Details of the Target

General Information of Target

Target ID LDTP10554
Target Name DnaJ homolog subfamily C member 30, mitochondrial (DNAJC30)
Gene Name DNAJC30
Gene ID 84277
Synonyms
WBSCR18; DnaJ homolog subfamily C member 30, mitochondrial; Williams-Beuren syndrome chromosomal region 18 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
Download
Sequence
MAICPELAQTDKSALANLSDETETLKNSTDEVQTSSSFSSSGGRQSSPLTSGSKLEREKQ
TPSLEQGDTQSELLDYKNYEKKLSKKWINYLKLKDSNFERHQPDTKLPTEITRVSDEELN
ALQSYCTMKINLIHRRGDSKKKTSSRHKKLHLGLDVEASERDAFSCTVPDELLNRIYFKN
MRTTPKQEAAAKQHISYQCPYCNRKRAELALSAFLKQKKTLLESFLLQERIDEHLHTKDF
LTRIGEAHQDFPRLSDDPRIIWKRLTEKSHIRYSGFERSETEQKLQRDGNSACHLPFSLP
FLKRLTLIKPELVIVNDNV
Target Bioclass
Other
Subcellular location
Mitochondrion inner membrane
Function
Mitochondrial protein enriched in neurons that acts as a regulator of mitochondrial respiration. Associates with the ATP synthase complex and facilitates ATP synthesis. May be a chaperone protein involved in the turnover of the subunits of mitochondrial complex I N-module. It facilitates the degradation of N-module subunits damaged by oxidative stress, and contributes to complex I functional efficiency.
Uniprot ID
Q96LL9
Ensemble ID
ENST00000395176.3
HGNC ID
HGNC:16410

