Details of the Target

General Information of Target

Target ID LDTP11611
Target Name Centrosomal protein of 44 kDa (CEP44)
Gene Name CEP44
Gene ID 80817
Synonyms
KIAA1712; Centrosomal protein of 44 kDa; Cep44; HBV PreS1-transactivated protein 3; PS1TP3
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKDKRKKKDRTWAEAARLALEKHPNSPMTAKQILEVIQKEGLKETSGTSPLACLNAMLHT
NTRIGDGTFFKIPGKSGLYALKKEESSCPADGTLDLVCESELDGTDMAEANAHGEENGVC
SKQVTDEASSTRDSSLTNTAVQSKLVSSFQQHTKKALKQALRQQQKRRNGVSMMVNKTVP
RVVLTPLKVSDEQSDSPSGSESKNGEADSSDKEMKHGQKSPTGKQTSQHLKRLKKSGLGH
LKWTKAEDIDIETPGSILVNTNLRALINKHTFASLPQHFQQYLLLLLPEVDRQMGSDGIL
RLSTSALNNEFFAYAAQGWKQRLAEGEFTPEMQLRIRQEIEKEKKTEPWKEKFFERFYGE
KLGMSREESVKLTTGPNNAGAQSSSSCGTSGLPVSAQTALAEQQPKSMKSPASPEPGFCA
TLCPMVEIPPKDIMAELESEDILIPEESVIQEEIAEEVETSICECQDENHKTIPEFSEEA
ESLTNSHEEPQIAPPEDNLESCVMMNDVLETLPHIEVKIEGKSESPQEEMTVVIDQLEVC
DSLIPSTSSMTHVSDTEHKESETAVETSTPKIKTGSSSLEGQFPNEGIAIDMELQSDPEE
QLSENACISETSFSSESPEGACTSLPSPGGETQSTSEESCTPASLETTFCSEVSSTENTD
KYNQRNSTDENFHASLMSEISPISTSPEISEASLMSNLPLTSEASPVSNLPLTSETSPMS
DLPLTSETSSVSSMLLTSETTFVSSLPLPSETSPISNSSINERMAHQQRKSPSVSEEPLS
PQKDESSATAKPLGENLTSQQKNLSNTPEPIIMSSSSIAPEAFPSEDLHNKTLSQQTCKS
HVDTEKPYPASIPELASTEMIKVKNHSVLQRTEKKVLPSPLELSVFSEGTDNKGNELPSA
KLQDKQYISSVDKAPFSEGSRNKTHKQGSTQSRLETSHTSKSSEPSKSPDGIRNESRDSE
ISKRKTAEQHSFGICKEKRARIEDDQSTRNISSSSPPEKEQPPREEPRVPPLKIQLSKIG
PPFIIKSQPVSKPESRASTSTSVSGGRNTGARTLADIKARAQQARAQREAAAAAAVAAAA
SIVSGAMGSPGEGGKTRTLAHIKEQTKAKLFAKHQARAHLFQTSKETRLPPPLSSKEGPP
NLEVSSTPETKMEGSTGVIIVNPNCRSPSNKSAHLRETTTVLQQSLNPSKLPETATDLSV
HSSDENIPVSHLSEKIVSSTSSENSSVPMLFNKNSVPVSVCSTAISGAIKEHPFVSSVDK
SSVLMSVDSANTTISACNISMLKTIQGTDTPCIAIIPKCIESTPISATTEGSSISSSMDD
KQLLISSSSASNLVSTQYTSVPTPSIGNNLPNLSTSSVLIPPMGINNRFPSEKIAIPGSE
EQATVSMGTTVRAALSCSDSVAVTDSLVAHPTVAMFTGNMLTINSYDSPPKLSAESLDKN
SGPRNRADNSGKPQQPPGGFAPAAINRSIPCKVIVDHSTTLTSSLSLTVSVESSEASLDL
QGRPVRTEASVQPVACPQVSVISRPEPVANEGIDHSSTFIAASAAKQDSKTLPATCTSLR
ELPLVPDKLNEPTAPSHNFAEQARGPAPFKSEADTTCSNQYNPSNRICWNDDGMRSTGQP
LVTHSGSSKQKEYLEQSCPKAIKTEHANYLNVSELHPRNLVTNVALPVKSELHEADKGFR
MDTEDFPGPELPPPAAEGASSVQQTQNMKASTSSPMEEAISLATDALKRVPGAGSSGCRL
SSVEANNPLVTQLLQGNLPLEKVLPQPRLGAKLEINRLPLPLQTTSVGKTAPERNVEIPP
SSPNPDGKGYLAGTLAPLQMRKRENHPKKRVARTVGEHTQVKCEPGKLLVEPDVKGVPCV
ISSGISQLGHSQPFKQEWLNKHSMQNRIVHSPEVKQQKRLLPSCSFQQNLFHVDKNGGFH
TDAGTSHRQQFYQMPVAARGPIPTAALLQASSKTPVGCNAFAFNRHLEQKGLGEVSLSSA
PHQLRLANMLSPNMPMKEGDEVGGTAHTMPNKALVHPPPPPPPPPPPPLALPPPPPPPPP
LPPPLPNAEVPSDQKQPPVTMETTKRLSWPQSTGICSNIKSEPLSFEEGLSSSCELGMKQ
VSYDQNEMKEQLKAFALKSADFSSYLLSEPQKPFTQLAAQKMQVQQQQQLCGNYPTIHFG
STSFKRAASAIEKSIGILGSGSNPATGLSGQNAQMPVQNFADSSNADELELKCSCRLKAM
IVCKGCGAFCHDDCIGPSKLCVACLVVR
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall. Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome.
Uniprot ID
Q9C0F1
Ensemble ID
ENST00000296519.6
HGNC ID
HGNC:29356

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 Deletion: p.M265Ter DBIA    Probe Info 
HCT116 Deletion: p.I106SfsTer8 .
IPC298 SNV: p.L126F DBIA    Probe Info 
RL952 Deletion: p.M375CfsTer9 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C28(2.10)  LDD0168  [2]
DBIA
 Probe Info  		C355(43.71)  LDD0209  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C244(0.00); C28(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C244(0.00); C28(0.00)  LDD0037  [4]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
NAIA_4
 Probe Info  		C244(0.00); C355(0.00); 0.00  LDD2226  [6]
NAIA_5
 Probe Info  		N.A.  LDD2225  [6]
TFBX
 Probe Info  		C355(0.00); C28(0.00)  LDD0027  [5]
Compound 10
 Probe Info  		N.A.  LDD2216  [7]
IPM
 Probe Info  		N.A.  LDD0005  [8]
VSF
 Probe Info  		N.A.  LDD0007  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C286
 Probe Info  		5.03  LDD1956  [11]
FFF probe14
 Probe Info  		20.00  LDD0477  [12]
FFF probe3
