Details of the Target

General Information of Target

Target ID LDTP11593
Target Name Histone-lysine N-methyltransferase SETD5 (SETD5)
Gene Name SETD5
Gene ID 55209
Synonyms
KIAA1757; Histone-lysine N-methyltransferase SETD5; EC 2.1.1.359; EC 2.1.1.367; SET domain-containing protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATLNSASTTGTTPSPGHNAPSLPSDTFSSSTPSDPVTKDPPAASSTSENMRSSEPGGQL
LESGCGLVPPKEIGEPQEGPDCGHFPPNDPGVEKDKEQEEEEEGLPPMDLSNHLFFTAGG
EAYLVAKLSLPGGSELLLPKGFPWGEAGIKEEPSLPFLAYPPPSHLTALHIQHGFDPIQG
FSSSDQILSHDTSAPSPAACEERHGAFWSYQLAPNPPGDPKDGPMGNSGGNHVAVFWLCL
LCRLGFSKPQAFMDHTQSHGVKLTPAQYQGLSGSPAVLQEGDEGCKALISFLEPKLPARP
SSDIPLDNSSTVNMEANVAQTEDGPPEAEVQALILLDEEVMALSPPSPPTATWDPSPTQA
KESPVAAGEAGPDWFPEGQEEDGGLCPPLNQSSPTSKEGGTLPAPVGSPEDPSDPPQPYR
LADDYTPAPAAFQGLSLSSHMSLLHSRNSCKTLKCPKCNWHYKYQQTLDVHMREKHPESN
SHCSYCSAGGAHPRLARGESYNCGYKPYRCDVCNYSTTTKGNLSIHMQSDKHLANLQGFQ
AGPGGQGSPPEASLPPSAGDKEPKTKSSWQCKVCSYETNISRNLRIHMTSEKHMQNVLML
HQGLPLGLPPGLMGPGPPPPPGATPTSPPELFQYFGPQALGQPQTPLAGPGLRPDKPLEA
QLLLNGFHHVGAPARKFPTSAPGSLSPDAHLPPSQLLGSSSDSLPTSPPPDDSLSLKVFR
CLVCQAFSTDSLELLLYHCSIGRSLPEAEWKEVAGDTHRCKLCCYGTQLKANFQLHLKTD
KHAQKYQLAAHLREGGGAMGTPSPASLGDGAPYGSVSPLHLRCNICDFESNSKEKMQLHA
RGAAHEENSQIYKFLLDMEGAEAGAELGLYHCLLCAWETPSRLAVLQHLRTPAHRDAQAQ
RRLQLLQNGPTTEEGLAALQSILSFSHGQLRTPGKAPVTPLAEPPTPEKDAQNKTEQLAS
EETENKTGPSRDSANQTTVYCCPYCSFLSPESSQVRAHTLSQHAVQPKYRCPLCQEQLVG
RPALHFHLSHLHNVVPECVEKLLLVATTVEMTFTTKVLSAPTLSPLDNGQEPPTHGPEPT
PSRDQAAEGPNLTPEASPDPLPEPPLASVEVPDKPSGSPGQPPSPAPSPVPEPDAQAEDV
APPPTMAEEEEGTTGELRSAEPAPADSRHPLTYRKTTNFALDKFLDPARPYKCTVCKESF
TQKNILLVHYNSVSHLHKMKKAAIDPSAPARGEAGAPPTTTAATDKPFKCTVCRVSYNQS
STLEIHMRSVLHQTRSRGTKTDSKIEGPERSQEEPKEGETEGEVGTEKKGPDTSGFISGL
PFLSPPPPPLDLHRFPAPLFTPPVLPPFPLVPESLLKLQQQQLLLPFYLHDLKVGPKLTL
AGPAPVLSLPAATPPPPPQPPKAELAEREWERPPMAKEGNEAGPSSPPDPLPNEAARTAA
