Details of the Target

General Information of Target

Target ID LDTP11864
Target Name BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (KCTD10)
Gene Name KCTD10
Gene ID 83892
Synonyms
ULR061; BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3; hBACURD3; BTB/POZ domain-containing protein KCTD10; Potassium channel tetramerization domain-containing protein 10
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWD
FLEQPICSVQPIDLNFVDEPSEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSM
DQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVS
FQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEV
VKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFT
TVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIR
KQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKES
LELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQ
LINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPP
PPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKG
ILDHRQLHEFSSPSHLLRTPSSASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWND
FNFDMDARRNKQQRIKEEGE
Target Bioclass
Other
Family
BACURD family
Subcellular location
Nucleus
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome.
Uniprot ID
Q9H3F6
Ensemble ID
ENST00000228495.11
HGNC ID
HGNC:23236

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.Y134C DBIA    Probe Info 
HEC1 SNV: p.A160T DBIA    Probe Info 
TOV21G SNV: p.R308L .
YSCCC SNV: p.S156L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C138(1.06)  LDD0531  [2]
ATP probe
 Probe Info  		K147(0.00); K151(0.00)  LDD0199  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD0147  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C278
 Probe Info  		58.49  LDD1948  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C138(1.06)  LDD0531  [2]
 LDCM0215  AC10 PaTu 8988t C138(1.20)  LDD1094  [2]
 LDCM0216  AC100 PaTu 8988t C138(0.98)  LDD1095  [2]
 LDCM0217  AC101 PaTu 8988t C138(1.01)  LDD1096  [2]
 LDCM0218  AC102 PaTu 8988t C138(0.86)  LDD1097  [2]
 LDCM0219  AC103 PaTu 8988t C138(1.00)  LDD1098  [2]
 LDCM0220  AC104 PaTu 8988t C138(0.89)  LDD1099  [2]
 LDCM0221  AC105 PaTu 8988t C138(0.88)  LDD1100  [2]
 LDCM0222  AC106 PaTu 8988t C138(0.94)  LDD1101  [2]
 LDCM0223  AC107 PaTu 8988t C138(1.07)  LDD1102  [2]
 LDCM0224  AC108 PaTu 8988t C138(0.95)  LDD1103  [2]
 LDCM0225  AC109 PaTu 8988t C138(0.96)  LDD1104  [2]
 LDCM0226  AC11 PaTu 8988t C138(1.17)  LDD1105  [2]
 LDCM0227  AC110 PaTu 8988t C138(1.03)  LDD1106  [2]
 LDCM0228  AC111 PaTu 8988t C138(1.03)  LDD1107  [2]
 LDCM0229  AC112 PaTu 8988t C138(0.88)  LDD1108  [2]
 LDCM0230  AC113 HCT 116 C138(0.87)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C138(0.87)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C138(0.94)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C138(0.91)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C138(0.97)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C138(0.93)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C138(0.86)  LDD0553  [2]
 LDCM0237  AC12 PaTu 8988t C138(0.91)  LDD1116  [2]
 LDCM0238  AC120 HCT 116 C138(0.84)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C138(0.94)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C138(1.00)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C138(0.74)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C138(0.85)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C138(0.95)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C138(0.84)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C138(0.89)  LDD0562  [2]
 LDCM0259  AC14 PaTu 8988t C138(1.29)  LDD1138  [2]
 LDCM0263  AC143 PaTu 8988t C138(0.85)  LDD1142  [2]
 LDCM0264  AC144 PaTu 8988t C138(0.86)  LDD1143  [2]
 LDCM0265  AC145 PaTu 8988t C138(0.82)  LDD1144  [2]
 LDCM0266  AC146 PaTu 8988t C138(1.03)  LDD1145  [2]
 LDCM0267  AC147 PaTu 8988t C138(0.90)  LDD1146  [2]
 LDCM0268  AC148 PaTu 8988t C138(1.06)  LDD1147  [2]
 LDCM0269  AC149 PaTu 8988t C138(0.98)  LDD1148  [2]
 LDCM0270  AC15 PaTu 8988t C138(1.20)  LDD1149  [2]
 LDCM0271  AC150 PaTu 8988t C138(1.19)  LDD1150  [2]
 LDCM0272  AC151 PaTu 8988t C138(1.38)  LDD1151  [2]
 LDCM0273  AC152 PaTu 8988t C138(1.03)  LDD1152  [2]
 LDCM0274  AC153 PaTu 8988t C138(1.15)  LDD1153  [2]
 LDCM0621  AC154 PaTu 8988t C138(1.13)  LDD2166  [2]
 LDCM0622  AC155 PaTu 8988t C138(1.09)  LDD2167  [2]
 LDCM0623  AC156 PaTu 8988t C138(1.00)  LDD2168  [2]
 LDCM0624  AC157 PaTu 8988t C138(1.02)  LDD2169  [2]
 LDCM0276  AC17 HCT 116 C138(0.99)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C138(0.91)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C138(0.80)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C138(1.08)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C138(0.90)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C138(0.82)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C138(1.01)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C138(0.82)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C138(0.92)  LDD0601  [2]
 LDCM0285  AC25 PaTu 8988t C138(0.87)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C138(1.35)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C138(1.49)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C138(1.49)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C138(1.46)  LDD1168  [2]