 Probe Info  		14.89  LDD0465  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C28(2.10)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C28(2.95)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C260(1.01); C99(1.14); C244(0.87); C28(1.00)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C260(0.98); C99(1.05); C244(1.12); C28(1.02)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C260(0.97); C99(1.04); C244(1.00); C355(0.94)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C260(1.01); C99(1.17); C244(0.99); C28(0.95)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C260(1.00); C99(1.02); C244(1.25); C355(1.08)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C260(0.90); C99(1.17); C244(1.00); C28(1.07)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C260(1.02); C99(1.14); C244(0.77); C28(1.01)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C260(1.07); C99(1.11); C244(1.11); C28(0.94)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C260(1.16); C99(1.07); C244(1.03); C355(1.69)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C260(1.00); C99(1.12); C244(0.90); C28(0.92)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C260(0.95); C99(1.14); C244(1.04); C28(0.99)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C260(0.98); C99(1.07); C244(0.99); C355(1.11)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C260(0.91); C99(1.21); C244(1.02); C355(1.09)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C260(0.96); C99(0.99); C244(0.98); C28(1.02)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C260(0.90); C99(1.01); C244(1.10); C355(0.92)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C260(1.00); C99(1.09); C244(0.87); C28(0.92)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C260(1.04); C99(1.14); C244(1.02); C28(1.00)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C260(0.97); C99(0.96); C244(0.82); C355(0.96)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C260(1.09); C99(1.28); C244(1.03); C28(0.96)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C260(1.03); C99(1.03); C244(1.25); C355(1.02)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C260(0.99); C99(1.07); C244(1.06); C355(0.99)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C260(1.00); C99(1.12); C244(1.17); C355(1.04)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C260(0.93); C99(1.11); C244(1.00); C28(1.05)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C260(0.97); C99(1.01); C244(0.94); C355(0.97)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C260(0.99); C99(1.08); C244(0.86); C28(0.94)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C260(0.98); C99(1.02); C244(1.12); C28(0.97)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C260(0.91); C99(1.10); C244(0.88); C355(1.00)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C260(0.98); C99(1.21); C244(0.91); C28(0.99)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C260(0.99); C99(1.01); C244(1.01); C355(0.99)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C260(0.99); C99(1.24); C244(1.34); C355(1.09)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C260(0.96); C99(1.16); C244(1.17); C28(0.94)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C260(1.11); C99(1.11); C244(1.09); C28(1.04)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C260(0.91); C99(1.04); C244(0.96); C355(1.00)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C260(1.04); C99(1.11); C244(0.87); C28(1.04)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C260(0.97); C99(1.06); C244(0.99); C28(0.92)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C260(0.94); C99(1.03); C244(0.94); C355(1.07)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C260(1.03); C99(1.20); C244(0.96); C28(0.99)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C260(0.95); C99(1.10); C244(1.05); C355(1.08)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C260(1.02); C99(1.01); C244(1.14); C355(0.95)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C260(0.90); C99(1.17); C244(1.02); C28(0.95)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C260(0.96); C99(1.06); C244(1.00); C355(0.97)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C260(1.03); C99(1.17); C244(0.82); C28(1.03)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C260(0.99); C99(1.05); C244(1.06); C355(1.01)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C260(0.97); C99(1.05); C244(1.07); C28(0.91)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C260(0.93); C99(1.03); C244(0.94); C355(0.94)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C260(0.99); C99(1.27); C244(0.99); C28(1.07)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C260(0.94); C99