KALLENFGFELVIQYNEGKQAVPPPPTPPPPEALGGGDKLACGACGKLFSNMLILKTHEE
HVHRRFLPFEALSRYAAQFRKSYDSLYPPLAEPPKPPDGSLDSPVPHLGPPFLVPEPEAG
GTRAPEERSRAGGHWPIEEEESSRGNLPPLVPAGRRFSRTKFTEFQTQALQSFFETSAYP
KDGEVERLASLLGLASRVVVVWFQNARQKARKNACEGGSMPTGGGTGGASGCRRCHATFS
CVFELVRHLKKCYDDQTLEEEEEEAERGEEEEEVEEEEVEEEQGLEPPAGPEGPLPEPPD
GEELSQAEATKAGGKEPEEKATPSPSPAHTCDQCAISFSSQDLLTSHRRLHFLPSLQPSA
PPQLLDLPLLVFGERNPLVAATSPMPGPPLKRKHEDGSLSPTGSEAGGGGEGEPPRDKRL
RTTILPEQLEILYRWYMQDSNPTRKMLDCISEEVGLKKRVVQVWFQNTRARERKGQFRST
PGGVPSPAVKPPATATPASLPKFNLLLGKVDDGTGREAPKREAPAFPYPTATLASGPQPF
LPPGKEATTPTPEPPLPLLPPPPPSEEEGPEEPPKASPESEACSLSAGDLSDSSASSLAE
PESPGAGGTSGGPGGGTGVPDGMGQRRYRTQMSSLQLKIMKACYEAYRTPTMQECEVLGE
EIGLPKRVIQVWFQNARAKEKKAKLQGTAAGSTGGSSEGLLAAQRTDCPYCDVKYDFYVS
CRGHLFSRQHLAKLKEAVRAQLKSESKCYDLAPAPEAPPALKAPPATTPASMPLGAAPTL
PRLAPVLLSGPALAQPPLGNLAPFNSGPAASSGLLGLATSVLPTTTVVQTAGPGRPLPQR
PMPDQTNTSTAGTTDPVPGPPTEPLGDKVSSERKPVAGPTSSSNDALKNLKALKTTVPAL
LGGQFLPFPLPPAGGTAPPAVFGPQLQGAYFQQLYGMKKGLFPMNPMIPQTLIGLLPNAL
LQPPPQPPEPTATAPPKPPELPAPGEGEAGEVDELLTGSTGISTVDVTHRYLCRQCKMAF
DGEAPATAHQRSFCFFGRGSGGSMPPPLRVPICTYHCLACEVLLSGREALASHLRSSAHR
RKAAPPQGGPPISITNAATAASAAVAFAKEEARLPHTDSNPKTTTTSTLLAL
Target Bioclass
Enzyme
Subcellular location
Nucleus
Function
Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion.
Uniprot ID
Q9C0A6
Ensemble ID
ENST00000402198.7
HGNC ID
HGNC:25566

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.A420T .
HT115 SNV: p.P1392T .
IGR1 SNV: p.D916E DBIA    Probe Info 
MEWO SNV: p.S476F DBIA    Probe Info 
RL952 SNV: p.R1275Q DBIA    Probe Info 
SNGM SNV: p.R1001Ter DBIA    Probe Info 
SNU308 Insertion: p.V571CfsTer42 .
SUPT1 SNV: p.M840T DBIA    Probe Info 
SW1271 SNV: p.P427L DBIA    Probe Info 
SW756 SNV: p.S1292L .
TOV21G SNV: p.S1323G .
