Details of the Target

General Information of Target

Target ID LDTP10880
Target Name GAS2-like protein 1 (GAS2L1)
Gene Name GAS2L1
Gene ID 10634
Synonyms
GAR22; GAS2-like protein 1; GAS2-related protein on chromosome 22; Growth arrest-specific protein 2-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMV
LIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFV
ALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLH
NLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMA
LLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTL
ASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAP
SSCIMDKNAALQNGIFCN
Target Bioclass
Other
Family
GAS2 family
Subcellular location
Cytoplasm, cytoskeleton
Function
Involved in the cross-linking of microtubules and microfilaments. Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers.
Uniprot ID
Q99501
Ensemble ID
ENST00000406549.7
HGNC ID
HGNC:16955

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C577(1.02)  LDD0078  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		C139(0.00); C110(0.00); C276(0.00)  LDD0166  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
IPM
 Probe Info  		C577(0.00); C289(0.00)  LDD0147  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C577(1.14)  LDD0531  [1]
 LDCM0216  AC100 HCT 116 C577(0.51)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C577(1.52)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C577(0.72)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C577(2.69)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C577(0.83)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C577(1.02)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C577(1.57)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C577(0.99)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C577(1.16)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C577(1.20)  LDD0542  [1]
 LDCM0227  AC110 HCT 116 C577(0.99)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C577(0.78)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C577(0.51)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C219(1.00); C221(1.00)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C219(0.99); C221(0.99)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C219(1.11); C221(1.11)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C219(0.91); C221(0.91)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C219(0.88); C221(0.88)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C219(0.82); C221(0.82)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C219(0.93); C221(0.93)  LDD0553  [1]
 LDCM0238  AC120 HCT 116 C219(0.90); C221(0.90)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C219(0.93); C221(0.93)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C219(1.04); C221(1.04)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C219(0.75); C221(0.75)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C219(0.87); C221(0.87)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C219(1.02); C221(1.02)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C219(0.87); C221(0.87)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C219(0.83); C221(0.83)  LDD0562  [1]
 LDCM0263  AC143 HCT 116 C219(0.78); C221(0.78)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C219(0.76); C221(0.76)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C219(0.68); C221(0.68)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C219(0.92); C221(0.92)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C219(0.83); C221(0.83)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C219(1.02); C221(1.02)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C219(0.95); C221(0.95)  LDD0586  [1]
 LDCM0271  AC150 HCT 116 C219(0.74); C221(0.74)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C219(0.81); C221(0.81)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C219(0.83); C221(0.83)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C219(1.00); C221(1.00)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C219(0.97); C221(0.97)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C219(0.88); C221(0.88)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C219(0.89); C221(0.89)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C219(0.86); C221(0.86)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C577(0.88)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C577(1.09)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C577(1.08)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C577(1.25)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C577(0.93)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C577(0.76)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C577(1.02)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C577(1.01)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C577(0.79)  LDD0601  [1]
 LDCM0285  AC25 HEK-293T C289(0.84)  LDD1524  [6]
 LDCM0290  AC3 HCT 116 C577(1.14)  LDD0607  [1]
 LDCM0294  AC33 HEK-293T C289(0.84)  LDD1533  [6]
 LDCM0296  AC35 HCT 116 C219(0.99); C221(0.99)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C219(1.19); C221(1.19)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C219(1.11); C221(1.11)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C219(1.16); C221(1.16)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C219(1.02); C221(1.02)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C577(1.19)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C219(1.12); C221(1.12)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C219(1.12); C221(1.12)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C219(1.07); C221(1.07)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C219(1.06); C221(1.06)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C219(1.16); C221(1.16)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C219(1.22); C221(1.22)  LDD0624  [1]
 LDCM0308  AC46 PaTu 8988t C219(1.05); C221(1.05)  LDD1187  [1]
 LDCM0309  AC47 PaTu 8988t C219(0.92); C221(0.92)  LDD1188  [1]
 LDCM0310  AC48 PaTu 8988t C219(0.93); C221(0.93)  LDD1189  [1]
 LDCM0311  AC49 PaTu 8988t C219(0.88); C221(0.88)  LDD1190  [1]
 LDCM0312  AC5 HCT 116 C577(1.14)  LDD0629  [1]
 LDCM0313  AC50 PaTu 8988t C219(0.91); C221(0.91)  LDD1192  [1]
 LDCM0314  AC51 PaTu 8988t C219(0.79); C221(0.79)  LDD1193  [1]
 LDCM0315  AC52 PaTu 8988t C219(0.84); C221(0.84)  LDD1194  [1]
 LDCM0316  AC53 PaTu 8988t C219(1.12); C221(1.12)  LDD1195  [1]
 LDCM0317  AC54 PaTu 8988t C219(1.04); C221(1.04)  LDD1196  [1]
 LDCM0318  AC55 PaTu 8988t C219(0.90); C221(0.90)  LDD1197  [1]
 LDCM0319  AC56 PaTu 8988t C219(0.96); C221(0.96)  LDD1198  [1]
 LDCM0320  AC57 HCT 116 C219(0.87); C221(0.87)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C219(0.98); C221(0.98)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C219(0.91); C221(0.91)  LDD0639  [1]
 LDCM0324  AC60 HCT 116 C219(0.75); C221(0.75)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C219(0.94); C221(0.94)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C219(0.85); C221(0.85)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C219(0.67); C221(0.67)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C219(0.74); C221(0.74)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C219(0.94); C221(0.94)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C219(0.94); C221(0.94)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C219(0.85); C221(0.85)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C577(0.78)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C577(1.73)  LDD0650  [1]