(1.07); C244(1.01); C355(0.95)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C260(0.91); C99(1.07); C244(1.19); C355(1.02)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C260(0.92); C99(1.06); C244(1.05); C28(0.94)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C260(1.02); C99(1.05); C244(1.08); C355(0.96)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C260(1.05); C99(1.09); C244(0.82); C28(0.96)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C260(1.01); C99(1.17); C244(1.05); C28(0.96)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C260(1.01); C99(1.11); C244(1.02); C355(0.89)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C260(1.01); C99(1.11); C244(1.18); C355(0.98)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C260(1.05); C99(1.37); C244(1.03); C28(1.05)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C260(1.03); C99(1.13); C244(1.09); C355(1.03)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C260(1.04); C99(1.14); C244(1.06); C355(1.37)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C260(0.96); C99(1.13); C244(1.03); C28(0.97)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C260(0.99); C99(1.04); C244(1.03); C355(0.96)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C260(0.99); C99(1.17); C244(1.08); C28(1.02)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C260(0.93); C99(1.05); C244(0.99); C355(0.99)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C260(1.07); C99(1.14); C244(1.02); C355(0.99)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C260(1.01); C99(1.11); C244(0.92); C28(0.95)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C260(0.99); C99(1.02); C244(1.00); C355(0.94)  LDD1514  [13]
 LDCM0156  Aniline NCI-H1299 11.81  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C260(1.05); C99(1.24); C244(1.07); C355(1.04)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C260(0.91); C99(1.05); C244(0.97); C355(1.18)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C260(0.97); C99(0.97); C244(0.96); C28(1.04)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C260(0.93); C99(1.09); C244(1.10); C355(1.10)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C260(0.96); C99(1.02); C355(1.03); C28(1.02)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C260(0.95); C99(1.05); C244(0.99); C355(1.06)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C260(0.94); C99(1.09); C244(0.99); C28(0.98)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C260(0.96); C99(1.13); C244(1.06); C355(0.97)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C260(1.00); C99(1.10); C355(1.01); C28(0.96)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C260(0.96); C99(1.01); C244(1.18); C355(0.88)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C260(1.05); C99(1.03); C244(0.88); C28(0.93)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C260(0.94); C99(1.16); C244(0.92); C355(0.95)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C260(1.03); C99(1.14); C244(1.10); C28(1.14)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C260(0.96); C99(1.04); C355(0.91); C28(0.91)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C260(0.96); C99(1.05); C244(1.10); C355(1.06)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C260(1.01); C99(1.11); C244(1.11); C28(1.18)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C260(0.99); C99(1.15); C244(0.98); C355(0.87)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C260(1.01); C99(1.26); C355(0.95); C28(0.96)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C260(1.04); C99(1.03); C244(1.06); C355(1.04)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C260(0.94); C99(1.06); C244(0.82); C28(1.03)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C260(1.00); C99(1.14); C244(0.92); C355(1.10)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C260(0.99); C99(1.07); C355(1.25); C28(1.00)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C260(1.02); C99(1.05); C244(1.09); C355(1.01)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C260(0.94); C99(1.06); C244(1.10); C355(0.97)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C260(0.94); C99(0.95); C244(1.15); C28(1.06)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