WM793 SNV: p.S1253I DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K600(2.23)  LDD2217  [1]
DBIA
 Probe Info  		C717(20.00); C721(20.00)  LDD0080  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
NAIA_4
 Probe Info  		C930(0.00); C1050(0.00)  LDD2226  [4]
IPM
 Probe Info  		C1050(0.00); C721(0.00); C821(0.00); C881(0.00)  LDD2156  [5]
Phosphinate-6
 Probe Info  		C1156(0.00); C1050(0.00)  LDD0018  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C821(20.00)  LDD0372  [7]
 LDCM0214  AC1 HCT 116 C402(0.59); C404(0.59)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C402(0.96); C404(0.96); C901(1.12); C910(1.12)  LDD0813  [2]
 LDCM0216  AC100 HCT 116 C717(0.96); C721(0.96); C901(0.94); C910(0.94)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C717(0.86); C721(0.86); C901(0.82); C910(0.82)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C717(1.03); C721(1.03); C901(0.70); C910(0.70)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C717(1.92); C721(1.92); C901(0.87); C910(0.87)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C717(1.15); C721(1.15); C901(0.81); C910(0.81)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C717(1.20); C721(1.20); C901(0.96); C910(0.96)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C717(1.60); C721(1.60); C901(1.02); C910(1.02)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C717(1.45); C721(1.21); C901(0.82); C910(0.82)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C717(1.01); C721(0.82); C901(0.85); C910(0.85)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C717(0.78); C721(0.84); C901(0.77); C910(0.77)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C402(0.95); C404(0.95); C901(1.31); C910(1.31)  LDD0824  [2]
 LDCM0227  AC110 HCT 116 C717(0.71); C721(0.76); C901(0.91); C910(0.91)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C717(0.92); C721(0.99); C901(0.80); C910(0.80)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C717(1.15); C721(1.25); C901(1.01); C910(1.01)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C717(0.88); C721(0.88); C901(0.90); C910(0.90)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C717(0.74); C721(0.91); C901(1.12); C910(1.03)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C717(0.73); C721(1.10); C901(1.08); C910(1.09)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C717(0.99); C721(0.97); C901(1.12); C910(0.94)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C717(0.61); C721(0.90); C901(0.95); C910(0.93)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C717(0.80); C721(0.81); C901(1.14); C910(0.93)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C717(0.72); C721(0.91); C901(0.98); C910(0.93)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C402(0.98); C404(0.98); C901(1.05); C910(1.05)  LDD0835  [2]
 LDCM0238  AC120 HCT 116 C717(0.80); C721(0.97); C901(1.03); C910(1.14)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C717(1.03); C721(0.86); C901(0.81); C910(0.75)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C717(0.88); C721(0.83); C901(0.94); C910(0.94)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C717(0.93); C721(0.56); C901(0.70); C910(0.70)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C717(0.78); C721(0.83); C901(1.03); C910(0.93)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C717(0.80); C721(0.85); C901(1.00); C910(1.08)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C717(0.85); C721(0.89); C901(1.05); C910(1.07)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C717(0.79); C721(0.79); C901(0.79); C910(0.79)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C402(1.21); C404(1.21); C901(1.71); C910(1.71)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C402(0.96); C404(0.96); C901(1.48); C910(1.48)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C402(0.89); C404(0.89); C901(1.83); C910(1.83)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C402(0.95); C404(0.95); C901(1.98); C910(1.98)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C402(0.94); C404(0.94); C901(1.41); C910(1.41)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C402(1.05); C404(1.05); C901(1.38); C910(1.38)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C402(0.94); C404(0.94); C901(1.56); C910(1.56)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C402(0.89); C404(0.89); C901(1.83); C910(1.83)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C402(1.00); C404(1.00); C901(1.23); C910(1.23)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C402(0.90); C404(0.90); C901(1.00); C910(1.00)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C402(1.01); C404(1.01); C901(1.20); C910(1.20)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C402(0.89); C404(0.89); C901(1.41); C910(1.41)  LDD0575  [2]
 LDCM0259  AC14 HEK-293T C402(1.00); C404(1.00); C901(1.04); C910(1.04)  LDD0857  [2]
