105 HEK-293T C595(2.05); C598(2.05)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C595(1.72); C598(1.72)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C595(1.73); C598(1.73)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C595(1.36); C598(1.36)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C595(1.26); C598(1.26)  LDD0976  [1]
 LDCM0380  CL110 HEK-293T C595(1.75); C598(1.75)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C595(1.14); C598(1.14)  LDD0979  [1]
 LDCM0382  CL112 HEK-293T C595(1.67); C598(1.67)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C595(1.67); C598(1.67)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C595(2.24); C598(2.24)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C595(1.08); C598(1.08)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C595(1.06); C598(1.06)  LDD0984  [1]
 LDCM0387  CL117 HEK-293T C595(1.30); C598(1.30)  LDD0985  [1]
 LDCM0388  CL118 HEK-293T C595(0.78); C598(0.78)  LDD0986  [1]
 LDCM0389  CL119 HEK-293T C595(0.87); C598(0.87)  LDD0987  [1]
 LDCM0391  CL120 HEK-293T C595(1.32); C598(1.32)  LDD0989  [1]
 LDCM0392  CL121 HEK-293T C595(0.82); C598(0.82)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C595(1.08); C598(1.08)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C595(0.97); C598(0.97)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C595(1.23); C598(1.23)  LDD0993  [1]
 LDCM0396  CL125 HCT 116 C595(0.72); C598(0.72)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C595(0.75); C598(0.75)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C595(0.71); C598(0.71)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C595(1.88); C598(1.88)  LDD0716  [1]
 LDCM0436  CL46 HCT 116 C595(0.95); C598(0.95)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C595(0.53); C598(0.53)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C595(0.61); C598(0.61)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C595(0.70); C598(0.70)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C595(0.72); C598(0.72)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C595(0.56); C598(0.56)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C595(1.22); C598(1.22)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C595(0.78); C598(0.78)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C595(1.21); C598(1.21)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C595(0.96); C598(0.96)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C595(0.61); C598(0.61)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C595(0.54); C598(0.54)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C595(0.71); C598(0.71)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C595(0.70); C598(0.70)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C595(0.65); C598(0.65)  LDD0769  [1]
 LDCM0453  CL61 HEK-293T C595(0.70); C598(0.70)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C595(0.98); C598(0.98)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C595(0.95); C598(0.95)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C595(1.39); C598(1.39)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C595(1.21); C598(1.21)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C595(1.13); C598(1.13)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C595(1.38); C598(1.38)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C595(1.21); C598(1.21)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C595(1.11); C598(1.11)  LDD1059  [1]
 LDCM0463  CL70 HEK-293T C595(1.13); C598(1.13)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C595(0.92); C598(0.92)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C595(2.02); C598(2.02)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C595(1.89); C598(1.89)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C595(0.88); C598(0.88)  LDD1065  [1]
 LDCM0469  CL76 HCT 116 C595(0.78); C598(0.78)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C595(0.87); C598(0.87)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C595(0.65); C598(0.65)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C595(0.84); C598(0.84)  LDD0789  [1]
 LDCM0474  CL80 HCT 116 C595(0.88); C598(0.88)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C595(0.87); C598(0.87)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C595(0.64); C598(0.64)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C595(0.82); C598(0.82)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C595(0.75); C598(0.75)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C595(0.89); C598(0.89)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C595(0.96); C598(0.96)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C595(0.63); C598(0.63)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C595(0.79); C598(0.79)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C595(1.03); C598(1.03)  LDD0800  [1]
 LDCM0485  CL90 HCT 116 C595(0.98); C598(0.98)  LDD0802  [1]
 LDCM0486  CL91 HEK-293T C595(0.99); C598(0.99)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C595(1.14); C598(1.14)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C595(1.09); C598(1.09)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C595(1.63); C598(1.63)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C595(1.37); C598(1.37)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C595(0.79); C598(0.79)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C595(1.23); C598(1.23)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C595(1.02); C598(1.02)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C595(1.03); C598(1.03)  LDD1092  [1]
 LDCM0468  Fragment33 HEK-293T C595(1.05); C598(1.05)  LDD1066  [1]
 LDCM0022  KB02 HCT 116 C595(4.16); C598(4.16)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C595(1.59); C598(1.59)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C595(3.10); C598(3.10)  LDD0082  [1]
 LDCM0021  THZ1 HCT 116 C595(1.21); C598(1.21)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adapter molecule crk (CRK) CRK family P46108
GRB2-related adapter protein 2 (GRAP2) GRB2/sem-5/DRK family O75791
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Cytoplasmic protein NCK2 (NCK2) . O43639

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.