C260(0.96); C99(1.12); C244(1.02); C355(1.02)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C260(0.93); C99(1.12); C355(1.10); C28(0.98)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C260(0.91); C99(1.08); C244(1.04); C355(0.91)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C260(0.97); C99(0.88); C244(0.90); C28(1.02)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C260(0.99); C99(1.22); C244(1.18); C355(1.11)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C260(0.97); C99(1.15); C355(0.90); C28(1.00)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C260(0.98); C99(1.05); C244(1.13); C355(0.99)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C260(1.00); C99(1.14); C244(0.92); C28(1.05)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C260(1.11); C99(1.11); C244(1.08); C355(1.12)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C260(0.99); C99(1.21); C355(1.12); C28(0.82)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C260(0.94); C99(1.07); C244(0.91); C355(1.01)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C260(0.93); C99(1.02); C244(0.93); C28(1.04)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C260(1.02); C99(1.35); C244(0.81); C28(0.94)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C260(0.92); C99(1.01); C244(1.16); C28(0.91)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C260(0.93); C99(1.03); C244(1.14); C355(1.05)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C260(1.01); C99(1.41); C355(1.05); C28(0.88)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C260(1.06); C99(1.45); C244(1.04); C28(1.01)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C260(1.08); C99(1.08); C244(0.84); C355(1.13)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C260(1.08); C99(0.95); C244(1.24); C355(1.11)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C260(0.96); C99(1.21); C244(1.11); C28(1.06)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C260(1.11); C99(1.04); C244(1.25); C355(0.95)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C260(0.96); C99(1.15); C244(0.98); C355(0.97)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C260(0.99); C99(1.33); C355(1.16); C28(0.91)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C260(1.02); C99(1.02); C244(0.96); C355(1.01)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C260(0.95); C99(1.17); C244(0.90); C28(1.00)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C260(0.97); C99(1.08); C244(1.08); C28(0.90)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C260(1.06); C99(1.02); C244(1.12); C355(0.93)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C260(0.97); C99(0.94); C244(1.06); C28(0.90)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C260(0.98); C99(1.11); C244(1.42); C355(1.10)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C260(1.07); C99(1.17); C244(1.02); C28(0.98)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C260(0.90); C99(1.01); C244(0.92); C355(1.12)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C260(1.03); C99(1.19); C244(1.23); C355(0.99)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C260(0.92); C99(1.00); C244(1.08); C28(1.01)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C260(1.06); C99(0.94); C244(1.18); C355(1.02)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C260(0.94); C99(1.19); C244(1.17); C355(0.91)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C260(0.95); C99(1.11); C244(0.98); C355(0.92)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C260(0.99); C99(1.00); C244(1.15); C28(1.03)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C260(0.93); C99(1.10); C244(1.08); C28(1.14)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C260(0.95); C99(1.12); C244(0.89); C28(1.03)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C260(1.02); C99(1.08); C244(1.20); C28(0.94)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C260(0.92); C99(1.00); C244(0.82); C355(0.92)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C260(0.97); C99(1.06); C244(1.02); C28(0.99)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C260(0.99); C99(0.97); C244(1.02); C355(1.05)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C260(1.15); C99(