 LDCM0260  AC140 HCT 116 C402(0.96); C404(0.96); C901(1.56); C910(1.56)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C402(0.89); C404(0.89); C901(1.45); C910(1.45)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C402(0.90); C404(0.90); C901(1.26); C910(1.26)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C717(0.87); C721(0.87); C901(0.96); C910(0.96)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C901(0.94); C910(0.96); C717(1.80); C721(1.80)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C901(1.03); C910(1.04); C717(1.21); C721(1.21)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C910(1.21); C901(1.26); C717(1.28); C721(1.28)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C910(1.15); C901(1.23); C717(2.03); C721(2.03)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C910(1.13); C901(1.69); C717(1.78); C721(1.78)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C910(1.15); C717(1.56); C721(1.56); C901(1.79)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C402(0.98); C404(0.98); C901(1.09); C910(1.09)  LDD0868  [2]
 LDCM0271  AC150 HCT 116 C717(0.89); C721(0.89); C910(0.98); C901(1.03)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C910(0.96); C901(0.96); C717(1.18); C721(1.18)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C901(1.14); C910(1.14); C717(1.36); C721(1.36)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C910(1.22); C901(1.48); C717(2.23); C721(2.23)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C717(1.02); C721(1.02); C901(1.16); C910(1.08)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C717(1.58); C721(1.58); C901(1.03); C910(1.02)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C717(1.16); C721(1.16); C901(1.23); C910(1.30)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C717(1.24); C721(1.24); C901(1.32); C910(1.32)  LDD2161  [2]
 LDCM0276  AC17 HEK-293T C402(0.81); C404(0.81); C717(1.30); C721(1.30)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C402(1.00); C404(1.00); C717(1.25); C721(1.25)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C402(0.86); C404(0.86); C717(1.12); C721(1.12)  LDD0876  [2]
 LDCM0279  AC2 HCT 116 C402(0.64); C404(0.64)  LDD0596  [2]
 LDCM0280  AC20 HEK-293T C402(0.91); C404(0.91); C717(1.11); C721(1.11)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C402(1.04); C404(1.04); C717(0.94); C721(0.94)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C402(1.10); C404(1.10); C717(1.09); C721(1.09)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C402(1.02); C404(1.02); C717(1.29); C721(1.29)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C402(1.03); C404(1.03); C717(1.18); C721(1.18)  LDD0882  [2]
 LDCM0285  AC25 HEK-293T C354(1.22); C402(0.84); C404(0.84); C717(1.01)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C354(1.09); C402(0.62); C404(0.62); C717(1.15)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C354(0.96); C402(0.89); C404(0.89); C717(1.09)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C354(1.03); C402(0.61); C404(0.61); C717(1.08)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C354(0.96); C402(0.71); C404(0.71); C717(1.05)  LDD0887  [2]
 LDCM0290  AC3 HCT 116 C402(0.63); C404(0.63)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C354(1.02); C402(0.90); C404(0.90); C717(1.16)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C354(1.45); C402(0.68); C404(0.68); C717(0.96)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C354(1.46); C402(0.92); C404(0.92); C717(1.04)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C354(1.08); C402(0.76); C404(0.76); C717(1.16)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C354(1.63); C402(0.80); C404(0.80); C717(1.07)  LDD0893  [2]
 LDCM0296  AC35 HCT 116 C402(1.08); C404(1.08)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C402(1.14); C404(1.14)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C402(1.00); C404(1.00)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C402(0.86); C404(0.86)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C402(0.92); C404(0.92)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C402(0.61); C404(0.61)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C402(0.92); C404(0.92)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C402(0.96); C404(0.96)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C402(0.88); C404(0.88)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C402(0.83); C404(0.83)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C402(1.04); C404(1.04)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C402(1.02); C404(1.02)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C402(0.87); C404(0.87); C721(0.75); C901(1.23)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C402(1.16); C404(1.16); C721(0.94); C901(1.12)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C402(0.88); C404(0.88); C721(0.84); C901(1.03)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C402(1.03); C404(1.03); C721(1.33); C901(0.83)  LDD0909  [2]
 LDCM0312  AC5 HCT 116 C402(0.72); C404(0.72)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C402(0.89); C404(0.89); C721(1.20); C901(1.22)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C402(0.97); C404(0.97); C721(1.22); C901(1.14)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C402(0.76); C404(0.76); C721(1.03); C901(1.15)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C402(0.73); C404(0.73); C721(1.28); C901(1.33)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C402(0.76); C404(0.76); C721(1.04); C901(1.25)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C402(0.88); C404(0.88); C721(0.91); C901(1.11)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C402(0.93); C404(0.93); C721(0.91); C901(1.04)  LDD0917  [2]