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C43(20.00)  LDD2227  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
DBIA
 Probe Info  		C43(1.18)  LDD0078  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [2]
Methacrolein
 Probe Info  		N.A.  LDD0218  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C43(0.95)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C43(0.94)  LDD0813  [3]
 LDCM0216  AC100 HCT 116 C43(1.57)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C43(1.01)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C43(1.23)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C43(1.27)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C43(1.16)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C43(1.35)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C43(1.82)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C43(1.21)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C43(1.20)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C43(0.85)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C43(0.68)  LDD0824  [3]
 LDCM0227  AC110 HCT 116 C43(1.22)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C43(2.06)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C43(1.21)  LDD0546  [3]
 LDCM0230  AC113 HEK-293T C43(1.15)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C43(1.11)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C43(0.77)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C43(1.65)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C43(1.10)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C43(1.27)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C43(1.39)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C43(1.07)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C43(1.29)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C43(1.49)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C43(1.61)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C43(2.23)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C43(1.25)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C43(3.32)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C43(1.98)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C43(2.38)  LDD0843  [3]
 LDCM0259  AC14 HEK-293T C43(1.07)  LDD0857  [3]
 LDCM0263  AC143 HEK-293T C43(1.02)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C43(1.06)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C43(1.19)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C43(0.90)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C43(0.97)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C43(0.89)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C43(0.76)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C43(0.95)  LDD0868  [3]
 LDCM0271  AC150 HEK-293T C43(0.87)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C43(1.40)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C43(0.82)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C43(1.10)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C43(0.82)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C43(1.33)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C43(1.10)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C43(0.78)  LDD2165  [3]
 LDCM0279  AC2 HEK-293T C43(1.15)  LDD0877  [3]
 LDCM0285  AC25 HCT 116 C43(1.16)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C43(1.34)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C43(1.35)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C43(1.51)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C43(1.35)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C43(0.84)  LDD0888  [3]
 LDCM0291  AC30 HCT 116 C43(1.80)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C43(1.47)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C43(1.77)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C43(1.44)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C43(1.68)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C43(0.81)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C43(0.45)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C43(0.39)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C43(0.65)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C43(0.67)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C43(1.11)  LDD0899  [3]
 LDCM0302  AC40 HCT 116 C43(0.71)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C43(0.57)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C43(0.89)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C43(0.82)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C43(0.78)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C43(1.09)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C43(0.94)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C43(1.57)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C43(1.02)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C43(1.36)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C43(1.00)  LDD0910  [3]
 LDCM0313  AC50 HCT 116 C43(1.31)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C43(0.86)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C43(1.17)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C43(1.39)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C43(1.62)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C43(1.92)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C43(1.94)  LDD0636  [3]
 LDCM0323  AC6 HEK-293T C43(0.90)  LDD0921  [3]
 LDCM0332  AC68 HCT 116 C43(1.27)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C43(0.97)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C43(0.80)  LDD0932  [3]
 LDCM0335  AC70 HCT 116 C43(1.11)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C43(1.05)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C43(0.94)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C43(1.56)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C43(1.43)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C43(1.70)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C43(0.93)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C43(1.37)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C43(1.21)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C43(1.03)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C43(0.74)  LDD0943  [3]
 LDCM0346  AC80 HCT 116 C43(1.49)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C43(1.31)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C43(1.43)  LDD0665  [3]
 LDCM0365  AC98 HCT 116 C43(0.87)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C43(1.44)  LDD0683  [3]
 LDCM0248  AKOS034007472 HEK-293T C43(1.05)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C43(0.98)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C43(1.09)  LDD0873  [3]
 LDCM0020  ARS-1620 HCC44 C43(1.18)  LDD0078  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0632  CL-Sc Hep-G2 C43(20.00)  LDD2227  [1]
 LDCM0369  CL100 HEK-293T C43(0.90)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C43(1.19)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C43(0.87)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C43(1.23)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C43(0.93)  LDD0971  [3]
 LDCM0376  CL107 HEK-293T C73(0.96)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C73(1.13)  LDD1581  [5]
 LDCM0381  CL111 HEK-293T C73(0.93)  LDD1585  [5]
 LDCM0382  CL112 HCT 116 C43(1.03)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C43(1.65)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C43(1.45)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C43(1.52)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C43(1.61)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C43(0.92)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C43(0.79)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C43(0.92)  LDD0706  [3]
 LDCM0391  CL120 HCT 116 C43(0.58)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C43(0.66)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C43(0.89)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C43(2.26)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C43(1.48)  LDD0712  [3]
 LDCM0398  CL127 HEK-293T C73(0.97)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C73(1.09)  LDD1603  [5]
 LDCM0402  CL15 HEK-293T C73(1.00)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C43(1.29)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C43(1.24)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C43(1.22)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C43(1.32)  LDD1004  [3]
 LDCM0408  CL20 HEK-293T C43(1.34)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C43(1.40)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C43(1.59)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C43(1.05)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C43(1.17)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C43(1.18)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C43(1.35)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C43(1.44)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C43(1.22)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C43(1.26)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C73(0.90)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C43(1.42)  LDD1017  [3]
 LDCM0420  CL31 HCT 116 C43(1.00)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C43(0.94)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C43(1.05)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C43(0.96)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C43(0.98)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C43(1.05)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C43(0.97)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C43(0.74)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C73(1.17)  LDD1633  [5]
 LDCM0430  CL40 HCT 116 C43(0.90)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C43(1.03)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C43(0.81)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C43(0.81)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C43(0.88)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C43(1.12)  LDD0752  [3]
 LDCM0443  CL52 HEK-293T C73(1.03)  LDD1646  [5]
 LDCM0453  CL61 HEK-293T C43(0.88)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C43(0.91)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C43(0.81)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C43(0.99)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C43(1.02)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C43(1.03)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C43(1.11)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C43(0.82)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C43(1.04)  LDD1059  [3]
 LDCM0463  CL70 HEK-293T C43(0.94)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C43(1.01)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C43(1.03)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C43(1.04)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C43(1.16)  LDD1065  [3]
 LDCM0469  CL76 HCT 116 C43(1.08)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C43(1.43)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C43(0.85)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C43(1.16)  LDD0789  [3]
 LDCM0474  CL80 HCT 116 C43(1.21)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C43(0.67)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C43(0.90)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C43(0.89)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C43(1.26)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C43(1.25)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C43(1.11)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C43(0.91)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C43(1.13)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C43(1.04)  LDD0800  [3]
 LDCM0485  CL90 HCT 116 C43(1.43)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C43(0.70)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C43(0.82)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C43(0.74)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C43(0.84)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C43(0.96)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C43(1.04)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C43(0.78)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C43(1.02)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C43(1.20)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C73(0.89)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C43(0.98)  LDD1066  [3]
 LDCM0427  Fragment51 HCT 116 C43(1.04)  LDD0744  [3]
 LDCM0022  KB02 HEK-293T C73(1.14)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C73(1.13)  LDD1497  [5]
 LDCM0024  KB05 HMCB C73(1.55)  LDD3312  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
rRNA methyltransferase 1, mitochondrial (MRM1) RNA methyltransferase TrmH family Q6IN84
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Microsomal glutathione S-transferase 2 (MGST2) MAPEG family Q99735
Methylsterol monooxygenase 1 (MSMO1) Sterol desaturase family Q15800
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bestrophin-2 (BEST2) Anion channel-forming bestrophin family Q8NFU1
Sodium/bile acid cotransporter 4 (SLC10A4) Bile acid:sodium symporter (BASS) family Q96EP9
Hippocampus abundant transcript-like protein 1 (MFSD14B) Major facilitator superfamily Q5SR56
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Organic solute transporter subunit alpha (SLC51A) OST-alpha family Q86UW1
Peroxisome assembly protein 12 (PEX12) Pex2/pex10/pex12 family O00623
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sialic acid-binding Ig-like lectin 12 (SIGLEC12) SIGLEC (sialic acid binding Ig-like lectin) family Q96PQ1
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Calcium-binding protein 8 (CALN1) . Q9BXU9
Fetal and adult testis-expressed transcript protein (FATE1) . Q969F0
Leucine-rich repeat-containing protein 25 (LRRC25) . Q8N386
Protein KASH5 (KASH5) . Q8N6L0
Transmembrane protein 52B (TMEM52B) . Q4KMG9

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840