1.04); C244(1.26); C355(0.97)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C260(0.93); C99(1.11); C244(1.04); C28(1.00)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C260(1.00); C99(1.04); C244(0.93); C355(1.00)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C260(1.00); C99(1.31); C244(1.16); C355(1.09)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C260(1.07); C99(1.21); C244(0.92); C28(0.99)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C260(0.94); C99(1.18); C355(1.05); C28(0.94)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C260(0.91); C99(0.90); C244(1.09); C28(0.96)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C260(0.93); C99(1.14); C244(0.66); C28(1.04)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C260(0.90); C99(1.21); C244(0.94); C28(0.93)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C260(0.94); C99(0.96); C244(1.51); C355(1.02)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C260(1.17); C99(1.30); C244(0.89); C28(1.06)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C260(0.99); C99(1.07); C244(1.11); C355(1.27)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C260(0.88); C99(1.05); C244(1.17); C355(1.05)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C260(0.96); C99(1.20); C244(1.14); C28(0.96)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C260(0.91); C99(1.05); C244(0.95); C28(0.97)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C260(0.98); C99(0.97); C244(1.04); C355(0.88)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C260(0.99); C99(1.19); C244(0.94); C355(0.97)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C260(0.94); C99(1.05); C355(1.05); C28(0.93)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C260(0.96); C99(1.05); C244(1.04); C355(1.02)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C260(0.85); C99(1.10); C244(0.83); C28(0.91)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C260(0.95); C99(1.05); C244(0.83); C28(0.94)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C260(1.00); C99(1.12); C244(0.96); C28(0.90)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C260(0.95); C99(0.99); C244(1.03); C355(0.99)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C260(1.11); C99(1.18); C244(0.97); C28(0.95)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C260(1.00); C99(1.04); C244(1.09); C355(1.17)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C260(0.95); C99(1.07); C244(1.08); C355(0.87)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C260(0.87); C99(1.02); C244(1.29); C355(1.08)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C260(0.99); C99(1.30); C244(1.00); C28(1.04)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C260(1.02); C99(1.00); C244(1.17); C355(1.05)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C260(0.90); C99(1.03); C244(1.06); C355(0.98)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C260(0.95); C99(1.22); C355(0.92); C28(0.92)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C260(0.91); C99(1.16); C244(1.01); C28(0.96)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C260(0.98); C99(1.20); C244(0.73); C28(1.29)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C260(0.97); C99(1.07); C244(1.15); C28(0.98)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C260(0.92); C99(1.04); C244(1.62); C355(0.95)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C260(0.93); C99(1.25); C244(1.07); C28(1.19)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C260(0.98); C99(1.11); C244(1.01); C28(0.94)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C260(1.04); C99(1.00); C244(1.04); C355(1.02)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C260(0.98); C99(1.10); C244(1.22); C355(0.99)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C260(1.00); C99(1.02); C244(0.90); C28(1.02)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C260(1.07); C99(1.04); C244(0.84); C355(1.00)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C260(0.97); C99(1.31); C244(1.02); C355(1.00)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C260(1.00); C99(1.48); C355(1.13); C28(0.84)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C260(1.04); C99(1.19); C244(0.94); C355(1.01)