 LDCM0320  AC57 HCT 116 C901(1.06); C910(1.06); C717(2.67); C721(2.67)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C717(0.89); C721(0.89); C901(1.00); C910(1.00)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C901(0.96); C910(0.96); C717(1.00); C721(1.00)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C402(0.88); C404(0.88); C901(1.02); C910(1.02)  LDD0921  [2]
 LDCM0324  AC60 HCT 116 C717(0.74); C721(0.74); C901(0.85); C910(0.85)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C901(1.00); C910(1.00); C717(2.02); C721(2.02)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C901(1.03); C910(1.03); C717(2.16); C721(2.16)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C901(0.57); C910(0.57); C717(1.34); C721(1.34)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C901(0.55); C910(0.55); C717(1.26); C721(1.26)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C717(0.71); C721(0.71); C901(1.07); C910(1.07)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C717(0.81); C721(0.81); C901(0.93); C910(0.93)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C901(0.70); C910(0.70); C717(0.86); C721(0.86)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C402(1.32); C404(1.32); C717(1.57); C721(1.57)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C717(1.09); C721(1.09); C402(1.27); C404(1.27)  LDD0650  [2]
 LDCM0334  AC7 HEK-293T C402(1.00); C404(1.00); C901(0.98); C910(0.98)  LDD0932  [2]
 LDCM0335  AC70 HCT 116 C402(1.17); C404(1.17); C717(1.36); C721(1.36)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C402(0.95); C404(0.95); C717(1.00); C721(1.00)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C717(1.06); C721(1.06); C402(1.16); C404(1.16)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C402(1.46); C404(1.46); C717(1.95); C721(1.95)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C402(1.63); C404(1.63); C717(2.00); C721(2.00)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C402(1.65); C404(1.65); C717(1.90); C721(1.90)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C402(1.15); C404(1.15); C717(1.43); C721(1.43)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C402(1.12); C404(1.12); C717(1.20); C721(1.20)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C402(1.21); C404(1.21); C717(1.26); C721(1.26)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C402(0.97); C404(0.97); C717(1.33); C721(1.33)  LDD0661  [2]
 LDCM0345  AC8 HEK-293T C402(1.19); C404(1.19); C901(1.04); C910(1.04)  LDD0943  [2]
 LDCM0346  AC80 HCT 116 C402(1.11); C404(1.11); C717(1.41); C721(1.41)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C717(0.78); C721(0.78); C402(1.17); C404(1.17)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C402(1.44); C404(1.44); C717(2.02); C721(2.02)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C402(0.98); C404(0.98); C717(1.52); C721(1.52)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C402(1.05); C404(1.05); C717(1.31); C721(1.31)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C402(0.93); C404(0.93); C901(1.20); C910(1.20)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C402(1.13); C404(1.13); C717(1.35); C721(1.35)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C402(1.02); C404(1.02); C901(1.16); C910(1.16)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C402(1.07); C404(1.07); C717(1.37); C721(1.37)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C402(0.90); C404(0.90); C717(1.42); C721(1.42)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C402(0.98); C404(0.98); C717(1.35); C721(1.35)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C402(0.76); C404(0.76); C717(1.38); C721(1.38)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C402(0.76); C404(0.76); C717(1.47); C721(1.47)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C402(0.76); C404(0.76); C717(1.24); C721(1.24)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C402(0.88); C404(0.88); C901(1.00); C910(1.00)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C402(0.75); C404(0.75); C717(1.37); C721(1.37)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C402(0.76); C404(0.76); C717(1.21); C721(1.21)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C402(0.78); C404(0.78); C717(1.64); C721(1.64)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C901(0.89); C910(0.89); C717(1.71); C721(1.71)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C901(0.73); C910(0.73); C717(0.87); C721(0.87)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C402(1.01); C404(1.01); C901(1.10); C910(1.10)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C402(0.98); C404(0.98); C901(1.12); C910(1.12)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C402(1.19); C404(1.19); C901(1.07); C910(1.07)  LDD0873  [2]
 LDCM0020  ARS-1620 HCC44 C717(1.21); C721(1.21); C402(1.11); C404(1.11)  LDD2171  [2]
 LDCM0367  CL1 HEK-293T C402(1.00); C404(1.00)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C402(0.81); C404(0.81)  LDD0966  [2]
 LDCM0369  CL100 HCT 116 C402(0.61); C404(0.61)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C402(0.88); C404(0.88); C901(1.24); C910(1.24)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C402(0.85); C404(0.85); C901(1.26); C910(1.26)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C402(0.93); C404(0.93); C901(1.21); C910(1.21)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C402(0.85); C404(0.85); C901(1.03); C910(1.03)  LDD0971  [2]