 LDCM0290  AC3 HCT 116 C138(1.17)  LDD0607  [2]
 LDCM0291  AC30 PaTu 8988t C138(1.28)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C138(1.23)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C138(1.30)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C138(1.27)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C138(1.02)  LDD1174  [2]
 LDCM0296  AC35 HCT 116 C138(1.00)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C138(0.91)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C138(1.04)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C138(0.89)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C138(0.91)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C138(0.96)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C138(1.01)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C138(0.77)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C138(0.85)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C138(0.81)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C138(1.00)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C138(0.99)  LDD0624  [2]
 LDCM0312  AC5 HCT 116 C138(1.20)  LDD0629  [2]
 LDCM0320  AC57 HEK-293T C138(1.07)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C138(0.95)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C138(0.97)  LDD0920  [2]
 LDCM0323  AC6 PaTu 8988t C138(0.94)  LDD1202  [2]
 LDCM0324  AC60 HEK-293T C138(1.40)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C138(1.15)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C138(1.14)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C138(1.21)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C138(1.14)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C138(1.00)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C138(1.01)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C138(1.03)  LDD0929  [2]
 LDCM0332  AC68 HCT 116 C138(0.86)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C138(0.92)  LDD0650  [2]
 LDCM0334  AC7 PaTu 8988t C138(0.88)  LDD1213  [2]
 LDCM0335  AC70 HCT 116 C138(1.07)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C138(0.96)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C138(1.01)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C138(1.10)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C138(1.02)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C138(1.15)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C138(1.06)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C138(1.05)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C138(1.08)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C138(1.22)  LDD0661  [2]
 LDCM0345  AC8 PaTu 8988t C138(0.82)  LDD1224  [2]
 LDCM0346  AC80 HCT 116 C138(1.26)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C138(1.02)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C138(1.18)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C138(1.38)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C138(1.53)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C138(1.78)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C138(1.32)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C138(1.14)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C138(1.66)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C138(1.21)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C138(1.02)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C138(1.09)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C138(1.19)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C138(1.09)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C138(0.99)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C138(1.35)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C138(0.98)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C138(1.55)  LDD0681  [2]
 LDCM0365  AC98 PaTu 8988t C138(0.89)  LDD1244  [2]
 LDCM0366  AC99 PaTu 8988t C138(0.98)  LDD1245  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C138(1.40)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C138(1.13)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C138(1.21)  LDD1154  [2]
 LDCM0367  CL1 PaTu 8988t C138(1.04)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C138(1.32)  LDD1247  [2]
 LDCM0369  CL100 HCT 116 C138(1.14)  LDD0686  [2]
 LDCM0370  CL101 PaTu 8988t C138(0.90)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C138(1.02)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C138(1.38)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C138(1.06)  LDD1252  [2]
 LDCM0374  CL105 HCT 116 C138(0.98)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C138(0.94)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C138(0.95)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C138(0.97)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C138(0.84)  LDD0695  [2]
 LDCM0379  CL11 PaTu 8988t C138(1.96)  LDD1258  [2]
 LDCM0380  CL110 HCT 116 C138(0.99)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C138(0.97)  LDD0698  [2]
