Details of the Target

General Information of Target

Target ID LDTP11227
Target Name tRNA-specific adenosine deaminase 1 (ADAT1)
Gene Name ADAT1
Gene ID 23536
Synonyms
tRNA-specific adenosine deaminase 1; hADAT1; EC 3.5.4.34; tRNA-specific adenosine-37 deaminase
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MALKAEGAALDCFEVTLKCEEGEDEEEAMVVAVIPRPEPMLRVTQQEKTPPPRPSPLEAG
SDGCEEPKQQVSWEQEFLVGSSPGGSGRALCMVCGAEIRAPSADTARSHILEQHPHTLDL
SPSEKSNILEAWSEGVALLQDVRAEQPSPPNSDSGQDAHPDPDANPDAARMPAEIVVLLD
SEDNPSLPKRSRPRGLRPLELPAVPATEPGNKKPRGQRWKEPPGEEPVRKKRGRPMTKNL
DPDPEPPSPDSPTETFAAPAEVRHFTDGSFPAGFVLQLFSHTQLRGPDSKDSPKDREVAE
GGLPRAESPSPAPPPGLRGTLDLQVIRVRMEEPPAVSLLQDWSRHPQGTKRVGAGDTSDW
PTVLSESSTTVAGKPEKGNGV
Target Bioclass
Enzyme
Family
ADAT1 family
Function Specifically deaminates adenosine-37 to inosine in tRNA-Ala.
Uniprot ID
Q9BUB4
Ensemble ID
ENST00000307921.7
HGNC ID
HGNC:228

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MCC13 Substitution: p.S457F DBIA    Probe Info 
MFE319 Deletion: p.F133LfsTer39 .
SNGM SNV: p.T242I .
SW1271 SNV: p.G275R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0403  [1]
DBIA
 Probe Info  		C334(0.86)  LDD0532  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
IA-alkyne
 Probe Info  		C334(0.00); C299(0.00); C48(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
AOyne
 Probe Info  		12.50  LDD0443  [7]
NAIA_5
 Probe Info  		C48(0.00); C70(0.00); C349(0.00); C263(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C186(1.18); C48(1.05); C233(1.10)  LDD1507  [8]
 LDCM0215  AC10 HCT 116 C334(0.86)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C334(0.68)  LDD0543  [2]
 LDCM0230  AC113 HEK-293T C334(1.00)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C334(0.88)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C334(1.53)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C334(0.84)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C334(0.83)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C334(1.06)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C334(1.07)  LDD0834  [2]
 LDCM0237  AC12 HCT 116 C334(0.94)  LDD0554  [2]
 LDCM0238  AC120 HEK-293T C334(1.00)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C334(1.15)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C334(1.57)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C334(1.36)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C334(1.13)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C334(1.04)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C334(1.08)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C334(1.27)  LDD0843  [2]
 LDCM0246  AC128 HEK-293T C334(0.57)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C334(0.85)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C334(0.64)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C334(0.55)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C334(0.91)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C334(0.92)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C334(0.84)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C334(0.77)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C334(0.83)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C334(1.02)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C334(1.52)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C334(0.80)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C334(0.56)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C334(0.83)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C334(1.04)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C334(0.80)  LDD0860  [2]
 LDCM0270  AC15 HCT 116 C334(0.84)  LDD0587  [2]
 LDCM0276  AC17 HCT 116 C334(1.89)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C334(0.91)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C334(0.96)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C186(1.18); C48(1.15); C233(1.34); C263(1.25)  LDD1518  [8]
 LDCM0280  AC20 HCT 116 C334(20.00)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C334(1.70)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C334(1.47)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C334(1.02)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C334(1.57)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C334(2.25)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C334(1.13)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C334(1.32)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C334(0.99)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C334(1.11)  LDD0606  [2]
 LDCM0290  AC3 HEK-293T C186(1.12); C48(1.07); C299(0.98); C394(0.92)  LDD1529  [8]
 LDCM0291  AC30 HCT 116 C334(0.89)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C334(1.20)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C334(0.52)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C334(0.78)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C334(0.47)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C334(1.25)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C334(2.39)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C334(3.30)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C334(1.22)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C334(1.13)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C186(1.20); C48(1.03); C233(1.21)  LDD1540  [8]
 LDCM0302  AC40 HCT 116 C334(0.99)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C334(1.03)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C334(0.88)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C334(0.73)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C334(1.35)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C334(0.60)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C334(0.63)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C334(0.68)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C334(1.37)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C334(0.78)  LDD0628  [2]
 LDCM0312  AC5 HEK-293T C186(1.07); C48(0.96)  LDD1551  [8]