 LDCM0335  AC70 HCT 116 C577(2.77)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C577(0.76)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C577(1.48)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C577(2.76)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C577(1.72)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C577(5.66)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C577(2.14)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C577(2.14)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C577(1.72)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C577(1.30)  LDD0661  [1]
 LDCM0346  AC80 HCT 116 C577(2.50)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C577(1.19)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C577(3.90)  LDD0665  [1]
 LDCM0365  AC98 HCT 116 C577(20.00)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C577(0.55)  LDD0683  [1]
 LDCM0356  AKOS034007680 HEK-293T C289(1.03)  LDD1570  [6]
 LDCM0020  ARS-1620 HCC44 C577(1.02)  LDD0078  [1]
 LDCM0632  CL-Sc Hep-G2 C276(0.46)  LDD2227  [4]
 LDCM0369  CL100 HCT 116 C577(1.04)  LDD0686  [1]
 LDCM0374  CL105 HCT 116 C577(0.58)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C577(1.07)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C577(0.78)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C577(0.93)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C577(0.84)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C577(0.69)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C577(0.94)  LDD0698  [1]
 LDCM0387  CL117 HCT 116 C219(1.30); C221(1.30)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C219(1.05); C221(1.05)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C219(1.10); C221(1.10)  LDD0706  [1]
 LDCM0391  CL120 HCT 116 C219(1.05); C221(1.05)  LDD0708  [1]
 LDCM0392  CL121 PaTu 8988t C219(0.96); C221(0.96)  LDD1271  [1]
 LDCM0393  CL122 PaTu 8988t C219(0.91); C221(0.91)  LDD1272  [1]
 LDCM0394  CL123 PaTu 8988t C219(0.96); C221(0.96)  LDD1273  [1]
 LDCM0395  CL124 PaTu 8988t C219(0.81); C221(0.81)  LDD1274  [1]
 LDCM0396  CL125 HCT 116 C219(0.78); C221(0.78)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C219(0.81); C221(0.81)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C219(0.82); C221(0.82)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C219(0.89); C221(0.89)  LDD0716  [1]
 LDCM0403  CL16 HCT 116 C219(0.86); C221(0.86)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C219(0.82); C221(0.82)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C219(0.78); C221(0.78)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C219(0.80); C221(0.80)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C219(0.86); C221(0.86)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C219(0.88); C221(0.88)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C219(1.10); C221(1.10)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C219(0.83); C221(0.83)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C219(0.86); C221(0.86)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C219(0.86); C221(0.86)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C219(0.76); C221(0.76)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C219(0.88); C221(0.88)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C219(0.82); C221(0.82)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C219(0.77); C221(0.77)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C219(0.82); C221(0.82)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C219(0.84); C221(0.84)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C219(0.73); C221(0.73)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C219(0.80); C221(0.80)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C219(0.88); C221(0.88)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C219(0.82); C221(0.82)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C219(0.99); C221(0.99)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C219(0.93); C221(0.93)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C219(0.83); C221(0.83)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C219(0.79); C221(0.79)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C219(0.79); C221(0.79)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C219(0.99); C221(0.99)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C219(0.83); C221(0.83)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C219(0.84); C221(0.84)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C219(0.89); C221(0.89)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C219(1.46); C221(1.46)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C219(1.25); C221(1.25)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C219(1.22); C221(1.22)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C219(1.46); C221(1.46)  LDD0756  [1]
 LDCM0440  CL5 HEK-293T C289(0.97)  LDD1644  [6]
 LDCM0441  CL50 HCT 116 C219(1.34); C221(1.34)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C219(1.34); C221(1.34)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C219(1.19); C221(1.19)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C219(1.04); C221(1.04)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C219(0.87); C221(0.87)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C219(1.30); C221(1.30)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C219(1.02); C221(1.02)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C219(1.35); C221(1.35)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C219(0.98); C221(0.98)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C219(1.07); C221(1.07)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C219(1.22); C221(1.22)  LDD0769  [1]
 LDCM0457  CL65 HEK-293T C289(1.30)  LDD1660  [6]
 LDCM0470  CL77 HEK-293T C289(1.21)  LDD1673  [6]
 LDCM0483  CL89 HEK-293T C289(0.93)  LDD1686  [6]
 LDCM0486  CL91 HCT 116 C577(0.83)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C577(0.92)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C577(0.93)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C577(0.99)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C577(0.89)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C577(1.00)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C577(1.18)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C577(1.07)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C577(0.93)  LDD0811  [1]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C289(1.23)  LDD1702  [7]
 LDCM0427  Fragment51 HCT 116 C219(0.89); C221(0.89)  LDD0744  [1]
 LDCM0022  KB02 786-O C289(2.51)  LDD2247  [8]
 LDCM0023  KB03 Jurkat C577(11.83)  LDD0209  [9]
 LDCM0024  KB05 MKN-1 C289(2.42)  LDD3331  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein-signaling modulator 2 (GPSM2) GPSM family P81274

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.