 LDCM0382  CL112 PaTu 8988t C138(1.08)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C138(1.40)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C138(1.12)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C138(1.26)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C138(1.38)  LDD1265  [2]
 LDCM0387  CL117 HCT 116 C138(0.89)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C138(0.78)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C138(0.75)  LDD0706  [2]
 LDCM0390  CL12 PaTu 8988t C138(1.78)  LDD1269  [2]
 LDCM0391  CL120 HCT 116 C138(0.85)  LDD0708  [2]
 LDCM0396  CL125 HEK-293T C138(1.00)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C138(1.08)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C138(1.08)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C138(0.97)  LDD0997  [2]
 LDCM0400  CL13 PaTu 8988t C138(1.56)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C138(1.74)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C138(1.60)  LDD1281  [2]
 LDCM0403  CL16 HEK-293T C138(0.91)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C138(1.11)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C138(0.82)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C138(0.97)  LDD1004  [2]
 LDCM0407  CL2 PaTu 8988t C138(1.19)  LDD1286  [2]
 LDCM0408  CL20 HEK-293T C138(0.94)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C138(0.80)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C138(1.01)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C138(0.96)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C138(0.82)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C138(0.74)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C138(0.95)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C138(0.75)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C138(0.82)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C138(1.05)  LDD1015  [2]
 LDCM0418  CL3 PaTu 8988t C138(1.11)  LDD1297  [2]
 LDCM0419  CL30 HEK-293T C138(0.92)  LDD1017  [2]
 LDCM0429  CL4 PaTu 8988t C138(1.03)  LDD1308  [2]
 LDCM0436  CL46 HCT 116 C138(0.82)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C138(0.78)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C138(0.85)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C138(0.84)  LDD0756  [2]
 LDCM0440  CL5 PaTu 8988t C138(1.56)  LDD1319  [2]
 LDCM0441  CL50 HCT 116 C138(0.87)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C138(0.87)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C138(0.82)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C138(0.90)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C138(0.86)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C138(0.81)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C138(0.92)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C138(0.92)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C138(0.84)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C138(0.88)  LDD0767  [2]
 LDCM0451  CL6 PaTu 8988t C138(1.33)  LDD1330  [2]
 LDCM0452  CL60 HCT 116 C138(0.80)  LDD0769  [2]
 LDCM0462  CL7 PaTu 8988t C138(1.26)  LDD1341  [2]
 LDCM0469  CL76 HCT 116 C138(0.81)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C138(0.61)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C138(1.02)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C138(0.90)  LDD0789  [2]
 LDCM0473  CL8 PaTu 8988t C138(1.34)  LDD1352  [2]
 LDCM0474  CL80 HCT 116 C138(1.91)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C138(0.82)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C138(0.99)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C138(0.86)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C138(1.07)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C138(0.98)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C138(0.88)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C138(0.88)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C138(0.89)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C138(1.27)  LDD0800  [2]
 LDCM0484  CL9 PaTu 8988t C138(1.11)  LDD1363  [2]
 LDCM0485  CL90 HCT 116 C138(1.23)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C138(1.23)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C138(1.44)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C138(0.88)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C138(1.06)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C138(1.09)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C138(1.09)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C138(1.15)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C138(1.11)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C138(1.02)  LDD0811  [2]
 LDCM0022  KB02 786-O C138(2.21)  LDD2247  [9]
 LDCM0023  KB03 786-O C138(2.50)  LDD2664  [9]
 LDCM0024  KB05 NCI-H1155 C138(3.26)  LDD3342  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cullin-3 (CUL3) Cullin family Q13618
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (KCTD13) BACURD family Q8WZ19
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (TNFAIP1) BACURD family Q13829
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (KCTD10) BACURD family Q9H3F6
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840