 LDCM0313  AC50 HCT 116 C334(0.54)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C334(1.70)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C334(0.60)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C334(0.47)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C334(0.48)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C334(0.58)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C334(0.65)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C334(1.01)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C334(1.22)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C334(1.15)  LDD0920  [2]
 LDCM0323  AC6 HCT 116 C334(0.64)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C334(1.13)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C334(1.38)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C334(1.24)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C334(1.27)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C334(1.12)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C334(1.17)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C334(1.22)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C334(1.19)  LDD0929  [2]
 LDCM0332  AC68 HCT 116 C334(0.52)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C334(0.52)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C334(0.73)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C334(0.42)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C334(0.72)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C334(0.76)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C334(0.62)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C334(0.49)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C334(0.60)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C334(0.52)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C334(0.67)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C334(0.79)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C334(1.27)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C334(0.87)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C334(0.70)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C334(0.64)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C334(0.54)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C334(0.28)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C334(0.27)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C334(0.37)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C334(0.73)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C334(0.44)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C334(0.85)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C334(0.43)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C334(1.36)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C334(0.30)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C334(0.27)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C334(0.62)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C334(0.51)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C334(0.38)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C334(0.35)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C334(0.40)  LDD0681  [2]
 LDCM0248  AKOS034007472 HCT 116 C334(1.04)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C334(0.92)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C334(0.34)  LDD0592  [2]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C48(1.62); C186(1.35); C263(0.66); C394(0.64)  LDD2227  [5]
 LDCM0367  CL1 HEK-293T C186(0.93); C48(0.84)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C186(1.05); C48(0.83); C334(1.13)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C186(1.14); C48(0.94)  LDD1573  [8]
 LDCM0370  CL101 HCT 116 C334(0.63)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C334(0.65)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C334(1.20)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C334(0.88)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C334(0.83)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C334(0.33)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C334(0.51)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C334(0.52)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C334(0.65)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C48(0.95); C233(0.97)  LDD1583  [8]
 LDCM0380  CL110 HCT 116 C334(0.55)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C334(0.85)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C334(1.14)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C334(0.61)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C334(1.27)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C334(0.90)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C334(1.21)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C334(0.69)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C334(0.79)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C334(0.83)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C186(0.90); C48(1.09)  LDD1594  [8]
 LDCM0391  CL120 HCT 116 C334(1.31)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C334(0.65)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C334(0.51)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C334(0.53)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C334(0.77)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C334(1.25)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C334(1.37)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C334(0.96)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C334(0.99)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C186(1.33); C48(0.84)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C186(1.19); C48(1.08); C233(1.05)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C186(1.06); C48(0.80); C233(1.23); C299(1.07)  LDD1606  [8]
 LDCM0403  CL16 PaTu 8988t C334(0.91)  LDD1282  [2]
 LDCM0404  CL17 PaTu 8988t C334(0.95)  LDD1283  [2]
 LDCM0405  CL18 PaTu 8988t C334(1.00)  LDD1284  [2]
 LDCM0406  CL19 PaTu 8988t C334(1.85)  LDD1285  [2]