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C260(0.92); C99(1.23); C244(1.17); C28(0.96)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C260(1.01); C99(1.22); C244(0.93); C28(0.92)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C260(1.13); C99(1.01); C244(1.16); C355(1.10)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C260(0.87); C99(1.30); C244(0.96); C28(0.94)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C260(0.91); C99(1.09); C244(1.14); C355(0.99)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C260(1.03); C99(1.32); C244(0.95); C28(0.90)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C260(1.00); C99(0.98); C244(1.17); C355(1.02)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C260(1.26); C99(1.11); C244(1.18); C355(1.04)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C260(0.94); C99(0.94); C244(0.99); C28(1.29)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C260(0.90); C99(1.09); C244(0.82); C355(1.01)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C260(0.99); C99(1.15); C244(0.99); C355(0.87)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C260(1.04); C99(1.30); C355(1.06); C28(1.03)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C260(1.04); C99(1.02); C244(0.86); C355(1.01)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C260(0.89); C99(0.82); C244(0.99); C355(0.99)  LDD1698  [13]
 LDCM0468  Fragment33 HEK-293T C260(0.93); C99(1.03); C244(1.02); C355(1.10)  LDD1671  [13]
 LDCM0427  Fragment51 HEK-293T C260(0.93); C99(1.05); C355(1.15); C28(0.88)  LDD1631  [13]
 LDCM0022  KB02 HEK-293T C260(0.97); C99(0.96); C28(1.04); C244(0.93)  LDD1492  [13]
 LDCM0023  KB03 Jurkat C355(43.71)  LDD0209  [3]
 LDCM0024  KB05 G361 C385(5.51)  LDD3311  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-alpha-acetyltransferase 10 (NAA10) Acetyltransferase family P41227
Cell division cycle protein 23 homolog (CDC23) APC8/CDC23 family Q9UJX2
Putative ATP-dependent RNA helicase DHX57 (DHX57) DEAD box helicase family Q6P158
Disco-interacting protein 2 homolog A (DIP2A) DIP2 family Q14689
DNA-directed RNA polymerase III subunit RPC3 (POLR3C) Eukaryotic RPC3/POLR3C RNA polymerase subunit family Q9BUI4
Ribonuclease P/MRP protein subunit POP5 (POP5) Eukaryotic/archaeal RNase P protein component 2 family Q969H6
26S proteasome non-ATPase regulatory subunit 3 (PSMD3) Proteasome subunit S3 family O43242
Mitogen-activated protein kinase 9 (MAPK9) CMGC Ser/Thr protein kinase family P45984
E3 ubiquitin-protein ligase RNF8 (RNF8) RNF8 family O76064
GTPase Era, mitochondrial (ERAL1) Era GTPase family O75616
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Other
Click To Hide/Show 26 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ABI gene family member 3 (ABI3) ABI family Q9P2A4
Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC1S6) BLOC1S6 family Q9UL45
Bystin (BYSL) Bystin family Q13895
Centromere protein P (CENPP) CENP-P/CTF19 family Q6IPU0
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Protein chibby homolog 2 (CBY2) Chibby family Q8NA61
Cysteine-rich hydrophobic domain-containing protein 2 (CHIC2) CHIC family Q9UKJ5
Dynactin subunit 2 (DCTN2) Dynactin subunit 2 family Q13561
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM74A4/A6 (FAM74A4; FAM74A6) FAM74 family Q5TZK3
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 (GNG11) G protein gamma family P61952
HAUS augmin-like complex subunit 1 (HAUS1) HAUS1 family Q96CS2
Inhibitor of growth protein 5 (ING5) ING family Q8WYH8
Phakinin (BFSP2) Intermediate filament family Q13515
Calcium-binding protein 39 (CAB39) Mo25 family Q9Y376
MORF4 family-associated protein 1-like 1 (MRFAP1L1) MORF4 family-associated protein family Q96HT8
RNA-binding protein 15 (RBM15) RRM Spen family Q96T37
Alpha-taxilin (TXLNA) Taxilin family P40222
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
Coiled-coil domain-containing protein 146 (CCDC146) . Q8IYE0
Coiled-coil domain-containing protein 185 (CCDC185) . Q8N715
Huntingtin-interacting protein M (H2AP) . O75409
Microspherule protein 1 (MCRS1) . Q96EZ8
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
Rhombotin-1 (LMO1) . P25800

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840