Details of the Target

General Information of Target

Target ID LDTP11202
Target Name Immediate early response gene 2 protein (IER2)
Gene Name IER2
Gene ID 9592
Synonyms
ETR101; PIP92; Immediate early response gene 2 protein; Protein ETR101
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTDTAEAVPKFEEMFASRFTENDKEYQEYLKRPPESPPIVEEWNSRAGGNQRNRGNRLQD
NRQFRGRDNRWGWPSDNRSNQWHGRSWGNNYPQHRQEPYYPQQYGHYGYNQRPPYGYY
Target Bioclass
Other
Family
IER family
Subcellular location
Cytoplasm
Function
DNA-binding protein that seems to act as a transcription factor. Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells. May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo. Promotes cell motility, seems to stimulate tumor metastasis.
Uniprot ID
Q9BTL4
Ensemble ID
ENST00000292433.4
HGNC ID
HGNC:28871

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C188(1.21); C200(1.21)  LDD0531  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C188(1.21); C200(1.21)  LDD0531  [1]
 LDCM0216  AC100 HCT 116 C188(1.34); C200(1.34)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C188(1.26); C200(1.26)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C188(1.11); C200(1.11)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C188(1.46); C200(1.46)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C188(1.04); C200(1.04)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C188(1.84); C200(1.84)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C188(1.88); C200(1.88)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C188(1.35); C200(1.35)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C188(1.19); C200(1.19)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C188(1.06); C200(1.06)  LDD0542  [1]
 LDCM0227  AC110 HCT 116 C188(1.40); C200(1.40)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C188(1.23); C200(1.23)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C188(1.44); C200(1.44)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C188(0.86); C200(0.86)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C188(0.94); C200(0.94)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C188(1.48); C200(1.48)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C188(1.08); C200(1.08)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C188(1.11); C200(1.11)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C188(0.87); C200(0.87)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C188(0.97); C200(0.97)  LDD0553  [1]
 LDCM0238  AC120 HCT 116 C188(0.97); C200(0.97)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C188(0.95); C200(0.95)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C188(1.08); C200(1.08)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C188(0.96); C200(0.96)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C188(0.92); C200(0.92)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C188(0.98); C200(0.98)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C188(0.94); C200(0.94)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C188(1.23); C200(1.23)  LDD0562  [1]
 LDCM0279  AC2 HCT 116 C188(0.77); C200(0.77)  LDD0596  [1]
 LDCM0285  AC25 HCT 116 C188(0.98); C200(0.98)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C188(0.97); C200(0.97)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C188(1.18); C200(1.18)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C188(1.24); C200(1.24)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C188(1.06); C200(1.06)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C188(0.98); C200(0.98)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C188(1.22); C200(1.22)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C188(1.12); C200(1.12)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C188(1.17); C200(1.17)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C188(1.01); C200(1.01)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C188(1.26); C200(1.26)  LDD0612  [1]
 LDCM0301  AC4 HCT 116 C188(1.13); C200(1.13)  LDD0618  [1]
 LDCM0312  AC5 HCT 116 C188(1.32); C200(1.32)  LDD0629  [1]
 LDCM0349  AC83 HCT 116 C188(0.88); C200(0.88)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C188(0.86); C200(0.86)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C188(0.83); C200(0.83)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C188(0.90); C200(0.90)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C188(0.88); C200(0.88)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C188(0.99); C200(0.99)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C188(0.95); C200(0.95)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C188(0.93); C200(0.93)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C188(0.88); C200(0.88)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C188(0.87); C200(0.87)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C188(0.85); C200(0.85)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C188(0.80); C200(0.80)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C188(0.94); C200(0.94)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C188(0.88); C200(0.88)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C188(0.93); C200(0.93)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C188(1.60); C200(1.60)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C188(1.09); C200(1.09)  LDD0683  [1]
 LDCM0369  CL100 HCT 116 C188(1.09); C200(1.09)  LDD0686  [1]
 LDCM0382  CL112 HCT 116 C188(0.88); C200(0.88)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C188(1.27); C200(1.27)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C188(0.97); C200(0.97)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C188(0.92); C200(0.92)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C188(1.01); C200(1.01)  LDD0703  [1]
 LDCM0403  CL16 HCT 116 C188(1.14); C200(1.14)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C188(1.20); C200(1.20)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C188(1.39); C200(1.39)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C188(1.26); C200(1.26)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C188(1.48); C200(1.48)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C188(1.49); C200(1.49)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C188(1.53); C200(1.53)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C188(1.39); C200(1.39)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C188(1.46); C200(1.46)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C188(1.31); C200(1.31)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C188(1.37); C200(1.37)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C188(1.10); C200(1.10)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C188(1.23); C200(1.23)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C188(1.08); C200(1.08)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C188(1.37); C200(1.37)  LDD0736  [1]
 LDCM0421  CL32 HCT 116 C188(1.08); C200(1.08)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C188(1.39); C200(1.39)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C188(0.89); C200(0.89)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C188(0.95); C200(0.95)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C188(0.93); C200(0.93)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C188(1.02); C200(1.02)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C188(1.15); C200(1.15)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C188(0.83); C200(0.83)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C188(1.03); C200(1.03)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C188(1.00); C200(1.00)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C188(1.00); C200(1.00)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C188(0.96); C200(0.96)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C188(1.01); C200(1.01)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C188(0.64); C200(0.64)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C188(0.47); C200(0.47)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C188(1.09); C200(1.09)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C188(0.81); C200(0.81)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C188(0.52); C200(0.52)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C188(0.63); C200(0.63)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C188(0.75); C200(0.75)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C188(0.75); C200(0.75)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C188(0.47); C200(0.47)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C188(0.51); C200(0.51)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C188(0.61); C200(0.61)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C188(0.48); C200(0.48)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C188(0.64); C200(0.64)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C188(0.78); C200(0.78)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C188(0.63); C200(0.63)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C188(1.10); C200(1.10)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C188(0.99); C200(0.99)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C188(1.22); C200(1.22)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C188(1.76); C200(1.76)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C188(1.19); C200(1.19)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C188(1.65); C200(1.65)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C188(1.20); C200(1.20)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C188(1.23); C200(1.23)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C188(0.98); C200(0.98)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C188(1.62); C200(1.62)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C188(1.18); C200(1.18)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C188(1.04); C200(1.04)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C188(1.03); C200(1.03)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C188(1.55); C200(1.55)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C188(0.79); C200(0.79)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C188(0.88); C200(0.88)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C188(0.96); C200(0.96)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C188(0.84); C200(0.84)  LDD0789  [1]
 LDCM0474  CL80 HCT 116 C188(0.93); C200(0.93)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C188(0.81); C200(0.81)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C188(0.86); C200(0.86)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C188(0.89); C200(0.89)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C188(0.84); C200(0.84)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C188(0.98); C200(0.98)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C188(0.82); C200(0.82)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C188(0.77); C200(0.77)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C188(0.79); C200(0.79)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C188(0.80); C200(0.80)  LDD0800  [1]
 LDCM0485  CL90 HCT 116 C188(0.37); C200(0.37)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C188(0.74); C200(0.74)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C188(0.65); C200(0.65)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C188(0.68); C200(0.68)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C188(0.67); C200(0.67)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C188(0.50); C200(0.50)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C188(0.80); C200(0.80)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C188(1.04); C200(1.04)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C188(1.00); C200(1.00)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C188(0.91); C200(0.91)  LDD0811  [1]
 LDCM0468  Fragment33 HCT 116 C188(1.01); C200(1.01)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C188(0.97); C200(0.97)  LDD0744  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.