 LDCM0374  CL105 HEK-293T C402(1.16); C404(1.16); C717(1.01); C721(1.01)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C402(1.01); C404(1.01); C717(1.17); C721(1.17)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C402(1.10); C404(1.10); C717(1.20); C721(1.20)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C402(1.05); C404(1.05); C717(1.25); C721(1.25)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C402(0.83); C404(0.83); C717(1.23); C721(1.23)  LDD0976  [2]
 LDCM0379  CL11 HEK-293T C402(0.67); C404(0.67)  LDD0977  [2]
 LDCM0380  CL110 HEK-293T C402(0.77); C404(0.77); C717(1.39); C721(1.39)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C402(1.05); C404(1.05); C717(1.44); C721(1.44)  LDD0979  [2]
 LDCM0382  CL112 HEK-293T C354(1.02); C402(0.73); C404(0.73); C717(1.11)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C354(1.09); C402(0.85); C404(0.85); C717(1.11)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C354(0.99); C402(0.59); C404(0.59); C717(1.27)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C354(1.24); C402(0.62); C404(0.62); C717(1.22)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C354(1.15); C402(0.81); C404(0.81); C717(1.21)  LDD0984  [2]
 LDCM0387  CL117 HCT 116 C402(0.90); C404(0.90)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C402(1.22); C404(1.22)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C402(1.05); C404(1.05)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C402(0.86); C404(0.86)  LDD0988  [2]
 LDCM0391  CL120 HCT 116 C402(0.97); C404(0.97)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C402(0.82); C404(0.82); C721(0.84); C901(0.89)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C402(0.92); C404(0.92); C721(1.05); C901(0.94)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C402(1.09); C404(1.09); C721(1.41); C901(0.83)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C402(0.85); C404(0.85); C721(1.25); C901(1.11)  LDD0993  [2]
 LDCM0396  CL125 HCT 116 C717(0.88); C721(0.88); C901(1.34); C910(1.34)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C901(0.79); C910(0.79); C717(1.41); C721(1.41)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C717(0.60); C721(0.60); C901(0.77); C910(0.77)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C717(0.80); C721(0.80); C901(0.97); C910(0.97)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C402(0.79); C404(0.79)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C402(0.71); C404(0.71)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C402(0.90); C404(0.90)  LDD1000  [2]
 LDCM0403  CL16 HEK-293T C402(1.34); C404(1.34); C717(0.99); C721(0.99)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C402(1.00); C404(1.00); C717(1.61); C721(1.61)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C402(1.26); C404(1.26); C717(0.97); C721(0.97)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C402(1.16); C404(1.16); C717(1.07); C721(1.07)  LDD1004  [2]
 LDCM0407  CL2 HEK-293T C402(1.15); C404(1.15)  LDD1005  [2]
 LDCM0408  CL20 HEK-293T C402(1.03); C404(1.03); C717(1.05); C721(1.05)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C402(1.27); C404(1.27); C717(2.28); C721(2.28)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C402(0.94); C404(0.94); C717(1.28); C721(1.28)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C402(0.98); C404(0.98); C717(1.07); C721(1.07)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C402(1.15); C404(1.15); C717(1.12); C721(1.12)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C402(1.29); C404(1.29); C717(1.19); C721(1.19)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C402(1.13); C404(1.13); C717(1.04); C721(1.04)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C402(1.18); C404(1.18); C717(0.98); C721(0.98)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C402(1.04); C404(1.04); C717(1.19); C721(1.19)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C402(0.92); C404(0.92); C717(1.32); C721(1.32)  LDD1015  [2]
 LDCM0418  CL3 HEK-293T C402(0.94); C404(0.94)  LDD1016  [2]
 LDCM0419  CL30 HEK-293T C402(1.00); C404(1.00); C717(1.28); C721(1.28)  LDD1017  [2]
 LDCM0420  CL31 HEK-293T C402(0.98); C404(1.17); C717(0.93)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C402(0.95); C404(1.13); C717(0.89)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C402(0.82); C404(0.90); C717(1.00)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C402(0.78); C404(1.06); C717(0.90)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C402(0.93); C404(1.24); C717(0.95)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C402(0.91); C404(1.11); C717(0.94)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C402(0.92); C404(1.08); C717(0.82)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C402(0.85); C404(1.45); C717(1.29)  LDD1026  [2]
 LDCM0429  CL4 HEK-293T C402(1.02); C404(1.02)  LDD1027  [2]
 LDCM0430  CL40 HEK-293T C402(0.83); C404(1.02); C717(0.93)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C402(0.77); C404(1.21); C717(1.14)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C402(0.84); C404(1.46); C717(1.08)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C402(0.72); C404(1.35); C717(1.28)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C402(0.90); C404(1.10); C717(0.92)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C402(0.92); C404(1.38); C717(1.03)  LDD1033  [2]