 LDCM0407  CL2 HEK-293T C186(1.17); C48(1.07); C233(1.02)  LDD1611  [8]
 LDCM0408  CL20 PaTu 8988t C334(1.14)  LDD1287  [2]
 LDCM0409  CL21 PaTu 8988t C334(0.67)  LDD1288  [2]
 LDCM0410  CL22 PaTu 8988t C334(0.82)  LDD1289  [2]
 LDCM0411  CL23 PaTu 8988t C334(0.68)  LDD1290  [2]
 LDCM0412  CL24 PaTu 8988t C334(1.62)  LDD1291  [2]
 LDCM0413  CL25 PaTu 8988t C334(0.70)  LDD1292  [2]
 LDCM0414  CL26 PaTu 8988t C334(0.69)  LDD1293  [2]
 LDCM0415  CL27 PaTu 8988t C334(0.67)  LDD1294  [2]
 LDCM0416  CL28 PaTu 8988t C334(1.03)  LDD1295  [2]
 LDCM0417  CL29 PaTu 8988t C334(1.00)  LDD1296  [2]
 LDCM0418  CL3 HEK-293T C186(1.21); C48(0.92); C233(1.12); C299(0.93)  LDD1622  [8]
 LDCM0419  CL30 PaTu 8988t C334(1.17)  LDD1298  [2]
 LDCM0420  CL31 HCT 116 C334(0.78)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C334(0.43)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C334(0.45)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C334(0.40)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C334(0.37)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C334(0.51)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C334(0.48)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C334(0.40)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C186(1.10); C48(0.97)  LDD1633  [8]
 LDCM0430  CL40 HCT 116 C334(0.52)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C334(0.49)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C334(0.65)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C334(0.48)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C334(0.49)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C334(0.38)  LDD0752  [2]
 LDCM0436  CL46 PaTu 8988t C334(0.60)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C334(0.70)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C334(0.51)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C334(0.70)  LDD1318  [2]
 LDCM0440  CL5 HEK-293T C186(1.07); C48(1.03); C233(1.07)  LDD1644  [8]
 LDCM0441  CL50 PaTu 8988t C334(0.56)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C334(0.64)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C334(0.57)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C334(0.53)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C334(0.49)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C334(0.53)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C334(0.63)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C334(0.94)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C334(0.42)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C334(0.61)  LDD1329  [2]
 LDCM0451  CL6 HEK-293T C186(1.08); C48(1.06); C233(1.19); C263(1.73)  LDD1654  [8]
 LDCM0452  CL60 PaTu 8988t C334(1.76)  LDD1331  [2]
 LDCM0453  CL61 PaTu 8988t C334(0.81)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C334(0.34)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C334(0.62)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C334(0.56)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C334(0.89)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C334(0.58)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C334(0.61)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C334(0.56)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C334(0.40)  LDD1340  [2]
 LDCM0462  CL7 HEK-293T C186(1.08); C48(1.01); C299(1.00); C394(1.24)  LDD1665  [8]
 LDCM0463  CL70 PaTu 8988t C334(0.82)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C334(0.66)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C334(1.00)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C334(0.31)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C334(0.84)  LDD1346  [2]
 LDCM0469  CL76 PaTu 8988t C334(1.33)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C334(1.16)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C334(1.14)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C334(2.44)  LDD1351  [2]
 LDCM0473  CL8 HEK-293T C186(0.90); C48(0.83); C233(0.89)  LDD1676  [8]
 LDCM0474  CL80 PaTu 8988t C334(1.16)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C334(1.00)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C334(1.14)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C334(1.14)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C334(0.96)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C334(1.71)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C334(1.04)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C334(0.95)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C334(0.79)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C334(1.13)  LDD1362  [2]
 LDCM0484  CL9 HEK-293T C186(1.00); C48(0.80)  LDD1687  [8]
 LDCM0485  CL90 PaTu 8988t C334(1.03)  LDD1364  [2]
 LDCM0486  CL91 HEK-293T C186(1.04); C48(0.84); C299(1.18); C394(1.17)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C186(1.09); C48(1.09); C233(1.11)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C186(1.06); C48(0.80)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C186(0.97); C48(0.99); C334(1.11)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C48(0.81); C233(0.86)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C186(1.06); C48(1.15)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C186(1.03); C48(0.96)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C186(1.12); C48(0.92); C233(1.14)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C186(1.10); C48(0.92); C233(0.95); C299(1.02)  LDD1697  [8]
 LDCM0634  CY-0357 Hep-G2 C263(0.65)  LDD2228  [5]
 LDCM0495  E2913 HEK-293T C186(1.14); C48(0.94); C233(0.99); C299(1.02)  LDD1698  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C48(1.26)  LDD1702  [9]
 LDCM0468  Fragment33 PaTu 8988t C334(0.43)  LDD1347  [2]
 LDCM0427  Fragment51 HCT 116 C334(0.46)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C186(1.15); C48(1.10)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C186(0.95); C48(0.96)  LDD1497  [8]
 LDCM0024  KB05 UACC257 C263(1.63)  LDD3325  [10]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840