 LDCM0436  CL46 HEK-293T C354(1.20); C402(0.78); C404(0.78)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C354(1.27); C402(0.90); C404(0.90)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C354(1.29); C402(0.74); C404(0.74)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C354(1.03); C402(0.92); C404(0.92)  LDD1037  [2]
 LDCM0440  CL5 HEK-293T C402(0.99); C404(0.99)  LDD1038  [2]
 LDCM0441  CL50 HEK-293T C354(1.02); C402(0.73); C404(0.73)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C354(0.93); C402(0.75); C404(0.75)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C354(1.24); C402(0.84); C404(0.84)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C354(1.11); C402(0.58); C404(0.58)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C354(0.97); C402(0.66); C404(0.66)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C354(0.98); C402(0.77); C404(0.77)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C354(1.11); C402(0.77); C404(0.77)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C354(1.10); C402(0.85); C404(0.85)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C354(0.89); C402(0.92); C404(0.92)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C354(0.92); C402(0.84); C404(0.84)  LDD1048  [2]
 LDCM0451  CL6 HEK-293T C402(0.78); C404(0.78)  LDD1049  [2]
 LDCM0452  CL60 HEK-293T C354(1.09); C402(0.76); C404(0.76)  LDD1050  [2]
 LDCM0453  CL61 HEK-293T C1156(0.91); C1050(0.88); C1244(1.09); C821(1.00)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C1050(1.19)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C1156(1.16); C1050(0.94); C821(1.04); C404(1.02)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C1156(0.91); C1050(1.22); C780(1.06); C404(1.14)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C1156(1.00); C1050(1.19); C780(0.99); C404(1.05)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C1050(1.26); C404(1.00)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C780(1.05); C404(1.09)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C1156(0.88); C1050(1.02); C404(1.02)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C1156(0.68); C1050(0.89); C821(0.81)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C402(0.95); C404(0.95)  LDD1060  [2]
 LDCM0463  CL70 HEK-293T C1050(1.01); C1244(1.18); C404(1.16)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C1156(0.90); C821(1.10)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C1156(1.18); C821(1.05); C1019(0.99)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C1156(1.01); C1050(1.00); C1244(1.18); C821(1.19)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C1050(1.04)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C404(0.99)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C404(0.97)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C404(0.93)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C404(0.90)  LDD1070  [2]
 LDCM0473  CL8 HEK-293T C402(0.54); C404(1.09)  LDD1071  [2]
 LDCM0474  CL80 HEK-293T C404(1.07)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C404(1.07)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C404(0.89)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C404(0.95)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C404(1.18)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C404(0.84)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C404(1.57)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C404(0.84)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C404(0.92)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C404(1.20)  LDD1081  [2]
 LDCM0484  CL9 HEK-293T C402(0.88); C404(1.17)  LDD1082  [2]
 LDCM0485  CL90 HEK-293T C404(0.86)  LDD1083  [2]
 LDCM0486  CL91 HCT 116 C402(1.01); C404(1.01)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C402(0.90); C404(0.90)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C402(0.87); C404(0.87)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C402(0.74); C404(0.74)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C402(0.81); C404(0.81)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C402(0.78); C404(0.78)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C402(0.76); C404(0.76)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C402(0.67); C404(0.67)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C402(0.62); C404(0.62)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C1156(0.90); C1050(1.34); C821(1.04); C404(1.19)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C1156(0.91); C1050(0.93); C821(1.15); C404(1.14)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C402(0.90); C404(1.14); C717(0.88)  LDD1025  [2]
 LDCM0022  KB02 HCT 116 C717(20.00); C721(20.00)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C717(16.10); C721(16.10)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C717(13.05); C721(13.05)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C717(1.21); C721(1.21); C402(1.11); C404(1.11)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Puratrophin-1 (PLEKHG4) . Q58EX7
Vinexin (SORBS3) . O60504

References

1 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402